SG10201502759TA - Raav-guanylate cyclase compositions and methods for treating leber's congenital amaurosis-1 (lca1) - Google Patents

Raav-guanylate cyclase compositions and methods for treating leber's congenital amaurosis-1 (lca1)

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Publication number
SG10201502759TA
SG10201502759TA SG10201502759TA SG10201502759TA SG10201502759TA SG 10201502759T A SG10201502759T A SG 10201502759TA SG 10201502759T A SG10201502759T A SG 10201502759TA SG 10201502759T A SG10201502759T A SG 10201502759TA SG 10201502759T A SG10201502759T A SG 10201502759TA
Authority
SG
Singapore
Prior art keywords
lca1
raav
methods
guanylate cyclase
congenital amaurosis
Prior art date
Application number
SG10201502759TA
Inventor
Shannon Elizabeth Boye
William W Hauswirth
Sanford Leon Boye
Original Assignee
Univ Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida filed Critical Univ Florida
Publication of SG10201502759TA publication Critical patent/SG10201502759TA/en

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P27/02Ophthalmic agents
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12Y406/00Phosphorus-oxygen lyases (4.6)
    • C12Y406/01Phosphorus-oxygen lyases (4.6.1)
    • C12Y406/01002Guanylate cyclase (4.6.1.2)
    • AHUMAN NECESSITIES
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    • C12N2750/14011Parvoviridae
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    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141Use of virus, viral particle or viral elements as a vector
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    • C12N2830/80Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85Vector systems having a special element relevant for transcription from vertebrates mammalian
SG10201502759TA 2010-04-23 2011-04-22 Raav-guanylate cyclase compositions and methods for treating leber's congenital amaurosis-1 (lca1) SG10201502759TA (en)

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SG10201800541SA SG10201800541SA (en) 2010-04-23 2011-04-22 Raav-guanylate cyclase compositions and methods for treating leber's congenital amaurosis-1 (lca1)
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SG2012076600A SG184876A1 (en) 2010-04-23 2011-04-22 Raav-guanylate cyclase compositions and methods for treating leber's congenital amaurosis-1 (lca1)
SG10201913135YA SG10201913135YA (en) 2010-04-23 2011-04-23 Raav-guanylate cyclase compositions and methods for treating leber's congenital amaurosis-1 (lca1)

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EP2561067B1 (en) 2018-11-14
JP2017114914A (en) 2017-06-29
US9816108B2 (en) 2017-11-14
DK3486320T3 (en) 2022-04-11
PL3486320T3 (en) 2022-05-09
WO2011133933A2 (en) 2011-10-27
JP2015091273A (en) 2015-05-14
CY1123008T1 (en) 2021-10-29
MX2012012367A (en) 2012-11-16
AU2011242527B2 (en) 2016-05-19
EA201291103A1 (en) 2013-10-30
IL264649B (en) 2021-01-31
ES2711256T3 (en) 2019-04-30
HUE041571T2 (en) 2019-05-28
JP2013526854A (en) 2013-06-27
SG10201913135YA (en) 2020-02-27
EP4056700A1 (en) 2022-09-14
EP3486320B1 (en) 2022-01-19
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