SE7711146L - Tiaprostaglandiner - Google Patents

Tiaprostaglandiner

Info

Publication number: SE7711146L
Authority: SE; Sweden
Prior art keywords: phenyl; substituted; och3; alkyl; carbon atoms
Prior art date: 1976-10-06

Application number

SE7711146A

Other languages

English (en)

Other versions

SE427656B (sv

Inventor

H-E Radunz

D Orth

M Baumgarth

H-J Schliep

H-J Enenkel

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-10-06

Filing date

1977-10-05

Publication date

1978-04-07

1977-10-05 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

1978-04-07 Publication of SE7711146L publication Critical patent/SE7711146L/sv

1983-04-25 Publication of SE427656B publication Critical patent/SE427656B/sv

Links

125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
-1 p-acetylaminophenyl Chemical group 0.000 abstract 2
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 2
125000004958 1,4-naphthylene group Chemical group 0.000 abstract 1
125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 abstract 1
RASOZFCGMARHFW-ROUUACIJSA-N 7-[(1s,2s)-2-heptylsulfanylcyclopentyl]heptanoic acid Chemical class CCCCCCCS[C@H]1CCC[C@@H]1CCCCCCC(O)=O RASOZFCGMARHFW-ROUUACIJSA-N 0.000 abstract 1
125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
230000036772 blood pressure Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5407—Acyclic saturated phosphonium compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Thiazole And Isothizaole Compounds (AREA)

SE7711146A 1976-10-06 1977-10-05 Forfarandet for framstellning av vissa fenylestrar av 13-tia-prostaglandiner SE427656B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2644972A DE2644972C2 (de)	1976-10-06	1976-10-06	Thiaprostansäurederivate, deren Herstellung und diese Verbindungen enthaltende Mittel

Publications (2)

Publication Number	Publication Date
SE7711146L true SE7711146L (sv)	1978-04-07
SE427656B SE427656B (sv)	1983-04-25

Family

ID=5989745

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE7711146A SE427656B (sv)	1976-10-06	1977-10-05	Forfarandet for framstellning av vissa fenylestrar av 13-tia-prostaglandiner

Country Status (18)

Country	Link
US (1)	US4309441A (sv)
JP (1)	JPS5346941A (sv)
AT (1)	AT365170B (sv)
AU (1)	AU510216B2 (sv)
BE (1)	BE859423A (sv)
CA (1)	CA1120927A (sv)
CH (3)	CH630072A5 (sv)
DE (1)	DE2644972C2 (sv)
ES (2)	ES462966A1 (sv)
FR (1)	FR2367061A1 (sv)
GB (1)	GB1549496A (sv)
HU (1)	HU178640B (sv)
IL (1)	IL53050A (sv)
IT (1)	IT1090237B (sv)
NL (1)	NL7710931A (sv)
PT (1)	PT67086B (sv)
SE (1)	SE427656B (sv)
ZA (1)	ZA775985B (sv)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5913723A (ja) *	1982-07-14	1984-01-24	メルク・パテント・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング	細胞保護作用を有する医薬及び１３−チア−プロスタグランジン誘導体の使用
DE3401542A1 (de) *	1984-01-18	1985-08-01	Merck Patent Gmbh, 6100 Darmstadt	Schwefelhaltige 6-ketoprostaglandine
AU568928B2 (en) *	1984-03-05	1988-01-14	Teijin Limited	7-thiaprostaglandins e1 and process for producing same
JPS63283835A (ja) *	1987-05-13	1988-11-21	Yaskawa Electric Mfg Co Ltd	リニア移動装置
CA2276666A1 (en)	1997-03-07	1998-09-11	Alcon Laboratories, Inc.	13-thia prostaglandins for use in glaucoma therapy

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH590220A5 (sv) *	1972-11-17	1977-07-29	Merck Patent Gmbh
DE2256537A1 (de) *	1972-11-17	1974-10-10	Merck Patent Gmbh	Neue sulfide
US3894062A (en) *	1973-11-23	1975-07-08	Upjohn Co	Substituted phenyl and naphthyl esters of PGE{HD 2
US3932486A (en) *	1974-01-08	1976-01-13	The Upjohn Company	Substituted tolyl esters of PGA2
US3931285A (en) *	1974-01-08	1976-01-06	The Upjohn Company	Substituted tolyl esters of PGE1
DE2422924A1 (de) *	1974-05-11	1975-11-27	Merck Patent Gmbh	Thiaprostaglandine
US3998869A (en) *	1974-11-14	1976-12-21	The Upjohn Company	Substituted anilide esters of 16-substituted PGE2
US3994956A (en) *	1974-11-14	1976-11-30	The Upjohn Company	Substituted anilide esters of 16-phenoxy and 17-phenyl PGE2 type compounds

