SE8904186L - Adenosinderivat, deras framstaellning och anvaendning - Google Patents

Adenosinderivat, deras framstaellning och anvaendning

Info

Publication number: SE8904186L
Authority: SE; Sweden
Prior art keywords: alkyl; derivatives; preparation; adenosin; adenosines
Prior art date: 1988-12-13

Application number

SE8904186A

Other languages

English (en)

Swedish (sv)

Other versions

SE8904186D0 (sv

Inventor

F Gadient

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-13

Filing date

1989-12-12

Publication date

1991-06-13

1989-12-12 Application filed by Sandoz Ag filed Critical Sandoz Ag

1989-12-12 Publication of SE8904186D0 publication Critical patent/SE8904186D0/xx

1991-06-13 Publication of SE8904186L publication Critical patent/SE8904186L/xx

Links

OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical class C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
150000003838 adenosines Chemical class 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
239000008280 blood Substances 0.000 abstract 1
210000004369 blood Anatomy 0.000 abstract 1
230000036772 blood pressure Effects 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
210000003989 endothelium vascular Anatomy 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
150000002632 lipids Chemical class 0.000 abstract 1
125000005394 methallyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

SE8904186A 1988-12-13 1989-12-12 Adenosinderivat, deras framstaellning och anvaendning SE8904186L (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3841881		1988-12-13

Publications (2)

Publication Number	Publication Date
SE8904186D0 SE8904186D0 (sv)	1989-12-12
SE8904186L true SE8904186L (sv)	1991-06-13

Family

ID=6369027

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8904186A SE8904186L (sv)	1988-12-13	1989-12-12	Adenosinderivat, deras framstaellning och anvaendning

Country Status (29)

Country	Link
US (1)	US5534503A (it)
JP (2)	JPH0725786B2 (it)
KR (1)	KR900009647A (it)
AT (1)	AT397964B (it)
AU (1)	AU618865B2 (it)
BE (1)	BE1003632A3 (it)
CA (1)	CA2005110A1 (it)
CH (1)	CH678327A5 (it)
CS (1)	CS411191A3 (it)
CY (1)	CY1829A (it)
DE (1)	DE3940021C2 (it)
DK (1)	DK626989A (it)
ES (1)	ES2022771A6 (it)
FR (1)	FR2640271B1 (it)
GB (1)	GB2226027B (it)
HK (1)	HK70895A (it)
HU (1)	HU211248A9 (it)
IE (1)	IE65506B1 (it)
IL (1)	IL92634A (it)
IT (1)	IT1237431B (it)
LU (1)	LU87639A1 (it)
MX (1)	MX9203613A (it)
MY (1)	MY106333A (it)
NL (1)	NL8903054A (it)
NZ (1)	NZ231701A (it)
PH (1)	PH27533A (it)
SE (1)	SE8904186L (it)
SG (1)	SG8695G (it)
ZA (1)	ZA899528B (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0725785B2 (ja) *	1989-01-11	1995-03-22	日本臓器製薬株式会社	アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物
DE4037363A1 (de) *	1990-04-09	1991-10-10	Europ Lab Molekularbiolog	2-0-alkylnukleotide sowie polymere, die solche nukleotide enthalten
SG80526A1 (en) *	1990-09-25	2001-05-22	Rhone Poulenc Rorer Int	Compounds having antihypertensive and anti- ischemic properies
US5561134A (en) *	1990-09-25	1996-10-01	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
HUT61567A (en) *	1990-12-07	1993-01-28	Sandoz Ag	Process for producing new pharmaceutical compositions comprising 2'-o-alkyladenosine derivatives and for producing 6-cyclohexyl-2'-o-methyladenosinehydrate
GB9111580D0 (en) *	1991-05-30	1991-07-24	Wellcome Found	Nucleoside derivative
EP0601322A3 (en) *	1992-10-27	1994-10-12	Nippon Zoki Pharmaceutical Co	Adenosine deaminase inhibitor.
PL316985A1 (en) *	1994-05-10	1997-03-03	Sandoz Ltd	Derivatives of adenosine
US6107300A (en) *	1996-03-27	2000-08-22	Dupont Pharmaceuticals	Arylamino fused pyrimidines
JP3619017B2 (ja)	1998-06-24	2005-02-09	日本臓器製薬株式会社	新規アラビノシルアデニン誘導体

