SE8204693L - MEDICINAL PRODUCTS WITH SPECIAL ANTI-RHYTHMIC AND SUPPORTIVE EFFECTS OF HEART HYPOXY AND PROCEDURE FOR PREPARING THEREOF - Google Patents
MEDICINAL PRODUCTS WITH SPECIAL ANTI-RHYTHMIC AND SUPPORTIVE EFFECTS OF HEART HYPOXY AND PROCEDURE FOR PREPARING THEREOFInfo
- Publication number
- SE8204693L SE8204693L SE8204693A SE8204693A SE8204693L SE 8204693 L SE8204693 L SE 8204693L SE 8204693 A SE8204693 A SE 8204693A SE 8204693 A SE8204693 A SE 8204693A SE 8204693 L SE8204693 L SE 8204693L
- Authority
- SE
- Sweden
- Prior art keywords
- cis
- effects
- pyrido
- hexahydro
- dimethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to (-)-cis-2,8-dimethyl- 2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole of the formula I <IMAGE> its salts, its preparation and appropriate pharmaceutical compositions, in particular having antiarrhythmic and subsidiary action in myocardial hypoxia. The compounds according to the invention also have a hypotensive, local anaesthetic, spasmolytic, x-adrenolytic and central sedative action. The compositions can be present in a liquid, semi-liquid and solid administration form. The compounds according to the invention are prepared from (+/-)-cis-2,8-dimethyl- 2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole via the salt with an optically active acid, advantageously (+)-O,O'-dibenzoyl-D-tartaric acid, from which the (-)-cis-isomer is liberated by rendering it alkaline and optionally converting it into a pharmaceutically suitable salt, preferably the dihydrochloride (m.p. 270-274 DEG C, with decomposition) or the dipalmitate (m.p. 55-56 DEG C). The active substances according to the invention eliminate cardiac arrhythmias in doses which are lower than the agents used hitherto and at the same time have relatively low acute toxicity and the ability to protect the cardiac muscle during oxygen deficiency. Central effects such as neuroleptic and thymoleptic effects are additionally present.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CS625481A CS229067B1 (en) | 1981-08-20 | 1981-08-20 | Medicinal preparation with antiarhythmic and supporting effect applied with hypoxia,and method of preparing active substance thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
SE8204693D0 SE8204693D0 (en) | 1982-08-13 |
SE8204693L true SE8204693L (en) | 1983-02-21 |
SE461831B SE461831B (en) | 1990-04-02 |
Family
ID=5409157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8204693A SE461831B (en) | 1981-08-20 | 1982-08-13 | ANTI-RHYTHMIC AND SUPPORTING MEDICINAL PRODUCTS IN MYOCARDIA HYPXI CONTAINING (-) - CIS-2,8 DIMETHYL-2,3,4,4A, 5,9B-HEXAHYDRO-1H-PYRIDO (4,3-B) INDOL |
Country Status (7)
Country | Link |
---|---|
JP (1) | JPS5865217A (en) |
BE (1) | BE894148A (en) |
CH (1) | CH651754A5 (en) |
CS (1) | CS229067B1 (en) |
DE (1) | DE3231088A1 (en) |
NL (1) | NL8203226A (en) |
SE (1) | SE461831B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2338537C2 (en) * | 2006-01-25 | 2008-11-20 | Сергей Олегович Бачурин | AGENT FOR TREATMENT OF SCHIZOPHRENIA ON BASIS OF HYDROGENATED PYDIDO (4,3-b) INDOLES (VERSIONS), PHARMACOLOGICAL AGENT ON ITS BASIS AND METHOD OF ITS APPLICATION |
US7728031B2 (en) * | 2006-02-24 | 2010-06-01 | Abbott Laboratories | Octahydro-pyrrolo[3,4-b]pyrrole derivatives |
KR20100054812A (en) * | 2007-08-01 | 2010-05-25 | 메디베이션 뉴롤로지 인코퍼레이티드 | Methods and compositions for treating schizophrenia using antipsychotic combination therapy |
EP2188288A1 (en) | 2007-09-11 | 2010-05-26 | Abbott Laboratories | Octahydro-pyrrolo[3,4-b]pyrrole n-oxides |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3657254A (en) * | 1969-10-31 | 1972-04-18 | Nikolai Konstantinovich Barkov | 3 6-dimethyl-1 2 3 4 4a 9a-hexahydro-gamma-carboline dihydrochloride |
AR205452A1 (en) * | 1973-12-06 | 1976-05-07 | Endo Lab | METHOD TO PREPARE NEW TRANS-2, 3, 4, 4A, 5, 9B-HEXAHYDRO-5-PHENYL-1H-PYRID (4,3-B) INDOLES |
-
1981
- 1981-08-20 CS CS625481A patent/CS229067B1/en unknown
-
1982
- 1982-08-13 SE SE8204693A patent/SE461831B/en not_active IP Right Cessation
- 1982-08-17 NL NL8203226A patent/NL8203226A/en not_active Application Discontinuation
- 1982-08-19 BE BE0/208843A patent/BE894148A/en not_active IP Right Cessation
- 1982-08-19 CH CH4967/82A patent/CH651754A5/en not_active IP Right Cessation
- 1982-08-20 JP JP57143510A patent/JPS5865217A/en active Granted
- 1982-08-20 DE DE19823231088 patent/DE3231088A1/en active Granted
Also Published As
Publication number | Publication date |
---|---|
SE461831B (en) | 1990-04-02 |
JPS5865217A (en) | 1983-04-18 |
SE8204693D0 (en) | 1982-08-13 |
BE894148A (en) | 1982-12-16 |
CH651754A5 (en) | 1985-10-15 |
DE3231088A1 (en) | 1983-03-10 |
JPS6360005B2 (en) | 1988-11-22 |
CS229067B1 (en) | 1984-04-16 |
DE3231088C2 (en) | 1990-02-22 |
NL8203226A (en) | 1983-03-16 |
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