RU2432357C2 - ПОЛИПЕПТИДЫ НЕТИПИРУЕМОЙ Haemophilus influenzae - Google Patents

ПОЛИПЕПТИДЫ НЕТИПИРУЕМОЙ Haemophilus influenzae Download PDF

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RU2432357C2
RU2432357C2 RU2006144093/10A RU2006144093A RU2432357C2 RU 2432357 C2 RU2432357 C2 RU 2432357C2 RU 2006144093/10 A RU2006144093/10 A RU 2006144093/10A RU 2006144093 A RU2006144093 A RU 2006144093A RU 2432357 C2 RU2432357 C2 RU 2432357C2
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Вега МАЗИНЬЯНИ (IT)
Вега МАЗИНЬЯНИ
Мария АРИКО (IT)
Мария АРИКО
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Новартис Вэксинс Энд Диагностикс С.Р.Л.
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Abstract

(57) Изобретение относится к биотехнологии. Описаны полипептиды, вызывающие иммунный ответ против Н. influenzae. Предложено антитело, селективно связывающее указанные полипептиды. Изобретение также относится к иммуногенной композиции, содержащей описанные полипептиды. Изобретение может быть использовано в медицине для лечения или профилактики заболевания и/или инфекции, вызванных H.influenzae, таких как средний отит. 4 н. и 5 з.п. ф-лы, 3 табл.

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Текст описания приведен в факсимильном виде.
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Claims (9)

1. Полипептид, вызывающий иммунный ответ против Н.influenzae, содержащий аминокислотную последовательность, имеющую идентичность последовательности, составляющую, по меньшей мере, 90%, по отношению к одной или более из SEQ ID NO:1566, 1570, 1938, 2368, 3310, 3520, 5088, 5089 и 5090.
2. Полипептид по п.1, применимый в качестве лекарственного средства.
3. Антитело, селективно связывающееся с полипептидом по п.1 или 2, полученное иммунизацией млекопитающего полипептидом по п.1 или 2.
4. Антитело по п.3, причем антитело представляет собой моноклональное антитело.
5. Антитело по п.3 или 4, применимое в качестве лекарственного средства.
6. Иммуногенная композиция, содержащая (а) полипептид и/или антитело по любому из предшествующих пунктов; и (b) фармацевтически приемлемый носитель.
7. Композиция по п.6, дополнительно содержащая адъювант вакцины.
8. Применение полипептида или антитела по любому из пп.1-5 в производстве лекарственного препарата для лечения или профилактики заболевания и/или инфекции, вызванных Н.influenzae.
9. Применение по п.8 для профилактики среднего отита, бронхита, конъюнктивита, синусита, инфекции мочевых путей, пневмонии, бактериемии, септического артрита, эпиглоттита, эмпиемы, перикардита, целлюлита, остеомиелита или менингита.
RU2006144093/10A 2004-05-14 2005-05-16 ПОЛИПЕПТИДЫ НЕТИПИРУЕМОЙ Haemophilus influenzae RU2432357C2 (ru)

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