SE9602646D0 - Pharmaceutically-useful compounds - Google Patents

Pharmaceutically-useful compounds

Info

Publication number
SE9602646D0
SE9602646D0 SE9602646A SE9602646A SE9602646D0 SE 9602646 D0 SE9602646 D0 SE 9602646D0 SE 9602646 A SE9602646 A SE 9602646A SE 9602646 A SE9602646 A SE 9602646A SE 9602646 D0 SE9602646 D0 SE 9602646D0
Authority
SE
Sweden
Prior art keywords
sup
pharmaceutically useful
useful compounds
thrombin
anticoagulants
Prior art date
Application number
SE9602646A
Other languages
English (en)
Swedish (sv)
Inventor
Thomas Antonsson
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9602646A priority Critical patent/SE9602646D0/xx
Publication of SE9602646D0 publication Critical patent/SE9602646D0/xx
Priority to ARP970102753A priority patent/AR007614A1/es
Priority to ZA975591A priority patent/ZA975591B/xx
Priority to SK1720-98A priority patent/SK172098A3/sk
Priority to IL12788597A priority patent/IL127885A0/xx
Priority to BR9710142A priority patent/BR9710142A/pt
Priority to CA002260190A priority patent/CA2260190A1/en
Priority to DE69715635T priority patent/DE69715635T2/de
Priority to AT97932085T priority patent/ATE224365T1/de
Priority to CN97197578A priority patent/CN1228765A/zh
Priority to US08/894,833 priority patent/US6221898B1/en
Priority to HU9902410A priority patent/HUP9902410A3/hu
Priority to CZ9912A priority patent/CZ1299A3/cs
Priority to EP97932085A priority patent/EP0917528B1/en
Priority to KR1019980710870A priority patent/KR20000022437A/ko
Priority to PL97331047A priority patent/PL331047A1/xx
Priority to PCT/SE1997/001150 priority patent/WO1998001422A1/en
Priority to JP10505123A priority patent/JP2000515505A/ja
Priority to AU35628/97A priority patent/AU726236C/en
Priority to NZ333394A priority patent/NZ333394A/xx
Priority to EEP199900006A priority patent/EE9900006A/xx
Priority to TR1998/02767T priority patent/TR199802767T2/xx
Priority to IDP972305A priority patent/ID19479A/id
Priority to IS4930A priority patent/IS4930A/is
Priority to NO986180A priority patent/NO986180L/no
Priority to US09/839,609 priority patent/US7074820B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/71—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C07D261/16—Benzene-sulfonamido isoxazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
    • C07F9/5304—Acyclic saturated phosphine oxides or thioxides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SE9602646A 1996-07-04 1996-07-04 Pharmaceutically-useful compounds SE9602646D0 (sv)

Priority Applications (26)

