SG10201401232QA - Quinazolinedione derivatives, preparation thereof and various therapeutic uses thereof - Google Patents

Quinazolinedione derivatives, preparation thereof and various therapeutic uses thereof

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Publication number
SG10201401232QA
SG10201401232QA SG10201401232QA SG10201401232QA SG10201401232QA SG 10201401232Q A SG10201401232Q A SG 10201401232QA SG 10201401232Q A SG10201401232Q A SG 10201401232QA SG 10201401232Q A SG10201401232Q A SG 10201401232QA SG 10201401232Q A SG10201401232Q A SG 10201401232QA
Authority
SG
Singapore
Prior art keywords
preparation
therapeutic uses
various therapeutic
quinazolinedione derivatives
quinazolinedione
Prior art date
Application number
SG10201401232QA
Inventor
Annie Clauss
Christophe Glaess
Gilbert Marciniak
Jean-Francois Nave
Bertrand Vivet
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41226702&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201401232Q(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of SG10201401232QA publication Critical patent/SG10201401232QA/en

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    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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SG10201401232QA 2009-04-09 2010-04-07 Quinazolinedione derivatives, preparation thereof and various therapeutic uses thereof SG10201401232QA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0901760A FR2944282B1 (en) 2009-04-09 2009-04-09 QUINAZOLINEDIONE DERIVATIVES, THEIR PREPARATION AND THEIR VARIOUS THERAPEUTIC APPLICATIONS

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SG10201401232QA true SG10201401232QA (en) 2014-08-28

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SG2011073442A SG175130A1 (en) 2009-04-09 2010-04-07 Quinazolinedione derivatives, preparation thereof and various therapeutic uses thereof
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US (1) US8722659B2 (en)
EP (1) EP2417130A2 (en)
JP (1) JP5564101B2 (en)
KR (1) KR20120028872A (en)
CN (1) CN102459244B (en)
AR (1) AR076233A1 (en)
AU (1) AU2010233594B2 (en)
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CA (1) CA2758233A1 (en)
CL (1) CL2011002522A1 (en)
CO (1) CO6440583A2 (en)
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FR (1) FR2944282B1 (en)
IL (1) IL215609A0 (en)
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NZ (1) NZ595768A (en)
SG (2) SG175130A1 (en)
TW (1) TW201040148A (en)
UY (1) UY32556A (en)
WO (1) WO2010116088A2 (en)
ZA (1) ZA201107363B (en)

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Publication number Priority date Publication date Assignee Title
US9220715B2 (en) 2010-11-08 2015-12-29 Omeros Corporation Treatment of addiction and impulse-control disorders using PDE7 inhibitors
EP2640395A4 (en) 2010-11-08 2014-01-22 Omeros Corp Treatment of addiction and impulse-control disorders using pde7 inhibitors
JP2015521177A (en) * 2012-05-07 2015-07-27 オメロス コーポレーション Treatment of addiction and impulse control disorders with PDE7 inhibitors
ITMI20130646A1 (en) * 2013-04-19 2014-10-20 Univ Bologna Alma Mater CHINAZOLINDIONIC COMPOUNDS WITH INHABITING ACTIVITIES ON SIRTUINES
CN106146413B (en) * 2015-04-03 2019-01-18 中南大学 2,4- (1H, 3H)-quinazolinedione derivatives and its preparation method and use
GB201517217D0 (en) * 2015-09-29 2015-11-11 Astex Therapeutics Ltd And Cancer Res Technology Ltd Pharmaceutical compounds
GB201517216D0 (en) * 2015-09-29 2015-11-11 Cancer Res Technology Ltd And Astex Therapeutics Ltd Pharmaceutical compounds
WO2024038090A1 (en) 2022-08-18 2024-02-22 Mitodicure Gmbh Use of substituted benzoxazole and benzofuran compounds for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3879393A (en) 1973-06-18 1975-04-22 Miles Lab Derivatives of 1,3-disubstituted 2,4(1h,3h)-quinazolinediones
EP0040793B1 (en) 1980-05-22 1985-08-28 Masayuki Ishikawa Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof
US5264437A (en) 1992-03-20 1993-11-23 Syntex (U.S.A.) Inc. Optionally substituted pyrido[2,3-d]pyridine-2,4(1H,3H)-diones and pyrido[2,]pyrimidine-2(1H,3H)-ones
EP0638567A4 (en) * 1993-02-18 1995-05-10 Kyowa Hakko Kogyo Kk Adenosine incorporation inhibitor.
HUP0101793A3 (en) * 1998-04-20 2003-02-28 Fujisawa Pharmaceutical Co Anthranilic acid derivatives as inhibitors of the cgmp-phosphodiesterase
WO2001044228A2 (en) * 1999-12-14 2001-06-21 Sanofi-Synthelabo Derivatives of quinazolinedione phthalimide, preparations thereof and their therapeutic uses
WO2006092692A1 (en) 2005-03-01 2006-09-08 Pfizer Limited Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain
MX2007010721A (en) 2005-03-01 2007-11-13 Pfizer Ltd Use of pde7 inhibitors for the treatment of neuropathic pain.
WO2007067946A2 (en) 2005-12-07 2007-06-14 The Regents Of The University Of California Diagnosis and treatment of chronic lymphocytic leukemia (cll)
MX2009010450A (en) 2007-03-27 2009-11-23 Omeros Corp The use of pde7 inhibitors for the treatment of movement disorders.
JPWO2008133155A1 (en) 2007-04-19 2010-07-22 アステラス製薬株式会社 Bicyclic heterocyclic compounds
FR2921926B1 (en) * 2007-10-03 2009-12-04 Sanofi Aventis QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATIONS THEREOF.
FR2944206B1 (en) * 2009-04-09 2012-12-28 Sanofi Aventis THERAPEUTIC APPLICATIONS IN THE CARDIOVASCULAR FIELD OF QUINAZOLINEDIONE DERIVATIVES

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