RU94046161A - Способы экспрессии, днк, кассета экспрессии, изолированный участок регуляции транскрипции, растение, семя, способ изменения метаболизма, часть растения, способ получения полипептидов - Google Patents
Способы экспрессии, днк, кассета экспрессии, изолированный участок регуляции транскрипции, растение, семя, способ изменения метаболизма, часть растения, способ получения полипептидовInfo
- Publication number
- RU94046161A RU94046161A RU94046161/13A RU94046161A RU94046161A RU 94046161 A RU94046161 A RU 94046161A RU 94046161/13 A RU94046161/13 A RU 94046161/13A RU 94046161 A RU94046161 A RU 94046161A RU 94046161 A RU94046161 A RU 94046161A
- Authority
- RU
- Russia
- Prior art keywords
- expression
- plant
- casette
- seed
- methods
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8222—Developmentally regulated expression systems, tissue, organ specific, temporal or spatial regulation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8222—Developmentally regulated expression systems, tissue, organ specific, temporal or spatial regulation
- C12N15/823—Reproductive tissue-specific promoters
- C12N15/8234—Seed-specific, e.g. embryo, endosperm
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Developmental Biology & Embryology (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Peptides Or Proteins (AREA)
- Fats And Perfumes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Заявляются ДНК - конструкции, включающие 5' - нетранслированные последовательности генов, активных от поздних глобулярный стадий и вплоть до созревания эмбриона. Указанные конструкции можно использовать для экспрессии представляющих интерес ДНК - последовательностей в течение фаз эмбрионального развития, которые предшествуют стадии накопления запасных белков.
Claims (1)
- Заявляются ДНК - конструкции, включающие 5' - нетранслированные последовательности генов, активных от поздних глобулярный стадий и вплоть до созревания эмбриона. Указанные конструкции можно использовать для экспрессии представляющих интерес ДНК - последовательностей в течение фаз эмбрионального развития, которые предшествуют стадии накопления запасных белков.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86235592A | 1992-04-02 | 1992-04-02 | |
US07/862,355 | 1992-04-02 | ||
PCT/CA1992/000161 WO1993021320A1 (en) | 1991-02-22 | 1992-04-15 | Oil-body proteins as carriers of high-value peptides in plants |
WOPCT/CA92/00161 | 1992-04-15 | ||
PCT/CA1993/000141 WO1993020216A1 (en) | 1991-02-22 | 1993-04-02 | Oil-body protein cis-elements as regulatory signals |
Publications (2)
Publication Number | Publication Date |
---|---|
RU94046161A true RU94046161A (ru) | 1997-05-10 |
RU2148647C1 RU2148647C1 (ru) | 2000-05-10 |
Family
ID=25683013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU94046161A RU2148647C1 (ru) | 1992-04-02 | 1993-04-02 | Способ экспрессии представляющей интерес последовательности днк в клетке семени, днк-конструкция, кассета экспрессии, изолированный регуляторный участок транскрипции и способ изменения специфичного для семян метаболизма |
Country Status (12)
Country | Link |
---|---|
US (1) | US5792922A (ru) |
EP (1) | EP0633940B1 (ru) |
JP (1) | JP3660354B2 (ru) |
KR (1) | KR100278456B1 (ru) |
AT (1) | ATE229076T1 (ru) |
AU (1) | AU678154B2 (ru) |
DE (1) | DE69332538T2 (ru) |
ES (1) | ES2187505T3 (ru) |
FI (1) | FI120314B (ru) |
NO (1) | NO321501B1 (ru) |
RU (1) | RU2148647C1 (ru) |
UA (1) | UA41319C2 (ru) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001042443A1 (fr) * | 1999-12-09 | 2001-06-14 | Institut Molekulyarnoi Biologii Im. V.A.Engelgardta Rossiiskoi Akademii Nauk | Procede de modification des proprietes genetiques d'un organisme |
RU2561463C2 (ru) * | 2009-04-22 | 2015-08-27 | Басф Плант Сайенс Компани Гмбх | Промотор целого семени |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6586661B1 (en) * | 1997-06-12 | 2003-07-01 | North Carolina State University | Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid |
