RU2013147763A - Способы и композиции, содержащие варианты сериновой протеазы - Google Patents
Способы и композиции, содержащие варианты сериновой протеазы Download PDFInfo
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- RU2013147763A RU2013147763A RU2013147763/10A RU2013147763A RU2013147763A RU 2013147763 A RU2013147763 A RU 2013147763A RU 2013147763/10 A RU2013147763/10 A RU 2013147763/10A RU 2013147763 A RU2013147763 A RU 2013147763A RU 2013147763 A RU2013147763 A RU 2013147763A
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- subtilisin
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- 239000000203 mixture Substances 0.000 title claims abstract 18
- 238000000034 method Methods 0.000 title claims 5
- 102000012479 Serine Proteases Human genes 0.000 title 1
- 108010022999 Serine Proteases Proteins 0.000 title 1
- 108090000787 Subtilisin Proteins 0.000 claims abstract 32
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 29
- 108091005804 Peptidases Proteins 0.000 claims abstract 14
- 239000004365 Protease Substances 0.000 claims abstract 14
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims abstract 13
- 241000193422 Bacillus lentus Species 0.000 claims abstract 10
- 238000006467 substitution reaction Methods 0.000 claims abstract 6
- 101000642797 Bacillus amyloliquefaciens Subtilisin BPN' Proteins 0.000 claims abstract 4
- 238000004140 cleaning Methods 0.000 claims abstract 4
- 230000002797 proteolythic effect Effects 0.000 claims abstract 4
- 150000001413 amino acids Chemical class 0.000 claims abstract 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract 3
- 241000193744 Bacillus amyloliquefaciens Species 0.000 claims abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108090000854 Oxidoreductases Proteins 0.000 claims 2
- 102000004316 Oxidoreductases Human genes 0.000 claims 2
- 238000005406 washing Methods 0.000 claims 2
- 108010065511 Amylases Proteins 0.000 claims 1
- 102000013142 Amylases Human genes 0.000 claims 1
- 108700038091 Beta-glucanases Proteins 0.000 claims 1
- 102100032487 Beta-mannosidase Human genes 0.000 claims 1
- 102000005575 Cellulases Human genes 0.000 claims 1
- 108010084185 Cellulases Proteins 0.000 claims 1
- 108010023736 Chondroitinases and Chondroitin Lyases Proteins 0.000 claims 1
- 102000011413 Chondroitinases and Chondroitin Lyases Human genes 0.000 claims 1
- 101710121765 Endo-1,4-beta-xylanase Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108090000371 Esterases Proteins 0.000 claims 1
- 108050009363 Hyaluronidases Proteins 0.000 claims 1
- 102000001974 Hyaluronidases Human genes 0.000 claims 1
- 108010029541 Laccase Proteins 0.000 claims 1
- 108090001060 Lipase Proteins 0.000 claims 1
- 102000004882 Lipase Human genes 0.000 claims 1
- 239000004367 Lipase Substances 0.000 claims 1
- 108090000128 Lipoxygenases Proteins 0.000 claims 1
- 102000003820 Lipoxygenases Human genes 0.000 claims 1
- 108010006035 Metalloproteases Proteins 0.000 claims 1
- 102000005741 Metalloproteases Human genes 0.000 claims 1
- 102000035195 Peptidases Human genes 0.000 claims 1
- 108700020962 Peroxidase Proteins 0.000 claims 1
- 102000003992 Peroxidases Human genes 0.000 claims 1
- 108010064785 Phospholipases Proteins 0.000 claims 1
- 102000015439 Phospholipases Human genes 0.000 claims 1
- 108010059820 Polygalacturonase Proteins 0.000 claims 1
- 108091007187 Reductases Proteins 0.000 claims 1
- 102000003425 Tyrosinase Human genes 0.000 claims 1
- 108060008724 Tyrosinase Proteins 0.000 claims 1
- 108090000637 alpha-Amylases Proteins 0.000 claims 1
- 108010084650 alpha-N-arabinofuranosidase Proteins 0.000 claims 1
- 235000019418 amylase Nutrition 0.000 claims 1
- 229940025131 amylases Drugs 0.000 claims 1
- 108010055059 beta-Mannosidase Proteins 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 claims 1
- 108010093305 exopolygalacturonase Proteins 0.000 claims 1
- 239000004744 fabric Substances 0.000 claims 1
- 108010002430 hemicellulase Proteins 0.000 claims 1
- 108010059345 keratinase Proteins 0.000 claims 1
- 108010062085 ligninase Proteins 0.000 claims 1
- 235000019421 lipase Nutrition 0.000 claims 1
- 108010087558 pectate lyase Proteins 0.000 claims 1
- 108010038851 tannase Proteins 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38681—Chemically modified or immobilised enzymes
