RU98119523A - COMPOUNDS OF PIPERAZIN AND PIPERIDINE - Google Patents
COMPOUNDS OF PIPERAZIN AND PIPERIDINEInfo
- Publication number
- RU98119523A RU98119523A RU98119523/04A RU98119523A RU98119523A RU 98119523 A RU98119523 A RU 98119523A RU 98119523/04 A RU98119523/04 A RU 98119523/04A RU 98119523 A RU98119523 A RU 98119523A RU 98119523 A RU98119523 A RU 98119523A
- Authority
- RU
- Russia
- Prior art keywords
- formula
- group
- compound
- salts
- phenyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 17
- GLUUGHFHXGJENI-UHFFFAOYSA-N piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000011780 sodium chloride Substances 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000005842 heteroatoms Chemical group 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 230000003993 interaction Effects 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- -1 cyano, aminocarbonyl Chemical group 0.000 claims 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 1
- 125000004429 atoms Chemical group 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Claims (6)
в которой A обозначает гетероциклическую группу с 5-7 атомами в кольце, содержащую 1-3 гетероатомами из группы O, N и S; R1 обозначает водород или фтор; R2 обозначает C1-4алкил, C1-4алкокси или оксогруппу, и p равен 0, 1 или 2; Z обозначает углерод или азот, и пунктирная линия обозначает простую связь, когда Z является азотом, и простую или двойную связь, когда Z является углеродом; R3 и R4 независимо друг от друга обозначают водород или C1-4алкил; n равен 1 или 2; R5 обозначает галоген, гидрокси, C1-4алкокси или C1-4алкил, и q равен 0, 1, 2 или 3; Y обозначает фенил, фуранил или тиенил, которые могут быть замещены 1-3 заместителями из группы гидрокси, галоген, C1-4алкокси, C1-4алкил, циано, аминокарбонил, моно- иди ди-C1-4алкиламинокарбонил; и их соли.1. The compounds of formula a
in which A denotes a heterocyclic group with 5-7 atoms in the ring, containing 1-3 heteroatoms from the group O, N and S; R 1 denotes hydrogen or fluorine; R 2 is C 1-4 alkyl, C 1-4 alkoxy or oxo, and p is 0, 1 or 2; Z is carbon or nitrogen, and the dotted line indicates a single bond when Z is nitrogen, and a single or double bond when Z is carbon; R 3 and R 4 independently of one another denote hydrogen or C 1-4 alkyl; n is 1 or 2; R 5 is halogen, hydroxy, C 1-4 alkoxy or C 1-4 alkyl, and q is 0, 1, 2 or 3; Y is phenyl, furanyl or thienyl, which may be substituted by 1 to 3 substituents from the group of hydroxy, halogen, C 1-4 alkoxy, C 1-4 alkyl, cyano, aminocarbonyl, mono di di C 1-4 alkylaminocarbonyl; and their salts.
в которой R1 и (R2)p имеют значения, указанные в п.1, n равен 1, R3, R4, (R5)q, Y и Z имеют значения, указанные в пункте 1, и их соли.
in which R 1 and (R 2 ) p have the meanings indicated in item 1, n is 1, R 3 , R 4 , (R 5 ) q, Y and Z have the meanings indicated in item 1 and their salts.
подвергают взаимодействию с соединением формулы
в которой X является отщепляемой группой; или b) соединение формулы n подвергают взаимодействию с соединением формулы
и формальдегидом; или c) соединение формулы n подвергают взаимодействию с соединением формулы
с последующим восстановлением кетогруппы; или d) соединение формулы
подвергают взаимодействию с соединением Y-Br; или e) соединение формулы
подвергают взаимодействию с соединением формулы
B(OH)2-Y
причем символы, используемые в этих формулах, имеют значения, указанные в п.1.6. The method of producing compounds claimed in claim 1, which is that a) a compound of the formula n
subjected to interaction with the compound of the formula
in which X is a leaving group; or b) a compound of formula n is reacted with a compound of formula
and formaldehyde; or c) a compound of formula n is reacted with a compound of formula
with the subsequent restoration of ketogroup; or d) a compound of the formula
subjected to interaction with the compound Y-Br; or e) a compound of the formula
subjected to interaction with the compound of the formula
B (OH) 2 -Y
moreover, the symbols used in these formulas have the meanings indicated in paragraph 1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96200864 | 1996-03-29 | ||
