RS59458B1 - N-[2-{4-[6-amino-5-(2,4-difluorobenzoil)-2-oksopiridin-1(2h)-il]-3,5-difluorofenil}etil]-l-alanin i njegov tetrabutil ester - Google Patents

N-[2-{4-[6-amino-5-(2,4-difluorobenzoil)-2-oksopiridin-1(2h)-il]-3,5-difluorofenil}etil]-l-alanin i njegov tetrabutil ester

Info

Publication number: RS59458B1
Authority: RS; Serbia
Prior art keywords: oxopyridin; difluorobenzoyl; difluorophenyl; alanine; ethyl
Prior art date: 2012-10-17

Application number

Other languages

English (en)

Inventor

Stéphane Pintat

Stephen John Davies

David Festus Charles Moffat

Original Assignee

Macrophage Pharma Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-10-17

Filing date

2013-10-15

Publication date

2019-11-29

2012-10-17 Priority claimed from GBGB1218640.9A external-priority patent/GB201218640D0/en

2013-04-16 Priority claimed from GB201306881A external-priority patent/GB201306881D0/en

2013-10-15 Application filed by Macrophage Pharma Ltd filed Critical Macrophage Pharma Ltd

2019-11-29 Publication of RS59458B1 publication Critical patent/RS59458B1/sr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

RSP20191330 2012-10-17 2013-10-15 N-[2-{4-[6-amino-5-(2,4-difluorobenzoil)-2-oksopiridin-1(2h)-il]-3,5-difluorofenil}etil]-l-alanin i njegov tetrabutil ester RS59458B1 (sr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB1218640.9A GB201218640D0 (en)	2012-10-17	2012-10-17	Chemical compounds
GB201306881A GB201306881D0 (en)	2013-04-16	2013-04-16	Chemical compounds
EP17168533.2A EP3222616B1 (en)	2012-10-17	2013-10-15	N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2h)-yl]-3,5-difluorophenyl}ethyl]-l-alanine and the terbutyl ester thereof

Publications (1)

Publication Number	Publication Date
RS59458B1 true RS59458B1 (sr)	2019-11-29

Family

ID=49488610

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
RS20170646A RS56184B1 (sr)	2012-10-17	2013-10-15	Terc-butil n-[2-{4-[6-amino-5-(2,4-difluorobenzoil)-2-oksopiridin-1(2h)-il]-3,5-difluorofenil}etil]-l-alaninat ili njegova so, hidrat ili solvat
RSP20191330 RS59458B1 (sr)	2012-10-17	2013-10-15	N-[2-{4-[6-amino-5-(2,4-difluorobenzoil)-2-oksopiridin-1(2h)-il]-3,5-difluorofenil}etil]-l-alanin i njegov tetrabutil ester

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
RS20170646A RS56184B1 (sr)	2012-10-17	2013-10-15	Terc-butil n-[2-{4-[6-amino-5-(2,4-difluorobenzoil)-2-oksopiridin-1(2h)-il]-3,5-difluorofenil}etil]-l-alaninat ili njegova so, hidrat ili solvat

Country Status (27)

Country	Link
US (3)	US9388136B2 (sr)
EP (2)	EP3222616B1 (sr)
JP (2)	JP6260975B2 (sr)
KR (1)	KR102164536B1 (sr)
CN (2)	CN106496106B (sr)
AU (1)	AU2013333636B2 (sr)
BR (1)	BR112015008167B1 (sr)
CA (1)	CA2888928C (sr)
CY (2)	CY1119080T1 (sr)
DK (2)	DK3222616T3 (sr)
ES (2)	ES2743768T3 (sr)
HK (1)	HK1211028A1 (sr)
HR (2)	HRP20171320T1 (sr)
HU (2)	HUE035525T2 (sr)
IL (2)	IL237863B (sr)
IN (1)	IN2015DN02721A (sr)
LT (1)	LT3222616T (sr)
MX (1)	MX364782B (sr)
NZ (1)	NZ706717A (sr)
PL (2)	PL3222616T3 (sr)
PT (2)	PT2909175T (sr)
RS (2)	RS56184B1 (sr)
RU (1)	RU2676329C2 (sr)
SG (2)	SG10201708166SA (sr)
SI (2)	SI3222616T1 (sr)
WO (1)	WO2014060742A1 (sr)
ZA (1)	ZA201501958B (sr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN106496106B (zh) *	2012-10-17	2019-05-10	巨噬细胞有限公司	丙氨酸衍生物
GB201713975D0 (en) *	2017-08-31	2017-10-18	Macrophage Pharma Ltd	Medical use