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL130136C (it) *	1966-10-20
DE2628202A1 (de) *	1976-06-23	1977-12-29	Max Planck Gesellschaft	Verfahren zur herstellung von 2'-substituierten-d-ribofuranosylpurinderivaten
CA1239397A (en) *	1983-08-01	1988-07-19	James A. Bristol	N.sup.6-substituted adenosines
DE3406533A1 (de) *	1984-02-23	1985-08-29	Boehringer Mannheim Gmbh, 6800 Mannheim	Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten
AU575438B2 (en) *	1984-10-26	1988-07-28	Warner-Lambert Company	N6 - substituted deoxyribose analogues of adenosines
US4755594A (en) *	1986-01-31	1988-07-05	Warner-Lambert Company	N6 -substituted adenosines
US4780452A (en) *	1986-09-08	1988-10-25	Burroughs Wellcome Co.	F-substituted-3-β-D-ribofuranosyl-3H-imidazo[4,5-b]pyridines and pharmaceutical compositions thereof
AU8274187A (en) *	1986-10-31	1988-05-25	Warner-Lambert Company	Heteroaromatic derivatives of adenosine
JPH0723394B2 (ja) *	1986-11-27	1995-03-15	日本臓器製薬株式会社	新規アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物
US4962194A (en) *	1987-04-02	1990-10-09	Warner-Lambert Company	Method of preparing 51,N6-disubstituted adenosines from inosines
GB8729994D0 (en) *	1987-12-23	1988-02-03	Glaxo Group Ltd	Chemical compounds
JPH0725785B2 (ja) *	1989-01-11	1995-03-22	日本臓器製薬株式会社	アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物

1989
- 1989-11-10 GB GB8925439A patent/GB2226027B/en not_active Expired - Lifetime
- 1989-12-04 FR FR8916087A patent/FR2640271B1/fr not_active Expired - Fee Related
- 1989-12-04 BE BE8901293A patent/BE1003632A3/fr not_active IP Right Cessation
- 1989-12-04 DE DE3940021A patent/DE3940021C2/de not_active Expired - Fee Related
- 1989-12-08 LU LU87639A patent/LU87639A1/fr unknown
- 1989-12-11 CA CA002005110A patent/CA2005110A1/en not_active Abandoned
- 1989-12-11 CH CH4442/89A patent/CH678327A5/de not_active IP Right Cessation
- 1989-12-11 NZ NZ231701A patent/NZ231701A/xx unknown
- 1989-12-11 MY MYPI89001738A patent/MY106333A/en unknown
- 1989-12-11 IL IL9263489A patent/IL92634A/en not_active IP Right Cessation
- 1989-12-11 AU AU46172/89A patent/AU618865B2/en not_active Ceased
- 1989-12-12 DK DK626989A patent/DK626989A/da not_active Application Discontinuation
- 1989-12-12 PH PH39675A patent/PH27533A/en unknown
- 1989-12-12 JP JP1324880A patent/JPH0725786B2/ja not_active Expired - Lifetime
- 1989-12-12 AT AT0280489A patent/AT397964B/de not_active IP Right Cessation
- 1989-12-12 IE IE396589A patent/IE65506B1/en not_active IP Right Cessation
- 1989-12-12 IT IT04864089A patent/IT1237431B/it active IP Right Grant
- 1989-12-12 SE SE8904186A patent/SE8904186L/xx not_active Application Discontinuation
- 1989-12-12 KR KR1019890018330A patent/KR900009647A/ko not_active Application Discontinuation
- 1989-12-13 NL NL8903054A patent/NL8903054A/nl not_active Application Discontinuation
- 1989-12-13 ES ES8904209A patent/ES2022771A6/es not_active Expired - Lifetime
- 1989-12-13 ZA ZA899528A patent/ZA899528B/xx unknown
1991
- 1991-12-27 CS CS914111A patent/CS411191A3/cs unknown
1992
- 1992-06-26 MX MX9203613A patent/MX9203613A/es unknown
1994
- 1994-09-22 JP JP6227610A patent/JPH07223961A/ja active Pending
- 1994-10-27 US US08/330,043 patent/US5534503A/en not_active Expired - Fee Related
1995
- 1995-01-18 SG SG8695A patent/SG8695G/en unknown
- 1995-05-11 HK HK70895A patent/HK70895A/xx not_active IP Right Cessation
- 1995-06-02 HU HU95P/P00151P patent/HU211248A9/hu unknown
- 1995-12-01 CY CY182995A patent/CY1829A/xx unknown

