RU94046140A - Соединения, промотирующие остеогенез и/или ингибирующие костную резорбцию - Google Patents
Соединения, промотирующие остеогенез и/или ингибирующие костную резорбциюInfo
- Publication number
- RU94046140A RU94046140A RU94046140/04A RU94046140A RU94046140A RU 94046140 A RU94046140 A RU 94046140A RU 94046140/04 A RU94046140/04 A RU 94046140/04A RU 94046140 A RU94046140 A RU 94046140A RU 94046140 A RU94046140 A RU 94046140A
- Authority
- RU
- Russia
- Prior art keywords
- bone resorption
- compounds
- inhibits bone
- promote osteogenesis
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
- C07J71/0047—Nitrogen only at position 2(3)
Abstract
Соединение представлено формулой, приведенной в описании, способно концентрироваться в костной ткани и обладает ингибирующим резорбцию и промотирующим окостенение действием.
Claims (1)
- Соединение представлено формулой, приведенной в описании, способно концентрироваться в костной ткани и обладает ингибирующим резорбцию и промотирующим окостенение действием.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN93110919.1 | 1993-03-25 | ||
CN 93110919 CN1092779A (zh) | 1993-03-25 | 1993-03-25 | 可用作带有***结构的骨靶向药物的化合物 |
JP35540493 | 1993-12-29 | ||
JP5-355404 | 1993-12-29 | ||
PCT/JP1994/000489 WO1994021667A1 (en) | 1993-03-25 | 1994-03-25 | Compound for inhibiting bone resorption and accelerating osteogenesis |
Publications (2)
Publication Number | Publication Date |
---|---|
RU94046140A true RU94046140A (ru) | 1997-02-10 |
RU2138507C1 RU2138507C1 (ru) | 1999-09-27 |
Family
ID=25743075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU94046140A RU2138507C1 (ru) | 1993-03-25 | 1994-03-25 | Производные тетрациклина |
Country Status (6)
Country | Link |
---|---|
US (2) | US5760214A (ru) |
EP (1) | EP0643071B1 (ru) |
JP (1) | JP3377856B2 (ru) |
DE (1) | DE69426684T2 (ru) |
RU (1) | RU2138507C1 (ru) |
WO (1) | WO1994021667A1 (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07242548A (ja) * | 1993-12-29 | 1995-09-19 | Isukura Sangyo Kk | 骨吸収抑制・骨形成促進剤 |
FR2757519B1 (fr) * | 1996-12-23 | 1999-06-11 | Hoechst Marion Roussel Inc | Steroides substitues en position 11, leur procede de preparation, leur application comme medicament et les compositions pharmaceutiques les renfermant |
WO2000066613A1 (en) * | 1999-04-30 | 2000-11-09 | Research Corporation Technologies, Inc. | Bone targeting agents for osteoporosis |
US20030181371A1 (en) * | 2001-12-28 | 2003-09-25 | Angiotech Pharmaceuticals, Inc. | Compositions and methods of using collajolie |
CA2509060A1 (en) * | 2002-12-27 | 2004-07-22 | Angiotech International Ag | Compositions and methods of using collagen and mmpi |
MXPA06007851A (es) * | 2004-01-15 | 2007-01-31 | Warner Chilcott Co Inc | Profarmacos di-esteroidales de etinil estradiol. |
US20070015741A1 (en) * | 2005-07-12 | 2007-01-18 | James Keown | Novel prodrugs of estradiol |
WO2007024338A2 (en) * | 2005-07-12 | 2007-03-01 | Warner Chilcott Company, Inc. | 3 -ester prodrugs of ethynylestradiol |
EP3423464B1 (en) * | 2016-03-03 | 2021-05-26 | Crystal Pharma, S.A.U. | Process and new intermediates for the preparation of 11-methylene steroids |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2997471A (en) * | 1958-08-18 | 1961-08-22 | Bristol Myers Co | Tetracycline derivatives |
US4925833A (en) * | 1983-12-29 | 1990-05-15 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis |
GR861167B (en) * | 1985-05-02 | 1986-09-30 | Research Corp | Bone targeted inhibitors of carbonic anhydrase |
