NL6409714A
(xx)
*
|
1962-10-30 |
1965-10-01 |
|
|
US3472848A
(en)
*
|
1966-11-17 |
1969-10-14 |
Merck & Co Inc |
3-hydroxy and 3-mercapto-pyrazinoyl-guanidines,corresponding ethers and thioethers and processes for their preparation
|
US3948895A
(en)
*
|
1971-09-28 |
1976-04-06 |
E. I. Du Pont De Nemours And Company |
Synthesis of 3,5-diaminopyrazinoic acid from 3,5-diamino-2,6-dicyanopyrazine and intermediates
|
US4085211A
(en)
*
|
1975-12-15 |
1978-04-18 |
Merck & Co., Inc. |
Pyrazinecarboxamides and processes for preparing same
|
US4087526A
(en)
*
|
1976-07-23 |
1978-05-02 |
Merck & Co., Inc. |
(3-Amino-5-substituted-6-fluoropyrazinoyl or pyrazamido)-guanidines and their derivatives bearing substituents on the guanidino nitrogens
|
US4208413A
(en)
*
|
1977-03-04 |
1980-06-17 |
Merck & Co., Inc. |
N-Pyrazinecarbonyl-N'-alkoxycarbonyl and N',N"-bis(alkoxycarbonyl)guanidines and processes for preparing same
|
US4108859A
(en)
*
|
1977-06-06 |
1978-08-22 |
The Dow Chemical Company |
Microbicidal (pyridinylamino) alkyl guanidines
|
US4140776A
(en)
*
|
1977-09-16 |
1979-02-20 |
Merck & Co., Inc. |
N-pyrazinecarbonyl-N'-acylguanidines
|
US4190655A
(en)
*
|
1978-08-28 |
1980-02-26 |
Merck & Co., Inc. |
Amiloride citrate
|
EP0009054A1
(en)
*
|
1978-09-19 |
1980-04-02 |
Merck & Co. Inc. |
N-Pyrazinecarbonyl-N'-substituted-sulfamoyl-guanidine and processes for preparing same
|
US4246406A
(en)
*
|
1979-03-27 |
1981-01-20 |
Merck & Co., Inc. |
Heterocyclic substituted pyrazinoylguanidines
|
US4224447A
(en)
*
|
1979-03-27 |
1980-09-23 |
Merck & Co., Inc. |
Novel pyrazinecarboxamides and processes for preparing same
|
US4362724A
(en)
*
|
1980-05-19 |
1982-12-07 |
Merck & Co., Inc. |
Method of treating edema and hypertension and pharmaceutical composition therefor in which the active ingredient comprises a novel substituted pyrazinyl-1,2,4-oxadiazole and a kaliuretic diuretic
|
US4309540A
(en)
*
|
1980-05-19 |
1982-01-05 |
Merck & Co., Inc. |
Substituted pyrazinyl-1,2,4-oxadiazoles
|
US4454132A
(en)
*
|
1981-03-16 |
1984-06-12 |
Merck & Co., Inc. |
Pharmaceutical compositions of novel substituted pyrazinyl-1,2,4-oxadiazoles useful in the treatment of edema and hypertension
|
US4510322A
(en)
*
|
1981-07-13 |
1985-04-09 |
Merck & Co., Inc. |
Indacrinone having enhanced uricosuric
|
US4663322A
(en)
*
|
1982-01-04 |
1987-05-05 |
Beyer Jr Karl H |
Antihypertensive hyperuretic and saluretic agent combinations
|
US4952582A
(en)
*
|
1982-01-04 |
1990-08-28 |
Beyer Jr Karl H |
Pyrazinoylguanidine and derivatives thereof having few polar substituents and being useful as hyperuretic agents
|
DE3312516A1
(de)
*
|
1983-04-07 |
1984-10-11 |
Brigitte Dr. 7400 Tübingen Pfeiffer |
Kernsubstituierte phenylalkylenguanidinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
|
US4604394A
(en)
*
|
1984-10-01 |
1986-08-05 |
Merck & Co., Inc. |
Antiarrhythmic compositions and method
|
DE3925847A1
(de)
*
|
1989-08-04 |
1991-02-07 |
Huels Chemische Werke Ag |
Verfahren zur herstellung von 3-aminopyrazin-2-carbonsaeuremethylester
|
AU654979B2
(en)
*
|
1990-10-05 |
1994-12-01 |
University Of North Carolina At Chapel Hill, The |
Method of administering amiloride
|
US5304125A
(en)
*
|
1990-10-05 |
