CO5170535A1 - DERIVATIVES OF N- [2- (4-AMINOPHENYL) ETHYL] 2,3-DIHIDRO-1,4- BENZODIOXIN-2-METHANAMINE, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS - Google Patents

DERIVATIVES OF N- [2- (4-AMINOPHENYL) ETHYL] 2,3-DIHIDRO-1,4- BENZODIOXIN-2-METHANAMINE, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS

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Publication number
CO5170535A1
CO5170535A1 CO00022433A CO00022433A CO5170535A1 CO 5170535 A1 CO5170535 A1 CO 5170535A1 CO 00022433 A CO00022433 A CO 00022433A CO 00022433 A CO00022433 A CO 00022433A CO 5170535 A1 CO5170535 A1 CO 5170535A1
Authority
CO
Colombia
Prior art keywords
group
alkylcarbamoyl
oxo
phenyl
alkoxy
Prior art date
Application number
CO00022433A
Other languages
Spanish (es)
Inventor
Evanno Yannick
Peretti Daniele De
Francois Gilbert Jean
Michel Peynot
Jocelyne Roy
Garcia Antonio Almario
Maria-Carmen Renones
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of CO5170535A1 publication Critical patent/CO5170535A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring

Abstract

Compuesto, en forma de enantiómero puro o de mezcla de enantiómeros, que responde a la fórmula general (I)<EMI FILE="00022433_1" ID="1" IMF=JPEG >en la cual X representa un átomo de hidrógeno o de halógeno o un grupo ciano, un grupo nitro, un grupo hidroxi, un grupo (C1-C4) alquilo, un grupo fenilo, un grupo tienilo, un grupo tienilmetoxi, un grupo (C1-C4) alcoxi, un grupo ciclo (C3-C6) alquilmetoxi, un grupo fenilmetoxi, un grupo (C1-C4) alcoxicarbonilo, un grupo (C1-C4) alcoxicarbonilmetilo, un grupo pirrolidin-1-ilcarbonilo, un grupo carbamoilo, un grupo N-(C1-C4) alquilcarbamoilo, un grupo N,N-di(C1-C4) alquilcarbamoilo, un grupo trifluorometilsulfoniloxi, un grupo dimetilaminocarboniloxi, un grupo dimetilaminocarbonilmetoxi, un grupo acetilamino, un grupo acetilaminometilo, o bien dos grupos elegidos entre los átomos de halógenos y los grupos nitro, ciano, (C1-C4) alquilos y (C1-C4) alcoxi, R1 representa un átomo de hidrógeno o un grupo metilo, y R2, tomado aisladamente, representa ya sea un grupo (C1-C4) alcanoilo, ya sea un grupo fenil (C1-C4) alcanoilo, ya sea un grupo metoxiacetilo, ya sea un grupo (C3-C6) cicloalquilcarbonilo, ya sea un grupo benzoilo eventualmente sustituido por un átomo de halógeno, por un grupo (C1-C4) alquilo, por un grupo (C1-C4) alcoxi, por un grupo metoximetilo o por un grupo metoxi y un grupo etilsulfonilo, ya sea un grupo N-fenilcarbamoilo, ya sea un grupo N-((C1-C4) alquilcarbamoilo, ya sea un grupo N-(2-metoxietil) carbamoilo, ya sea un grupo (C1-C4) alcoxicarbonilo, ya sea un grupo (C1-C4)alquilsulfonilo, ya sea un grupo fenilsulfonilo, ya sea un grupo piridin-4-ilcarbonilo, ya sea también un grupo divalente de fórmula COCH2 ó COCH2CH2 enlazado al ciclo fenilo en posición orto del átomo de nitrógeno, de manera tal de formar con este ciclo un grupo 2-oxo-3H-indol-5-ilo ó 2-oxo-3,4-dihidroquinolein-6-ilo, o también NR1R2 representa un grupo 2-oxo-4,5-dihidrooxazolidin-3-ilo, en estado de base o de sal de adición a un ácido.Compound, in the form of a pure enantiomer or mixture of enantiomers, which responds to the general formula (I) <EMI FILE = "00022433_1" ID = "1" IMF = JPEG> in which X represents a hydrogen or halogen atom or a cyano group, a nitro group, a hydroxy group, a (C1-C4) alkyl group, a phenyl group, a thienyl group, a thienylmethoxy group, an (C1-C4) alkoxy group, a cyclo (C3-C6) group ) alkylmethoxy, a phenylmethoxy group, a (C1-C4) alkoxycarbonyl group, a (C1-C4) alkoxycarbonylmethyl group, a pyrrolidin-1-ylcarbonyl group, a carbamoyl group, an N- (C1-C4) alkylcarbamoyl group, a group N, N-di (C1-C4) alkylcarbamoyl, a trifluoromethylsulfonyloxy group, a dimethylaminocarbonyloxy group, a dimethylaminocarbonylmethoxy group, an acetylamino group, an acetylaminomethyl group, or two groups chosen from halogen atoms and nitro, cyano groups, ( C1-C4) alkyls and (C1-C4) alkoxy, R1 represents a hydrogen atom or a methyl group, and R2, taken in isolation, represents either a (C1-C4) alkanoyl group, either a phenyl (C1-C4) alkanoyl group, either a methoxyacetyl group, either a (C3-C6) cycloalkylcarbonyl group, or a benzoyl group optionally substituted by a halogen atom, by a (C1-C4) alkyl group, by a (C1-C4) alkoxy group, by a methoxymethyl group or by a methoxy group and an ethylsulfonyl group, either an N-phenylcarbamoyl group, either a group N - ((C1-C4) alkylcarbamoyl, either an N- (2-methoxyethyl) carbamoyl group, either a (C1-C4) alkoxycarbonyl group, either a (C1-C4) alkylsulfonyl group, or a phenylsulfonyl group , either a pyridin-4-ylcarbonyl group, also a divalent group of formula COCH2 or COCH2CH2 linked to the ortho-phenyl cycle of the nitrogen atom, so as to form a 2-oxo-3H- group with this cycle. indole-5-yl or 2-oxo-3,4-dihydroquinoline-6-yl, or NR1R2 also represents a 2-oxo-4,5-dihydrooxazolidin-3-yl group, in the base or additive salt state On to an acid.