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Detergent Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Developing Agents For Electrophotography (AREA)
Abstract
1. Композиция для очистки и/или обработки, содержащая вспомогательное вещество и выделенный вариант субтилизина, при этом указанный вариант субтилизина является зрелой формой, имеющей протеолитическую активность, и содержит аминокислотную последовательность, содержащую комбинацию аминокислотных замен в положениях T022R+V104I+Q245R, и при этом аминокислотные положения варианта субтилизина пронумерованы в соответствии с нумерацией соответствующих аминокислотных положений в аминокислотной последовательности Bacillus amyloliquefaciens субтилизина BPN', представленной в SEQ ID NO:1.2. Композиция по п. 1, отличающаяся тем, что указанный вариант субтилизина является зрелой формой, имеющей протеолитическую активность, и содержит аминокислотную последовательность, содержащую комбинацию аминокислотных замен в положениях, выбранных из T022R+V104I+A232V+Q245R, T022R+S103A+V104I+Q245R, T022R+S103A+V104I+A232V+Q245R, T022R+S101G+V104I+Q245R, и при этом аминокислотные положения варианта субтилизина пронумерованы в соответствии с нумерацией соответствующих аминокислотных положений в аминокислотной последовательности Bacillus amyloliquefaciens субтилизина BPN′, представленной в SEQ ID NO: 1.3. Композиция по любому из пп. 1 или 2, отличающаяся тем, что выделенный вариант субтилизина представляет собой вариант субтилизина Bacillus lentus субтилизин GG36 протеазы, при этом указанная Bacillus lentus субтилизин GG36 протеаза содержит аминокислотную последовательность, представленную в SEQ ID NO: 2.4. Композиция по любому из пп. 1 или 2, отличающаяся тем, что выделенный вариант субтилизина имеет, по меньшей мере, 90% аминокислотную идентичность с указанной Bacillus lentus субтилизин GG36 протеазой, содержащей аминокислотную последовательнос
Claims (13)
1. Композиция для очистки и/или обработки, содержащая вспомогательное вещество и выделенный вариант субтилизина, при этом указанный вариант субтилизина является зрелой формой, имеющей протеолитическую активность, и содержит аминокислотную последовательность, содержащую комбинацию аминокислотных замен в положениях T022R+V104I+Q245R, и при этом аминокислотные положения варианта субтилизина пронумерованы в соответствии с нумерацией соответствующих аминокислотных положений в аминокислотной последовательности Bacillus amyloliquefaciens субтилизина BPN', представленной в SEQ ID NO:1.
2. Композиция по п. 1, отличающаяся тем, что указанный вариант субтилизина является зрелой формой, имеющей протеолитическую активность, и содержит аминокислотную последовательность, содержащую комбинацию аминокислотных замен в положениях, выбранных из T022R+V104I+A232V+Q245R, T022R+S103A+V104I+Q245R, T022R+S103A+V104I+A232V+Q245R, T022R+S101G+V104I+Q245R, и при этом аминокислотные положения варианта субтилизина пронумерованы в соответствии с нумерацией соответствующих аминокислотных положений в аминокислотной последовательности Bacillus amyloliquefaciens субтилизина BPN′, представленной в SEQ ID NO: 1.
3. Композиция по любому из пп. 1 или 2, отличающаяся тем, что выделенный вариант субтилизина представляет собой вариант субтилизина Bacillus lentus субтилизин GG36 протеазы, при этом указанная Bacillus lentus субтилизин GG36 протеаза содержит аминокислотную последовательность, представленную в SEQ ID NO: 2.
4. Композиция по любому из пп. 1 или 2, отличающаяся тем, что выделенный вариант субтилизина имеет, по меньшей мере, 90% аминокислотную идентичность с указанной Bacillus lentus субтилизин GG36 протеазой, содержащей аминокислотную последовательность, представленную в SEQ ID NO: 2.
5. Композиция по любому из пп. 1 или 2, отличающаяся тем, что общий суммарный заряд выделенного варианта субтилизина составляет -1, 0, +1, +2, +3, +4, +5, -1, -2, -3, -4 или -5 относительно общего суммарного заряда Bacillus lentus субтилизин GG36 протеазы, предпочтительно 0, +1, +2, +3, +4 или +5 относительно общего суммарного заряда Bacillus lentus субтилизин GG36 протеазы.
6. Композиция по любому из пп. 1 или 2 отличающаяся тем, что общий суммарный заряд выделенного варианта субтилизина составляет +1, 0, -1, -2, -3 или -4 относительно общего суммарного заряда Bacillus lentus субтилизин GG36 протеазы, предпочтительно 0, -1, -2, -3 или -4 относительно общего суммарного заряда Bacillus lentus субтилизин GG36 протеазы.
