RU94030817A - DNA, PROTEIN, VECTOR, CELL, METHOD OF PRODUCT RECEIVING - Google Patents

DNA, PROTEIN, VECTOR, CELL, METHOD OF PRODUCT RECEIVING

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Publication number
RU94030817A
RU94030817A RU94030817/13A RU94030817A RU94030817A RU 94030817 A RU94030817 A RU 94030817A RU 94030817/13 A RU94030817/13 A RU 94030817/13A RU 94030817 A RU94030817 A RU 94030817A RU 94030817 A RU94030817 A RU 94030817A
Authority
RU
Russia
Prior art keywords
dna
fgd
serine
vector
protein
Prior art date
Application number
RU94030817/13A
Other languages
Russian (ru)
Other versions
RU2154671C1 (en
Inventor
П. Берлингейм Ричард
Original Assignee
Вакер-Хеми ГмбХ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Вакер-Хеми ГмбХ filed Critical Вакер-Хеми ГмбХ
Publication of RU94030817A publication Critical patent/RU94030817A/en
Application granted granted Critical
Publication of RU2154671C1 publication Critical patent/RU2154671C1/en

Links

Claims (1)

Раскрыта ДНК, кодирующая 3-фосфоглицератдегидрогена (ФГД) с пониженной чувствительностью к ингибированию серином по сравнению с ФГД дикого типа, т. е. ДНК кодирует ФГД, обладающую хоть каким-то полезным для биосинтеза уровнем ферментативной активности и сохраняющую такую активность при более высоком содержании серила, чем это характерно для дикого типа (немодифицированной) ФГД. Раскрыты также: а) ФГД с аминокислотной последовательностью указанной созданной генной инженерией ДНК; Ь) экспрессионные вектора, содержащие созданную генной инженерией ДНК и регуляторную ДНК, расположенную и ориентированную для экспрессии созданной генной инженерией ДНК в экспрессионной системе хозяина; с) клетки, содержащие такие экспрессионные вектора, и d) способы получения серина или происходящих из серина соединений культивированием таких клеток.DNA encoding 3-phosphoglycerate dehydrogen (FGD) with reduced susceptibility to serine inhibition compared to wild-type FGD, i.e., DNA encodes FGD, which has at least some level of enzymatic activity useful for biosynthesis and retains such activity at higher content, is disclosed. serila than is typical for wild-type (unmodified) FGD. Also disclosed are: a) FGD with the amino acid sequence of the indicated created genetic engineering of DNA; B) expression vectors containing genetically engineered DNA and regulatory DNA located and oriented for the expression of the genetically engineered DNA in the host expression system; c) cells containing such expression vectors, and d) methods for producing serine or compounds derived from serine by culturing such cells.
RU94030817/13A 1991-12-12 1992-08-17 Dna fragment encoding 3-phosphoglycerate dehydrogenase, 3-phosphoglycerate dehydrogenase, method of serine producing RU2154671C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP91121385 1991-12-12
DE91121385,8 1991-12-12
DE91121385.8 1991-12-12

Publications (2)

Publication Number Publication Date
RU94030817A true RU94030817A (en) 1996-03-10
RU2154671C1 RU2154671C1 (en) 2000-08-20

Family

ID=8207424

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94030817/13A RU2154671C1 (en) 1991-12-12 1992-08-17 Dna fragment encoding 3-phosphoglycerate dehydrogenase, 3-phosphoglycerate dehydrogenase, method of serine producing

Country Status (19)

Country Link
US (1) US5618716A (en)
EP (1) EP0620853B1 (en)
JP (1) JP2584409B2 (en)
KR (1) KR0132258B1 (en)
CN (1) CN1065914C (en)
AU (1) AU668359B2 (en)
BR (1) BR9206902A (en)
CA (1) CA2124214C (en)
CZ (1) CZ285915B6 (en)
DE (1) DE69208894T2 (en)
ES (1) ES2084373T3 (en)
FI (1) FI113665B (en)
HU (1) HU217795B (en)
RU (1) RU2154671C1 (en)
SK (1) SK279805B6 (en)
TW (1) TW313589B (en)
UA (1) UA39861C2 (en)
WO (1) WO1993012235A1 (en)
ZA (1) ZA926405B (en)

