RU94040170A - Изохинолины - Google Patents

Изохинолины

Info

Publication number
RU94040170A
RU94040170A RU94040170/04A RU94040170A RU94040170A RU 94040170 A RU94040170 A RU 94040170A RU 94040170/04 A RU94040170/04 A RU 94040170/04A RU 94040170 A RU94040170 A RU 94040170A RU 94040170 A RU94040170 A RU 94040170A
Authority
RU
Russia
Prior art keywords
esters
compounds
salts
pharmaceutically acceptable
addition
Prior art date
Application number
RU94040170/04A
Other languages
English (en)
Other versions
RU2144027C1 (ru
Inventor
Рето Наэф
Ch]
Original Assignee
Сандоз Лтд. (CH)
Сандоз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сандоз Лтд. (CH), Сандоз Лтд. filed Critical Сандоз Лтд. (CH)
Publication of RU94040170A publication Critical patent/RU94040170A/ru
Application granted granted Critical
Publication of RU2144027C1 publication Critical patent/RU2144027C1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Соединения, эфиры и соли, образующиеся в результате добавления фармацевтически приемлемых кислот, пригодны для использования в качестве фармацевтических средств, в частности для терапии астмы.

Claims (1)

  1. Соединения, эфиры и соли, образующиеся в результате добавления фармацевтически приемлемых кислот, пригодны для использования в качестве фармацевтических средств, в частности для терапии астмы.
RU94040170A 1993-11-05 1994-11-04 Изохинолины, способ их получения и фармацевтическая композиция на их основе RU2144027C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9322828.6 1993-11-05
GB939322828A GB9322828D0 (en) 1993-11-05 1993-11-05 Organic compounds

Publications (2)

Publication Number Publication Date
RU94040170A true RU94040170A (ru) 1996-10-10
RU2144027C1 RU2144027C1 (ru) 2000-01-10

Family

ID=10744697

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94040170A RU2144027C1 (ru) 1993-11-05 1994-11-04 Изохинолины, способ их получения и фармацевтическая композиция на их основе

Country Status (26)

Country Link
US (1) US5747506A (ru)
EP (1) EP0664289A3 (ru)
JP (1) JPH07188176A (ru)
KR (1) KR950014073A (ru)
CN (1) CN1051998C (ru)
AT (1) AT404940B (ru)
AU (1) AU685852B2 (ru)
CA (1) CA2135000A1 (ru)
CH (1) CH688478A5 (ru)
CZ (1) CZ282329B6 (ru)
DE (1) DE4438737A1 (ru)
FI (1) FI945191A (ru)
FR (1) FR2711989B1 (ru)
GB (2) GB9322828D0 (ru)
HK (1) HK1005776A1 (ru)
HU (1) HU217120B (ru)
IL (1) IL111518A (ru)
IT (1) IT1273993B (ru)
NO (1) NO302293B1 (ru)
NZ (1) NZ264851A (ru)
PE (1) PE30395A1 (ru)
PL (1) PL178210B1 (ru)
RU (1) RU2144027C1 (ru)
SK (1) SK280298B6 (ru)
TW (1) TW353067B (ru)
ZA (1) ZA948738B (ru)

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GB9312853D0 (en) 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5591776A (en) 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5922751A (en) 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US6166041A (en) 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
ID19155A (id) * 1996-12-13 1998-06-18 Tanabe Seiyaku Co Turunan-turunan piridin, pembuatannya dan intermediet untuk pembuatannya
US5919794A (en) * 1998-05-11 1999-07-06 Virginia Commonwealth University Methods of using pharmaceutical tetrahydroisoquinolines
US6200771B1 (en) * 1998-10-15 2001-03-13 Cell Pathways, Inc. Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia
IL132407A0 (en) * 1998-10-21 2001-03-19 Pfizer Prod Inc Method for treating congestive heart failure
DE19930614A1 (de) * 1999-07-02 2001-01-04 Mann & Hummel Filter Filtereinsatz
BRPI0013478B8 (pt) 1999-08-21 2016-12-27 Altana Pharma Ag medicamento compreendendo inibidor pde e uso de roflumilast
CA2402413A1 (en) * 2000-03-14 2001-09-20 The University Of Western Ontario Compositions and methods for affecting osteogenesis
KR20030045184A (ko) 2000-11-14 2003-06-09 알타나 파마 아게 포스포디에스테라제 억제제로서 (디히드로)이소퀴놀린유도체
AU2002224835A1 (en) * 2000-11-14 2002-05-27 Byk Gulden Lomberg Chemische Fabrik G.M.B.H. Dihydroisoquinolines as novel phosphodiesterase inhibitors
DE10229762A1 (de) * 2002-07-03 2004-01-22 Aventis Pharma Deutschland Gmbh Pyrazoloisoquinolinenderivaten zur Inhibierung von NFkappaB-induzierende Kinase
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
JP2006522151A (ja) 2003-04-01 2006-09-28 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 不妊症におけるホスホジエステラーゼ阻害剤
US7795385B2 (en) * 2004-12-17 2010-09-14 Bexar Global, Inc. Use of bombesin/gastrin-releasing peptide antagonists for the treatment of inflammatory conditions, acute lung injury and bipolar disorder
CA2688161C (en) 2007-06-04 2020-10-20 Kunwar Shailubhai Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
BRPI0919282A2 (pt) * 2008-10-02 2017-03-28 Asahi Kasei Pharma Corp composto, composição farmacêutica, inibidor de ikkb, método para inibir ikkb, métodos para prevenir e/ou tratar uma doença ou sintoma associado com nf-kb, uma doença ou sintoma associado com ikkb, e uma doença ou sintoma associado com reação inflamatória aguda ou crônica em mamíferos
BRPI0920246A2 (pt) 2008-10-17 2017-06-27 Winconsin Alumni Res Foundation método de preparação de alfa-beta peptídios biologicamente ativos.
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2012118972A2 (en) 2011-03-01 2012-09-07 Synegy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
AU2014218599C1 (en) 2013-02-25 2018-09-06 Bausch Health Ireland Limited Guanylate cyclase receptor agonists for use in colonic cleansing
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CN105764916B (zh) 2013-06-05 2021-05-18 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
IL280864B2 (en) 2013-08-09 2024-03-01 Ardelyx Inc Compounds and methods for inhibiting phosphate transport
CN114340631A (zh) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 用于降低患者的血清磷酸盐的组合

