RU1831483C - Способ получени макролидных соединений - Google Patents

Способ получени макролидных соединений

Info

Publication number
RU1831483C
RU1831483C SU874203050A SU4203050A RU1831483C RU 1831483 C RU1831483 C RU 1831483C SU 874203050 A SU874203050 A SU 874203050A SU 4203050 A SU4203050 A SU 4203050A RU 1831483 C RU1831483 C RU 1831483C
Authority
RU
Russia
Prior art keywords
hydroxyl
group
class
followed
compound
Prior art date
Application number
SU874203050A
Other languages
English (en)
Inventor
Р.Сантерлэнд Дерек
З.Перейра Осви
М.Нобл Хейзел
В.Дж.Рэмсей Майкл
Б.Вард Джон
А.Флеттон Ричард
П.Тили Эдвард
Портер Нил
Ноббл Дэвид
Original Assignee
Глэксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Глэксо Груп Лимитед filed Critical Глэксо Груп Лимитед
Application granted granted Critical
Publication of RU1831483C publication Critical patent/RU1831483C/ru
Priority to LV931144A priority Critical patent/LV5678A3/xx
Priority to MD940087A priority patent/MD20B1/xx
Priority to MD94-0129A priority patent/MD123C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N49/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group, wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group, wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Insects & Arthropods (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Изобретение касаетс  макролидоа, в частности получени  соединени  общей ф-лы bJOR, № Н.Сгде RI - СНз, CaHs или изо-СзН ; R2 - низший а л кил и группа NOR2 находитс  в Е-конфи- гурации; ОНз - гидроксил, обладающих ан- тигельминтной активностью, что может быть использовано в медицине. Цель - создание новых более активных веществ указанного класса. Синтез ведут оксимированием соответствующего кетона, в котором группа ОРз-может быть гидрокси- лом или защищенным гидроксилом, с помощью соединени  ф-лы II: R2 - Н или низший алкил: R20-NH2, с последующим выделением целевого продукта или, при необходимости , сн тием защитной группы с гидроксила -ORcj. В другом случае, когда Rz1 Н и ORa - защищенный гидроксил, то подвергают этерификации галогенидом ф-лы III: R2 - Y. где Y - галоген, с последующим сн тием защиты с гидроксила. Новые вещества снижают до 98% поражение гельминтами при низкой токсичности. 2 табл. (Л

Description

Таблица
Та бл и ц а 2
SU874203050A 1986-06-06 1987-06-05 Способ получени макролидных соединений RU1831483C (ru)

Priority Applications (3)

Application Number Priority Date Filing Date Title
LV931144A LV5678A3 (lv) 1986-06-06 1993-10-08 Panemiens makrolido savienojumu iegusanai
MD940087A MD20B1 (ro) 1986-06-06 1994-04-27 Procedeu de obtinere a compusilor macrolidici
MD94-0129A MD123C2 (ru) 1986-06-06 1994-05-31 Способ получения макролидных соединений

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868613790A GB8613790D0 (en) 1986-06-06 1986-06-06 Chemical compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
SU925052125A Division RU2099334C1 (ru) 1986-06-06 1992-07-07 Макролидные соединения, композиция, обладающая антибиотической активностью, ветеринарная композиция, инсектоакарицидонематоцидная композиция и способ уничтожения насекомых и/или клещей, нематод

Publications (1)

Publication Number Publication Date
RU1831483C true RU1831483C (ru) 1993-07-30

Family

ID=10599054

Family Applications (1)

Application Number Title Priority Date Filing Date
SU874203050A RU1831483C (ru) 1986-06-06 1987-06-05 Способ получени макролидных соединений

Country Status (10)

Country Link
AP (1) AP38A (ru)
GB (1) GB8613790D0 (ru)
GE (1) GEP19970660B (ru)
LT (3) LT3676B (ru)
LV (1) LV5678A3 (ru)
MD (3) MD20B1 (ru)
RU (1) RU1831483C (ru)
SU (1) SU1731060A3 (ru)
UA (2) UA12797A (ru)
ZA (1) ZA874052B (ru)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB216646A (en) 1923-04-17 1924-06-05 Reginald Arthur Angier Improvements in feeding troughs for pigs and other animals
DE3532794A1 (de) * 1984-09-14 1986-04-17 Glaxo Group Ltd., London Antibiotika, verfahren zu deren herstellung und diese verbindungen enthaltende mittel
DE3446134A1 (de) * 1984-12-18 1986-06-26 G. Düsterloh GmbH, 4322 Sprockhövel Reversierbare hydraulische maschine
ES8802229A1 (es) * 1985-04-30 1988-04-16 Glaxo Group Ltd Un procedimiento para preparar nuevos derivados lactonicos macrociclicos.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Патент GB № 2166436, кл. С 07 D 493/22. опублик. 08.05.86. *

Also Published As

Publication number Publication date
LV5678A3 (lv) 1994-10-20
ZA874052B (en) 1988-02-24
MD123C2 (ru) 1995-06-30
LTIP1649A (en) 1995-07-25
AP8700065A0 (en) 1987-05-01
UA12797A (uk) 1997-02-28
GB8613790D0 (en) 1986-07-09
LT2643B (lt) 1994-04-25
MD123B1 (ro) 1994-12-31
SU1731060A3 (ru) 1992-04-30
LTIP1076A (en) 1995-04-25
UA18587A (ru) 1997-12-25
MD1026G2 (ru) 1999-06-30
MD20C2 (ru) 1994-05-31
LT3676B (en) 1996-01-25
AP38A (en) 1989-04-13
GEP19970660B (en) 1997-01-04
MD940360A (en) 1996-04-30
MD20B1 (ro) 1994-05-31

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