SE444680B - N-alkynyl-n'-/w/(ev substituerad tiazolyl)metyltio/alkyl/-derivat av n"-cyanoguanidin och av 1,1-diamino-2-substituerad etylen som er histamin-h?712-receptorblockeringsmedel - Google Patents

N-alkynyl-n'-/w/(ev substituerad tiazolyl)metyltio/alkyl/-derivat av n"-cyanoguanidin och av 1,1-diamino-2-substituerad etylen som er histamin-h?712-receptorblockeringsmedel

Info

Publication number
SE444680B
SE444680B SE7910392A SE7910392A SE444680B SE 444680 B SE444680 B SE 444680B SE 7910392 A SE7910392 A SE 7910392A SE 7910392 A SE7910392 A SE 7910392A SE 444680 B SE444680 B SE 444680B
Authority
SE
Sweden
Prior art keywords
compound
formula
histamine
pharmaceutically acceptable
toxic
Prior art date
Application number
SE7910392A
Other languages
English (en)
Swedish (sv)
Other versions
SE7910392L (sv
Inventor
A A Algieri
R R Crenshaw
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE7910392L publication Critical patent/SE7910392L/xx
Publication of SE444680B publication Critical patent/SE444680B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
SE7910392A 1978-12-18 1979-12-17 N-alkynyl-n'-/w/(ev substituerad tiazolyl)metyltio/alkyl/-derivat av n"-cyanoguanidin och av 1,1-diamino-2-substituerad etylen som er histamin-h?712-receptorblockeringsmedel SE444680B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/970,517 US4200578A (en) 1978-12-18 1978-12-18 Thiazole derivatives

Publications (2)

Publication Number Publication Date
SE7910392L SE7910392L (sv) 1980-06-19
SE444680B true SE444680B (sv) 1986-04-28

Family

ID=25517073

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7910392A SE444680B (sv) 1978-12-18 1979-12-17 N-alkynyl-n'-/w/(ev substituerad tiazolyl)metyltio/alkyl/-derivat av n"-cyanoguanidin och av 1,1-diamino-2-substituerad etylen som er histamin-h?712-receptorblockeringsmedel

Country Status (24)