US6635806B1 (en) * | 1998-05-14 | 2003-10-21 | Dekalb Genetics Corporation | Methods and compositions for expression of transgenes in plants |
DE19923571A1 (de) * | 1999-05-21 | 2000-11-23 | Kws Saat Ag | Nukleotid-Sequenz zur Erhöhung der Abwehrreaktion einer Pflanze gegen Pathogenbefall |
US20030140372A1 (en) * | 1999-06-07 | 2003-07-24 | Shen Jennie Bih-Jien | Genes for desaturases to alter lipid profiles in corn |
US6784342B1 (en) | 1999-08-04 | 2004-08-31 | The University Of British Columbia | Regulation of embryonic transcription in plants |
US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
IL154596A0 (en) | 2000-08-25 | 2003-09-17 | Basf Plant Science Gmbh | Plant polynucleotides encoding novel prenyl proteases |
WO2002018607A2 (en) * | 2000-08-30 | 2002-03-07 | North Carolina State University | Transgenic plants containing molecular decoys that alter protein content therein |
BR0116220A (pt) * | 2000-12-19 | 2003-09-23 | Sembiosys Genetics Inc | Métodos para a produção de proteìnas multiméricas e composições relacionadas |
US20030167524A1 (en) * | 2000-12-19 | 2003-09-04 | Rooijen Gijs Van | Methods for the production of multimeric protein complexes, and related compositions |
US7122720B2 (en) | 2001-04-24 | 2006-10-17 | Cornell Research Foundation, Inc. | Synthetic nucleic acid molecule for imparting multiple traits |
JP4771656B2 (ja) | 2001-05-30 | 2011-09-14 | カリックス・バイオ−ベンチャーズ・インコーポレイテッド | 植物人工染色体、その使用及び植物人工染色体の製造方法 |
US20060179514A1 (en) * | 2001-07-05 | 2006-08-10 | Sembiosys Genetics, Inc. | Methods for the production of multimeric protein complexes, and related compositions |
CN105131104B (zh) | 2001-10-10 | 2018-11-16 | 诺和诺德公司 | 肽的重构和糖缀合 |
DK1578771T3 (da) | 2001-10-10 | 2013-06-10 | Novo Nordisk As | Remodellering og glycokonjugering af peptider |
US7329798B2 (en) * | 2002-06-28 | 2008-02-12 | University Of Guelph | Harvest-inducible regulatory elements and methods of using same |
WO2004002216A2 (en) | 2002-06-28 | 2004-01-08 | University Of Guelph | Harvest-inducible genes from alfalfa (medicago sativa) and methods of use thereof |
IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
US8486376B2 (en) | 2002-10-25 | 2013-07-16 | Foamix Ltd. | Moisturizing foam containing lanolin |
KR101108439B1 (ko) | 2002-10-25 | 2012-01-31 | 포믹스 리미티드 | 화장료 및 약제용 거품제 |
US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
US8119150B2 (en) * | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Non-flammable insecticide composition and uses thereof |
US8119109B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Foamable compositions, kits and methods for hyperhidrosis |
AU2004213797B2 (en) | 2003-02-14 | 2009-09-17 | Biogen Ma Inc. | An expression cassette and vector for transient or stable expression of exogenous molecules |
EP2338333B1 (en) | 2003-04-09 | 2017-09-06 | ratiopharm GmbH | Glycopegylation methods and proteins/peptides produced by the methods |
US7575739B2 (en) | 2003-04-28 | 2009-08-18 | Foamix Ltd. | Foamable iodine composition |
EA014887B1 (ru) | 2003-06-17 | 2011-02-28 | Сембайосиз Джинетикс Инк. | Способ экспрессии инсулина в семенах растения, способ получения семян растений, содержащих инсулин, и растения, способные производить семена, содержащие инсулин |
US8795693B2 (en) | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
US8486374B2 (en) | 2003-08-04 | 2013-07-16 | Foamix Ltd. | Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses |
EP1684603A2 (en) * | 2003-10-02 | 2006-08-02 | Vector Tobacco Ltd. | Tobacco product labeling system |
AU2006298442A1 (en) | 2005-05-09 | 2007-04-12 | Foamix Ltd. | Saccharide foamable compositions |
AU2006249983B2 (en) | 2005-05-23 | 2011-03-17 | Arcadia Biosciences, Inc. | Safflower with elevated gamma-linolenic acid |