Application Number Priority Date Filing Date Title
SE9602646A SE9602646D0 (sv) 1996-07-04 1996-07-04 Pharmaceutically-useful compounds
ARP970102753A AR007614A1 (es) 1996-07-04 1997-06-23 Compuesto derivado de amidino, formulacion farmaceutica que lo incluye, metodos para la elaboracion de medicamentos que contienen a dicho compuesto, yproceso para la preparacion de dicho compuesto.
ZA975591A ZA975591B (en) 1996-07-04 1997-06-24 New amidino derivatives and their use as thrombininhibitors
TR1998/02767T TR199802767T2 (xx) 1996-07-04 1997-06-26 Trombin �nleyiciler olarak yeni amidino t�revleri.
CZ9912A CZ1299A3 (cs) 1996-07-04 1997-06-26 Nový amidinový derivát a jeho použití jako inhibitoru thrombinu
KR1019980710870A KR20000022437A (ko) 1996-07-04 1997-06-26 신규 아미디노 유도체 및 트롬빈 억제제로서의 그의 용도
BR9710142A BR9710142A (pt) 1996-07-04 1997-06-26 Composto formulação farmacêutica utilização de um composto e processo para tratamento de uma condição em que é requerida inibição da trombina
CA002260190A CA2260190A1 (en) 1996-07-04 1997-06-26 New amidino derivatives and their use as thrombin inhibitors
DE69715635T DE69715635T2 (de) 1996-07-04 1997-06-26 Neue amidinoderivate und ihre anwendung als thrombin inhibitoren
AT97932085T ATE224365T1 (de) 1996-07-04 1997-06-26 Neue amidinoderivate und ihre anwendung als thrombin inhibitoren
CN97197578A CN1228765A (zh) 1996-07-04 1997-06-26 新脒基衍生物和它们作为凝血酶抑制剂的用途
US08/894,833 US6221898B1 (en) 1996-07-04 1997-06-26 Amidino derivatives and their use as thrombin inhibitors
HU9902410A HUP9902410A3 (en) 1996-07-04 1997-06-26 Amidino derivatives, preparation and use as thrombin inhibitors thereof, pharmaceutical compositions containing these compounds
SK1720-98A SK172098A3 (en) 1996-07-04 1997-06-26 New amidino derivatives and their use as thrombin inhibitors
EP97932085A EP0917528B1 (en) 1996-07-04 1997-06-26 New amidino derivatives and their use as thrombin inhibitors
IL12788597A IL127885A0 (en) 1996-07-04 1997-06-26 Amidino derivatives and their use as thrombin inhibitors
PL97331047A PL331047A1 (en) 1996-07-04 1997-06-26 Novel amidinic derivatives and their application as inhibitors of thrombosin
PCT/SE1997/001150 WO1998001422A1 (en) 1996-07-04 1997-06-26 New amidino derivatives and their use as thrombin inhibitors
JP10505123A JP2000515505A (ja) 1996-07-04 1997-06-26 新規なアミジノ誘導体およびトロンビン阻害剤としてのその使用
AU35628/97A AU726236C (en) 1996-07-04 1997-06-26 New amidino derivatives and their use as thrombin inhibitors
NZ333394A NZ333394A (en) 1996-07-04 1997-06-26 Amidino derivatives and their use as thrombin inhibitors
EEP199900006A EE9900006A (et) 1996-07-04 1997-06-26 Uued amidinoderivaadid ja nende kasutamine trombiini inhibiitoritena
IDP972305A ID19479A (id) 1996-07-04 1997-07-02 Turunan-turunan amidino baru dan pemakaian sebagai penghambat-penghambat trombin
IS4930A IS4930A (is) 1996-07-04 1998-12-21 Nýjar amidínóafleiður og notkun þeirra sem þrombínhemla
NO986180A NO986180L (no) 1996-07-04 1998-12-29 Nye amidinoderivater og deres anvendelse som trombininhibitorer
US09/839,609 US7074820B2 (en) 1996-07-04 2001-04-23 Amidino derivatives and their use as thrombin inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9602646A SE9602646D0 (sv) 1996-07-04 1996-07-04 Pharmaceutically-useful compounds

Publications (1)

Publication Number Publication Date
SE9602646D0 true SE9602646D0 (sv) 1996-07-04

Family

ID=20403276

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9602646A SE9602646D0 (sv) 1996-07-04 1996-07-04 Pharmaceutically-useful compounds

Country Status (24)

