RU93048539A - Производные оксазолидина, обладающие противодиабетическими свойствами и действием против ожирения, их получение и терапевтическое применение - Google Patents
Производные оксазолидина, обладающие противодиабетическими свойствами и действием против ожирения, их получение и терапевтическое применениеInfo
- Publication number
- RU93048539A RU93048539A RU93048539/04A RU93048539A RU93048539A RU 93048539 A RU93048539 A RU 93048539A RU 93048539/04 A RU93048539/04 A RU 93048539/04A RU 93048539 A RU93048539 A RU 93048539A RU 93048539 A RU93048539 A RU 93048539A
- Authority
- RU
- Russia
- Prior art keywords
- production
- therapeutic use
- action against
- possessing anti
- against obesity
- Prior art date
Links
- 208000008589 Obesity Diseases 0.000 title claims 3
- 235000020824 obesity Nutrition 0.000 title claims 3
- 230000003178 anti-diabetic Effects 0.000 title 2
- 229940053194 antiepileptics Oxazolidine derivatives Drugs 0.000 title 1
- 150000002917 oxazolidines Chemical class 0.000 title 1
- 230000001225 therapeutic Effects 0.000 title 1
- 206010012601 Diabetes mellitus Diseases 0.000 claims 2
- 206010062060 Hyperlipidaemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000005418 aryl aryl group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 201000005577 familial hyperlipidemia Diseases 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical group O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 229910052717 sulfur Chemical group 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
Claims (1)
- Соединение формулы I
в которой R представляет собой алкильную группу; X является кислородом или серой; Y представляет собой атом водорода или группу формулы -A-COOH, в которой A представляет собой алкиленовую группу; Ar является арилом или замещенной арильной группой; и их фармацевтически приемлемые соли и эфиры используют для лечения или профилактики диабета, ожирения, гиперлипемии, гипергликемии, осложнений диабета, вызванных ожирением, гипертензии и остеопороза.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP23114092 | 1992-08-31 | ||
JP4-231140 | 1992-08-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93048539A true RU93048539A (ru) | 1996-05-20 |
RU2090564C1 RU2090564C1 (ru) | 1997-09-20 |
Family
ID=16918916
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU9393048539A RU2090564C1 (ru) | 1992-08-31 | 1993-08-30 | Производные оксазолидина, или их фармацевтически приемлемые соли, или сложные эфиры и способ их получения |
Country Status (22)
Country | Link |
---|---|
US (1) | US5436257A (ru) |
EP (1) | EP0590793B1 (ru) |
JP (1) | JP3201891B2 (ru) |
KR (1) | KR940003955A (ru) |
CN (1) | CN1036588C (ru) |
AT (1) | ATE185564T1 (ru) |
AU (1) | AU663611B2 (ru) |
CA (1) | CA2105149A1 (ru) |
CZ (1) | CZ287027B6 (ru) |
DE (1) | DE69326736T2 (ru) |
DK (1) | DK0590793T3 (ru) |
ES (1) | ES2139633T3 (ru) |
FI (1) | FI933802A (ru) |
GR (1) | GR3031887T3 (ru) |
HK (1) | HK1011979A1 (ru) |
HU (1) | HUT67087A (ru) |
IL (1) | IL106839A (ru) |
NO (1) | NO302121B1 (ru) |
NZ (1) | NZ248532A (ru) |
RU (1) | RU2090564C1 (ru) |
TW (1) | TW318181B (ru) |
ZA (1) | ZA936324B (ru) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5498621A (en) * | 1992-05-01 | 1996-03-12 | Pfizer Inc. | Oxazolidinedione hypoglycemic agents |
NO303782B1 (no) * | 1994-03-23 | 1998-08-31 | Sankyo Co | Tiazolidin- og oksazolidinderivater og farmas°ytiske preparater inneholdende slike, samt deres anvendelse til fremstilling av medikamenter |
CZ289317B6 (cs) * | 1994-04-11 | 2002-01-16 | Sankyo Company Limited | Heterocyklická sloučenina, farmaceutický prostředek ji obsahující a její pouľití |
SK111195A3 (en) * | 1994-09-13 | 1997-06-04 | Sandoz Technology Ltd | Bicyclic ethers substituted with oxazole and thiazole, process for producing thereof and pharmaceutical composition containing same |
JPH09136877A (ja) * | 1995-06-16 | 1997-05-27 | Takeda Chem Ind Ltd | 複素環化合物、その製造法及び用途 |
EP0783888A1 (en) | 1995-12-26 | 1997-07-16 | Sankyo Company Limited | Use of troglitazone and related thiazolidinediones in the manufacture of a medicament for the treatment and prophylaxis of osteoporosis |
TW399051B (en) * | 1996-01-31 | 2000-07-21 | Ssp Co Ltd | A novel benzoazine thiazolidinedione derivative and pharmaceutical composition for reducing blood glucose |
US5801173A (en) * | 1996-05-06 | 1998-09-01 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
US5919782A (en) * | 1996-05-06 | 1999-07-06 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
US5889025A (en) * | 1996-05-06 | 1999-03-30 | Reddy's Research Foundation | Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
US5889032A (en) * | 1996-05-06 | 1999-03-30 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
CZ298812B6 (cs) | 1996-07-01 | 2008-02-13 | Dr. Reddy's Laboratories Limited | Azolidindionové deriváty, způsob jejich přípravy, farmaceutické kompozice s jejich obsahem a jejich použití v léčbě diabetu a příbuzných nemocí |
