SE400777B - PROCEDURE FOR THE PREPARATION OF 2,4-DIAMINO-5-BENZYLPYRIMIDINES WITH ANTIBACTERIAL EFFECT - Google Patents

PROCEDURE FOR THE PREPARATION OF 2,4-DIAMINO-5-BENZYLPYRIMIDINES WITH ANTIBACTERIAL EFFECT

Info

Publication number
SE400777B
SE400777B SE7006713A SE671370A SE400777B SE 400777 B SE400777 B SE 400777B SE 7006713 A SE7006713 A SE 7006713A SE 671370 A SE671370 A SE 671370A SE 400777 B SE400777 B SE 400777B
Authority
SE
Sweden
Prior art keywords
benzylpyrimidines
diamino
procedure
preparation
antibacterial effect
Prior art date
Application number
SE7006713A
Other languages
Swedish (sv)
Inventor
R M Cresswell
J W Mentha
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of SE400777B publication Critical patent/SE400777B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SE7006713A 1969-05-16 1970-05-15 PROCEDURE FOR THE PREPARATION OF 2,4-DIAMINO-5-BENZYLPYRIMIDINES WITH ANTIBACTERIAL EFFECT SE400777B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2517169 1969-05-16

Publications (1)

Publication Number Publication Date
SE400777B true SE400777B (en) 1978-04-10

Family

ID=10223379

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7006713A SE400777B (en) 1969-05-16 1970-05-15 PROCEDURE FOR THE PREPARATION OF 2,4-DIAMINO-5-BENZYLPYRIMIDINES WITH ANTIBACTERIAL EFFECT
SE7308030A SE398878B (en) 1969-05-16 1973-06-07 PROCEDURE FOR THE PREPARATION OF SUBSTITUTED 2,4-DIAMINO-5-BENZYLPYRIMIDINES

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE7308030A SE398878B (en) 1969-05-16 1973-06-07 PROCEDURE FOR THE PREPARATION OF SUBSTITUTED 2,4-DIAMINO-5-BENZYLPYRIMIDINES

Country Status (14)

Country Link
JP (1) JPS505184B1 (en)
AT (1) AT308082B (en)
BR (1) BR6915082D0 (en)
CA (1) CA994812A (en)
CH (1) CH544071A (en)
DE (1) DE2023977C2 (en)
ES (3) ES379700A1 (en)
FI (1) FI56375C (en)
FR (1) FR2070070A1 (en)
IL (1) IL34433A (en)
IT (1) IT1021507B (en)
NL (2) NL173395C (en)
PL (1) PL92440B1 (en)
SE (2) SE400777B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1469521A (en) * 1973-01-05 1977-04-06 Wellcome Found Antimicrobial preparations
US4687861A (en) * 1984-11-28 1987-08-18 Ciba-Geigy Corporation Microbicidal compositions
WO2005095359A1 (en) * 2004-03-05 2005-10-13 F. Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3049544A (en) * 1962-08-14 Method for the preparation of
DE1103931B (en) 1957-02-21 1961-04-06 Wellcome Found Process for the preparation of 2,4-diamino-5-benzylpyrimidine derivatives
DE1303727B (en) 1959-09-03 1976-02-05 Ausscheidung aus: 14 45 176 The Wellcome Foundation Ltd., London Alpha-arylidene-substituted propioni-iriles
NL122146C (en) * 1960-09-02
DE1620729A1 (en) 1965-07-08 1970-08-20 Wellcome Found Process for the preparation of substituted benzylpyrimidines
GB1261455A (en) 1969-03-06 1972-01-26 Burroughs Wellcome Co Improvements in or relating to substituted acrylonitriles

Also Published As

Publication number Publication date
AT308082B (en) 1973-06-25
CA994812A (en) 1976-08-10
PL92440B1 (en) 1977-04-30
NL7007108A (en) 1970-11-18
FI56375B (en) 1979-09-28
ES406726A1 (en) 1975-10-01
IL34433A (en) 1971-10-20
IT1021507B (en) 1978-02-20
BR6915082D0 (en) 1973-03-08
NL173395B (en) 1983-08-16
ES379700A1 (en) 1973-01-16
NL8004796A (en) 1980-11-28
DE2023977A1 (en) 1971-02-18
ES406725A1 (en) 1975-10-01
IL34433A0 (en) 1970-07-19
DE2023977C2 (en) 1984-03-15
JPS505184B1 (en) 1975-02-28
FR2070070A1 (en) 1971-09-10
FI56375C (en) 1980-01-10
CH544071A (en) 1973-11-15
FR2070070B1 (en) 1974-10-11
NL173395C (en) 1984-01-16
SE398878B (en) 1978-01-23

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