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MXPA04007838A (es)	2002-02-12	2004-10-15	Smithkline Beecham Corp	Derivados de nicotamida utiles como inhibidores p38.
BR0308429A (pt)	2002-03-14	2005-01-11	Bayer Healthcare Ag	Aroilpiridinonas monocìclicas como agentes antiinflamatórios
GB0509225D0 (en)	2005-05-05	2005-06-15	Chroma Therapeutics Ltd	Inhibitors of enzymatic activity
GB0509223D0 (en)	2005-05-05	2005-06-15	Chroma Therapeutics Ltd	Enzyme inhibitors
GB0509227D0 (en)	2005-05-05	2005-06-15	Chroma Therapeutics Ltd	Intracellular enzyme inhibitors
EP3530290A1 (en)	2005-05-05	2019-08-28	GlaxoSmithKline Intellectual Property Development Limited	Alpha aminoacid ester-drug conjugates hydrolysable by carboxylesterase
GB0510204D0 (en)	2005-05-19	2005-06-22	Chroma Therapeutics Ltd	Enzyme inhibitors
GB0608837D0 (en)	2006-05-04	2006-06-14	Chroma Therapeutics Ltd	Inhibitors of MAP kinase
AU2007246869B2 (en)	2006-05-04	2012-10-18	Macrophage Pharma Limited	p38 MAP kinase inhibitors
GB0608855D0 (en) *	2006-05-04	2006-06-14	Chroma Therapeutics Ltd	Inhibitors of MAP kinase enzymes
GB0608821D0 (en)	2006-05-04	2006-06-14	Chroma Therapeutics Ltd	DHFR enzyme inhibitors
GB0608823D0 (en)	2006-05-04	2006-06-14	Chroma Therapeutics Ltd	Inhibitors of P13 kinase
GB0619753D0 (en)	2006-10-06	2006-11-15	Chroma Therapeutics Ltd	Enzyme inhibitors
GB0621203D0 (en)	2006-10-25	2006-12-06	Chroma Therapeutics Ltd	PLK inhibitors
WO2008050096A1 (en)	2006-10-25	2008-05-02	Chroma Therapeutics Ltd.	Pteridine derivatives as polo-like kinase inhibitors useful in the treatment of cancer
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US8106091B2 (en)	2006-11-01	2012-01-31	Chroma Therapeutics Ltd.	Inhibitors of IKK-beta serine-threonine protein kinase
BRPI0718056A2 (pt)	2006-11-01	2013-11-05	Chroma Therapeutics Ltd	Inibidores da proteína cinase ikk-beta serina-treonina
EP2220044A1 (en)	2007-11-07	2010-08-25	Chroma Therapeutics Limited	P38 map kinase inhibitors
WO2009106844A1 (en) *	2008-02-29	2009-09-03	Chroma Therapeutics Ltd.	Inhibitors of p38 map kinase
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GB0807451D0 (en)	2008-04-24	2008-05-28	Chroma Therapeutics Ltd	Inhibitors of PLK
WO2009130475A1 (en)	2008-04-26	2009-10-29	Chroma Therapeutics Ltd.,	Substituted thiophenecarboxamides as ikk-beta serine-, threonine-protein kinase inhibitors
GB0903480D0 (en)	2009-02-27	2009-04-08	Chroma Therapeutics Ltd	Enzyme Inhibitors
GB0907120D0 (en)	2009-04-24	2009-06-03	Chroma Therapeutics Ltd	Inhibitors of IKK-ß serine-threonine protein kinase
GB201009853D0 (en)	2010-06-11	2010-07-21	Chroma Therapeutics Ltd	HSP90 inhibitors
GB201021467D0 (en)	2010-12-17	2011-02-02	Chroma Therapeutics Ltd	Imaging agents
GB201211310D0 (en)	2012-06-26	2012-08-08	Chroma Therapeutics Ltd	CSF-1R kinase inhibitors
CN106496106B (zh) *	2012-10-17	2019-05-10	巨噬细胞有限公司	丙氨酸衍生物

