SE7909655L - Sett att framstella treo-3-amino-2-hydroxibutyrylaminoettiksyror samt even nya mellanprodukter derfor och sett att framstella dessa - Google Patents

Sett att framstella treo-3-amino-2-hydroxibutyrylaminoettiksyror samt even nya mellanprodukter derfor och sett att framstella dessa

Info

Publication number: SE7909655L
Authority: SE; Sweden
Prior art keywords: amino; image; general formula; represented; threo
Prior art date: 1978-11-25

Application number

SE7909655A

Other languages

English (en)

Other versions

SE452888B (sv

Inventor

H Umezawa

T Aoyagi

T Shirai

R Nishizawa

M Suzuki

T Saino

Original Assignee

Nippon Kayaku Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-11-25

Filing date

1979-11-22

Publication date

1980-05-26

1978-11-25 Priority claimed from JP14550978A external-priority patent/JPS5572151A/ja

1978-12-13 Priority claimed from JP15315778A external-priority patent/JPS5579353A/ja

1979-11-22 Application filed by Nippon Kayaku Kk filed Critical Nippon Kayaku Kk

1980-05-26 Publication of SE7909655L publication Critical patent/SE7909655L/sv

1987-12-21 Publication of SE452888B publication Critical patent/SE452888B/sv

Links

239000002253 acid Substances 0.000 title abstract 3
150000007513 acids Chemical class 0.000 title abstract 3
239000000543 intermediate Substances 0.000 title abstract 3
150000001875 compounds Chemical class 0.000 abstract 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
150000002148 esters Chemical group 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
239000007858 starting material Substances 0.000 abstract 2
MUQYXPVMHCCFJE-UHFFFAOYSA-N 2-amino-2-hydroxy-4-oxobutanoic acid Chemical compound OC(=O)C(O)(N)CC=O MUQYXPVMHCCFJE-UHFFFAOYSA-N 0.000 abstract 1
QVPLPSZGHFSYEQ-UHFFFAOYSA-N 2-amino-2-hydroxybutanoic acid Chemical compound CCC(N)(O)C(O)=O QVPLPSZGHFSYEQ-UHFFFAOYSA-N 0.000 abstract 1
QTRAXZHIRXYYPP-UHFFFAOYSA-N 3-amino-2-hydroxybutanoic acid Chemical compound CC(N)C(O)C(O)=O QTRAXZHIRXYYPP-UHFFFAOYSA-N 0.000 abstract 1
125000003974 3-carbamimidamidopropyl group Chemical group C(N)(=N)NCCC* 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
-1 amino, hydroxy Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
150000001721 carbon Chemical group 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
125000000524 functional group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
238000005897 peptide coupling reaction Methods 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
- C07C209/48—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of nitriles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/54—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SE7909655A 1978-11-25 1979-11-22 Sett att framstella treo-3-amino-2-hydroxibutanoylaminoettiksyror SE452888B (sv)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP14550978A JPS5572151A (en)	1978-11-25	1978-11-25	Threo-(2rs)-3-amino-2-hydroxy-4-oxo-4-phenylbutyric acid, its ester, and their preparation
JP15315778A JPS5579353A (en)	1978-12-13	1978-12-13	Preparation of (2s,3r)-3-amino-2-hydroxy-4- phenylbutanoylaminoacetic acid and its intermediate

Publications (2)

Publication Number	Publication Date
SE7909655L true SE7909655L (sv)	1980-05-26
SE452888B SE452888B (sv)	1987-12-21

Family

ID=26476602

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
SE7909655A SE452888B (sv)	1978-11-25	1979-11-22	Sett att framstella treo-3-amino-2-hydroxibutanoylaminoettiksyror
SE8106084A SE453748B (sv)	1978-11-25	1981-10-14	(2s,3r)-3-amino-2-hydroxi-4-(4-metoxifenyl)-butanoyl-(s)-leucin
SE8403931A SE466200B (sv)	1978-11-25	1984-07-31	Treo-3-skyddad amino-2-hydroxi-4-oxosmoersyra eller dess ester samt ett saett foer framstaellning daerav

