SE9302152D0 - A method and apparatus for analysing polynucleotide sequences - Google Patents

A method and apparatus for analysing polynucleotide sequences

Info

Publication number
SE9302152D0
SE9302152D0 SE19939302152A SE9302152A SE9302152D0 SE 9302152 D0 SE9302152 D0 SE 9302152D0 SE 19939302152 A SE19939302152 A SE 19939302152A SE 9302152 A SE9302152 A SE 9302152A SE 9302152 D0 SE9302152 D0 SE 9302152D0
Authority
SE
Sweden
Prior art keywords
polynucleotide
oligonucleotide primers
base
interest
sets
Prior art date
Application number
SE19939302152A
Other languages
English (en)
Other versions
SE501439C2 (sv
SE9302152L (sv
Inventor
Thomas *Caskey C
Original Assignee
Pharmacia Lkb Biotechnology Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Lkb Biotechnology Ab filed Critical Pharmacia Lkb Biotechnology Ab
Priority to SE9302152A priority Critical patent/SE501439C2/sv
Publication of SE9302152D0 publication Critical patent/SE9302152D0/sv
Priority to DE69421277T priority patent/DE69421277T2/de
Priority to US08/564,100 priority patent/US6153379A/en
Priority to EP99200676A priority patent/EP0969103A3/en
Priority to AT94921363T priority patent/ATE185843T1/de
Priority to EP94921363A priority patent/EP0705349B1/en
Priority to AU72121/94A priority patent/AU698553B2/en
Priority to ES94921363T priority patent/ES2141828T3/es
Priority to JP50308095A priority patent/JP3722833B2/ja
Priority to CA002164715A priority patent/CA2164715A1/en
Priority to PCT/US1994/007086 priority patent/WO1995000669A1/en
Publication of SE9302152L publication Critical patent/SE9302152L/sv
Publication of SE501439C2 publication Critical patent/SE501439C2/sv
Priority to US09/711,476 priority patent/US7001722B1/en
Priority to US10/254,828 priority patent/US20030082613A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SE9302152A 1993-06-22 1993-06-22 Sätt och anordning för analys av polynukleotidsekvenser SE501439C2 (sv)

Priority Applications (13)

Application Number Priority Date Filing Date Title
SE9302152A SE501439C2 (sv) 1993-06-22 1993-06-22 Sätt och anordning för analys av polynukleotidsekvenser
PCT/US1994/007086 WO1995000669A1 (en) 1993-06-22 1994-06-22 Parallel primer extension approach to nucleic acid sequence analysis
AU72121/94A AU698553B2 (en) 1993-06-22 1994-06-22 Parallel primer extension approach to nucleic acid sequence analysis
JP50308095A JP3722833B2 (ja) 1993-06-22 1994-06-22 核酸配列分析の平行プライマー拡張手法
EP99200676A EP0969103A3 (en) 1993-06-22 1994-06-22 Parallel primer extension approach to nucleic acid sequence analysis
AT94921363T ATE185843T1 (de) 1993-06-22 1994-06-22 Nukleinsäure-sequenzanalyse durch die methode der parallelen primerextension
EP94921363A EP0705349B1 (en) 1993-06-22 1994-06-22 Parallel primer extension approach to nucleic acid sequence analysis
DE69421277T DE69421277T2 (de) 1993-06-22 1994-06-22 NUKLEINSäURE-SEQUENZANALYSE DURCH DIE METHODE DER PARALLELEN PRIMEREXTENSION
ES94921363T ES2141828T3 (es) 1993-06-22 1994-06-22 Acceso a analisis de secuencias de acidos nucleicos por extension de cebadores en paralelo.
US08/564,100 US6153379A (en) 1993-06-22 1994-06-22 Parallel primer extension approach to nucleic acid sequence analysis
CA002164715A CA2164715A1 (en) 1993-06-22 1994-06-22 Parallel primer extension approach to nucleic acid sequence analysis
US09/711,476 US7001722B1 (en) 1993-06-22 2000-11-13 Parallel primer extension approach to nucleic acid sequence analysis
US10/254,828 US20030082613A1 (en) 1993-06-22 2002-09-25 Parallel primer extension approach to nucleic acid sequence analysis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9302152A SE501439C2 (sv) 1993-06-22 1993-06-22 Sätt och anordning för analys av polynukleotidsekvenser

Publications (3)