Country Link
US (2) US6221898B1 (xx)
EP (1) EP0917528B1 (xx)
JP (1) JP2000515505A (xx)
KR (1) KR20000022437A (xx)
CN (1) CN1228765A (xx)
AR (1) AR007614A1 (xx)
AT (1) ATE224365T1 (xx)
BR (1) BR9710142A (xx)
CA (1) CA2260190A1 (xx)
CZ (1) CZ1299A3 (xx)
DE (1) DE69715635T2 (xx)
EE (1) EE9900006A (xx)
HU (1) HUP9902410A3 (xx)
ID (1) ID19479A (xx)
IL (1) IL127885A0 (xx)
IS (1) IS4930A (xx)
NO (1) NO986180L (xx)
NZ (1) NZ333394A (xx)
PL (1) PL331047A1 (xx)
SE (1) SE9602646D0 (xx)
SK (1) SK172098A3 (xx)
TR (1) TR199802767T2 (xx)
WO (1) WO1998001422A1 (xx)
ZA (1) ZA975591B (xx)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
TW499412B (en) 1996-11-26 2002-08-21 Dimensional Pharm Inc Aminoguanidines and alkoxyguanidines as protease inhibitors
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
DE60039533D1 (de) * 1999-12-23 2008-08-28 Ampac Fine Chemicals Llc Verbessertes verfahren zur herstellung von 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diamin
US6548706B2 (en) 1999-12-23 2003-04-15 Aerojet Fine Chemicals Llc Preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl) -p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines
EP1331221B1 (en) * 2000-10-04 2009-01-14 Kissei Pharmaceutical Co., Ltd. 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation
AR035216A1 (es) * 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
US7129233B2 (en) 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
US7067539B2 (en) 2001-02-08 2006-06-27 Schering Corporation Cannabinoid receptor ligands
US7507767B2 (en) 2001-02-08 2009-03-24 Schering Corporation Cannabinoid receptor ligands
AR034517A1 (es) * 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
JP4209659B2 (ja) 2001-11-15 2009-01-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 アミジノ誘導体並びにそれを用いた抗血液凝固剤および血栓症治療剤
EP1312602A1 (en) * 2001-11-15 2003-05-21 Eisai Co., Ltd. Amidino derivatives, and anticoagulants and thrombosis therapeutic agents containing them
ATE430727T1 (de) * 2001-12-20 2009-05-15 Bristol Myers Squibb Co Alpha-(n-sulfonamid)acetamidderivate als beta- amyloidinhibitoren
SE0201661D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab New salts
SE0201659D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
US20050026168A1 (en) * 2002-12-13 2005-02-03 Genesis Group Inc. Method for the detection of risk factors associated with myocardial infarction
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
US7524354B2 (en) * 2005-07-07 2009-04-28 Research Foundation Of State University Of New York Controlled synthesis of highly monodispersed gold nanoparticles
TW200827336A (en) * 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
US20090061000A1 (en) * 2007-08-31 2009-03-05 Astrazeneca Ab Pharmaceutical formulation use 030
RU2481329C2 (ru) * 2008-06-23 2013-05-10 Астеллас Фарма Инк. Сульфонамидные соединения или их соли
GB0815782D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815781D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815784D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
CN106220618B (zh) 2010-12-16 2019-04-26 阿勒根公司 作为趋化因子受体调节剂的硫衍生物
CN102358753B (zh) * 2011-10-14 2013-06-05 山西大学 一种胰蛋白酶抑制剂活性片段衍生物及其制备方法和应用

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178398B (en) 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
HU192646B (en) 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
CA1341029C (en) 1985-02-04 2000-06-20 Michael Kolb Peptidase inhibitors
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0362002B1 (en) 1988-09-01 1995-07-26 Merrell Dow Pharmaceuticals Inc. HIV protease inhibitors
ZA897515B (en) 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
TW201303B (xx) 1990-07-05 1993-03-01 Hoffmann La Roche
CA2075154A1 (en) 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
SE9102462D0 (sv) 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
NZ245039A (en) 1991-11-12 1994-12-22 Lilly Co Eli N-phenylalanyl and n-phenylglycyl derivatives of the dipeptide of l-azetidine-2-carboxylic acid and l-arginine aldehyde; anti-blood clotting compositions
SE9103612D0 (sv) 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
US5264457A (en) 1992-02-14 1993-11-23 G. D. Searle & Co. Phenyl amidines sulfonamides useful as platelet aggregation inhibitors
US5760235A (en) 1992-03-04 1998-06-02 Gyogyszerkutato Intezet Kft. Anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for preparation thereof
TW223629B (xx) 1992-03-06 1994-05-11 Hoffmann La Roche
US5583146A (en) 1992-12-02 1996-12-10 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
AU675981B2 (en) 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
TW257757B (xx) 1993-03-03 1995-09-21 Boehringer Mannheim Gmbh
JPH06340619A (ja) 1993-05-03 1994-12-13 Bristol Myers Squibb Co グアニジニルまたはアミジニル置換メチルアミノ複素環トロンビン抑制剤
SE9301916D0 (sv) 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US5780631A (en) 1993-06-03 1998-07-14 Astra Aktiebolag Starting materials in the synthesis of thrombin and kininogenase inhibitors
EP0648780A1 (en) 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
TW394760B (en) 1993-09-07 2000-06-21 Hoffmann La Roche Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same
AU1025795A (en) 1994-01-27 1995-08-03 Mitsubishi Chemical Corporation Prolineamide derivatives
US5726159A (en) 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
ZA951617B (en) 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
US5707966A (en) 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5705487A (en) 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5561146A (en) 1994-06-10 1996-10-01 Bristol-Myers Squibb Company Modified guanidino and amidino thrombin inhibitors
DE4421052A1 (de) 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
US5510369A (en) 1994-07-22 1996-04-23 Merck & Co., Inc. Pyrrolidine thrombin inhibitors
DE4430755A1 (de) 1994-08-30 1996-03-07 Boehringer Mannheim Gmbh Neue Phosphanoxide, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
DE4430757A1 (de) 1994-08-30 1996-03-07 Boehringer Mannheim Gmbh Neue 4-Aminopyridazine, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
NZ296210A (en) * 1994-12-02 1998-05-27 Yamanouchi Pharma Co Ltd Amidinonaphthyl derivatives to inhibit activated blood coagulation factor x
EA199700186A1 (ru) 1995-02-17 1998-02-26 Басф Акциенгезельшафт Новые дипептидные амидины, используемые в качестве ингибиторов тромбина
US5710130A (en) 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US5629324A (en) 1995-04-10 1997-05-13 Merck & Co., Inc. Thrombin inhibitors
IL118007A0 (en) 1995-05-24 1996-08-04 Du Pont Merck Pharma Isoxazoline compounds pharmaceutical compositions containing them and their use
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
HUP9802764A3 (en) 1995-09-29 2000-03-28 Dimensional Pharm Inc Guanidino protease inhibitors
US5792769A (en) 1995-09-29 1998-08-11 3-Dimensional Pharmaceuticals, Inc. Guanidino protease inhibitors
AR005245A1 (es) 1995-12-21 1999-04-28 Astrazeneca Ab Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion
HUP9902256A3 (en) 1995-12-29 2000-01-28 Dimensional Pharm Inc Amidino protease inhibitors and pharmaceutical compositions containing them
WO1997047299A1 (en) 1996-06-12 1997-12-18 3-Dimensional Pharmaceuticals, Inc. Amidino and guanidino heterocyclic protease inhibitors
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
DE19632772A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine
DE19632773A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Thrombininhibitoren
US6285302B1 (en) 1998-12-28 2001-09-04 Texas Instruments Incorporated Runlength-limited code and method