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
SE8106084A SE453748B (sv)	1978-11-25	1981-10-14	(2s,3r)-3-amino-2-hydroxi-4-(4-metoxifenyl)-butanoyl-(s)-leucin
SE8403931A SE466200B (sv)	1978-11-25	1984-07-31	Treo-3-skyddad amino-2-hydroxi-4-oxosmoersyra eller dess ester samt ett saett foer framstaellning daerav

Country Status (13)

Country	Link
US (3)	US4281180A (sv)
AR (1)	AR227636A1 (sv)
AU (1)	AU530362B2 (sv)
CA (3)	CA1182125A (sv)
CH (3)	CH653669A5 (sv)
DE (2)	DE2954076C2 (sv)
DK (1)	DK162288C (sv)
ES (1)	ES486572A1 (sv)
FR (3)	FR2442227A1 (sv)
GB (2)	GB2090595B (sv)
IT (2)	IT1194593B (sv)
NL (2)	NL188162C (sv)
SE (3)	SE452888B (sv)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4370318A (en) *	1980-07-07	1983-01-25	Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai	Bestatin-related compounds as immunopotentiator
JPS5767516A (en) *	1980-09-24	1982-04-24	Microbial Chem Res Found	Novel analgesic agent
GB2094786B (en) *	1981-03-04	1985-09-11	Ici Plc	Herbicidal and fungicidal amide derivatives
JPS58110553A (ja) *	1981-12-24	1983-07-01	Microbial Chem Res Found	ベスタチンのγ型結晶及びその製造法
JPS606647A (ja) *	1983-06-17	1985-01-14	Microbial Chem Res Found	アルフアメニン及びその関連化合物と合成法
JPS62205095A (ja) *	1986-03-04	1987-09-09	Toyo Jozo Co Ltd	新生理活性物質アルドスタチンおよびその製造法
US4681972A (en) *	1986-09-16	1987-07-21	Warner-Lambert Company	Separation of diastereomers
US4871870A (en) *	1987-03-16	1989-10-03	Biomeasure, Inc.	Immunomodulators and method of making same
IT1216104B (it) *	1988-03-16	1990-02-22	Zambon Spa	Peptidi ad attivita' farmaceutica.
IT1217567B (it) *	1988-05-11	1990-03-30	Zambon Spa	Processo diastereoselettivo per la preparazione di intermedi utili per la sintesi di derivati peptidici
JPH0759507B2 (ja) *	1989-02-23	1995-06-28	日本化薬株式会社	骨髄異形成症候群治療剤
NL9101380A (nl) *	1991-08-13	1993-03-01	Dsm Nv	Werkwijze voor de bereiding van een alfa-aminozuur, de overeenkomstige ester en amide.
US5455353A (en) *	1993-03-24	1995-10-03	Hoffmann-La Roche Inc.	4-(benzyl-2-oxo-oxazolidin-5 ylmethyl)N tertbutyl-decahydroisoquinoline-3-carboxamides
US5656603A (en) *	1995-05-31	1997-08-12	Loyola University Of Chicago	Aminopeptidase P inhibitors and uses thereof
CA2312385A1 (en) *	1999-06-22	2000-12-22	Daiso Co., Ltd.	Process for producing erythro-3-amino-2-hydroxybutyric acid derivatives
JP2005029470A (ja) *	2001-06-21	2005-02-03	Japan Energy Electronic Materials Inc	新規ノルスタチン誘導体
ES2602826T3 (es) *	2009-05-28	2017-02-22	Novartis Ag	Derivados aminobutíricos sustituidos como inhibidores de neprilisina
MA33364B1 (fr)	2009-05-28	2012-06-01	Novartis Ag	Dérivés aminobutyriques substitués en tant qu'inhibiteurs de néprilysine
JO2967B1 (en)	2009-11-20	2016-03-15	نوفارتس ايه جي	Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
CN101891647B (zh) *	2010-03-15	2012-12-19	浙江普洛康裕制药有限公司	一种乌苯美司的制备方法
ME02295B (me) *	2010-12-15	2016-02-20	Theravance Biopharma R&D Ip Llc	Inhibitori neprilizina