1976
- 1976-10-06 DE DE2644972A patent/DE2644972C2/de not_active Expired
1977
- 1977-09-27 PT PT67086A patent/PT67086B/pt unknown
- 1977-10-03 GB GB40927/77A patent/GB1549496A/en not_active Expired
- 1977-10-04 FR FR7729767A patent/FR2367061A1/fr active Granted
- 1977-10-04 IT IT51267/77A patent/IT1090237B/it active
- 1977-10-05 NL NL7710931A patent/NL7710931A/xx not_active Application Discontinuation
- 1977-10-05 JP JP12044177A patent/JPS5346941A/ja active Granted
- 1977-10-05 SE SE7711146A patent/SE427656B/sv not_active IP Right Cessation
- 1977-10-05 IL IL53050A patent/IL53050A/xx unknown
- 1977-10-05 CA CA000288185A patent/CA1120927A/en not_active Expired
- 1977-10-05 HU HU77ME2109A patent/HU178640B/hu not_active IP Right Cessation
- 1977-10-05 CH CH1217477A patent/CH630072A5/de not_active IP Right Cessation
- 1977-10-05 AT AT0710377A patent/AT365170B/de not_active IP Right Cessation
- 1977-10-06 AU AU29426/77A patent/AU510216B2/en not_active Expired
- 1977-10-06 ES ES462966A patent/ES462966A1/es not_active Expired
- 1977-10-06 BE BE2056316A patent/BE859423A/xx not_active IP Right Cessation
- 1977-10-06 ZA ZA00775985A patent/ZA775985B/xx unknown
1978
- 1978-08-11 ES ES472511A patent/ES472511A1/es not_active Expired
1979
- 1979-11-21 US US06/096,348 patent/US4309441A/en not_active Expired - Lifetime
1982
- 1982-05-27 CH CH328382A patent/CH639950A5/de not_active IP Right Cessation
1983
- 1983-02-04 CH CH65183A patent/CH640832A5/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
SE427656B (sv)	1983-04-25
US4309441A (en)	1982-01-05
FR2367061B1 (sv)	1981-02-13
GB1549496A (en)	1979-08-08
CH630072A5 (de)	1982-05-28
PT67086B (en)	1979-02-22
JPS5346941A (en)	1978-04-27
PT67086A (en)	1977-10-01
ES472511A1 (es)	1979-10-01
ES462966A1 (es)	1978-11-01
ATA710377A (de)	1981-05-15
BE859423A (nl)	1978-04-06
AU510216B2 (en)	1980-06-12
CH640832A5 (de)	1984-01-31
AT365170B (de)	1981-12-28
CA1120927A (en)	1982-03-30
NL7710931A (nl)	1978-04-10
DE2644972C2 (de)	1986-06-19
HU178640B (en)	1982-06-28
ZA775985B (en)	1978-05-30
IT1090237B (it)	1985-06-26
AU2942677A (en)	1979-04-12
DE2644972A1 (de)	1978-04-13
FR2367061A1 (fr)	1978-05-05
CH639950A5 (de)	1983-12-15
IL53050A (en)	1981-12-31
IL53050A0 (en)	1977-12-30
JPS6225141B2 (sv)	1987-06-01

Legal Events

Date

Code

Title

Description

1995-01-31

NUG

Patent has lapsed

Ref document number: 7711146-6

Effective date: 19920510

Format of ref document f/p: F

Publication	Publication Date	Title
ES493275A0 (es)	1981-09-01	Procedimiento para la preparacion de nuevas 2-alcoxi-fenil- imidazo(4,5-b)piridinas
MX5680E (es)	1983-12-08	Procedimiento para la preparacion de 2-(2-alcoxietil)-2'-hidroxi-6,7-benzomorfanos
BR8202861A (pt)	1983-04-26	Composto composicao farmaceutica processo para baixar a pressao sanguinea de seres humanos processo para preparar um composto e process para preparar uma composicao farmaceutica
SE7707341L (sv)	1978-02-13	4-hydroxifenylalkanolamin-derivat och forfarande for framstellning derav
ES494791A0 (es)	1981-07-01	Procedimiento para la preparacion de acidos oxirancarboxili-cos sustituidos
SE7901405L (sv)	1979-08-18	Nya substituerade 2-fenylimino-imidazolidiner och deras syraadditionssaltersamt lekemedel innehallande dessa foreningar och forfarande for framstellning derav
SE7605819L (sv)	1976-11-25	Nya propargyl-2-fenylaminoimidazolin-(2), dess syraadditionssalter, lekemedel innehallande dessa och forfarande for framstellning derav
SE7707689L (sv)	1978-01-04	2-brom-6-fluor-n-2-imidazolidinylidenbensamin dess syraadditionssalter, lekemedel innehallande dessa och forfarande for framstellning derav
SE7711146L (sv)	1978-04-07	Tiaprostaglandiner
ES543368A0 (es)	1986-08-01	Procedimiento para la obtencion de derivados de 1-fluoro-1- -azolil-2,2-diaril-etano
ES465225A1 (es)	1978-09-16	Procedimiento para la preparacion de n-cicloalcohilmetil-2- fenilamino-imidazolinas-(2).
ES476408A1 (es)	1979-04-01	Un procedimiento de preparacion de derivados de 2,4-tiazoli-dindiona.
ES524990A0 (es)	1984-05-16	Procedimiento para preparar derivados de tieno-tiazol
SE7514477L (sv)	1976-06-22	Forfarande for framstellning och anvendning av nya xantinderivat
ES517995A0 (es)	1984-01-16	Un procedimiento para la preparacion de un compuesto de hidroxibencilaminobenceno, dotado de propiedades antiinflamatorias.
SE8402361D0 (sv)	1984-05-02	Novel acylaminophenol derivatives
SE7607021L (sv)	1976-12-20	Alkin-derivat och forfarande for framstellning derav
DK82583D0 (da)	1983-02-23	Furyloxazolyleddikesyrederivater og fremgangsmader til fremstilling deraf
SE7607818L (sv)	1977-01-11	Sett att framstella nya fenoxialkylaminpyridyletrar
MX160562A (es)	1990-03-23	Un proceso para preparar derivados de cloruro de aninosulfenilo
ATE36536T1 (de)	1988-09-15	Phosphoroimidate.
ES532180A0 (es)	1985-01-01	Procedimiento para preparar nuevas semicarbazidas
SE8003476L (sv)	1980-11-10	Isokinolinderivat
RU93043526A (ru)	1996-04-20	Инденоиндольные соединения, способ их получения, фармацевтическая композиция, противоокислительная композиция, способ стабилизации