US6114526A (en) | 1996-07-01 | 2000-09-05 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
US5885997A (en) * | 1996-07-01 | 1999-03-23 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
USRE39266E1 (en) | 1996-07-01 | 2006-09-05 | Dr. Reddy's Laboratories, Limited | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
US6372750B2 (en) | 1996-07-01 | 2002-04-16 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases |
CN1221417A (zh) * | 1996-07-26 | 1999-06-30 | 雷迪博士研究基金会 | 具有抗糖尿病、降低血脂、抗高血压性能的噻唑烷二酮化合物,其制备方法及其药物组合物 |
US7407978B2 (en) * | 1999-04-06 | 2008-08-05 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
US6498170B2 (en) | 2000-07-17 | 2002-12-24 | Wyeth | Cyclamine sulfonamides as β-3 adrenergic receptor agonists |
US6410734B1 (en) | 2000-07-17 | 2002-06-25 | Wyeth | 2-substituted thiazolidinones as beta-3 adrenergic receptor agonists |
US6465501B2 (en) | 2000-07-17 | 2002-10-15 | Wyeth | Azolidines as β3 adrenergic receptor agonists |
US6525202B2 (en) | 2000-07-17 | 2003-02-25 | Wyeth | Cyclic amine phenyl beta-3 adrenergic receptor agonists |
US6537994B2 (en) | 2000-07-17 | 2003-03-25 | Wyeth | Heterocyclic β3 adrenergic receptor agonists |
US6794401B2 (en) * | 2003-01-17 | 2004-09-21 | Bexel Pharmaceuticals, Inc. | Amino acid phenoxy ethers |
WO2006041921A2 (en) * | 2004-10-05 | 2006-04-20 | Auspex Pharmaceuticals, Inc. | Preparation and uses of rhodanine derivatives |
CA2766033C (en) * | 2009-06-25 | 2016-09-20 | Alkermes, Inc. | Prodrugs of nh-acidic compounds |
ES2394349B1 (es) | 2012-08-29 | 2013-11-04 | Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii | Uso de agonistas selectivos de receptores beta-3 adrenérgicos para el tratamiento de hipertensión pulmonar |
CA3092335A1 (en) | 2018-03-05 | 2019-09-12 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
CN115433144B (zh) * | 2022-10-09 | 2023-09-19 | 燃点(南京)生物医药科技有限公司 | 一种脂肪酸酯类化合物及其制备方法和应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5522636A (en) * | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
JPS6051189A (ja) * | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
JPS6242903A (ja) | 1985-08-16 | 1987-02-24 | Earth Chem Corp Ltd | ハエ誘引剤 |
HU203330B (en) * | 1987-06-10 | 1991-07-29 | Pfizer | Process for producing oxazolidin-2-one derivatives and hypoglychemic pharmaceutical compositions containing them |
EP0295828A1 (en) * | 1987-06-13 | 1988-12-21 | Beecham Group Plc | Novel compounds |
EP0842925A1 (en) * | 1987-09-04 | 1998-05-20 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
JPH0231079A (ja) | 1988-07-20 | 1990-02-01 | Kubota Ltd | 作業車の変速操作構造 |
GB8820389D0 (en) * | 1988-08-26 | 1988-09-28 | Beecham Group Plc | Novel compounds |
US5143930A (en) | 1990-02-07 | 1992-09-01 | Sankyo Company, Limited | Thiazolidine derivatives with anti-diabetic activity, their preparation and their use |
US5037842A (en) * | 1990-06-05 | 1991-08-06 | Pfizer Inc. | Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents |
GB9023584D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
GB9023583D0 (en) | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
-
1993
- 1993-08-27 ZA ZA936324A patent/ZA936324B/xx unknown
- 1993-08-27 EP EP93306812A patent/EP0590793B1/en not_active Expired - Lifetime
- 1993-08-27 CZ CZ19931763A patent/CZ287027B6/cs not_active IP Right Cessation
- 1993-08-27 AT AT93306812T patent/ATE185564T1/de not_active IP Right Cessation
- 1993-08-27 DK DK93306812T patent/DK0590793T3/da active
- 1993-08-27 ES ES93306812T patent/ES2139633T3/es not_active Expired - Lifetime
- 1993-08-27 DE DE69326736T patent/DE69326736T2/de not_active Expired - Fee Related
- 1993-08-30 RU RU9393048539A patent/RU2090564C1/ru active
- 1993-08-30 AU AU44965/93A patent/AU663611B2/en not_active Ceased
- 1993-08-30 IL IL106839A patent/IL106839A/en not_active IP Right Cessation
- 1993-08-30 NZ NZ248532A patent/NZ248532A/en unknown
- 1993-08-30 TW TW082107018A patent/TW318181B/zh active
- 1993-08-30 CA CA002105149A patent/CA2105149A1/en not_active Abandoned
- 1993-08-30 NO NO933080A patent/NO302121B1/no not_active IP Right Cessation
- 1993-08-30 US US08/114,006 patent/US5436257A/en not_active Expired - Fee Related
- 1993-08-30 HU HU9302449A patent/HUT67087A/hu unknown
- 1993-08-31 FI FI933802A patent/FI933802A/fi unknown
- 1993-08-31 JP JP21547193A patent/JP3201891B2/ja not_active Expired - Fee Related
- 1993-08-31 KR KR1019930017239A patent/KR940003955A/ko not_active Application Discontinuation
- 1993-08-31 CN CN93118829A patent/CN1036588C/zh not_active Expired - Fee Related
-
1998
- 1998-12-10 HK HK98113087A patent/HK1011979A1/xx not_active IP Right Cessation
-
1999
- 1999-11-18 GR GR990402978T patent/GR3031887T3/el unknown
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