Also Published As

Publication number Publication date
BR9710142A (pt) 1999-08-10
CN1228765A (zh) 1999-09-15
CZ1299A3 (cs) 1999-06-16
US20020040043A1 (en) 2002-04-04
HUP9902410A2 (hu) 1999-11-29
DE69715635T2 (de) 2003-08-07
IS4930A (is) 1998-12-21
AU726236B2 (en) 2000-11-02
IL127885A0 (en) 1999-10-28
TR199802767T2 (xx) 1999-04-21
CA2260190A1 (en) 1998-01-15
NZ333394A (en) 2000-08-25
EP0917528A1 (en) 1999-05-26
ZA975591B (en) 1998-12-24
NO986180D0 (no) 1998-12-29
ID19479A (id) 1998-07-16
PL331047A1 (en) 1999-06-21
KR20000022437A (ko) 2000-04-25
JP2000515505A (ja) 2000-11-21
WO1998001422A1 (en) 1998-01-15
HUP9902410A3 (en) 2001-10-29
EE9900006A (et) 1999-06-15
SK172098A3 (en) 1999-06-11
DE69715635D1 (de) 2002-10-24
AR007614A1 (es) 1999-11-10
NO986180L (no) 1999-03-04
ATE224365T1 (de) 2002-10-15
US7074820B2 (en) 2006-07-11
US6221898B1 (en) 2001-04-24
EP0917528B1 (en) 2002-09-18
AU3562897A (en) 1998-02-02

Similar Documents

Publication Publication Date Title
SE9602646D0 (sv) Pharmaceutically-useful compounds
SE9602263D0 (sv) New amino acid derivatives
MY121222A (en) Prodrugs of thrombin inhibitors
MX9800146A (es) Nuevos inhibidores de trombina, su preparacion y su uso.
CA2294059A1 (en) New amidino derivatives and their use as thrombin inhibitors
ID28008A (id) Senyawa-senyawa baru
ATE304532T1 (de) Inhibitoren von serin proteasen
SE9804313D0 (sv) New compounds
SE0001803D0 (sv) New compounds i
AU8039501A (en) New amidino derivatives and their use as thrombin inhibitors
SE0102921D0 (sv) Pharmaceutically useful compounds
IL160068A0 (en) Mew mandelic acid derivatives and their use as thrombin inhibitors
TWI264434B (en) New mandelic acid derivatives and their use as thrombin inhibitors