SE0400021D0 - Non-nucleoside reverse transcriptase inhibitors - Google Patents

Non-nucleoside reverse transcriptase inhibitors

Info

Publication number
SE0400021D0
SE0400021D0 SE0400021A SE0400021A SE0400021D0 SE 0400021 D0 SE0400021 D0 SE 0400021D0 SE 0400021 A SE0400021 A SE 0400021A SE 0400021 A SE0400021 A SE 0400021A SE 0400021 D0 SE0400021 D0 SE 0400021D0
Authority
SE
Sweden
Prior art keywords
alkyl
orx
nrxrx
reverse transcriptase
transcriptase inhibitors
Prior art date
Application number
SE0400021A
Other languages
Swedish (sv)
Inventor
Christer Sahlberg
Stefan Lindstroem
Nathalie Roue
Christian Sund
Original Assignee
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivir Ab filed Critical Medivir Ab
Priority to SE0400021A priority Critical patent/SE0400021D0/en
Publication of SE0400021D0 publication Critical patent/SE0400021D0/en
Priority to PCT/SE2004/002034 priority patent/WO2005066131A1/en
Priority to JP2006549182A priority patent/JP4762917B2/en
Priority to EP04809207A priority patent/EP1701942B1/en
Priority to CN2004800423227A priority patent/CN1926108B/en
Priority to CA2550187A priority patent/CA2550187C/en
Priority to DK04809207.6T priority patent/DK1701942T3/en
Priority to US10/584,933 priority patent/US7915295B2/en
Priority to EA200601289A priority patent/EA009700B1/en
Priority to NZ548367A priority patent/NZ548367A/en
Priority to SG200809639-8A priority patent/SG149070A1/en
Priority to BRPI0418306A priority patent/BRPI0418306B8/en
Priority to ES04809207T priority patent/ES2337794T3/en
Priority to AT04809207T priority patent/ATE451357T1/en
Priority to DE602004024584T priority patent/DE602004024584D1/en
Priority to AU2004312284A priority patent/AU2004312284B2/en
Priority to ZA200605395A priority patent/ZA200605395B/en
Priority to IL176740A priority patent/IL176740A/en
Priority to HK07109407.1A priority patent/HK1101400A1/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of the formula Z: where; A is CH or N; R1 is a substituent to a carbon atom in the ring containing A selected from -S(=O)pRa, where Ra is -C1-C4 alkyl, -ORx, -NRxRx, -NHNRxRx, - NHNHC(=O)ORx, -NRxOH; -C(=O)-Rb, where Rb is -CT-C4-alkyl, ORx, -NRxRx, -NHNRxRx, -NHC1-C3-alkyl-C(=O)Orx -NRxRc, where Rc is H, C1-C4 alkyl, -NRxRx; -C(=0)Rd, -CN, S(=O)pRx where Rd is Rd is C1-C4-alkyl, -ORx, -NRxRx C1-C3-alkyl-O-Cl-C3alkylC(=O)ORx, -C1-C3-alkyl-COORx; -C1-C3alkyl-OH or C1-C4 alkyl ethers or esters thereof (O-Cl-C3alkyl)q-O-Rx a 5 or 6 membered aromatic ring having 1-3 hetero atoms p is 1 or 2; Rx is independently selected from H, C1-C4 alkyl or acetyl; or a pair of Rx can together with the adjacent N atom form a ring; L is -0-, -S(=O),- or -CH2-, where r is 0, 1 or 2; R3-R7 are substituents as defined in the specification; X is -(CR8R8')n-D-(CR8R8')m-; D is a bond, -NR9-, -0-, -S-, -S(=0)- or -S(=0)2-; and pharmaceutically acceptable salts and prodrugs thereof, have utility as HIVantivirals.
SE0400021A 2004-01-08 2004-01-08 Non-nucleoside reverse transcriptase inhibitors SE0400021D0 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
SE0400021A SE0400021D0 (en) 2004-01-08 2004-01-08 Non-nucleoside reverse transcriptase inhibitors