CN102391145B (zh) *	2011-08-31	2014-07-02	深圳万乐药业有限公司	一种乌苯美司中间体的光学异构体的拆分方法
AP2015008621A0 (en)	2013-02-14	2015-07-31	Novartis Ag	Substituted bisphenyl butanoic nep 'neutral endopeptidase' inhibitors
WO2014126972A1 (en)	2013-02-14	2014-08-21	Novartis Ag	Substituted bisphenyl butanoic acid derivatives as nep inhibitors with improved in vivo efficacy
CN103360277A (zh) *	2013-04-01	2013-10-23	上海信谊万象药业股份有限公司	一种乌苯美司重结晶的方法
CN103333089A (zh) *	2013-06-20	2013-10-02	深圳万乐药业有限公司	N-[(2s,3r)-4-苯基-3-苄基-3-苄氧甲酰氨基-2-羟基丁酰]-l-亮氨酸苄酯的晶型及其制备方法
CN106117075B (zh) *	2016-01-14	2020-06-12	上海信谊万象药业股份有限公司	一种新型乌苯美司重结晶方法
EP3481799A1 (en) *	2016-07-05	2019-05-15	Novartis AG	New process for early sacubitril intermediates
CN106631880B (zh) *	2016-08-01	2018-06-01	四川青木制药有限公司	一种乌苯美司δ晶型及其制备方法
CN106831473B (zh) *	2017-02-22	2019-07-16	江西瑞雅药业有限公司	3-酰胺基-4-(2’-烷氧基-4-联苯基)丁酸衍生物及其制备方法、药物组合物
AU2022376563A1 (en)	2021-11-01	2023-12-07	Alkahest, Inc.	Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases
CN115784918A (zh) *	2022-11-24	2023-03-14	四川青木制药有限公司	一种高纯度乌苯美司中间体的制备方法
CN115594606A (zh) *	2022-12-16	2023-01-13	成都傲科新技术有限责任公司（Cn）	苏式-2-羟基-3-乙酰氨基-4-苯基羰基丁酸不对称合成方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2242086A1 (en) *	1973-09-03	1975-03-28	Aries Robert	Antibacterial, antiviral dihydroxy butyric acid derivs - active against Gram-positive and -negative cocci and bacilli
US4179573A (en) *	1974-07-01	1979-12-18	Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai	(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
US4029547A (en) *	1974-07-01	1977-06-14	Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai	Biologically active substance, bestatin, and production thereof
US4052449A (en) *	1974-07-01	1977-10-04	Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai	Biologically active substance, bestatin, and production thereof
US4189604A (en) *	1975-07-22	1980-02-19	Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai	Bestatin
GB1510477A (en) *	1975-07-22	1978-05-10	Microbial Chem Res Found	Peptides and to amino acid intermediates thereof
CA1066304A (en) *	1975-09-12	1979-11-13	Yani Christidis	Process for manufacturing n-acyl derivatives of hydroxyarylgycines and novel products resulting therefrom
FR2351952A1 (fr) *	1975-09-12	1977-12-16	Nobel Hoechst Chimie	Procede de fabrication de derives n-acyles de glycines a substituees par des radicaux aromatiques
JPS609487B2 (ja) *	1976-03-26	1985-03-11	財団法人微生物化学研究会	免疫制癌剤
US4105789A (en) *	1976-05-10	1978-08-08	E. R. Squibb & Sons, Inc.	Carboxyalkylacylamino acids
GB1540019A (en) *	1977-06-01	1979-02-07	Microbial Chem Res Found	Bestatin derivatives
FR2393788A2 (fr) *	1977-06-10	1979-01-05	Microbial Chem Res Found	Derives de bestatine
JPS6026099B2 (ja) *	1977-09-21	1985-06-21	財団法人微生物化学研究会	ペプチド、その酸附加塩およびその製造法
US4243678A (en) *	1977-12-30	1981-01-06	Byk Gulden Lomberg Chemische Fabrik Gmbh	Acylhydrocarbylaminoalkanoic acids, compositions and uses