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Publication number Priority date Publication date Assignee Title
GB645139A (en) * 1946-10-22 1950-10-25 Servita Gyogyszeryar Es Vegyip Improved process for the production of isoquinoline derivatives
GB1400425A (en) * 1971-09-22 1975-07-16 Rolland Sa A Substituted 3-hydroxymethyl-isoquinolines and derivatives
US3878215A (en) * 1971-12-01 1975-04-15 Sandoz Ag 2-Alkyl-3-substituted-4-aryl isoquinolines
US4018927A (en) * 1973-12-17 1977-04-19 The Regents Of The University Of Michigan Treatment of proliferating skin diseases with papaverine alkaloids
KR840002104B1 (ko) * 1980-08-08 1984-11-15 부자 앙드레 신규 이소퀴놀린 유도체의 제법
HU183479B (en) * 1981-06-16 1984-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new 6,7-diethoxy-1-aracket-4-ethoxy-3-hydroxy-benzyl-bracket closed-3,4-dihydroisoquinolin
DE3244594A1 (de) * 1982-12-02 1984-06-07 Hoechst Ag, 6230 Frankfurt 1-phenylisochinolinderivate und verfahren zu ihrer herstellung, diese verbindung enthaltende pharmazeutische praeparate und deren anwendung
GB8328052D0 (en) * 1983-10-20 1983-11-23 Beecham Group Plc Compounds
US4761403A (en) * 1986-04-09 1988-08-02 Abbott Laboratories Lipoxygenase inhibiting compounds
HU196758B (en) * 1986-05-21 1989-01-30 Gyogyszerkutato Intezet Process for production of 3-hidroxi-methil-quinolines and medical compositions containing them
PH25651A (en) * 1986-05-21 1991-08-21 Duphar Int Res New di, tetrahydroisoquinoline derivatives
GB8800397D0 (en) * 1988-01-08 1988-02-10 Sandoz Ltd Improvements in/relating to organic compounds
GB9027055D0 (en) * 1990-12-13 1991-02-06 Sandoz Ltd Organic compounds

Also Published As

Publication number Publication date
AT404940B (de) 1999-03-25
HUT71350A (en) 1995-11-28
GB2283488B (en) 1997-12-03
CN1106801A (zh) 1995-08-16
HU9403184D0 (en) 1994-12-28
TW353067B (en) 1999-02-21
CZ269894A3 (en) 1995-07-12
ATA204894A (de) 1998-08-15
IL111518A0 (en) 1995-01-24
GB2283488A (en) 1995-05-10
ZA948738B (en) 1996-05-06
EP0664289A3 (en) 1995-09-13
RU2144027C1 (ru) 2000-01-10
US5747506A (en) 1998-05-05
NZ264851A (en) 1996-04-26
FR2711989A1 (fr) 1995-05-12
CA2135000A1 (en) 1995-05-06
GB9322828D0 (en) 1993-12-22
CZ282329B6 (cs) 1997-06-11
NO944187L (no) 1995-05-08
PL305705A1 (en) 1995-05-15
IT1273993B (it) 1997-07-14
AU7761094A (en) 1995-05-18
SK280298B6 (sk) 1999-11-08
FR2711989B1 (fr) 1996-06-14
SK131994A3 (en) 1995-06-07
NO944187D0 (no) 1994-11-03
ITRM940706A1 (it) 1996-05-03
JPH07188176A (ja) 1995-07-25
KR950014073A (ko) 1995-06-15
PE30395A1 (es) 1995-10-25
AU685852B2 (en) 1998-01-29
ITRM940706A0 (it) 1994-11-03
HU217120B (hu) 1999-11-29
CN1051998C (zh) 2000-05-03
HK1005776A1 (en) 1999-01-22
FI945191A (fi) 1995-05-06
DE4438737A1 (de) 1995-05-11
CH688478A5 (de) 1997-10-15
FI945191A0 (fi) 1994-11-03
EP0664289A2 (en) 1995-07-26
PL178210B1 (pl) 2000-03-31
IL111518A (en) 1999-06-20
GB9421985D0 (en) 1994-12-21
NO302293B1 (no) 1998-02-16

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