RS56361B1 - Sinteza zaštićenih 3'-amino nukleozidnih monomera - Google Patents

Sinteza zaštićenih 3'-amino nukleozidnih monomera

Info

Publication number
RS56361B1
RS56361B1 RS20170923A RSP20170923A RS56361B1 RS 56361 B1 RS56361 B1 RS 56361B1 RS 20170923 A RS20170923 A RS 20170923A RS P20170923 A RSP20170923 A RS P20170923A RS 56361 B1 RS56361 B1 RS 56361B1
Authority
RS
Serbia
Prior art keywords
synthesis
protected
nucleoside monomers
amino nucleoside
amino
Prior art date
Application number
RS20170923A
Other languages
English (en)
Inventor
Sergei M Gryaznov
Krisztina Pongracz
Daria Zielinska
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geron Corp filed Critical Geron Corp
Publication of RS56361B1 publication Critical patent/RS56361B1/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
RS20170923A 2004-07-02 2005-06-30 Sinteza zaštićenih 3'-amino nukleozidnih monomera RS56361B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58519304P 2004-07-02 2004-07-02
EP05768112.4A EP1778711B1 (en) 2004-07-02 2005-06-30 Synthesis of protected 3'-amino nucleoside monomers
PCT/US2005/023633 WO2006014387A1 (en) 2004-07-02 2005-06-30 Synthesis of protected 3’-amino nucleoside monomers

Publications (1)

Publication Number Publication Date
RS56361B1 true RS56361B1 (sr) 2017-12-29

Family

ID=35478430

Family Applications (2)

Application Number Title Priority Date Filing Date
RS20170923A RS56361B1 (sr) 2004-07-02 2005-06-30 Sinteza zaštićenih 3'-amino nukleozidnih monomera
RS20210593A RS61840B1 (sr) 2004-07-02 2005-06-30 Sinteza zaštićenih 3'-amino 5'-fosforamidit nukleozidnih monomera

Family Applications After (1)

Application Number Title Priority Date Filing Date
RS20210593A RS61840B1 (sr) 2004-07-02 2005-06-30 Sinteza zaštićenih 3'-amino 5'-fosforamidit nukleozidnih monomera

Country Status (18)

Country Link
US (8) US7485717B2 (sr)
EP (2) EP3296312B1 (sr)
KR (1) KR101279393B1 (sr)
CN (1) CN100558739C (sr)
CA (1) CA2571601C (sr)
CY (2) CY1119536T1 (sr)
DK (2) DK3296312T3 (sr)
ES (2) ES2643296T3 (sr)
HK (1) HK1252664A1 (sr)
HR (2) HRP20171705T1 (sr)
HU (2) HUE054463T2 (sr)
LT (2) LT1778711T (sr)
ME (1) ME02933B (sr)
PL (2) PL3296312T3 (sr)
PT (2) PT1778711T (sr)
RS (2) RS56361B1 (sr)
SI (2) SI3296312T1 (sr)
WO (1) WO2006014387A1 (sr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1667522T3 (en) 2003-09-09 2018-03-05 Geron Corp MODIFIED OLIGONUCLEOTIDES FOR TELOMERASE INHIBITION
ATE503014T1 (de) 2003-11-04 2011-04-15 Geron Corp Rna-amidate und thioamidateur rnai
US7485717B2 (en) 2004-07-02 2009-02-03 Geron Corporation Synthesis of protected 3′-amino nucleoside monomers
WO2007127163A2 (en) * 2006-04-24 2007-11-08 Geron Corporation Cns-tumor treatment method and composition
WO2008054711A2 (en) 2006-10-30 2008-05-08 Geron Corporation Combined telomerase inhibitor and gemcitabine for the treatment of cancer
ES2407957T3 (es) * 2007-03-09 2013-06-17 Geron Corporation Tratamiento de carcinomas con una combinación de inhibidores de la vía EGF y de la telomerasa
SI3029154T1 (en) 2008-10-17 2018-02-28 Geron Corporation Method for identifying patient sensitivity to telomerase inhibition therapy
ES2972330T3 (es) 2012-11-30 2024-06-12 Geron Corp Marcadores diagnósticos para el tratamiento de trastornos proliferativos celulares con inhibidores de la telomerasa
FI3646876T3 (fi) 2012-12-07 2024-05-14 Geron Corp Telomeraasinestäjä imetelstaatti myeloproliferatiivisten sairauksien ja myeloproliferatiivisten kasvainten hoitoa varten
US9375485B2 (en) 2012-12-07 2016-06-28 Geron Corporation Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
CN104231008B (zh) * 2013-06-07 2017-03-01 沈阳药科大学 核苷类药物5’‑位氨基酸酯的区域选择性合成方法
CA2925500C (en) 2013-09-30 2023-03-14 Geron Corporation Phosphorodiamidate backbone linkage for oligonucleotides
JOP20200257A1 (ar) 2014-05-01 2017-06-16 Geron Corp تركيبات أوليجو نوكليوتيد وطرق لتحضيرها
HUE051148T2 (hu) 2015-04-23 2021-03-01 Geron Corp Eljárás polinukleotid elõállítására többértékû kation-só készítmények alkalmazásával
DK3652187T3 (da) 2017-07-10 2021-12-13 Geron Corp Forbedret fremgangsmåde til fremstilling af imetelstat
CN117143942A (zh) * 2023-10-30 2023-12-01 泰兴合全药业有限公司 3’-氨基-2’,3’-双脱氧鸟苷5’-三磷酸的合成方法