EP96200864.5 | 1996-03-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU98119523A true RU98119523A (en) | 2000-10-20 |
RU2178414C2 RU2178414C2 (en) | 2002-01-20 |
Family
ID=8223832
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU98119523/04A RU2178414C2 (en) | 1996-03-29 | 1997-03-20 | Derivatives of piperazine and piperidine and method of their synthesis |
Country Status (25)
Country | Link |
---|---|
US (1) | US6225312B1 (en) |
EP (1) | EP0889889B1 (en) |
JP (1) | JP3989554B2 (en) |
CN (1) | CN1100055C (en) |
AT (1) | ATE340173T1 (en) |
AU (1) | AU708053B2 (en) |
BR (1) | BRPI9708389B8 (en) |
CA (1) | CA2250347C (en) |
CZ (1) | CZ294413B6 (en) |
DE (1) | DE69736704T2 (en) |
DK (1) | DK0889889T3 (en) |
ES (1) | ES2271967T3 (en) |
HU (1) | HU227454B1 (en) |
IL (1) | IL126187A0 (en) |
NO (1) | NO320970B1 (en) |
NZ (1) | NZ331860A (en) |
PL (1) | PL189256B1 (en) |
PT (1) | PT889889E (en) |
RU (1) | RU2178414C2 (en) |
SK (1) | SK285119B6 (en) |
TR (1) | TR199801942T2 (en) |
TW (1) | TW422846B (en) |
UA (1) | UA52656C2 (en) |
WO (1) | WO1997036893A1 (en) |
ZA (1) | ZA972639B (en) |
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US20030186838A1 (en) * | 2000-05-12 | 2003-10-02 | Feenstra Roelof W. | Use of compounds having combined dopamine d2, 5-ht1a and alpha adrenoreceptor agonistic action for treating cns disorders |
SK286778B6 (en) * | 2000-05-12 | 2009-05-07 | Solvay Pharmaceuticals B. V. | Piperazine and piperidine compounds, method for their preparation and pharmaceutical compositions comprising the same and their use |
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US7964604B2 (en) | 2005-02-18 | 2011-06-21 | Solvay Pharmaceuticals B.V. | Bifeprunox mesylate maintenance dose compositions and methods for using the same |
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US7786126B2 (en) | 2006-06-16 | 2010-08-31 | Solvay Pharmaceuticals B.V. | Combination preparations comprising SLV308 and a dopamine agonist |
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DK2445502T4 (en) * | 2009-06-25 | 2022-11-28 | Alkermes Pharma Ireland Ltd | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHOLOGICAL DISORDERS |
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-
1997
- 1997-03-20 PL PL97329123A patent/PL189256B1/en not_active IP Right Cessation
- 1997-03-20 RU RU98119523/04A patent/RU2178414C2/en not_active IP Right Cessation
- 1997-03-20 US US09/155,608 patent/US6225312B1/en not_active Expired - Lifetime
- 1997-03-20 PT PT97908288T patent/PT889889E/en unknown
- 1997-03-20 CN CN97193520A patent/CN1100055C/en not_active Expired - Fee Related
- 1997-03-20 UA UA98105745A patent/UA52656C2/en unknown
- 1997-03-20 DE DE69736704T patent/DE69736704T2/en not_active Expired - Lifetime
- 1997-03-20 TR TR1998/01942T patent/TR199801942T2/en unknown
- 1997-03-20 AT AT97908288T patent/ATE340173T1/en active
- 1997-03-20 EP EP97908288A patent/EP0889889B1/en not_active Expired - Lifetime
- 1997-03-20 DK DK97908288T patent/DK0889889T3/en active
- 1997-03-20 BR BRPI9708389A patent/BRPI9708389B8/en not_active IP Right Cessation
- 1997-03-20 CZ CZ19983068A patent/CZ294413B6/en not_active IP Right Cessation
- 1997-03-20 AU AU20294/97A patent/AU708053B2/en not_active Ceased
- 1997-03-20 JP JP53488697A patent/JP3989554B2/en not_active Expired - Fee Related
- 1997-03-20 SK SK1331-98A patent/SK285119B6/en not_active IP Right Cessation
- 1997-03-20 HU HU9902471A patent/HU227454B1/en not_active IP Right Cessation
- 1997-03-20 ES ES97908288T patent/ES2271967T3/en not_active Expired - Lifetime
- 1997-03-20 CA CA002250347A patent/CA2250347C/en not_active Expired - Fee Related
- 1997-03-20 NZ NZ331860A patent/NZ331860A/en not_active IP Right Cessation
- 1997-03-20 WO PCT/EP1997/001461 patent/WO1997036893A1/en active IP Right Grant
- 1997-03-20 IL IL12618797A patent/IL126187A0/en not_active IP Right Cessation
- 1997-03-26 ZA ZA9702639A patent/ZA972639B/en unknown
- 1997-03-28 TW TW086104056A patent/TW422846B/en not_active IP Right Cessation
-
1998
- 1998-09-28 NO NO19984533A patent/NO320970B1/en not_active IP Right Cessation
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