2013
- 2013-10-15 CN CN201610944341.3A patent/CN106496106B/zh not_active Expired - Fee Related
- 2013-10-15 EP EP17168533.2A patent/EP3222616B1/en active Active
- 2013-10-15 PL PL17168533T patent/PL3222616T3/pl unknown
- 2013-10-15 AU AU2013333636A patent/AU2013333636B2/en not_active Ceased
- 2013-10-15 PL PL13783363T patent/PL2909175T3/pl unknown
- 2013-10-15 HU HUE13783363A patent/HUE035525T2/en unknown
- 2013-10-15 PT PT137833638T patent/PT2909175T/pt unknown
- 2013-10-15 WO PCT/GB2013/052689 patent/WO2014060742A1/en active Application Filing
- 2013-10-15 CA CA2888928A patent/CA2888928C/en active Active
- 2013-10-15 SI SI201331557T patent/SI3222616T1/sl unknown
- 2013-10-15 DK DK17168533.2T patent/DK3222616T3/da active
- 2013-10-15 DK DK13783363.8T patent/DK2909175T3/en active
- 2013-10-15 ES ES17168533T patent/ES2743768T3/es active Active
- 2013-10-15 NZ NZ706717A patent/NZ706717A/en not_active IP Right Cessation
- 2013-10-15 MX MX2015004368A patent/MX364782B/es active IP Right Grant
- 2013-10-15 SI SI201330714T patent/SI2909175T1/sl unknown
- 2013-10-15 CN CN201380054069.6A patent/CN104781235B/zh not_active Expired - Fee Related
- 2013-10-15 JP JP2015537346A patent/JP6260975B2/ja not_active Expired - Fee Related
- 2013-10-15 PT PT17168533T patent/PT3222616T/pt unknown
- 2013-10-15 SG SG10201708166SA patent/SG10201708166SA/en unknown
- 2013-10-15 RS RS20170646A patent/RS56184B1/sr unknown
- 2013-10-15 LT LTEP17168533.2T patent/LT3222616T/lt unknown
- 2013-10-15 RU RU2015115213A patent/RU2676329C2/ru active
- 2013-10-15 BR BR112015008167-3A patent/BR112015008167B1/pt not_active IP Right Cessation
- 2013-10-15 HU HUE17168533A patent/HUE046132T2/hu unknown
- 2013-10-15 RS RSP20191330 patent/RS59458B1/sr unknown
- 2013-10-15 SG SG11201502515VA patent/SG11201502515VA/en unknown
- 2013-10-15 IN IN2721DEN2015 patent/IN2015DN02721A/en unknown
- 2013-10-15 EP EP13783363.8A patent/EP2909175B1/en active Active
- 2013-10-15 US US14/436,404 patent/US9388136B2/en active Active
- 2013-10-15 ES ES13783363.8T patent/ES2635240T3/es active Active
- 2013-10-15 KR KR1020157012809A patent/KR102164536B1/ko active IP Right Grant
2015
- 2015-03-20 ZA ZA2015/01958A patent/ZA201501958B/en unknown
- 2015-03-22 IL IL237863A patent/IL237863B/en active IP Right Grant
- 2015-12-01 HK HK15111816.2A patent/HK1211028A1/xx not_active IP Right Cessation
2016
- 2016-06-15 US US15/183,612 patent/US9896417B2/en active Active
2017
- 2017-07-17 CY CY20171100756T patent/CY1119080T1/el unknown
- 2017-08-31 HR HRP20171320TT patent/HRP20171320T1/hr unknown
- 2017-10-11 JP JP2017197466A patent/JP6464244B2/ja not_active Expired - Fee Related
- 2017-12-25 IL IL256560A patent/IL256560B/en active IP Right Grant
2018
- 2018-01-03 US US15/861,586 patent/US10370332B2/en not_active Expired - Fee Related
2019
- 2019-09-23 CY CY20191101002T patent/CY1122194T1/el unknown
- 2019-10-15 HR HRP20191874TT patent/HRP20191874T1/hr unknown

Also Published As

Publication number	Publication date
SG10201708166SA (en)	2017-11-29
US9896417B2 (en)	2018-02-20
PT3222616T (pt)	2019-09-26
RU2015115213A (ru)	2016-12-10
CA2888928A1 (en)	2014-04-24
ES2635240T3 (es)	2017-10-03
SI2909175T1 (sl)	2017-08-31
CN106496106B (zh)	2019-05-10
PL3222616T3 (pl)	2019-12-31
BR112015008167B1 (pt)	2020-11-17
AU2013333636B2 (en)	2017-11-23
LT3222616T (lt)	2019-09-10
US20150246883A1 (en)	2015-09-03
HRP20191874T1 (hr)	2020-01-10
PL2909175T3 (pl)	2017-10-31
EP2909175A1 (en)	2015-08-26
CN104781235A (zh)	2015-07-15
US20160297760A1 (en)	2016-10-13
MX364782B (es)	2019-05-07
KR20150067376A (ko)	2015-06-17
RU2676329C2 (ru)	2018-12-28
SI3222616T1 (sl)	2019-10-30
CA2888928C (en)	2020-05-26
ES2743768T3 (es)	2020-02-20
CY1122194T1 (el)	2020-11-25
HUE046132T2 (hu)	2020-02-28
IL237863B (en)	2018-06-28
PT2909175T (pt)	2017-09-13
EP2909175B1 (en)	2017-06-07
NZ706717A (en)	2018-02-23
IN2015DN02721A (sr)	2015-09-04
MX2015004368A (es)	2015-06-10
DK3222616T3 (da)	2019-08-19
HK1211028A1 (en)	2016-05-13
US10370332B2 (en)	2019-08-06
SG11201502515VA (en)	2015-05-28
EP3222616B1 (en)	2019-07-17
BR112015008167A2 (pt)	2017-07-04
AU2013333636A1 (en)	2015-04-09
ZA201501958B (en)	2016-01-27
JP2018048160A (ja)	2018-03-29
CY1119080T1 (el)	2018-01-10
JP6464244B2 (ja)	2019-02-06
CN106496106A (zh)	2017-03-15
HRP20171320T1 (hr)	2017-10-20
HUE035525T2 (en)	2018-05-28
KR102164536B1 (ko)	2020-10-12
IL256560B (en)	2019-07-31
WO2014060742A1 (en)	2014-04-24
RS56184B1 (sr)	2017-11-30
US9388136B2 (en)	2016-07-12
CN104781235B (zh)	2016-12-21
US20180127371A1 (en)	2018-05-10
EP3222616A1 (en)	2017-09-27
IL256560A (en)	2018-02-28
JP6260975B2 (ja)	2018-01-17
JP2015534974A (ja)	2015-12-07
DK2909175T3 (en)	2017-08-14

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