RS59003B1 - Antitela sa histidinom modifikovanim lakim lancem i genetski modifikovane nehumane životinje koje ih generišu - Google Patents

Antitela sa histidinom modifikovanim lakim lancem i genetski modifikovane nehumane životinje koje ih generišu

Info

Publication number: RS59003B1
Authority: RS; Serbia
Prior art keywords: generating; light chain; same; genetically modified; chain antibodies
Prior art date: 2013-09-18

Application number

RS20190873A

Other languages

English (en)

Inventor

John Mcwhirter

Lynn Macdonald

Andrew J Murphy

Original Assignee

Regeneron Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-09-18

Filing date

2014-09-18

Publication date

2019-08-30

2013-09-18 Priority claimed from US14/030,424 external-priority patent/US20140013456A1/en

2014-09-18 Application filed by Regeneron Pharma filed Critical Regeneron Pharma

2019-08-30 Publication of RS59003B1 publication Critical patent/RS59003B1/sr

Links

HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Environmental Sciences (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Animal Behavior & Ethology (AREA)
Animal Husbandry (AREA)
Biodiversity & Conservation Biology (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

RS20190873A 2013-09-18 2014-09-18 Antitela sa histidinom modifikovanim lakim lancem i genetski modifikovane nehumane životinje koje ih generišu RS59003B1 (sr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US14/030,424 US20140013456A1 (en)	2012-03-16	2013-09-18	Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same
PCT/US2014/056285 WO2015042250A1 (en)	2013-09-18	2014-09-18	Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same
EP14781761.3A EP3046412B1 (en)	2013-09-18	2014-09-18	Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same

Publications (1)

Publication Number	Publication Date
RS59003B1 true RS59003B1 (sr)	2019-08-30

Family

ID=51663490

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
RS20190873A RS59003B1 (sr)	2013-09-18	2014-09-18	Antitela sa histidinom modifikovanim lakim lancem i genetski modifikovane nehumane životinje koje ih generišu

Country Status (25)

Country	Link
EP (2)	EP3549437B1 (sr)
JP (3)	JP6621750B2 (sr)
KR (2)	KR102150414B1 (sr)
CN (2)	CN111019953A (sr)
AU (2)	AU2014323527B2 (sr)
BR (1)	BR112016005912A2 (sr)
CA (1)	CA2922892C (sr)
CY (1)	CY1121798T1 (sr)
DK (1)	DK3046412T3 (sr)
ES (2)	ES2962489T3 (sr)
HK (1)	HK1225913A1 (sr)
HR (1)	HRP20191233T1 (sr)
HU (1)	HUE044747T2 (sr)
IL (2)	IL244226B (sr)
LT (1)	LT3046412T (sr)
MX (1)	MX362904B (sr)
MY (1)	MY191512A (sr)
PL (1)	PL3046412T3 (sr)
PT (1)	PT3046412T (sr)
RS (1)	RS59003B1 (sr)
RU (2)	RU2019121863A (sr)
SG (2)	SG10201810825YA (sr)
SI (1)	SI3046412T1 (sr)
TR (1)	TR201909967T4 (sr)
WO (1)	WO2015042250A1 (sr)