Publication Number Publication Date
SE9302152D0 true SE9302152D0 (sv) 1993-06-22
SE9302152L SE9302152L (sv) 1994-12-23
SE501439C2 SE501439C2 (sv) 1995-02-13

Family

ID=20390371

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9302152A SE501439C2 (sv) 1993-06-22 1993-06-22 Sätt och anordning för analys av polynukleotidsekvenser

Country Status (9)

Country Link
EP (2) EP0705349B1 (sv)
JP (1) JP3722833B2 (sv)
AT (1) ATE185843T1 (sv)
AU (1) AU698553B2 (sv)
CA (1) CA2164715A1 (sv)
DE (1) DE69421277T2 (sv)
ES (1) ES2141828T3 (sv)
SE (1) SE501439C2 (sv)
WO (1) WO1995000669A1 (sv)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07203998A (ja) * 1994-01-26 1995-08-08 Hamamatsu Photonics Kk 核酸塩基配列決定方法
GB9507238D0 (en) 1995-04-07 1995-05-31 Isis Innovation Detecting dna sequence variations
US5763175A (en) * 1995-11-17 1998-06-09 Lynx Therapeutics, Inc. Simultaneous sequencing of tagged polynucleotides
WO1997035033A1 (en) 1996-03-19 1997-09-25 Molecular Tool, Inc. Method for determining the nucleotide sequence of a polynucleotide
US6143529A (en) * 1996-08-14 2000-11-07 Exact Laboratories, Inc. Methods for improving sensitivity and specificity of screening assays
US5888778A (en) * 1997-06-16 1999-03-30 Exact Laboratories, Inc. High-throughput screening method for identification of genetic mutations or disease-causing microorganisms using segmented primers
US6566101B1 (en) 1997-06-16 2003-05-20 Anthony P. Shuber Primer extension methods for detecting nucleic acids
JP4789294B2 (ja) * 1997-08-22 2011-10-12 ソレクサ・インコーポレイテッド ローリングプライマーを用いたｄｎａ伸長および分析
US6322968B1 (en) 1997-11-21 2001-11-27 Orchid Biosciences, Inc. De novo or “universal” sequencing array
AU754436B2 (en) 1998-03-16 2002-11-14 Millennium Pharmaceuticals, Inc. Methods and compositions for diagnosing and treating chromosome-18p related disorders
US6872521B1 (en) 1998-06-16 2005-03-29 Beckman Coulter, Inc. Polymerase signaling assay
US6245507B1 (en) 1998-08-18 2001-06-12 Orchid Biosciences, Inc. In-line complete hyperspectral fluorescent imaging of nucleic acid molecules
US6150105A (en) * 1998-08-20 2000-11-21 Genetic Assays, Inc. Methods of screening nucleic acids for nucleotide variations
AU779220B2 (en) 1999-07-26 2005-01-13 Clinical Micro Sensors, Inc. Sequence determination of nucleic acids using electronic detection
US6528319B1 (en) 1999-09-02 2003-03-04 Amersham Biosciences Corp Method for anchoring oligonucleotides to a substrate
US6586177B1 (en) 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
WO2001025485A2 (en) * 1999-10-06 2001-04-12 Amersham Biosciences Corp Method for detecting mutations using arrayed primer extension
US6596483B1 (en) 1999-11-12 2003-07-22 Motorola, Inc. System and method for detecting molecules using an active pixel sensor
DE10010282B4 (de) * 2000-02-25 2006-11-16 Epigenomics Ag Verfahren zur Detektion von Cytosin-Methylierung in DNA Proben
DE10010280B4 (de) 2000-02-25 2006-08-10 Epigenomics Ag Verfahren zur Detektion von Cytosin-Methylierung in DNA Proben
AU4099001A (en) * 2000-03-13 2001-09-24 Genset Nucleic acid detection method and system
US6376191B1 (en) * 2000-03-22 2002-04-23 Mergen, Ltd. Microarray-based analysis of polynucleotide sequence variations
ATE353975T1 (de) 2000-04-06 2007-03-15 Epigenomics Ag Diagnose von mit apoptose assoziierten erkrankungen mittels ermittlung des methylierungszustandes von apoptose-assozierten genen
JP2003000268A (ja) 2000-08-25 2003-01-07 Pfizer Prod Inc 血管新生にかかわる疾患を診断および治療するための方法および組成物
AU2001216942A1 (en) * 2000-11-24 2002-06-03 Asper Ou Method of optimising the sequences of synthetic nucleic acids
GB0105790D0 (en) * 2001-03-08 2001-04-25 Expresson Biosystems Ltd Detecting binding of mRNA to an oligonnucleotide array using RNA dependent nucleic acid modifying enzymes