7. Композиция для очистки и/или обработки по любому из пп. 1 или 2, отличающаяся тем, что общий суммарный заряд выделенного варианта субтилизина получен путем одной или больше замен, выбранных из: А001Е, V004E, R010H/A, Q012E, A015D, N018D, R019H/S, V026D, К027Е, N043D, R045C/T/S/P, S049D, V051E, G061E, N062D/E, N076D, N077D, S078D, S087D, А098Е, S101D, S106E, G115Е, Gl18D, N123D, S128D, Р129Е, S130D/E, S132D, А158Е, G159D/E, S160D, S166D, R170T, N183D, N184D, N185E, R186H, S188D/E, А194Е, A200D, Y209E, A215D, N204D, S212D, L217D/E, N218D, А230Е, K235F, N237D, К237Е, N238D, S240D, N243D, Q245D, R247L, N248D/E, К251С, N263D, N269D/E, A272D, А273Е или R275H/S, и при этом аминокислотные положения варианта протеазы пронумерованы в соответствии с нумерацией соответствующих аминокислотных положений в аминокислотной последовательности Bacillus amyloliquefaciens субтилизина BPN′, представленной в SEQ ID NO: 1.
8. Композиция для очистки и/или обработки по любому из пп. 1 или 2, отличающаяся тем, что общий суммарный заряд выделенного варианта субтилизина получен путем одной или больше замен, выбранных из: A001R, V004R, Q012R, P014R, H017R, N018R/K, G020K/R, T022R/K, S024R/K, G025R, D032I, D041K/L/N, N043R/K, G046R, A048R, F050R/K, P055R, S056R/K, T057R, Q059K, G061R, N076K, S078R, P086R, S087R, E089G/P/I, G097R, S099R, Q109R, G115R, G118R, S132K, S144R, G159R/K, D181C/S/T, L196K, N204K, Q206R, K235R, Q236R/K, K237R, N238R, S240R, W241R, S242R/K, V244R, Q245R/K, N248R, H249R, N252R/K, S256R, G258R, Т260К, N269R/K или E271F/H/T/L/W/R/S/I/A/G/V, и при этом аминокислотные положения варианта протеазы пронумерованы в соответствии с нумерацией соответствующих аминокислотных положений в аминокислотной последовательности Bacillus amyloliquefaciens субтилизина BPN′, представленной в SEQ ID NO: 1.
9. Композиция по любому из пп. 1 или 2, отличающаяся тем, что дополнительно содержит, по меньшей мере, один дополнительный фермент, выбранный из гемицеллюлаз, целлюлаз, пероксидаз, протеаз, металлопротеаз, ксиланаз, липаз, фосфолипаз, эстераз, пергидролаз, кутиназ, пектиназ, пектат-лиаз, маннаназ, кератиназ, редуктаз, оксидаз, фенолоксидаз, липоксигеназ, лигниназ, пуллуланаз, танназ, пентозаназ, маланаз, β-глюканаз, арабинозидаз, гиалуронидаз, хондроитиназ, лакказ, и амилаз, или любой их комбинации.
10. Способ получения композиции по любому из предыдущих пунктов, включающий стадию, на которой смешивают вспомогательное вещество с вариантом протеазы.
11. Способ обработки поверхности, предпочтительно, ткани, включающий стадию, на которой вводят в контакт поверхность с водным моющим раствором, содержащим композицию по любому из пп. 1-9.
12. Способ по п. 11, отличающийся тем, что водный моющий раствор имеет проводимость от 0,1 до 3 мСм/см, предпочтительно от 0,3 до 2,5 мСм/см.