DK224589A (da) * | 1988-05-09 | 1989-11-10 | Merck & Co Inc | Polymalonsyreforbindelse og farmaceutisk praeparat indeholdende en saadan forbindelse |
US5183815A (en) * | 1991-01-22 | 1993-02-02 | Merck & Co., Inc. | Bone acting agents |
EP0496520A1 (en) * | 1991-01-22 | 1992-07-29 | Merck & Co. Inc. | Novel bone acting agents |
JPH07242548A (ja) * | 1993-12-29 | 1995-09-19 | Isukura Sangyo Kk | 骨吸収抑制・骨形成促進剤 |
-
1994
- 1994-03-25 WO PCT/JP1994/000489 patent/WO1994021667A1/ja active IP Right Grant
- 1994-03-25 US US08/338,505 patent/US5760214A/en not_active Expired - Fee Related
- 1994-03-25 EP EP94910542A patent/EP0643071B1/en not_active Expired - Lifetime
- 1994-03-25 JP JP07786494A patent/JP3377856B2/ja not_active Expired - Fee Related
- 1994-03-25 RU RU94046140A patent/RU2138507C1/ru active
- 1994-03-25 DE DE69426684T patent/DE69426684T2/de not_active Expired - Fee Related
-
1997
- 1997-07-03 US US08/888,108 patent/US6028207A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1994021667A1 (en) | 1994-09-29 |
RU2138507C1 (ru) | 1999-09-27 |
US5760214A (en) | 1998-06-02 |
EP0643071A4 (en) | 1995-10-25 |
US6028207A (en) | 2000-02-22 |
JP3377856B2 (ja) | 2003-02-17 |
EP0643071B1 (en) | 2001-02-14 |
EP0643071A1 (en) | 1995-03-15 |
DE69426684D1 (de) | 2001-03-22 |
JPH07233190A (ja) | 1995-09-05 |
DE69426684T2 (de) | 2001-09-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69528829T2 (de) | Präparate zur hemmung der durch osteoklasten vermittelten knochenresorption | |
BR9408246A (pt) | Composto derivado de 3-azabicicloalcano N-substituído | |
DE10075033I2 (de) | substituierte Pyrazolyl-benzolsulfonamide zur Behandlung von Entzündungen. | |
FI961506A0 (fi) | Distamysiini A -analogit antituumorisina ja antiviraalisina aineina | |
AUPP268898A0 (en) | High modulus polyurethane compositions | |
BRPI0213063B8 (pt) | composto antibiótico de ação dupla, sua composição farmacêutica e seu uso | |
ATE206409T1 (de) | N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1-h- benzo(b)(1,5)-diazepin-3-yl)-acetamide | |
RU94046140A (ru) | Соединения, промотирующие остеогенез и/или ингибирующие костную резорбцию | |
BR0008689A (pt) | Composição antioxidante | |
ES2128051T3 (es) | Isomero de doble enlace de la equilina, procedente de la isomerizacion acida de la equilina. | |
ATE270667T1 (de) | 2-amino-benzoxazinone zur behandlung von viralen infektionen | |
DK1089625T3 (da) | Ektoparasiticide midler | |
ATE252833T1 (de) | Biozidzusammensetzung und diese verwendendes sterilisationsverfahren | |
BR9906975A (pt) | Composto, uso do mesmo, composição farmacêutica, e, processo para estimular a liberação do hormÈnio do crescimento pela pituitária de um mamìfero | |
CA2162604A1 (en) | Osteogenesis promoter and osteoporosis remedy | |
ES2105708T3 (es) | Carbamoilhidroxilaminas y su empleo en la quimica polimerica. | |
SE9300106D0 (sv) | Komposition foer att paaskynda saarlaekning | |
NO960271L (no) | Tiokarbamoylforbindelser anvendt som mikrobiocider | |
ATE113843T1 (de) | Verwendung eines prolylendopeptidase-inhibitors zur behandlung von aids. | |
ITRM940566A1 (it) | Composti organici | |
CA2032311A1 (en) | 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aromatase and 19-hydroxylase inhibitors | |
SE9504617D0 (sv) | Active compounds II | |
MY111499A (en) | 1 - < [ - cyclopropyl - - (substituted oxy) - o - tolyl] sulfamoyl> -3- (4,6- dimethoxy - 2 - pyrimidinyl) urea herbicidal agents |