US6777189B2 (en) 2001-03-30 2004-08-17 Applera Corporation Nucleic acid analysis using non-templated nucleotide addition
US6653082B2 (en) 2001-05-17 2003-11-25 Baylor College Of Medicine Substrate-bound cleavage assay for nucleic acid analysis
EP1578913B1 (en) 2001-08-14 2014-02-19 Sentigen Biosciences, Inc. Nucleic acids and proteins of insect or83b odorant receptor genes and uses thereof
DE10154317B4 (de) 2001-10-26 2005-06-09 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierungen in immobilisierten DNA Proben
EP1340818A1 (en) 2002-02-27 2003-09-03 Epigenomics AG Method and nucleic acids for the analysis of a colon cell proliferative disorder
DE10245145B4 (de) * 2002-09-27 2004-12-02 IPK-Institut für Pflanzengenetik und Kulturpflanzenforschung Verfahren zum Nachweis von SNPs auf polydimensionalen Microarrays
WO2004035803A2 (en) 2002-10-01 2004-04-29 Epigenomics Ag Method and nucleic acids for the treatment of breast cell proliferative disorders
WO2005059172A2 (en) 2003-12-11 2005-06-30 Epigenomics Ag Method and nucleic acids for the improved treatment of breast cell proliferative disorders
US20050053980A1 (en) 2003-06-20 2005-03-10 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
EP2354250A1 (en) 2003-06-23 2011-08-10 Epigenomics AG Methods and nucleic acids for analyses of colorectal cell proliferative disorders
US8163488B2 (en) 2003-06-23 2012-04-24 Epigenomics Ag Methods and nucleic acids for analysis of colon proliferative disorders
JP4955385B2 (ja) 2003-06-23 2012-06-20 エピゲノミクス アクチェンゲゼルシャフト 結腸直腸細胞増殖障害の分析のための方法及び核酸
US9181587B2 (en) 2003-12-01 2015-11-10 Epigenomics Ag Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
WO2006002344A1 (en) 2004-06-23 2006-01-05 Epigenomics Ag Methods and nucleic acids for the detection of metastasis of colon cell proliferative disorders
US20090298054A1 (en) 2004-07-18 2009-12-03 Epigenomics Ag Epigenetic methods and nucleic acids for the detection of breast cell proliferative disorders
EP1784508B1 (en) 2004-08-09 2012-10-03 Generation Biotech, LLC Method for nucleic acid isolation and amplification
WO2006047787A2 (en) 2004-10-27 2006-05-04 Exact Sciences Corporation Method for monitoring disease progression or recurrence
EP2213749A1 (en) 2004-12-02 2010-08-04 Epigenomics AG Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders
EA013634B1 (ru) 2005-04-15 2010-06-30 Эпиджиномикс Аг Способы и нуклеиновые кислоты для анализов клеточных пролиферативных нарушений
WO2007044071A2 (en) 2005-04-21 2007-04-19 Exact Sciences Corporation Analysis of heterogeneous nucleic acid samples
EP2345743A1 (en) 2005-05-02 2011-07-20 University of Southern California DNA methylation markers associated with the CpG island methylator phenotyp (CIMP) in human colorectal cancer
EP1934369A2 (en) 2005-09-29 2008-06-25 Epigenomics AG Methods and nucleic acids for the analysis of gene expression associated with tissue classification
US8912129B2 (en) 2005-11-17 2014-12-16 Epigenomics Ag Method for the determination of the DNA methylation level of a CPG position in identical cells within a tissue sample
ES2587068T3 (es) 2006-04-17 2016-10-20 Epigenomics Ag Métodos y ácidos nucleicos para la detección de desórdenes celulares proliferativos colorrectales
CA2657576C (en) 2006-07-14 2023-10-31 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
US20100143902A1 (en) 2006-07-21 2010-06-10 Epigenomics Ag Methods and nucleic acids for analyses of cellular proliferative disorders
ES2615354T3 (es) 2006-11-24 2017-06-06 Epigenomics Ag Métodos y ácidos nucleicos para el análisis de la expresión de genes asociados con el desarrollo de trastornos proliferativos de células de próstata
PL2258871T3 (pl) 2007-01-19 2014-10-31 Epigenomics Ag Sposoby i kwasy nukleinowe do analizy zaburzeń proliferacyjnych komórki