Also Published As

Publication number	Publication date
GB8925439D0 (en)	1989-12-28
FR2640271A1 (fr)	1990-06-15
MX9203613A (es)	1992-07-01
DK626989A (da)	1990-06-14
CA2005110A1 (en)	1990-06-13
JPH02218689A (ja)	1990-08-31
NL8903054A (nl)	1990-07-02
AT397964B (de)	1994-08-25
IT1237431B (it)	1993-06-04
KR900009647A (ko)	1990-07-05
IE65506B1 (en)	1995-11-01
ES2022771A6 (es)	1991-12-01
IL92634A (en)	1994-01-25
LU87639A1 (fr)	1991-09-18
SE8904186D0 (sv)	1989-12-12
ATA280489A (de)	1993-12-15
IE893965L (en)	1990-06-13
CY1829A (en)	1995-12-01
JPH07223961A (ja)	1995-08-22
CS411191A3 (en)	1992-06-17
SG8695G (en)	1995-06-16
NZ231701A (en)	1992-09-25
US5534503A (en)	1996-07-09
HK70895A (en)	1995-05-19
DE3940021C2 (de)	1994-08-25
DK626989D0 (da)	1989-12-12
FR2640271B1 (fr)	1995-02-03
BE1003632A3 (fr)	1992-05-12
GB2226027B (en)	1992-05-20
ZA899528B (en)	1991-08-28
MY106333A (en)	1995-05-30
CH678327A5 (it)	1991-08-30
JPH0725786B2 (ja)	1995-03-22
AU4617289A (en)	1990-06-21
DE3940021A1 (de)	1990-06-21
GB2226027A (en)	1990-06-20
IT8948640A0 (it)	1989-12-12
PH27533A (en)	1993-08-18
AU618865B2 (en)	1992-01-09
HU211248A9 (en)	1995-11-28
IL92634A0 (en)	1990-08-31

Legal Events

Date

Code

Title

Description

1999-05-03

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LU91196I2 (fr)	2005-10-31	Picoxystrobin et ses dérivlés pharmaceutiquement acceptables(ACANTO).
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ES2066000T3 (es)	1995-03-01	Compuestos derivados de pirimidinediona, metodo de produccion de los mismos y agentes antirritmicos que los contienen.
DE69012840D1 (de)	1994-11-03	Adenosin-Derivate, die eine Aktivität gegen Bluthochdruck haben.
FR2391723A1 (fr)	1978-12-22	Composition therapeutique a base de cetone aliphatique pour le traitement des ulceres peptiques
ATE112762T1 (de)	1994-10-15	Herstellung und verwendung von n-jodopropargyl- oxycarbonylaminosäure-estern als antimicrobielle mittel.
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DK601583A (da)	1984-06-29	Carbamyloxybenzhydrolderivater
KR910002456A (ko)	1991-02-25	당뇨병 치료용 제약 조성물
ATE100439T1 (de)	1994-02-15	2-(2-hydroxy-3-phenoxypropylamino)-ethoxybenzol derivate.
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ATE58141T1 (de)	1990-11-15	1-hydroxy-5-oxo-5h-pyrido(3,2-a>-phenoxazin-3carbons\|ureester.
EP0396078A3 (de)	1991-12-11	1-Hydroxi-azolverbindungen und diese enthaltende Fungizide
DE59003731D1 (de)	1994-01-20	0-(1,2,4-Triazolyl-1)-0-Phenyl-Acetale und diese enthaltende Fungizide.
DK380482A (da)	1983-02-27	1-aryloxy-3-alkylamino-2-propanoler og fremgangsmaade til deres fremstilling