RU2008139315A - Избирательные андрогенные рецепторные модуляторы - Google Patents
Избирательные андрогенные рецепторные модуляторы Download PDFInfo
- Publication number
- RU2008139315A RU2008139315A RU2008139315/04A RU2008139315A RU2008139315A RU 2008139315 A RU2008139315 A RU 2008139315A RU 2008139315/04 A RU2008139315/04 A RU 2008139315/04A RU 2008139315 A RU2008139315 A RU 2008139315A RU 2008139315 A RU2008139315 A RU 2008139315A
- Authority
- RU
- Russia
- Prior art keywords
- compound according
- compound
- cyano
- pharmaceutically acceptable
- receptor modulators
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
1. Соединение формулы (I) !! или изомер, метаболит, или фармацевтически приемлемая соль или сложный эфир этого соединения. ! 2. Соединение по п.1, которое представляет собой (2S)-3-(4-циано-3-фторфенокси)-N-(4-циано-3-метилфенил)-2-гидрокси-2-метилпропионамид. ! 3. Фармацевтическая композиция, включающая соединение по п.1 или 2, вместе с фармацевтически приемлемым носителем. ! 4. Способ лечения или предупреждения состояния, обусловленных андрогенными рецепторами (АР), включающий введение пациенту, нуждающемуся в этом терапевтически эффективного количества соединения по п.1 или 2.
Claims (4)
1. Соединение формулы (I)
или изомер, метаболит, или фармацевтически приемлемая соль или сложный эфир этого соединения.
2. Соединение по п.1, которое представляет собой (2S)-3-(4-циано-3-фторфенокси)-N-(4-циано-3-метилфенил)-2-гидрокси-2-метилпропионамид.
3. Фармацевтическая композиция, включающая соединение по п.1 или 2, вместе с фармацевтически приемлемым носителем.
4. Способ лечения или предупреждения состояния, обусловленных андрогенными рецепторами (АР), включающий введение пациенту, нуждающемуся в этом терапевтически эффективного количества соединения по п.1 или 2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77841706P | 2006-03-03 | 2006-03-03 | |
| US60/778,417 | 2006-03-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2008139315A true RU2008139315A (ru) | 2010-04-10 |
| RU2435756C2 RU2435756C2 (ru) | 2011-12-10 |
Family
ID=37994519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008139315/04A RU2435756C2 (ru) | 2006-03-03 | 2007-03-02 | Избирательные андрогенные рецепторные модуляторы |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8501814B2 (ru) |
| EP (1) | EP1991523B1 (ru) |
| JP (1) | JP5373405B2 (ru) |
| AU (1) | AU2007220419B2 (ru) |
| CA (1) | CA2642598C (ru) |
| NO (1) | NO341158B1 (ru) |
| NZ (1) | NZ570533A (ru) |
| RU (1) | RU2435756C2 (ru) |
| WO (1) | WO2007099200A1 (ru) |
| ZA (1) | ZA200807551B (ru) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8309603B2 (en) | 2004-06-07 | 2012-11-13 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| US9730908B2 (en) | 2006-08-24 | 2017-08-15 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| US10010521B2 (en) | 2006-08-24 | 2018-07-03 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| US9844528B2 (en) | 2006-08-24 | 2017-12-19 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| MX2010009162A (es) | 2008-02-22 | 2010-12-21 | Radius Health Inc | Moduladores selectivos del receptor de androgeno. |
| US8268872B2 (en) | 2008-02-22 | 2012-09-18 | Radius Health, Inc. | Selective androgen receptor modulators |
| JP2011519916A (ja) * | 2008-07-02 | 2011-07-14 | ファーマコステック カンパニー リミテッド | アミド誘導体の製造方法 |
| CA2788907A1 (en) | 2010-02-04 | 2011-08-11 | Radius Health, Inc. | Selective androgen receptor modulators |
| EP3106159A1 (en) | 2010-05-12 | 2016-12-21 | Radius Health, Inc. | Therapeutic regimens |
| US8642632B2 (en) | 2010-07-02 | 2014-02-04 | Radius Health, Inc. | Selective androgen receptor modulators |
| FI20105806A0 (fi) * | 2010-07-15 | 2010-07-15 | Medeia Therapeutics Ltd | Uudet aryyliamidijohdannaiset, joilla on antiandrogeenisia ominaisuuksia |
| US9133182B2 (en) | 2010-09-28 | 2015-09-15 | Radius Health, Inc. | Selective androgen receptor modulators |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| CA2943611A1 (en) | 2014-03-28 | 2015-10-01 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
| US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
| TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
| RU2022108295A (ru) | 2016-06-22 | 2022-04-06 | Эллипсес Фарма Лтд | Способы лечения ar+ рака молочной железы |
| KR102557321B1 (ko) | 2017-01-05 | 2023-07-18 | 래디어스 파마슈티컬스, 인코포레이티드 | Rad1901-2hcl의 다형 형태 |
| EP3817821A1 (en) | 2018-07-04 | 2021-05-12 | Radius Pharmaceuticals, Inc. | Polymorphic forms of rad 1901-2hcl |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU88769I2 (fr) * | 1982-07-23 | 1996-11-05 | Zeneca Ltd | Bicalutamide et ses sels et esters pharmaceutiquement acceptables (Casodex (R)) |
| GB8617653D0 (en) * | 1986-07-18 | 1986-08-28 | Ici Plc | Amide derivatives |
| US7855229B2 (en) * | 2000-08-24 | 2010-12-21 | University Of Tennessee Research Foundation | Treating wasting disorders with selective androgen receptor modulators |
| FI20030958A0 (fi) * | 2003-06-27 | 2003-06-27 | Orion Corp | Uusia yhdisteitä |
-
2007
- 2007-03-02 EP EP07712597A patent/EP1991523B1/en active Active
- 2007-03-02 AU AU2007220419A patent/AU2007220419B2/en not_active Ceased
- 2007-03-02 RU RU2008139315/04A patent/RU2435756C2/ru not_active IP Right Cessation
- 2007-03-02 JP JP2008556805A patent/JP5373405B2/ja not_active Expired - Fee Related
- 2007-03-02 NZ NZ570533A patent/NZ570533A/en not_active IP Right Cessation
- 2007-03-02 WO PCT/FI2007/000055 patent/WO2007099200A1/en active Application Filing
- 2007-03-02 CA CA2642598A patent/CA2642598C/en not_active Expired - Fee Related
- 2007-03-02 US US12/280,026 patent/US8501814B2/en not_active Expired - Fee Related
-
2008
- 2008-09-02 ZA ZA200807551A patent/ZA200807551B/xx unknown
- 2008-09-26 NO NO20084114A patent/NO341158B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007099200A1 (en) | 2007-09-07 |
| AU2007220419A1 (en) | 2007-09-07 |
| NZ570533A (en) | 2011-02-25 |
| US8501814B2 (en) | 2013-08-06 |
| AU2007220419B2 (en) | 2012-03-15 |
| JP5373405B2 (ja) | 2013-12-18 |
| CA2642598C (en) | 2014-05-27 |
| ZA200807551B (en) | 2009-06-24 |
| JP2009528333A (ja) | 2009-08-06 |
| NO341158B1 (no) | 2017-09-04 |
| EP1991523B1 (en) | 2012-08-15 |
| NO20084114L (no) | 2008-09-26 |
| US20090054525A1 (en) | 2009-02-26 |
| RU2435756C2 (ru) | 2011-12-10 |
| EP1991523A1 (en) | 2008-11-19 |
| CA2642598A1 (en) | 2007-09-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20190303 |