AU2008254986A1 (en) * 2007-05-14 2008-11-27 Insight Genetics, Inc. Methods of screening nucleic acids for single nucleotide variations
US7635566B2 (en) 2007-06-29 2009-12-22 Population Genetics Technologies Ltd. Methods and compositions for isolating nucleic acid sequence variants
EP2302069A1 (en) 2007-12-11 2011-03-30 Epigenomics AG Methods and nucleic acids for analyses of cell proliferative disorders
ES2669439T3 (es) 2009-06-26 2018-05-25 Epigenomics Ag Métodos y ácidos nucleicos para el análisis del carcinoma de vejiga
US20110104695A1 (en) 2009-11-05 2011-05-05 Epigenomics Ag Methods of predicting therapeutic efficacy of cancer therapy
WO2011139721A1 (en) 2010-04-27 2011-11-10 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
DK2729579T3 (en) 2011-07-08 2018-01-08 Epigenomics Ag PROCEDURES AND NUCLEIC ACIDS FOR DETERMINING THE PROGRAM FOR A CANCER PATIENT
CN105378108A (zh) 2013-03-13 2016-03-02 雅培分子公司 用于分离核酸的***和方法
ES2712798T3 (es) 2013-03-14 2019-05-14 Exact Sciences Dev Co Llc Detección de neoplasias
CN105378107A (zh) 2013-03-14 2016-03-02 雅培分子公司 多重甲基化-特异性扩增***和方法
WO2015124921A1 (en) 2014-02-19 2015-08-27 The University Court Of The University Of Edinburgh Methods and uses for determining the presence of inflammatory bowel disease
CN106460046A (zh) 2014-03-31 2017-02-22 梅奥医学教育和研究基金会 检测结直肠赘生物
EP3227687A4 (en) 2014-12-05 2018-10-24 Prelude, Inc. Dcis recurrence and invasive breast cancer
CN113981057A (zh) 2014-12-12 2022-01-28 精密科学公司 用于进行甲基化检测测定的组合物和方法
WO2016160454A1 (en) 2015-03-27 2016-10-06 Exact Sciences Corporation Detecting esophageal disorders
AU2016343937B2 (en) 2015-10-30 2023-01-19 Exact Sciences Corporation Multiplex amplification detection assay and isolation and detection of DNA from plasma
AU2017260630B2 (en) 2016-05-05 2023-07-13 Exact Sciences Corporation Detection of lung neoplasia by analysis of methylated DNA
CN109642228B (zh) 2016-07-19 2022-09-13 精密科学发展有限责任公司 甲基化对照dna
US20180066320A1 (en) 2016-09-02 2018-03-08 Mayo Foundation For Medical Education And Research Detecting hepatocellular carcinoma
CN110475875B (zh) 2017-01-27 2024-06-25 精密科学公司 通过分析甲基化dna检测结肠瘤形成
US20220187301A1 (en) 2018-09-14 2022-06-16 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer
EP3880847A2 (en) 2018-11-16 2021-09-22 Oslo Universitetssykehus HF Methods and compositions for characterizing bladder cancer
KR20220092561A (ko) 2019-10-31 2022-07-01 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 난소암 검출
CA3188230A1 (en) 2020-08-19 2022-02-24 John B. Kisiel Detecting non-hodgkin lymphoma
WO2022165247A1 (en) 2021-01-29 2022-08-04 Mayo Foundation For Medical Education And Research Detecting the presence or absence of multiple types of cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202231A (en) * 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
GB8810400D0 (en) * 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5547839A (en) * 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
WO1992010588A1 (en) * 1990-12-06 1992-06-25 Affymax Technologies N.V. Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides
US6004744A (en) * 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer

Also Published As

Publication number Publication date
AU698553B2 (en) 1998-10-29
WO1995000669A1 (en) 1995-01-05
EP0705349A1 (en) 1996-04-10
SE501439C2 (sv) 1995-02-13
CA2164715A1 (en) 1995-01-05
DE69421277T2 (de) 2000-05-31
SE9302152L (sv) 1994-12-23
JP3722833B2 (ja) 2005-11-30
EP0969103A3 (en) 2004-01-02
EP0969103A2 (en) 2000-01-05
AU7212194A (en) 1995-01-17
EP0705349B1 (en) 1999-10-20
JPH09501312A (ja) 1997-02-10
ATE185843T1 (de) 1999-11-15
DE69421277D1 (de) 1999-11-25
ES2141828T3 (es) 2000-04-01

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