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US4046720A (en) 1974-01-17 1977-09-06 California Institute Of Technology Crosslinked, porous, polyacrylate beads
US4413070A (en) 1981-03-30 1983-11-01 California Institute Of Technology Polyacrolein microspheres
US4678814A (en) 1981-03-30 1987-07-07 California Institute Of Technology Polyacrolein microspheres
US5185444A (en) * 1985-03-15 1993-02-09 Anti-Gene Deveopment Group Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
US4659774A (en) 1985-11-01 1987-04-21 American Hoechst Corporation Support for solid-phase oligonucleotide synthesis
JP3122460B2 (ja) 1990-08-31 2001-01-09 リージエンツ・オブ・ザ・ユニバーシテイ・オブ・ミネソタ 固相用途のためのポリエチレングリコール誘導体
US5281701A (en) 1991-07-12 1994-01-25 Applied Biosystems, Inc. Process and compounds for RNA synthesis
US5476925A (en) * 1993-02-01 1995-12-19 Northwestern University Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups
US5599922A (en) * 1994-03-18 1997-02-04 Lynx Therapeutics, Inc. Oligonucleotide N3'-P5' phosphoramidates: hybridization and nuclease resistance properties
US5726297A (en) * 1994-03-18 1998-03-10 Lynx Therapeutics, Inc. Oligodeoxyribonucleotide N3' P5' phosphoramidates
EP0754242A4 (en) * 1994-03-18 1997-06-11 Lynx Therapeutics Inc SYNTHESIS AND SUBSTANCE, HYBRIDIZATION AND NUCLEASE-RESISTANT PROPERTIES OF OLIGONUCLEOTID-N3'-m (7) P5'-PHOSPHORAMIDATE
US5705621A (en) 1995-11-17 1998-01-06 Isis Pharmaceuticals, Inc. Oligomeric phosphite, phosphodiester, Phosphorothioate and phosphorodithioate compounds and intermediates for preparing same
US5859233A (en) * 1996-02-21 1999-01-12 Lynx Therapeutics, Inc. Synthons for synthesis of oligonucleotide N3-P5 phosphoramidates
US5684143A (en) * 1996-02-21 1997-11-04 Lynx Therapeutics, Inc. Oligo-2'-fluoronucleotide N3'->P5' phosphoramidates
WO1998028442A1 (en) 1996-12-20 1998-07-02 Geron Corporation Methods for detecting and inhibiting the rna component of telomerase
US5998604A (en) * 1997-09-15 1999-12-07 The Perkin-Elmer Corporation Polynucleotide purification method
US6465628B1 (en) 1999-02-04 2002-10-15 Isis Pharmaceuticals, Inc. Process for the synthesis of oligomeric compounds
AU767646B2 (en) * 1999-09-10 2003-11-20 Geron Corporation Oligonucleotide N3'-P5' thiophosphoramidates: their synthesis and use
US7321029B2 (en) 2000-01-21 2008-01-22 Geron Corporation 2′-arabino-fluorooligonucleotide N3′→P5′ phosphoramidates: their synthesis and use
JP2002060341A (ja) 2000-08-21 2002-02-26 Terumo Corp 止血剤
WO2002060341A2 (en) 2001-01-30 2002-08-08 Medstar Research Institute Inhibition of proteasomes to prevent restenosis
WO2002077184A2 (en) 2001-03-23 2002-10-03 Geron Corporation Oligonucleotide conjugates
US7563618B2 (en) 2001-03-23 2009-07-21 Geron Corporation Oligonucleotide conjugates
DK1667522T3 (en) * 2003-09-09 2018-03-05 Geron Corp MODIFIED OLIGONUCLEOTIDES FOR TELOMERASE INHIBITION
US20120329858A1 (en) 2010-08-04 2012-12-27 Geron Corporation Modified oligonucleotides for telomerase inhibition
ATE503014T1 (de) 2003-11-04 2011-04-15 Geron Corp Rna-amidate und thioamidateur rnai
US7485717B2 (en) 2004-07-02 2009-02-03 Geron Corporation Synthesis of protected 3′-amino nucleoside monomers
WO2008127305A2 (en) 2006-11-01 2008-10-23 Biogen Idec Ma Inc. Method of isolating biomacromolecules using low ph and divalent cations
FI3646876T3 (fi) 2012-12-07 2024-05-14 Geron Corp Telomeraasinestäjä imetelstaatti myeloproliferatiivisten sairauksien ja myeloproliferatiivisten kasvainten hoitoa varten
JOP20200257A1 (ar) * 2014-05-01 2017-06-16 Geron Corp تركيبات أوليجو نوكليوتيد وطرق لتحضيرها