1994-04-19 |
The University Of North Carolina |
Apparatus for administering solid particulate aerosols to the lungs
|
TW213903B
(xx)
*
|
1991-08-16 |
1993-10-01 |
Boehringer Ingelheim Kg |
|
US6169107B1
(en)
|
1993-04-28 |
2001-01-02 |
Sumitomo Pharmaceutical Co., Ltd. |
Indoloylguanidine derivatives
|
DE4337609A1
(de)
*
|
1993-11-04 |
1995-05-11 |
Boehringer Ingelheim Kg |
Neue Pyrazincarboxamidderivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
|
US5656256A
(en)
*
|
1994-12-14 |
1997-08-12 |
The University Of North Carolina At Chapel Hill |
Methods of treating lung disease by an aerosol containing benzamil or phenamil
|
TW372967B
(en)
*
|
1994-12-27 |
1999-11-01 |
Kanebo Ltd |
1,4 benzoxazine derivative, pharmaceutical composition containing the same and use thereof
|
US5635160A
(en)
*
|
1995-06-07 |
1997-06-03 |
The University Of North Carolina At Chapel Hill |
Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions
|
US5628984A
(en)
*
|
1995-07-31 |
1997-05-13 |
University Of North Carolina At Chapel Hill |
Method of detecting lung disease
|
US5801177A
(en)
*
|
1995-12-14 |
1998-09-01 |
Beyer, Jr.; Karl H. |
Method for controlling and/or lowering serum glucose and fatty acid concentrations and hypertensive blood pressure in non-insulin-dependent diabetic patients
|
US5877217A
(en)
*
|
1995-12-26 |
1999-03-02 |
Alteon Inc. |
N-acylaminoalkyl-hydrazinecarboximidamides
|
DE69828892D1
(de)
*
|
1997-08-29 |
2005-03-10 |
Univ North Carolina |
Verwendung von uridin-5'-diphosphat und analoge zur behandlung von lungenerkrankungen
|
EP1143896B1
(en)
*
|
1998-10-20 |
2006-12-13 |
The University of North Carolina at Chapel Hill |
Methods of hydrating the nasal mucosal surface
|
EP1161242A4
(en)
*
|
1999-01-29 |
2004-06-30 |
Beyer Camille F |
COMPOSITION AND METHOD FOR TREATING DIABETES
|
ATE390414T1
(de)
|
1999-07-19 |
2008-04-15 |
Univ North Carolina |
Arzneimittelwirkstoffe mit zwei kovalent verknüpften wirkstoffgruppen (natriumkanalblocker/p2y2 rezeptor agonist) zur behandlung von schleimhäuten
|
PT1336407E
(pt)
|
2000-11-21 |
2006-07-31 |
Sankyo Co |
Composicao contendo um antagonista do receptor de angiotensina e um diuretico e sua utilizacao para o tratamento da hipertensao
|
US6858615B2
(en)
*
|
2002-02-19 |
2005-02-22 |
Parion Sciences, Inc. |
Phenyl guanidine sodium channel blockers
|
US6858614B2
(en)
|
2002-02-19 |
2005-02-22 |
Parion Sciences, Inc. |
Phenolic guanidine sodium channel blockers
|
CA2484209C
(en)
*
|
2002-05-03 |
2013-06-11 |
Exelixis, Inc. |
Protein kinase modulators and methods of use
|
US7704995B2
(en)
*
|
2002-05-03 |
2010-04-27 |
Exelixis, Inc. |
Protein kinase modulators and methods of use
|
AU2003250483A1
(en)
|
2002-08-19 |
2004-03-11 |
Pfizer Products Inc. |
Combination therapy for hyperproliferative diseases
|
US6903105B2
(en)
*
|
2003-02-19 |
2005-06-07 |
Parion Sciences, Inc. |
Sodium channel blockers
|
AU2004248859C1
(en)
*
|
2003-06-26 |
2011-11-24 |
Biotron Limited |
Antiviral acylguanidine compounds and methods
|
EP2617709B8
(en)
*
|
2003-06-26 |
2022-12-21 |
Biotron Limited |
Guanidine derivatives as antiviral agents
|
US7326706B2
(en)
*
|
2003-08-15 |
2008-02-05 |
Bristol-Myers Squibb Company |
