SE8302747L - Indol-naphthyridines - Google Patents

Indol-naphthyridines

Info

Publication number
SE8302747L
SE8302747L SE8302747A SE8302747A SE8302747L SE 8302747 L SE8302747 L SE 8302747L SE 8302747 A SE8302747 A SE 8302747A SE 8302747 A SE8302747 A SE 8302747A SE 8302747 L SE8302747 L SE 8302747L
Authority
SE
Sweden
Prior art keywords
enantiomers
naphthyridines
indol
enantiomer
hitherto
Prior art date
Application number
SE8302747A
Other languages
Swedish (sv)
Other versions
SE8302747D0 (en
Inventor
A Wick
J Bertin
J Frost
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of SE8302747D0 publication Critical patent/SE8302747D0/en
Publication of SE8302747L publication Critical patent/SE8302747L/en

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C10M129/02—Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing oxygen having a carbon chain of less than 30 atoms
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    • C10M2227/00—Organic non-macromolecular compounds containing atoms of elements not provided for in groups C10M2203/00, C10M2207/00, C10M2211/00, C10M2215/00, C10M2219/00 or C10M2223/00 as ingredients in lubricant compositions
    • C10M2227/06—Organic compounds derived from inorganic acids or metal salts
    • C10M2227/065—Organic compounds derived from inorganic acids or metal salts derived from Ti or Zr
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2227/00—Organic non-macromolecular compounds containing atoms of elements not provided for in groups C10M2203/00, C10M2207/00, C10M2211/00, C10M2215/00, C10M2219/00 or C10M2223/00 as ingredients in lubricant compositions
    • C10M2227/06—Organic compounds derived from inorganic acids or metal salts
    • C10M2227/066—Organic compounds derived from inorganic acids or metal salts derived from Mo or W
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10N—INDEXING SCHEME ASSOCIATED WITH SUBCLASS C10M RELATING TO LUBRICATING COMPOSITIONS
    • C10N2010/00—Metal present as such or in compounds
    • C10N2010/04—Groups 2 or 12
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
    • F02B—INTERNAL-COMBUSTION PISTON ENGINES; COMBUSTION ENGINES IN GENERAL
    • F02B1/00—Engines characterised by fuel-air mixture compression
    • F02B1/02—Engines characterised by fuel-air mixture compression with positive ignition
    • F02B1/04—Engines characterised by fuel-air mixture compression with positive ignition with fuel-air mixture admission into cylinder
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
    • F02F—CYLINDERS, PISTONS OR CASINGS, FOR COMBUSTION ENGINES; ARRANGEMENTS OF SEALINGS IN COMBUSTION ENGINES
    • F02F7/00—Casings, e.g. crankcases or frames
    • F02F7/006—Camshaft or pushrod housings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Enantiomers of the title compound of the formula: <IMAGE> which have hitherto not been characterised specifically, are isolated from their mixtures by preparing addition salts with an enantiomer of a chiral acid. The diastereoisomers obtained are separated by fractional crystallisation and then converted back to the form of the base or of a pharmaceutically acceptable acid addition salt. The enantiomers of the above named compound are useful in therapy as they possess an antianoxic activity.
SE8302747A 1982-05-18 1983-05-16 Indol-naphthyridines SE8302747L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8208632A FR2527210A1 (en) 1982-05-18 1982-05-18 ENANTIOMERS OF HEXAHYDRO-2,3,3A, 4,5,6 1H-INDOLO (3,2,1-DE) (NAPHTHYRIDINE-1,5), THEIR SEPARATION METHOD AND THEIR THERAPEUTIC APPLICATION

Publications (2)

Publication Number Publication Date
SE8302747D0 SE8302747D0 (en) 1983-05-16
SE8302747L true SE8302747L (en) 1983-11-19

Family

ID=9274131

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8302747A SE8302747L (en) 1982-05-18 1983-05-16 Indol-naphthyridines

Country Status (19)

Country Link
JP (1) JPS58210083A (en)
AU (1) AU1461683A (en)
BE (1) BE896764A (en)
CH (1) CH654579B (en)
DE (1) DE3317961A1 (en)
DK (1) DK219183A (en)
ES (1) ES522478A0 (en)
FR (1) FR2527210A1 (en)
GB (1) GB2120250A (en)
GR (1) GR78568B (en)
HU (1) HU189660B (en)
IL (1) IL68721A0 (en)
IT (1) IT1194244B (en)
LU (1) LU84808A1 (en)
NL (1) NL8301739A (en)
NO (1) NO831737L (en)
PT (1) PT76716B (en)
SE (1) SE8302747L (en)
ZA (1) ZA833539B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU84664A1 (en) * 1983-02-25 1984-11-08 Onmichem S A ALKYL-4-INDOLONAPHTYRIDINES AND THEIR THERAPEUTIC APPLICATION
US5231181A (en) * 1991-03-21 1993-07-27 Syntex (U.S.A.) Inc. Process for the preparation of (8as,12as,13as)-decahydroisoquino ((2,1-g) (1,6)-naphthyridin-8-one derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8203367A1 (en) * 1980-07-03 1982-04-01 Omnichem Sa Indolo-naphthyridines and their use as medicaments.
FR2494693A1 (en) * 1980-11-21 1982-05-28 Synthelabo DERIVATIVES OF HEXAHYDRO-2,3,3A, 4,5,6 1H-INDOLO (3,2,1-DE) (NAPHTHYRIDINE-1,5), THEIR PREPARATION AND THEIR THERAPEUTIC USE

Also Published As

Publication number Publication date
DK219183D0 (en) 1983-05-17
BE896764A (en) 1983-11-17
FR2527210A1 (en) 1983-11-25
GB8313625D0 (en) 1983-06-22
ES8403126A1 (en) 1984-03-01
PT76716B (en) 1986-03-27
GB2120250A (en) 1983-11-30
FR2527210B1 (en) 1985-04-12
ZA833539B (en) 1984-02-29
IL68721A0 (en) 1983-09-30
PT76716A (en) 1983-06-01
DE3317961A1 (en) 1983-11-24
ES522478A0 (en) 1984-03-01
NO831737L (en) 1983-11-21
DK219183A (en) 1983-11-19
JPS58210083A (en) 1983-12-07
AU1461683A (en) 1983-11-24
IT1194244B (en) 1988-09-14
IT8321143A0 (en) 1983-05-17
SE8302747D0 (en) 1983-05-16
LU84808A1 (en) 1985-03-21
HU189660B (en) 1986-07-28
CH654579B (en) 1986-02-28
NL8301739A (en) 1983-12-16
GR78568B (en) 1984-09-27

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