Country Link
US (1) US4200578A (fr)
JP (1) JPS5583768A (fr)
KR (3) KR830001920B1 (fr)
AT (1) AT375354B (fr)
AU (1) AU533014B2 (fr)
BE (1) BE880662A (fr)
CA (1) CA1133909A (fr)
CH (1) CH642956A5 (fr)
DE (1) DE2950838A1 (fr)
DK (1) DK533979A (fr)
ES (2) ES8101569A1 (fr)
FI (1) FI793904A (fr)
FR (1) FR2444674B1 (fr)
GB (1) GB2038822B (fr)
GR (1) GR73586B (fr)
HU (1) HU182461B (fr)
IE (1) IE49320B1 (fr)
IL (1) IL58960A (fr)
IT (1) IT1164076B (fr)
LU (1) LU82000A1 (fr)
NL (1) NL7909054A (fr)
SE (1) SE444680B (fr)
YU (3) YU292179A (fr)
ZA (1) ZA796814B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE31588E (en) * 1977-06-03 1984-05-22 Bristol-Myers Company Imidazolylmethylthioethyl alkynyl guanidines
GR71929B (fr) * 1979-11-13 1983-08-19 Ici Ltd
US4760075A (en) * 1980-10-02 1988-07-26 Eli Lilly And Company N-thiazolylmethylthioalkyl-N-alkyl-amidines and related compounds
US4382090A (en) * 1980-10-02 1983-05-03 Eli Lilly And Company N-Thiazolylmethylthioalkyl-N'alkylamidines and related compounds
US4904792A (en) * 1980-10-02 1990-02-27 Eli Lilly And Company N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds
US4375547A (en) * 1980-10-02 1983-03-01 Eli Lilly And Company N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine
NZ202797A (en) * 1981-12-28 1985-08-30 Lilly Co Eli Pyrimidine derivatives and pharmaceutical compositions
US4474794A (en) * 1982-03-19 1984-10-02 Eli Lilly And Company N-Thiazolylmethylthioalkyl-N1 -alkenyl (or alkynyl)guanidines and related compounds
US4458077A (en) * 1982-11-22 1984-07-03 American Home Products Corporation Heterocyclic anti-ulcer agents
JPS59104370A (ja) * 1982-12-03 1984-06-16 Kotobuki Seiyaku Kk チアゾ−ル誘導体及びその製造方法
RO87706A (fr) * 1983-02-07 1985-10-31 Eli Lilly And Co,Us Procede pour preparer nizatidine
ZA869438B (en) * 1985-12-18 1988-07-27 Lilly Co Eli Synthesis of nizatidine
JPH0247453U (fr) * 1988-09-29 1990-03-30
US20230349922A1 (en) 2020-08-11 2023-11-02 Université De Strasbourg H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer
CN111974333B (zh) * 2020-08-19 2023-06-09 宁夏亚东化工有限公司 噻唑生产线及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE758146A (fr) * 1969-10-29 1971-04-28 Smith Kline French Lab Derives de l'amidine
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
US4083988A (en) * 1972-09-05 1978-04-11 Smith Kline & French Laboratories Limited Pharmacologically active compounds
BE804144A (fr) 1972-09-05 1974-02-28 Smith Kline French Lab Cyanoguanidines
GB1421792A (en) 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
GB1553070A (en) 1975-05-21 1979-09-19 Smith Kline French Lab Thiourea guanidine and 1-nitro-2,2-diaminoethylene derivatives
NZ186965A (en) 1977-04-20 1980-02-21 Ici Ltd Guanidino derivatives and pharmaceutical compositions
US4112234A (en) * 1977-08-22 1978-09-05 Bristol-Myers Company Imidazolylmethylthioethyl alkynyl guanidines

Also Published As

Publication number Publication date
GB2038822A (en) 1980-07-30
AU533014B2 (en) 1983-10-27
BE880662A (fr) 1980-06-17
FR2444674A1 (fr) 1980-07-18
CA1133909A (fr) 1982-10-19
KR840004685A (ko) 1984-10-22
KR840004686A (ko) 1984-10-22
HU182461B (en) 1984-01-30
FI793904A (fi) 1980-06-19
JPS639512B2 (fr) 1988-02-29
ES8106715A1 (es) 1981-09-01
YU259482A (en) 1983-02-28
ZA796814B (en) 1980-11-26
KR830001263A (ko) 1983-04-29
CH642956A5 (fr) 1984-05-15
KR840001074B1 (ko) 1984-07-31
ES493718A0 (es) 1981-09-01
KR840001075B1 (ko) 1984-07-31
IE792436L (en) 1980-06-18
JPS5583768A (en) 1980-06-24
DE2950838A1 (de) 1980-07-03
GR73586B (fr) 1984-03-26
AT375354B (de) 1984-07-25
IL58960A0 (en) 1980-03-31
LU82000A1 (de) 1980-07-21
ATA793779A (de) 1983-12-15
IT1164076B (it) 1987-04-08
YU259382A (en) 1983-02-28
ES487035A0 (es) 1980-12-16
AU5371679A (en) 1980-06-26
KR830001920B1 (ko) 1983-09-23
ES8101569A1 (es) 1980-12-16
IT7950977A0 (it) 1979-12-04
SE7910392L (sv) 1980-06-19
FR2444674B1 (fr) 1986-03-28
US4200578A (en) 1980-04-29
NL7909054A (nl) 1980-06-20
GB2038822B (en) 1983-01-19
IE49320B1 (en) 1985-09-18
IL58960A (en) 1983-06-15
YU292179A (en) 1983-02-28
DK533979A (da) 1980-06-19

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