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CN112812184A (zh)	2011-02-25	2021-05-18	中外制药株式会社	FcγRIIb特异性Fc抗体
WO2013047748A1 (ja)	2011-09-30	2013-04-04	中外製薬株式会社	複数の生理活性を有する抗原の消失を促進する抗原結合分子
EP3517550A1 (en)	2011-11-30	2019-07-31	Chugai Seiyaku Kabushiki Kaisha	Drug containing carrier into cell for forming immune complex
KR102273985B1 (ko)	2012-08-24	2021-07-06	추가이 세이야쿠 가부시키가이샤	ＦｃγＲＩＩｂ 특이적 Ｆｃ영역 개변체
ES2876009T3 (es)	2012-12-27	2021-11-11	Chugai Pharmaceutical Co Ltd	Polipéptido heterodimerizado
MX2015014017A (es)	2013-04-02	2016-02-10	Chugai Pharmaceutical Co Ltd	Variante de la region fc.
SG11201700841QA (en)	2014-12-19	2017-03-30	Chugai Pharmaceutical Co Ltd	Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
WO2016125495A1 (en)	2015-02-05	2016-08-11	Chugai Seiyaku Kabushiki Kaisha	Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof
US11359009B2 (en)	2015-12-25	2022-06-14	Chugai Seiyaku Kabushiki Kaisha	Anti-myostatin antibodies and methods of use
TWI693940B (zh)	2016-08-05	2020-05-21	日商中外製藥股份有限公司	Ｉｌ-８相關疾病之治療用或預防用組成物
EP3897117A1 (en) *	2018-12-21	2021-10-27	Compass Therapeutics LLC	Transgenic mouse expressing common human light chain
US20230071042A1 (en) *	2019-12-18	2023-03-09	Bristo-Myers Squibb Company	Bcr transgenic mice with a common leader sequence
TW202229328A (zh)	2020-09-11	2022-08-01	美商再生元醫藥公司	抗原特異性抗體之鑑定及產生
AU2021400584A1 (en)	2020-12-16	2023-06-29	Regeneron Pharmaceuticals, Inc.	Mice expressing humanized fc alpha receptors
CN114568343B (zh) *	2022-03-11	2023-04-07	成都合拓创展生物科技有限公司	制备眼病模型的头具及其应用