13. Способ по п. 11, отличающийся тем, что водный моющий раствор имеет проводимость от более 3 до 30 мСм/см, предпочтительно от 3,5 до 20 мСм/см, и предпочтительно композиция является композицией по п. 2.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2011/035319 WO2011140316A1 (en) | 2010-05-06 | 2011-05-05 | Consumer products with protease variants |
| USPCT/US2011/035319 | 2011-05-05 | ||
| PCT/US2012/036503 WO2012151480A2 (en) | 2011-05-05 | 2012-05-04 | Compositions and methods comprising serine protease variants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2013147763A true RU2013147763A (ru) | 2015-11-10 |
| RU2663114C2 RU2663114C2 (ru) | 2018-08-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013147763A RU2663114C2 (ru) | 2011-05-05 | 2012-05-04 | Способы и композиции, содержащие варианты сериновой протеазы |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP2705145B1 (ru) |
| JP (2) | JP5933688B2 (ru) |
| CN (1) | CN106065381B (ru) |
| MX (1) | MX357386B (ru) |
| RU (1) | RU2663114C2 (ru) |
| WO (1) | WO2012151480A2 (ru) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3097174A1 (en) | 2014-01-22 | 2016-11-30 | The Procter & Gamble Company | Method of treating textile fabrics |
| EP3097172A1 (en) | 2014-01-22 | 2016-11-30 | The Procter & Gamble Company | Method of treating textile fabrics |
| EP3097173B1 (en) | 2014-01-22 | 2020-12-23 | The Procter and Gamble Company | Fabric treatment composition |
| EP3097175B1 (en) | 2014-01-22 | 2018-10-17 | The Procter and Gamble Company | Fabric treatment composition |
| WO2015144932A1 (en) * | 2014-03-28 | 2015-10-01 | Novozymes A/S | Enzyme variants and polynucleotides encoding same |
| DE102014009813A1 (de) | 2014-07-03 | 2016-01-07 | Biopract Gmbh | Verfahren zur Prophylaxe von Pilzinfektionen bei Nutz- und Zierpflanzen, bevorzugt beim Weinbau, sowie bei Gehölzen |
| WO2016081437A1 (en) | 2014-11-17 | 2016-05-26 | The Procter & Gamble Company | Benefit agent delivery compositions |
| CN107820515A (zh) | 2015-04-29 | 2018-03-20 | 宝洁公司 | 洗涤剂组合物 |
| CN117683589A (zh) | 2015-04-29 | 2024-03-12 | 宝洁公司 | 洗涤织物的方法 |
| JP2018517803A (ja) | 2015-04-29 | 2018-07-05 | ザ プロクター アンド ギャンブル カンパニー | 布地の処理方法 |
| EP3088502B1 (en) | 2015-04-29 | 2018-05-23 | The Procter and Gamble Company | Method of treating a fabric |
| CN112143591A (zh) | 2015-04-29 | 2020-12-29 | 宝洁公司 | 处理织物的方法 |
| CN108291180A (zh) | 2015-11-26 | 2018-07-17 | 宝洁公司 | 包含蛋白酶和经包封的脂肪酶的液体洗涤剂组合物 |
| JP2017132901A (ja) * | 2016-01-27 | 2017-08-03 | 株式会社ベネフィット−イオン | 洗濯前処理剤及び洗濯方法 |
| MX2019006422A (es) | 2016-12-02 | 2019-08-01 | Procter & Gamble | Composiciones de limpieza que incluyen enzimas. |
| MX2019006421A (es) | 2016-12-02 | 2019-08-01 | Procter & Gamble | Composiciones de limpieza que incluyen enzimas. |
| EP3559226B1 (en) | 2016-12-21 | 2023-01-04 | Danisco US Inc. | Bacillus gibsonii-clade serine proteases |
| EP3891277A1 (en) * | 2018-12-03 | 2021-10-13 | Novozymes A/S | Powder detergent compositions |
| WO2023225459A2 (en) | 2022-05-14 | 2023-11-23 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
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| NL114069C (ru) | 1955-10-27 | |||
| GB849433A (en) | 1957-08-22 | 1960-09-28 | Raymond Woolston | Hair washing preparations |
| NL136759C (ru) | 1966-02-16 | |||
| GB1296839A (ru) | 1969-05-29 | 1972-11-22 | ||
| US3646015A (en) | 1969-07-31 | 1972-02-29 | Procter & Gamble | Optical brightener compounds and detergent and bleach compositions containing same |
| GB1372034A (en) | 1970-12-31 | 1974-10-30 | Unilever Ltd | Detergent compositions |
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| CN102224233A (zh) | 2008-09-25 | 2011-10-19 | 荷兰联合利华有限公司 | 液体洗涤剂 |
| EP2362897A2 (en) * | 2008-11-11 | 2011-09-07 | Danisco US Inc. | Compositions and methods comprising serine protease variants |
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| EP2585431B1 (en) | 2010-06-28 | 2017-09-06 | Basf Se | Metal free bleaching composition |
| GB201011511D0 (en) | 2010-07-08 | 2010-08-25 | Unilever Plc | Composions comprising optical benefits agents |
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- 2012-05-04 CN CN201610329893.3A patent/CN106065381B/zh active Active
- 2012-05-04 RU RU2013147763A patent/RU2663114C2/ru active
- 2012-05-04 JP JP2014508193A patent/JP5933688B2/ja active Active
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|---|---|
| WO2012151480A2 (en) | 2012-11-08 |
| CN106065381A (zh) | 2016-11-02 |
| JP5933688B2 (ja) | 2016-06-15 |
| MX357386B (es) | 2018-07-06 |
| JP6367161B2 (ja) | 2018-08-01 |
| CN103502446A (zh) | 2014-01-08 |
| MX2013012950A (es) | 2013-12-16 |
| CN106065381B (zh) | 2019-07-26 |
| RU2663114C2 (ru) | 2018-08-01 |
| WO2012151480A3 (en) | 2013-03-21 |
| EP2705145A2 (en) | 2014-03-12 |
| JP2015228867A (ja) | 2015-12-21 |
| JP2014514415A (ja) | 2014-06-19 |
| EP2705145B1 (en) | 2020-06-17 |
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