Pyrazine modulators of cannabinoid receptors
|
CA2534568A1
(en)
*
|
2003-08-18 |
2005-03-24 |
Parion Sciences, Inc. |
Aliphatic pyrazinoylguanidine sodium channel blockers
|
US20050090505A1
(en)
*
|
2003-08-18 |
2005-04-28 |
Johnson Michael R. |
Methods of reducing risk of infection from pathogens
|
JP4805824B2
(ja)
*
|
2003-08-18 |
2011-11-02 |
パリオン・サイエンシィズ・インコーポレーテッド |
キャップ化ピラジノイルグアニジンナトリウムチャネルブロッカー
|
US7745442B2
(en)
|
2003-08-20 |
2010-06-29 |
Parion Sciences, Inc. |
Methods of reducing risk of infection from pathogens
|
US20090253714A1
(en)
*
|
2003-08-20 |
2009-10-08 |
Johnson Michael R |
Methods of reducing risk of infection from pathogens
|
US20070099968A1
(en)
*
|
2004-06-26 |
2007-05-03 |
Biotron Limited |
Antiviral compounds and methods
|
US20070021439A1
(en)
*
|
2005-07-25 |
2007-01-25 |
Parion Sciences, Inc. |
Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
|
US7741317B2
(en)
|
2005-10-21 |
2010-06-22 |
Bristol-Myers Squibb Company |
LXR modulators
|
US8642278B2
(en)
*
|
2005-11-22 |
2014-02-04 |
University Of South Florida |
Inhibition of cell proliferation
|
US7888376B2
(en)
|
2005-11-23 |
2011-02-15 |
Bristol-Myers Squibb Company |
Heterocyclic CETP inhibitors
|
CN101663262B
(zh)
|
2006-12-01 |
2014-03-26 |
百时美施贵宝公司 |
用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
|
WO2009049159A1
(en)
|
2007-10-10 |
2009-04-16 |
Parion Sciences, Inc. |
Delivering osmolytes by nasal cannula
|
WO2009139948A1
(en)
*
|
2008-02-26 |
2009-11-19 |
Johnson Michael R |
Poly aromatic sodium channel blockers
|
DE102008053024B4
(de)
|
2008-10-24 |
2015-04-30 |
RUHR-UNIVERSITäT BOCHUM |
Verwendung von Amilorid-Derivaten zur Bekämpfung von Insekten und Milben
|
US8247436B2
(en)
|
2010-03-19 |
2012-08-21 |
Novartis Ag |
Pyridine and pyrazine derivative for the treatment of CF
|
US8945605B2
(en)
|
2011-06-07 |
2015-02-03 |
Parion Sciences, Inc. |
Aerosol delivery systems, compositions and methods
|
CN103687488B
(zh)
|
2011-06-27 |
2015-06-10 |
帕里昂科学公司 |
化学和代谢稳定的具有钠通道阻滞剂活性的二肽
|
AR086745A1
(es)
|
2011-06-27 |
2014-01-22 |
Parion Sciences Inc |
3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
|
SI2855435T1
(sl)
|
2012-05-29 |
2018-09-28 |
Parion Sciences Inc. |
Dendrimeru podobni amino amidi, ki imajo delovanje blokatorja natrijevih kanalov za zdravljenje suhih oči in drugih mukoznih bolezni
|
JP6392242B2
(ja)
|
2012-12-17 |
2018-09-19 |
パリオン・サイエンシィズ・インコーポレーテッド |
粘膜への水分付与が不十分であることが好都合である疾患の治療に有用なクロロ−ピラジンカルボキサミド誘導体
|
CN104995178B
(zh)
|
2012-12-17 |
2018-06-26 |
帕里昂科学公司 |
3,5-二氨基-6-氯-n-(n-(4-苯基丁基)甲脒基)吡嗪-2-甲酰胺化合物
|
EP2986599A1
(en)
|
2013-04-17 |
2016-02-24 |
Pfizer Inc. |
N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
|
JP6449870B2
(ja)
*
|
2013-07-08 |
2019-01-09 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
肺および気道の疾患を処置するための上皮性ナトリウムチャネルの阻害剤としてのアミロライド型化合物
|
US9102633B2
(en)
|
2013-12-13 |
2015-08-11 |
Parion Sciences, Inc. |
Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
|
WO2016055901A1
(en)
|
2014-10-08 |
2016-04-14 |
Pfizer Inc. |
Substituted amide compounds
|
WO2018021520A1
(ja)
|
2016-07-29 |
2018-02-01 |
東レ株式会社 |
グアニジン誘導体及びその医薬用途
|
JOP20210193A1
(ar)
|
2019-01-18 |
2023-01-30 |
Astrazeneca Ab |
مثبطات pcsk9 وطرق استخدامها
|