RU2219902C1 - Оральная композиция, имеющая противомикробную активность для уменьшения зубного налета и лечения гингивита (варианты), способ уменьшения зубного налета и лечения гингивита - Google Patents
Оральная композиция, имеющая противомикробную активность для уменьшения зубного налета и лечения гингивита (варианты), способ уменьшения зубного налета и лечения гингивита Download PDFInfo
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Abstract
Изобретение относится к оральным композициям, содержащим источник ионов двухвалентного олова, источник фторид-иона и полимерный минеральный поверхностно-активный агент, который связывает олово (2), причем композиции обеспечивают адекватную терапевтическую эффективность при минимальных побочных эффектах окрашивания зубов и вяжущего вкуса. Композиция одновременно обеспечивает уменьшение и контроль наддесневого зубного камня. Оральные композиции могут быть приготовлены в виде однофазных или двухфазных композиций. Изобретение также предлагает способ эффективной доставки композиций, содержащих двухвалентное олово, с минимальным побочным эффектом окрашивания зубов или вяжущего вкуса и с эффективным контролем зубного камня путем применения субъектом стабильной композиции средства для очистки зубов, содержащей клинически эффективное количество дифторида олова и/или других солей олова (2) в сочетании с источником фторид-ионов и полимерного минерального поверхностно-активного агента, предпочтительно фосфат- или фосфонатсодержащего полимера. 3 с. и 16 з.п.ф-лы, 5 табл.
Description
Текст описания в факсимильном виде (см. графическую часть).
Claims (19)
1. Оральная композиция, имеющая противомикробную активность для уменьшения зубного налета и лечения гингивита, имеющая пониженное окрашивание и вяжущий вкус, содержащая а. источник иона двухвалентного олова, б. источник фторид-иона; и в. полимерный минеральный поверхностно-активный агент, где указанный полимерный минеральный поверхностно-активный агент связывает ионы двухвалентного олова и имеет сродство к минеральным поверхностям.
2. Композиция по п.1, где источник ионов двухвалентного олова доставляет от 3000 до 15000 ч./млн ионов олова (2).
3. Композиция по п.1, где источник фторид-ионов способен обеспечивать от 50 до 3500 ч./млн фторид-ионов.
4. Композиция по п.1, где полимерный минеральный поверхностно-активный агент составляет от 1 до 20%.
5. Композиция по п.4, где полимерный минеральный поверхностно-активный агент представляет собой фосфорилированный полимер.
6. Композиция по п.5, где фосфорилированный полимер представляет собой конденсированный полифосфат, имеющий длину цепочки 4 или более.
7. Композиция по п.1, где источник фторид-ионов включает дифторид олова.
8. Композиция по п.7, где источник ионов двухвалентного олова включает сочетание дифторида олова и дигидрата дихлорида олова.
9. Композиция по п.7, дополнительно содержащая глюконатную соль.
10. Композиция по п.6, где мольное отношение фосфат-аниона к иону двухвалентного олова составляет от 0,2:1 до 5:1.
11. Композиция по п.6, где конденсированный фосфатный полимер имеет среднюю длину цепочки 21.
12. Композиция по п.1, где отношение балльного показателя in vitro модели гликолиза и восстановления роста зубного налета к балльному показателю in vitro модели пятен чая на пленке зубного налета составляет, по меньшей мере, 1,2.
13. Композиция по п.1, где балльный показатель in vitro модели гликолиза и восстановления роста зубного налета составляет, по меньшей мере, 60%, предпочтительно, по меньшей мере, 70% и более предпочтительно, по меньшей мере, приблизительно 80%.
14. Композиция по п.1, где балльный показатель in vitro модели пятен чая на пленке зубного налета составляет менее чем 75%, предпочтительно менее чем 60%, более предпочтительно менее чем 50%, и наиболее предпочтительно менее чем 25%.
15. Композиция по п.1, где оральная композиция дополнительно содержит полоксамер.
16. Оральная композиция, имеющая противомикробную активность для уменьшения зубного налета и лечения гингивита, имеющая пониженное окрашивание и вяжущий вкус, содержащая а. первую композицию, содержащую источник фторид-ионов и источник ионов двухвалентного олова, б. вторую композицию, содержащую линейный полифосфат, имеющий среднюю длину цепочки 4 или более, где композиция имеет суммарное содержание воды вплоть до 20%, где указанный полифосфат связывает ионы двухвалентного олова при контакте внутри полости рта первой композиции и второй композиции.
17. Композиция по п.16, где первая композиция имеет суммарное содержание воды от 5 до 95%.
18. Композиция по п.17, где вторая композиция содержит абразивный полирующий материал.