CO00022433A 1999-03-30 2000-03-29 DERIVATIVES OF N- [2- (4-AMINOPHENYL) ETHYL] 2,3-DIHIDRO-1,4- BENZODIOXIN-2-METHANAMINE, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS CO5170535A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9903936A FR2791675B1 (en) 1999-03-30 1999-03-30 DERIVATIVES OF N- [2- (4-AMINOPHENYL) ETHYL] -2,3-DIHYDRO-1,4- BENZODIOXINNE-2-METHANAMINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
CO5170535A1 true CO5170535A1 (en) 2002-06-27

Family

ID=9543788

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00022433A CO5170535A1 (en) 1999-03-30 2000-03-29 DERIVATIVES OF N- [2- (4-AMINOPHENYL) ETHYL] 2,3-DIHIDRO-1,4- BENZODIOXIN-2-METHANAMINE, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS

Country Status (6)

Country Link
AU (1) AU3660700A (en)
CO (1) CO5170535A1 (en)
FR (1) FR2791675B1 (en)
PE (1) PE20001598A1 (en)
UY (1) UY26085A1 (en)
WO (1) WO2000058301A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0117396D0 (en) 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
WO2006089053A2 (en) 2005-02-17 2006-08-24 Wyeth Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives
BRPI0610046A2 (en) * 2005-04-22 2010-05-25 Wyeth Corp benzodioxane and benzodioxolane derivatives and uses of these
CA2605587A1 (en) 2005-04-22 2006-11-02 Wyeth Chromane and chromene derivatives and uses thereof
AR060493A1 (en) * 2006-04-18 2008-06-18 Wyeth Corp DERIVATIVES OF BENZODIOXAN AND BENZODIOXOLAN. OBTAINING PROCESSES.
WO2008052086A1 (en) * 2006-10-24 2008-05-02 Wyeth Benzodioxane derivatives and uses thereof
MX2010011724A (en) 2008-04-29 2010-11-30 Nsab Af Neurosearch Sweden Ab Modulators of dopamine neurotransmission.
JP2011519839A (en) * 2008-04-29 2011-07-14 エヌエスエイビー、フィリアル アヴ ノイロサーチ スウェーデン エービー、スヴェーリエ Modulator of dopamine neurotransmission
US8492372B2 (en) 2008-04-29 2013-07-23 Integrated Research Laboratories Sweden Ab Modulators of dopamine neurotransmission

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1054104A (en) * 1962-07-20
CA1147342A (en) * 1977-10-12 1983-05-31 Kazuo Imai Process of producing novel phenylethanolamine derivatives

Also Published As

Publication number Publication date
FR2791675B1 (en) 2001-05-04
AU3660700A (en) 2000-10-16
UY26085A1 (en) 2000-10-31
PE20001598A1 (en) 2001-04-01
WO2000058301A1 (en) 2000-10-05
FR2791675A1 (en) 2000-10-06

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