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WO2007117410A2 (en) *	2006-03-31	2007-10-18	Medarex, Inc.	Transgenic animals expressing chimeric antibodies for use in preparing human antibodies
ES2398076T3 (es)	2006-06-02	2013-03-13	Regeneron Pharmaceuticals, Inc.	Anticuerpos de alta afinidad contra el receptor de IL-6 humano
EP3521311A1 (en)	2008-04-11	2019-08-07	Chugai Seiyaku Kabushiki Kaisha	Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
CN102272161A (zh) *	2008-11-06	2011-12-07	阿雷克森制药公司	免疫原性降低的工程抗体与制备方法
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US20140013456A1 (en) *	2012-03-16	2014-01-09	Regeneron Pharmaceuticals, Inc.	Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same
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2014
- 2014-09-18 ES ES19159475T patent/ES2962489T3/es active Active
- 2014-09-18 AU AU2014323527A patent/AU2014323527B2/en active Active
- 2014-09-18 DK DK14781761.3T patent/DK3046412T3/da active
- 2014-09-18 MX MX2016003638A patent/MX362904B/es active IP Right Grant
- 2014-09-18 KR KR1020167009721A patent/KR102150414B1/ko active IP Right Grant
- 2014-09-18 ES ES14781761T patent/ES2738679T3/es active Active
- 2014-09-18 PL PL14781761T patent/PL3046412T3/pl unknown
- 2014-09-18 PT PT14781761T patent/PT3046412T/pt unknown
- 2014-09-18 LT LTEP14781761.3T patent/LT3046412T/lt unknown
- 2014-09-18 RS RS20190873A patent/RS59003B1/sr unknown
- 2014-09-18 SG SG10201810825YA patent/SG10201810825YA/en unknown
- 2014-09-18 BR BR112016005912A patent/BR112016005912A2/pt not_active IP Right Cessation
- 2014-09-18 SI SI201431271T patent/SI3046412T1/sl unknown
- 2014-09-18 CN CN201911266988.5A patent/CN111019953A/zh active Pending
- 2014-09-18 CN CN201480061443.XA patent/CN105722387B/zh active Active
- 2014-09-18 HU HUE14781761 patent/HUE044747T2/hu unknown
- 2014-09-18 CA CA2922892A patent/CA2922892C/en active Active
- 2014-09-18 TR TR2019/09967T patent/TR201909967T4/tr unknown
- 2014-09-18 SG SG11201601272YA patent/SG11201601272YA/en unknown
- 2014-09-18 EP EP19159475.3A patent/EP3549437B1/en active Active
- 2014-09-18 EP EP14781761.3A patent/EP3046412B1/en active Active
- 2014-09-18 JP JP2016543984A patent/JP6621750B2/ja active Active
- 2014-09-18 RU RU2019121863A patent/RU2019121863A/ru unknown
- 2014-09-18 RU RU2016114306A patent/RU2694728C2/ru active
- 2014-09-18 WO PCT/US2014/056285 patent/WO2015042250A1/en active Application Filing
- 2014-09-18 KR KR1020207024599A patent/KR20200103882A/ko not_active Application Discontinuation
- 2014-09-18 MY MYPI2016700599A patent/MY191512A/en unknown
2016
- 2016-02-22 IL IL244226A patent/IL244226B/en active IP Right Grant
- 2016-12-16 HK HK16114363A patent/HK1225913A1/zh unknown
2019
- 2019-01-16 JP JP2019004905A patent/JP2019068850A/ja not_active Withdrawn
- 2019-01-21 IL IL264358A patent/IL264358A/en unknown
- 2019-07-10 CY CY20191100728T patent/CY1121798T1/el unknown
- 2019-07-10 HR HRP20191233TT patent/HRP20191233T1/hr unknown
2020
- 2020-03-03 JP JP2020035905A patent/JP2020078350A/ja not_active Withdrawn
2021
- 2021-01-15 AU AU2021200228A patent/AU2021200228A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP2016533768A (ja)	2016-11-04
CN105722387B (zh)	2020-01-17
KR20160049018A (ko)	2016-05-04
CN111019953A (zh)	2020-04-17
EP3549437C0 (en)	2023-10-25
RU2019121863A (ru)	2019-08-29
TR201909967T4 (tr)	2019-07-22
RU2694728C2 (ru)	2019-07-16
MY191512A (en)	2022-06-28
IL244226B (en)	2019-02-28
AU2021200228A1 (en)	2021-03-18
PL3046412T3 (pl)	2019-11-29
AU2014323527B2 (en)	2020-10-15
JP6621750B2 (ja)	2019-12-18
CN105722387A (zh)	2016-06-29
AU2014323527A1 (en)	2016-04-07
CA2922892A1 (en)	2015-03-26
KR102150414B1 (ko)	2020-09-02
EP3549437A1 (en)	2019-10-09
ES2962489T3 (es)	2024-03-19
CY1121798T1 (el)	2020-07-31
EP3046412B1 (en)	2019-04-10
DK3046412T3 (da)	2019-07-15
JP2020078350A (ja)	2020-05-28
RU2016114306A3 (sr)	2018-04-26
JP2019068850A (ja)	2019-05-09
BR112016005912A2 (pt)	2017-09-26
PT3046412T (pt)	2019-07-16
KR20200103882A (ko)	2020-09-02
WO2015042250A4 (en)	2015-05-28
LT3046412T (lt)	2019-07-25
SI3046412T1 (sl)	2019-08-30
ES2738679T3 (es)	2020-01-24
MX2016003638A (es)	2016-07-21
SG11201601272YA (en)	2016-03-30
HK1225913A1 (zh)	2017-09-22
WO2015042250A9 (en)	2016-04-28
SG10201810825YA (en)	2019-01-30
MX362904B (es)	2019-02-25
CA2922892C (en)	2022-06-14
IL244226A0 (en)	2016-04-21
EP3549437B1 (en)	2023-10-25
HRP20191233T1 (hr)	2019-10-18
WO2015042250A1 (en)	2015-03-26
RU2016114306A (ru)	2017-10-23
IL264358A (en)	2019-02-28
HUE044747T2 (hu)	2019-11-28
EP3046412A1 (en)	2016-07-27

Publication	Publication Date	Title
IL282452B (en)	2022-03-01	Histidine-engineered light chain antibodies, and non-human animals genetically modified for their preparation
IL264358A (en)	2019-02-28	Histidine engineered light chain antibodies and non-human animals genetically engineered to produce them
HK1258227A1 (zh)	2019-11-08	具有修飾的免疫球蛋白重鏈序列的非人類動物