19. Способ уменьшения зубного налета и лечения гингивита у субъекта без повышенного окрашивания зубов, включающий применение композиции, содержащей а. источник иона двухвалентного олова, б. источник фторид-иона; и в. полимерный минеральный поверхностно-активный агент, где указанный полимерный минеральный поверхностно-активный агент связывает ионы двухвалентного олова и имеет сродство к минеральным поверхностям.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16535099P | 1999-11-12 | 1999-11-12 | |
US60/165,350 | 1999-11-12 |
Publications (2)
Publication Number | Publication Date |
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RU2219902C1 true RU2219902C1 (ru) | 2003-12-27 |
RU2002115627A RU2002115627A (ru) | 2004-01-27 |
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RU2002115627/15A RU2219902C1 (ru) | 1999-11-12 | 2000-11-10 | Оральная композиция, имеющая противомикробную активность для уменьшения зубного налета и лечения гингивита (варианты), способ уменьшения зубного налета и лечения гингивита |
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US (3) | US6555094B1 (ru) |
EP (2) | EP2238965A1 (ru) |
JP (1) | JP3860471B2 (ru) |
CN (1) | CN1200685C (ru) |
AT (1) | ATE476955T1 (ru) |
AU (1) | AU1479301A (ru) |
CA (1) | CA2389174C (ru) |
DE (1) | DE60044819D1 (ru) |
ES (1) | ES2350177T3 (ru) |
HK (1) | HK1049611A1 (ru) |
MX (1) | MXPA02004787A (ru) |
PL (1) | PL206023B1 (ru) |
RU (1) | RU2219902C1 (ru) |
WO (1) | WO2001034108A1 (ru) |
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- 2000-11-10 ES ES00977110T patent/ES2350177T3/es not_active Expired - Lifetime
- 2000-11-10 PL PL355965A patent/PL206023B1/pl unknown
- 2000-11-10 RU RU2002115627/15A patent/RU2219902C1/ru active
- 2000-11-10 DE DE60044819T patent/DE60044819D1/de not_active Expired - Lifetime
- 2000-11-10 AU AU14793/01A patent/AU1479301A/en not_active Abandoned
- 2000-11-10 US US09/710,440 patent/US6555094B1/en not_active Expired - Lifetime
- 2000-11-10 AT AT00977110T patent/ATE476955T1/de not_active IP Right Cessation
- 2000-11-10 WO PCT/US2000/030809 patent/WO2001034108A1/en active Application Filing
- 2000-11-10 EP EP10171585A patent/EP2238965A1/en not_active Withdrawn
- 2000-11-10 CN CNB008182701A patent/CN1200685C/zh not_active Expired - Lifetime
- 2000-11-10 EP EP00977110A patent/EP1227788B1/en not_active Revoked
- 2000-11-10 CA CA002389174A patent/CA2389174C/en not_active Expired - Lifetime
- 2000-11-10 JP JP2001536109A patent/JP3860471B2/ja not_active Expired - Lifetime
- 2000-11-10 MX MXPA02004787A patent/MXPA02004787A/es active IP Right Grant
-
2003
- 2003-01-14 HK HK03100347.7A patent/HK1049611A1/zh unknown
- 2003-01-24 US US10/351,205 patent/US6821507B2/en not_active Expired - Lifetime
-
2004
- 2004-10-28 US US10/975,963 patent/US20050112070A1/en not_active Abandoned
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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RU2469700C2 (ru) * | 2006-10-02 | 2012-12-20 | Дзе Проктер Энд Гэмбл Компани | Композиции для ухода за полостью рта, содержащие олово (ii) |
Also Published As
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EP1227788A1 (en) | 2002-08-07 |
CN1420757A (zh) | 2003-05-28 |
PL355965A1 (en) | 2004-05-31 |
AU1479301A (en) | 2001-06-06 |
US20050112070A1 (en) | 2005-05-26 |
EP2238965A1 (en) | 2010-10-13 |
RU2002115627A (ru) | 2004-01-27 |
CA2389174A1 (en) | 2001-05-17 |
US20030152527A1 (en) | 2003-08-14 |
PL206023B1 (pl) | 2010-06-30 |
DE60044819D1 (de) | 2010-09-23 |
US6821507B2 (en) | 2004-11-23 |
EP1227788B1 (en) | 2010-08-11 |
ATE476955T1 (de) | 2010-08-15 |
US6555094B1 (en) | 2003-04-29 |
WO2001034108A1 (en) | 2001-05-17 |
CN1200685C (zh) | 2005-05-11 |
JP3860471B2 (ja) | 2006-12-20 |
JP2003513899A (ja) | 2003-04-15 |
HK1049611A1 (zh) | 2003-05-23 |
CA2389174C (en) | 2007-01-23 |
ES2350177T3 (es) | 2011-01-19 |
MXPA02004787A (es) | 2002-08-30 |
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