1979
- 1979-11-22 IT IT27487/79A patent/IT1194593B/it active
- 1979-11-22 AU AU53115/79A patent/AU530362B2/en not_active Ceased
- 1979-11-22 GB GB8200496A patent/GB2090595B/en not_active Expired
- 1979-11-22 ES ES486572A patent/ES486572A1/es not_active Expired
- 1979-11-22 AR AR278992A patent/AR227636A1/es active
- 1979-11-22 CH CH6192/83A patent/CH653669A5/de not_active IP Right Cessation
- 1979-11-22 GB GB7940413A patent/GB2037754B/en not_active Expired
- 1979-11-22 FR FR7928830A patent/FR2442227A1/fr active Granted
- 1979-11-22 CA CA000340428A patent/CA1182125A/en not_active Expired
- 1979-11-22 DE DE2954076A patent/DE2954076C2/de not_active Expired
- 1979-11-22 CH CH5649/81A patent/CH653687A5/de not_active IP Right Cessation
- 1979-11-22 DK DK496379A patent/DK162288C/da active
- 1979-11-22 DE DE19792947140 patent/DE2947140A1/de active Granted
- 1979-11-22 SE SE7909655A patent/SE452888B/sv not_active IP Right Cessation
- 1979-11-22 CH CH10433/79A patent/CH650265A5/de not_active IP Right Cessation
- 1979-11-22 NL NLAANVRAGE7908510,A patent/NL188162C/xx not_active IP Right Cessation
- 1979-11-23 US US06/096,693 patent/US4281180A/en not_active Expired - Lifetime
1980
- 1980-05-12 FR FR8010563A patent/FR2449078A1/fr active Granted
- 1980-11-28 US US06/211,035 patent/US4391986A/en not_active Expired - Lifetime
1981
- 1981-07-10 FR FR8113611A patent/FR2483409B1/fr not_active Expired
- 1981-10-06 NL NL8104545A patent/NL8104545A/nl not_active Application Discontinuation
- 1981-10-14 SE SE8106084A patent/SE453748B/sv not_active IP Right Cessation
- 1981-12-15 IT IT8125614A patent/IT1211147B/it active
- 1981-12-31 US US06/336,492 patent/US4453003A/en not_active Expired - Lifetime
1982
- 1982-06-14 CA CA000405157A patent/CA1170667A/en not_active Expired
- 1982-08-24 CA CA000410051A patent/CA1167464A/en not_active Expired
1984
- 1984-07-31 SE SE8403931A patent/SE466200B/sv not_active IP Right Cessation

Also Published As

Publication number	Publication date
SE452888B (sv)	1987-12-21
DE2947140A1 (de)	1980-06-12
DK162288B (da)	1991-10-07
IT1194593B (it)	1988-09-22
GB2037754A (en)	1980-07-16
GB2090595B (en)	1983-05-11
AR227636A1 (es)	1982-11-30
DK496379A (da)	1980-05-26
FR2442227A1 (fr)	1980-06-20
AU5311579A (en)	1980-05-29
CA1167464A (en)	1984-05-15
SE466200B (sv)	1992-01-13
CA1170667A (en)	1984-07-10
NL8104545A (nl)	1982-02-01
CA1182125A (en)	1985-02-05
ES486572A1 (es)	1980-09-16
NL188162C (nl)	1992-04-16
DK162288C (da)	1992-03-16
CH653687A5 (de)	1986-01-15
DE2947140C2 (sv)	1991-11-28
IT8125614A0 (it)	1981-12-15
CH650265A5 (de)	1985-07-15
SE8403931L (sv)	1984-07-31
NL188162B (nl)	1991-11-18
FR2483409B1 (fr)	1986-05-09
SE453748B (sv)	1988-02-29
FR2442227B1 (sv)	1984-11-09
IT1211147B (it)	1989-09-29
FR2483409A1 (fr)	1981-12-04
US4281180A (en)	1981-07-28
FR2449078B1 (sv)	1984-09-14
SE8403931D0 (sv)	1984-07-31
GB2037754B (en)	1983-01-06
CH653669A5 (de)	1986-01-15
IT7927487A0 (it)	1979-11-22
GB2090595A (en)	1982-07-14
SE8106084L (sv)	1981-10-14
FR2449078A1 (fr)	1980-09-12
AU530362B2 (en)	1983-07-14
DE2954076C2 (sv)	1988-02-25
US4453003A (en)	1984-06-05
NL7908510A (nl)	1980-05-28
US4391986A (en)	1983-07-05

