SE8204693L - MEDICINAL PRODUCTS WITH SPECIAL ANTI-RHYTHMIC AND SUPPORTIVE EFFECTS OF HEART HYPOXY AND PROCEDURE FOR PREPARING THEREOF - Google Patents

MEDICINAL PRODUCTS WITH SPECIAL ANTI-RHYTHMIC AND SUPPORTIVE EFFECTS OF HEART HYPOXY AND PROCEDURE FOR PREPARING THEREOF

Info

Publication number
SE8204693L
SE8204693L SE8204693A SE8204693A SE8204693L SE 8204693 L SE8204693 L SE 8204693L SE 8204693 A SE8204693 A SE 8204693A SE 8204693 A SE8204693 A SE 8204693A SE 8204693 L SE8204693 L SE 8204693L
Authority
SE
Sweden
Prior art keywords
cis
effects
pyrido
hexahydro
dimethyl
Prior art date
Application number
SE8204693A
Other languages
Swedish (sv)
Other versions
SE461831B (en
SE8204693D0 (en
Inventor
S Stolc
L Benes
V Bauer
M Tichy
Original Assignee
Ceskoslovenska Akademie Ved
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ceskoslovenska Akademie Ved filed Critical Ceskoslovenska Akademie Ved
Publication of SE8204693D0 publication Critical patent/SE8204693D0/en
Publication of SE8204693L publication Critical patent/SE8204693L/en
Publication of SE461831B publication Critical patent/SE461831B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to (-)-cis-2,8-dimethyl- 2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole of the formula I <IMAGE> its salts, its preparation and appropriate pharmaceutical compositions, in particular having antiarrhythmic and subsidiary action in myocardial hypoxia. The compounds according to the invention also have a hypotensive, local anaesthetic, spasmolytic, x-adrenolytic and central sedative action. The compositions can be present in a liquid, semi-liquid and solid administration form. The compounds according to the invention are prepared from (+/-)-cis-2,8-dimethyl- 2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole via the salt with an optically active acid, advantageously (+)-O,O'-dibenzoyl-D-tartaric acid, from which the (-)-cis-isomer is liberated by rendering it alkaline and optionally converting it into a pharmaceutically suitable salt, preferably the dihydrochloride (m.p. 270-274 DEG C, with decomposition) or the dipalmitate (m.p. 55-56 DEG C). The active substances according to the invention eliminate cardiac arrhythmias in doses which are lower than the agents used hitherto and at the same time have relatively low acute toxicity and the ability to protect the cardiac muscle during oxygen deficiency. Central effects such as neuroleptic and thymoleptic effects are additionally present.
SE8204693A 1981-08-20 1982-08-13 ANTI-RHYTHMIC AND SUPPORTING MEDICINAL PRODUCTS IN MYOCARDIA HYPXI CONTAINING (-) - CIS-2,8 DIMETHYL-2,3,4,4A, 5,9B-HEXAHYDRO-1H-PYRIDO (4,3-B) INDOL SE461831B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS625481A CS229067B1 (en) 1981-08-20 1981-08-20 Medicinal preparation with antiarhythmic and supporting effect applied with hypoxia,and method of preparing active substance thereof

Publications (3)

Publication Number Publication Date
SE8204693D0 SE8204693D0 (en) 1982-08-13
SE8204693L true SE8204693L (en) 1983-02-21
SE461831B SE461831B (en) 1990-04-02

Family

ID=5409157

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8204693A SE461831B (en) 1981-08-20 1982-08-13 ANTI-RHYTHMIC AND SUPPORTING MEDICINAL PRODUCTS IN MYOCARDIA HYPXI CONTAINING (-) - CIS-2,8 DIMETHYL-2,3,4,4A, 5,9B-HEXAHYDRO-1H-PYRIDO (4,3-B) INDOL

Country Status (7)

Country Link
JP (1) JPS5865217A (en)
BE (1) BE894148A (en)
CH (1) CH651754A5 (en)
CS (1) CS229067B1 (en)
DE (1) DE3231088A1 (en)
NL (1) NL8203226A (en)
SE (1) SE461831B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2338537C2 (en) * 2006-01-25 2008-11-20 Сергей Олегович Бачурин AGENT FOR TREATMENT OF SCHIZOPHRENIA ON BASIS OF HYDROGENATED PYDIDO (4,3-b) INDOLES (VERSIONS), PHARMACOLOGICAL AGENT ON ITS BASIS AND METHOD OF ITS APPLICATION
US7728031B2 (en) * 2006-02-24 2010-06-01 Abbott Laboratories Octahydro-pyrrolo[3,4-b]pyrrole derivatives
KR20100054812A (en) * 2007-08-01 2010-05-25 메디베이션 뉴롤로지 인코퍼레이티드 Methods and compositions for treating schizophrenia using antipsychotic combination therapy
EP2188288A1 (en) 2007-09-11 2010-05-26 Abbott Laboratories Octahydro-pyrrolo[3,4-b]pyrrole n-oxides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3657254A (en) * 1969-10-31 1972-04-18 Nikolai Konstantinovich Barkov 3 6-dimethyl-1 2 3 4 4a 9a-hexahydro-gamma-carboline dihydrochloride
AR205452A1 (en) * 1973-12-06 1976-05-07 Endo Lab METHOD TO PREPARE NEW TRANS-2, 3, 4, 4A, 5, 9B-HEXAHYDRO-5-PHENYL-1H-PYRID (4,3-B) INDOLES

Also Published As

Publication number Publication date
SE461831B (en) 1990-04-02
JPS5865217A (en) 1983-04-18
SE8204693D0 (en) 1982-08-13
BE894148A (en) 1982-12-16
CH651754A5 (en) 1985-10-15
DE3231088A1 (en) 1983-03-10
JPS6360005B2 (en) 1988-11-22
CS229067B1 (en) 1984-04-16
DE3231088C2 (en) 1990-02-22
NL8203226A (en) 1983-03-16

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