AU2004312284A AU2004312284B2 (en) 2004-01-08 2004-12-30 Non-nucleotide reverse transcriptase inhibitors
EA200601289A EA009700B1 (en) 2004-01-08 2004-12-30 Non-nucleotide reverse transcriptase inhibitors
SG200809639-8A SG149070A1 (en) 2004-01-08 2004-12-30 Non-nucleotide reverse transcriptase inhibitors
EP04809207A EP1701942B1 (en) 2004-01-08 2004-12-30 Non-nucleotide reverse transcriptase inhibitors
CN2004800423227A CN1926108B (en) 2004-01-08 2004-12-30 Non-nucleotide reverse transcriptase inhibitors
CA2550187A CA2550187C (en) 2004-01-08 2004-12-30 Non-nucleoside reverse transcriptase inhibitors
DK04809207.6T DK1701942T3 (en) 2004-01-08 2004-12-30 Non-nucleotide reverse transcriptase inhibitors
US10/584,933 US7915295B2 (en) 2004-01-08 2004-12-30 Non-nucleotide reverse transcriptase inhibitors
PCT/SE2004/002034 WO2005066131A1 (en) 2004-01-08 2004-12-30 Non-nucleotide reverse transcriptase inhibitors
NZ548367A NZ548367A (en) 2004-01-08 2004-12-30 Non-nucleoside reverse transcriptase inhibitors
JP2006549182A JP4762917B2 (en) 2004-01-08 2004-12-30 Non-nucleoside reverse transcriptase inhibitors
BRPI0418306A BRPI0418306B8 (en) 2004-01-08 2004-12-30 compound n-[(1s,1ar,7br)-4,7-difluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromen-1-yl]-n-[5-(4-(sulfonamido)phenoxy )-2-pyridinyl]urea, pharmaceutical composition and use of said compound for prophylaxis or treatment of HIV-1 infections
ES04809207T ES2337794T3 (en) 2004-01-08 2004-12-30 NON-NUCLEOSIDE INHIBITORS OF THE REVERSE TRANSCRIPT.
AT04809207T ATE451357T1 (en) 2004-01-08 2004-12-30 NON-NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITORS
DE602004024584T DE602004024584D1 (en) 2004-01-08 2004-12-30 INHIBITORS OF THE NON-NUCLEOTIDIC REVERSE TRANSCRIPTASE
ZA200605395A ZA200605395B (en) 2004-01-08 2006-06-29 Non-nucleotide reverse transcriptase inhibitors
IL176740A IL176740A (en) 2004-01-08 2006-07-06 Non-nucleotide reverse transcriptase inhibitors, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for the prophylaxis or treatment of hiv-1 infections
HK07109407.1A HK1101400A1 (en) 2004-01-08 2007-08-29 Non-nucleotide reverse transcriptase inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0400021A SE0400021D0 (en) 2004-01-08 2004-01-08 Non-nucleoside reverse transcriptase inhibitors

Publications (1)

Publication Number Publication Date
SE0400021D0 true SE0400021D0 (en) 2004-01-08

Family

ID=31493006

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0400021A SE0400021D0 (en) 2004-01-08 2004-01-08 Non-nucleoside reverse transcriptase inhibitors

Country Status (3)

Country Link
CN (1) CN1926108B (en)
SE (1) SE0400021D0 (en)
ZA (1) ZA200605395B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105693725A (en) * 2016-03-22 2016-06-22 河南师范大学 Method for synthesizing chiral ternary purine carbocyclic nucleoside analogue through intramolecular asymmetric cycloaddition

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0100733D0 (en) * 2001-03-05 2001-03-05 Medivir Ab Non-nucleoside reverse transcriptase inhibitors

Also Published As

Publication number Publication date
ZA200605395B (en) 2007-04-25
CN1926108A (en) 2007-03-07
CN1926108B (en) 2010-06-09

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