Also Published As

Publication number Publication date
US20240034748A1 (en) 2024-02-01
US8748593B2 (en) 2014-06-10
LT3296312T (lt) 2021-06-10
HUE054463T2 (hu) 2021-09-28
US20200377543A1 (en) 2020-12-03
US7485717B2 (en) 2009-02-03
US20060009636A1 (en) 2006-01-12
DK3296312T3 (da) 2021-05-03
CN1997658A (zh) 2007-07-11
HK1252664A1 (zh) 2019-05-31
CN100558739C (zh) 2009-11-11
LT1778711T (lt) 2017-10-25
HRP20171705T1 (hr) 2017-12-15
US20190031707A1 (en) 2019-01-31
US10035815B2 (en) 2018-07-31
US10738073B2 (en) 2020-08-11
PL3296312T3 (pl) 2021-10-25
KR20070042155A (ko) 2007-04-20
PT3296312T (pt) 2021-05-11
ES2643296T3 (es) 2017-11-22
US20090105468A1 (en) 2009-04-23
PL1778711T3 (pl) 2018-01-31
DK1778711T3 (en) 2017-10-02
KR101279393B1 (ko) 2013-07-04
EP3296312A1 (en) 2018-03-21
CA2571601C (en) 2013-01-08
CY1119536T1 (el) 2018-03-07
US20150038692A1 (en) 2015-02-05
US20230089101A1 (en) 2023-03-23
US20160362440A1 (en) 2016-12-15
US9365606B2 (en) 2016-06-14
WO2006014387A1 (en) 2006-02-09
PT1778711T (pt) 2017-10-19
HRP20210787T1 (hr) 2021-06-25
ME02933B (me) 2018-04-20
EP1778711B1 (en) 2017-08-16
RS61840B1 (sr) 2021-06-30
CA2571601A1 (en) 2006-02-09
SI1778711T1 (sl) 2017-11-30
EP3296312B1 (en) 2021-03-17
SI3296312T1 (sl) 2021-08-31
HUE037166T2 (hu) 2018-08-28
CY1124335T1 (el) 2022-07-22
ES2868452T3 (es) 2021-10-21
EP1778711A1 (en) 2007-05-02

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