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US6250918B1 (en) 1999-11-30 2001-06-26 Orametrix, Inc. Method and apparatus for simulating tooth movement for an orthodontic patient
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DE10331291A1 (en) * 2003-07-10 2005-02-17 Consortium für elektrochemische Industrie GmbH Variants of 3-phosphoglycerate dehydrogenase with reduced inhibition by L-serine and genes coding for it
JP2008531234A (en) 2005-03-07 2008-08-14 アライン テクノロジー， インコーポレイテッド Various dental aligners
US20060275731A1 (en) 2005-04-29 2006-12-07 Orthoclear Holdings, Inc. Treatment of teeth by aligners
DE102005049527B4 (en) * 2005-10-17 2013-05-08 Forschungszentrum Jülich GmbH Process for the preparation of L-serine, gene sequence, vectors and microorganism
RU2006129690A (en) 2006-08-16 2008-02-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) METHOD FOR PRODUCING L-AMINO ACID USING BACTERIA OF THE Enterobacteriaceae FAMILY IN WHICH EXPRESSION OF THE ydiN GENE, ydiB GENE OR THEIR COMBINATION IS DECREASED
JP2010017081A (en) * 2006-10-10 2010-01-28 Ajinomoto Co Inc Method for producing l-amino acid
JP2010017082A (en) * 2006-10-10 2010-01-28 Ajinomoto Co Inc Method for producing l-amino acid
EP2192170B1 (en) 2007-09-04 2017-02-15 Ajinomoto Co., Inc. Amino acid-producing microorganism and method of producing amino acid
JP5332237B2 (en) * 2008-03-06 2013-11-06 味の素株式会社 L-cysteine producing bacterium and method for producing L-cysteine
US8383372B2 (en) * 2008-03-06 2013-02-26 Ajinomoto Co., Inc. L-cysteine producing bacterium and a method for producing L-cysteine
ES2549003T3 (en) 2008-12-31 2015-10-22 Metabolic Explorer Method for the preparation of diols
CN102639691B (en) * 2009-11-30 2014-04-16 味之素株式会社 L-cysteine-producing bacterium, and process for production of L-cysteine
WO2012001003A1 (en) 2010-07-02 2012-01-05 Metabolic Explorer Method for the preparation of hydroxy acids
DE102011075656A1 (en) 2011-05-11 2012-03-29 Wacker Chemie Ag Producing L-cystine useful as food additive, preferably in baking industry, as ingredient in cosmetics and as starting material for producing active pharmaceutical ingredient, comprises fermenting microorganism strain in fermentation medium
DE102011078481A1 (en) 2011-06-30 2013-01-03 Wacker Chemie Ag Process for the fermentative production of natural L-cysteine
DE102012208359A1 (en) 2012-05-18 2013-11-21 Wacker Chemie Ag Process for the fermentative production of L-cysteine and derivatives of this amino acid
DE102012216527A1 (en) 2012-09-17 2014-03-20 Wacker Chemie Ag Process for the fermentative production of L-cysteine and derivatives of this amino acid
WO2014049382A2 (en) 2012-09-26 2014-04-03 Metabolic Explorer Ethylenediamine fermentative production by a recombinant microorganism
DE102013209274A1 (en) 2013-05-17 2014-11-20 Wacker Chemie Ag Microorganism and method for fermentative overproduction of gamma-glutamylcysteine and derivatives of this dipeptide
CN113710798A (en) 2019-02-20 2021-11-26 布拉斯科公司 Degradation pathways for pentoses and hexoses
US12006526B2 (en) 2019-02-20 2024-06-11 Braskem S.A. Microorganisms and methods for the production of oxygenated compounds from hexoses
CN116018400A (en) 2020-06-26 2023-04-25 瓦克化学股份公司 Improved cysteine producing strains
WO2023165684A1 (en) 2022-03-01 2023-09-07 Wacker Chemie Ag Improved cysteine-producing strains

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