RU96121584A - MODIFIED NUCLEOSID-5'-TRIPHOSPHATES AS INHIBITORS OR SUBSTRATES OF DNA-POLYMERASE AND ANTI-VIRUS AGENTS - Google Patents
MODIFIED NUCLEOSID-5'-TRIPHOSPHATES AS INHIBITORS OR SUBSTRATES OF DNA-POLYMERASE AND ANTI-VIRUS AGENTSInfo
- Publication number
- RU96121584A RU96121584A RU96121584/04A RU96121584A RU96121584A RU 96121584 A RU96121584 A RU 96121584A RU 96121584/04 A RU96121584/04 A RU 96121584/04A RU 96121584 A RU96121584 A RU 96121584A RU 96121584 A RU96121584 A RU 96121584A
- Authority
- RU
- Russia
- Prior art keywords
- triphosphates
- inhibitors
- substrates
- polymerase
- dna
- Prior art date
Links
- 101700011961 DPOM Proteins 0.000 title claims 2
- 101710029649 MDV043 Proteins 0.000 title claims 2
- 101700061424 POLB Proteins 0.000 title claims 2
- 101700054624 RF1 Proteins 0.000 title claims 2
- 239000003443 antiviral agent Substances 0.000 title claims 2
- 239000003112 inhibitor Substances 0.000 title claims 2
- 239000000758 substrate Substances 0.000 title claims 2
- 239000001226 triphosphate Substances 0.000 title claims 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical group O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 4
- RWQNBRDOKXIBIV-UHFFFAOYSA-N Thymine Chemical group CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims 2
- 229940035893 Uracil Drugs 0.000 claims 2
- 229960000643 Adenine Drugs 0.000 claims 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical group NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 1
- OPTASPLRGRRNAP-UHFFFAOYSA-N Cytosine Chemical group NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 1
- 229940104302 Cytosine Drugs 0.000 claims 1
- UYTPUPDQBNUYGX-UHFFFAOYSA-N Guanine Chemical group O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 1
- 229940113082 Thymine Drugs 0.000 claims 1
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical group C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000001810 isothiocyanato group Chemical group *N=C=S 0.000 claims 1
- 239000002777 nucleoside Substances 0.000 claims 1
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 1
Claims (1)
где B - тимин, аденин, урацил, гуанин, цитозин или урацил, замещенный в 5-положении;
A -
R' - H, N3, SH, NH2, F, Cl, CN, NCO, NCS, NOH;
R'' - H или R' и R'' вместе образуют двойную связь;
Z - O, CH2;
R''' - Alkyl, Aryl, OAlkyl, OAryl, NHAlkyl, NHAryl, O-Gly;
X' = X'' = H, Br, F; или X'=H, а X''=F, Br, NH2, CH2NH2, NHAlk, NHAryl; или X'=F, а X''=Br; или X'=CH3, а X''=NH2.Modified nucleoside 5'-triphosphates of the general formula
where B is thymine, adenine, uracil, guanine, cytosine, or uracil substituted in the 5-position;
A -
R 'is H, N 3 , SH, NH 2 , F, Cl, CN, NCO, NCS, NOH;
R "is H or R" and R "together form a double bond;
Z is O, CH 2 ;
R '' - Alkyl, Aryl, OAlkyl, OAryl, NHAlkyl, NHAryl, O-Gly;
X '= X''= H, Br, F; or X '= H, and X "= F, Br, NH 2 , CH 2 NH 2 , NHAlk, NHAryl; or X '= F, and X "= Br; or X '= CH 3 , and X "= NH 2 .
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU96121584/04A RU2183213C2 (en) | 1996-11-05 | 1996-11-05 | Modified nucleoside-5'-triphosphates as antiviral agents |
| PCT/RU1997/000348 WO1998020017A1 (en) | 1996-11-05 | 1997-11-05 | Modified nucleoside-5'-triphosphates |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU96121584/04A RU2183213C2 (en) | 1996-11-05 | 1996-11-05 | Modified nucleoside-5'-triphosphates as antiviral agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU96121584A true RU96121584A (en) | 1999-02-10 |
| RU2183213C2 RU2183213C2 (en) | 2002-06-10 |
Family
ID=20187094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU96121584/04A RU2183213C2 (en) | 1996-11-05 | 1996-11-05 | Modified nucleoside-5'-triphosphates as antiviral agents |
Country Status (2)
| Country | Link |
|---|---|
| RU (1) | RU2183213C2 (en) |
| WO (1) | WO1998020017A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7138384B1 (en) | 1997-08-29 | 2006-11-21 | The Regents Of The University Of California | Modulators of DNA cytosine-5 methyltransferase and methods for use thereof |
| US7285658B2 (en) | 2002-02-28 | 2007-10-23 | Biota, Inc. | Nucleotide mimics and their prodrugs |
| ES2543834T3 (en) | 2004-03-04 | 2015-08-24 | K.U.Leuven Research & Development | Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections and intermediates for their production |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU455958A1 (en) * | 1973-03-23 | 1975-01-05 | Предприятие П/Я А-1758 | The way thymidine-5 "-diphosphate |
| JPS58225097A (en) * | 1982-06-23 | 1983-12-27 | Yamasa Shoyu Co Ltd | Nucleoside 5'-alkyl or alkenylphosphate |
| DE3490262T1 (en) * | 1983-05-24 | 1985-11-28 | Sri International, Menlo Park, Calif. | Antivirus agents |
| KR880000093B1 (en) * | 1984-12-07 | 1988-02-23 | 보령제약 주식회사 | Process for the preparation of neucleoside derivative |
| SE462497B (en) * | 1988-11-30 | 1990-07-02 | Clas Fredrik Runesson Kaelland | CAUSED TO ACTIVATE DETERMINATION POLYMERASES |
| CA2479846C (en) * | 1989-05-15 | 2007-07-24 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Scienc Es Of The Czech Republic | Phosphonomethoxymethylpurine/pyrimidine derivatives |
-
1996
- 1996-11-05 RU RU96121584/04A patent/RU2183213C2/en active
-
1997
- 1997-11-05 WO PCT/RU1997/000348 patent/WO1998020017A1/en active Application Filing
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