US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
US20090049569A1 (en) * | 2007-08-13 | 2009-02-19 | Pioneer Hi-Bred International, Inc. | Seed-Preferred Regulatory Elements |
WO2009069006A2 (en) | 2007-11-30 | 2009-06-04 | Foamix Ltd. | Foam containing benzoyl peroxide |
US8518376B2 (en) | 2007-12-07 | 2013-08-27 | Foamix Ltd. | Oil-based foamable carriers and formulations |
WO2009072007A2 (en) | 2007-12-07 | 2009-06-11 | Foamix Ltd. | Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof |
CA2712120A1 (en) | 2008-01-14 | 2009-07-23 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
EP2298883B1 (en) * | 2008-05-28 | 2016-07-27 | Kyoto University | Novel selection marker gene and use thereof |
CA2760186C (en) | 2009-04-28 | 2019-10-29 | Foamix Ltd. | Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof |
CA2769677A1 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
WO2011013009A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
EP2482788B1 (en) | 2009-10-02 | 2022-12-14 | Journey Medical Corporation | Topical tetracycline compositions |
US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
US10398641B2 (en) | 2016-09-08 | 2019-09-03 | Foamix Pharmaceuticals Ltd. | Compositions and methods for treating rosacea and acne |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ221259A (en) * | 1986-07-31 | 1990-05-28 | Calgene Inc | Seed specific transcriptional regulation |
AU3073592A (en) * | 1991-11-15 | 1993-06-15 | E.I. Du Pont De Nemours And Company | Beta -ketoacyl-acp synthetase ii genes from plants |
-
1993
- 1993-04-02 UA UA94105980A patent/UA41319C2/ru unknown
- 1993-04-02 AT AT93907716T patent/ATE229076T1/de active
- 1993-04-02 AU AU38844/93A patent/AU678154B2/en not_active Expired
- 1993-04-02 ES ES93907716T patent/ES2187505T3/es not_active Expired - Lifetime
- 1993-04-02 US US08/313,098 patent/US5792922A/en not_active Expired - Lifetime
- 1993-04-02 KR KR1019940703487A patent/KR100278456B1/ko not_active IP Right Cessation
- 1993-04-02 EP EP93907716A patent/EP0633940B1/en not_active Expired - Lifetime
- 1993-04-02 RU RU94046161A patent/RU2148647C1/ru active
- 1993-04-02 JP JP51693593A patent/JP3660354B2/ja not_active Expired - Lifetime
- 1993-04-02 DE DE69332538T patent/DE69332538T2/de not_active Expired - Lifetime
-
1994
- 1994-09-30 FI FI944550A patent/FI120314B/fi not_active IP Right Cessation
- 1994-09-30 NO NO19943664A patent/NO321501B1/no not_active IP Right Cessation
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001042443A1 (fr) * | 1999-12-09 | 2001-06-14 | Institut Molekulyarnoi Biologii Im. V.A.Engelgardta Rossiiskoi Akademii Nauk | Procede de modification des proprietes genetiques d'un organisme |
RU2561463C2 (ru) * | 2009-04-22 | 2015-08-27 | Басф Плант Сайенс Компани Гмбх | Промотор целого семени |
US10519458B2 (en) | 2009-04-22 | 2019-12-31 | Basf Plant Science Company Gmbh | Whole seed specific promoter |
US11629353B2 (en) | 2009-04-22 | 2023-04-18 | Basf Plant Science Company Gmbh | Whole seed specific promoter |
Also Published As
Publication number | Publication date |
---|---|
NO943664L (no) | 1994-11-15 |
NO321501B1 (no) | 2006-05-15 |
UA41319C2 (ru) | 2001-09-17 |
US5792922A (en) | 1998-08-11 |
KR950700995A (ko) | 1995-02-20 |
EP0633940A1 (en) | 1995-01-18 |
JPH07505525A (ja) | 1995-06-22 |
NO943664D0 (no) | 1994-09-30 |
FI120314B (fi) | 2009-09-15 |
KR100278456B1 (ko) | 2001-01-15 |
DE69332538D1 (de) | 2003-01-16 |
RU2148647C1 (ru) | 2000-05-10 |
JP3660354B2 (ja) | 2005-06-15 |
FI944550A0 (fi) | 1994-09-30 |
AU678154B2 (en) | 1997-05-22 |
ATE229076T1 (de) | 2002-12-15 |
AU3884493A (en) | 1993-11-08 |
ES2187505T3 (es) | 2003-06-16 |
DE69332538T2 (de) | 2003-11-06 |
EP0633940B1 (en) | 2002-12-04 |
FI944550A (fi) | 1994-11-30 |
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