Legal Events

Date

Code

Title

Description

1995-01-31

NUG

Patent has lapsed

Ref document number: 7909655-8

Effective date: 19940610

Format of ref document f/p: F

Publication	Publication Date	Title
SE7909655L (sv)	1980-05-26	Sett att framstella treo-3-amino-2-hydroxibutyrylaminoettiksyror samt even nya mellanprodukter derfor och sett att framstella dessa
EP0738703A3 (en)	1999-04-28	Acrylic acid derivatives, method for preparing the acrylic acid derivatives, and acrylic acid polymers
YU128985A (en)	1988-02-29	Process for obtaining new derivatives of pyrole
ATE35417T1 (de)	1988-07-15	Verfahren zur herstellung von phosphorhaltigen cyanhydrinderivaten.
SE7606736L (sv)	1977-01-23	Bestatin-foreningar och sett for framstellning derav
NO162815C (no)	1990-02-21	Fremgangsmaate for optisk spaltning av racemiske blandinger av alfa-naftyl-propionsyre.
ATE14428T1 (de)	1985-08-15	Verfahren zur herstellung von bromhaltigen 1,3dioxolen-2-ones.
RO87991A (ro)	1985-11-30	Procedeu pentru prepararea unor esteri tiazolidinici substituiti ai unor acizi minerali
SI9420074B (sl)	2004-02-29	Postopek za pripravo N-substituiranih glicinskih kislin ali glicin estrov in uporaba tega postopka za sintezo indiga
FI873443A (fi)	1987-08-07	Norfloxacinmellanprodukt.
KR840005107A (ko)	1984-11-03	피리미디온 및 그의 산부가염의 제조방법
Dziemidowicz et al.	2005	Potassium trimethylsilanolate-mediated conversion of dialkyl phosphonates to their anhydrous potassium monoalkyl phosphonates under mild, non-aqueous conditions
ES8608538A1 (es)	1986-07-16	Procedimiento para la preparacion de esteres alquilicos de alfa-l-aspartil-l-fenilalanina
JPS5612395A (en)	1981-02-06	Oxazolinoazetidinone derivative
DE69213680D1 (de)	1996-10-17	Neues Verfahren zur Herstellung von 20-Oxo, 17-Alpha, 21-Dihydroxy Derivaten von Pregnan und neue Zwischenprodukte dafür
JPS5461163A (en)	1979-05-17	Novel compound
KR850007065A (ko)	1985-10-30	포스폰산 디에스테르의 제조방법
KR920007971A (ko)	1992-05-27	벤조퀴논 화합물
GB1482388A (en)	1977-08-10	Method of producing 6-beta-amidinopenicillanic acid derivatives
ATE29253T1 (de)	1987-09-15	Verfahren zur herstellung von 4-chinolinonen.
JPS5655356A (en)	1981-05-15	Preparation of alkylenediamine derivative
TH17067A (th)	1995-11-29	"สารประกอบ โพรพิลีนไกลคอน โมโนอัลคิล อีเธอร์ เอสเทอร์ และกรรมวิธีสำหรับการเตรียมสารประกอบเหล่านี้"
DE69319113D1 (de)	1998-07-16	Verbessertes verfahren zur herstellung von n-phenyl-n-methoxyacetyl-dl-alanin-methylesterderivaten
KR960022427A (ko)	1996-07-18	2-(4'치환 아릴)프로피온산의 새로운 제조방법
ES8300338A1 (es)	1982-11-01	Un procedimiento para la preparacion de derivados de acido fosfinico y fosfonico.