RS49629B - Farmaceutska formulacija omeprazola - Google Patents

Farmaceutska formulacija omeprazola

Info

Publication number
RS49629B
RS49629B YUP-608/99A YU60899A RS49629B RS 49629 B RS49629 B RS 49629B YU 60899 A YU60899 A YU 60899A RS 49629 B RS49629 B RS 49629B
Authority
RS
Serbia
Prior art keywords
omeprazole
determined
cloud point
hpmc
solution
Prior art date
Application number
YUP-608/99A
Other languages
English (en)
Inventor
Magnus Erickson
Lars Josefsson
Original Assignee
Astra Aktiebolaget,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20407122&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS49629(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astra Aktiebolaget, filed Critical Astra Aktiebolaget,
Publication of YU60899A publication Critical patent/YU60899A/sh
Publication of RS49629B publication Critical patent/RS49629B/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Oralna farmaceutska formulacija sa entero prevlakom koja sadrži kao aktivnu supstancu jedinjenje izabrano iz grupe omeprazola, alkalne soli omeprazola, (-) enantiomera omeprazola i alkalne soli (-) enantniomera operazola, u kojoj formulacija sadrži z rnasti materijal od aktivne supstance i opciono jedinjenja koje alkalno reaguje, a aktivna supstanca je u smeši sa jednim ili više farmaceutski prihvatljivih ekscipijenata kao što su sredstva za vezivanje, punioci i/ili sredstva za dezintegraciju, i na pomenutom zrnastom materijalu je sloj za razdvajanje i prevlaka od entero sloja, naznačena time, što je sredstvo za vezivanje i/ili sastojak sloja za razdvajanje hidroksipropil metilceluloza (HPMC) niske viskoznosti sa tačkom zamućenja najmanje 45.6°C određenom kao temperatura na kojoj je transmisija svetlosti specifičnog sistema 96%, i gde je tačka zamućenja određena rastvaranjem HPMC u koncentraciji od 1.2% u smeši 0.235 M rastvora fosfatnog pufera i simulirane želudačne tečnosti pH 1.2 u odnosu 4:5 pri pH rastvora između 6.75 i 6.85, ili što je sredstvo za vezivanje i/ili sastojak sloja za razdvajanje, HPMC niske viskoznosti sa tačkom zamućenja najmanje 44.5°C određenom kao temperatura na kojoj je transmisija svetlosti specifičnog sistema 95% i gde je tačka zamućenja određena rastvaranjem HPMC niske viskoznosti u koncentraciji od 1.0% u 0.235 M rastvoru smeše fosfatnog pufera i simulirane želudačne tečnosti pH 1.2 u odnosu 4:5 pri pH rastvora između 6.75 i 6.85. Prijava sadrži još 17 zahteva.
YUP-608/99A 1997-05-28 1998-05-18 Farmaceutska formulacija omeprazola RS49629B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9702000A SE9702000D0 (sv) 1997-05-28 1997-05-28 New pharmaceutical formulation

Publications (2)

Publication Number Publication Date
YU60899A YU60899A (sh) 2002-06-19
RS49629B true RS49629B (sr) 2007-08-03

Family

ID=20407122

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-608/99A RS49629B (sr) 1997-05-28 1998-05-18 Farmaceutska formulacija omeprazola

Country Status (41)

Country Link
US (1) US6090827A (sr)
EP (1) EP0984773B1 (sr)
JP (1) JP4649001B2 (sr)
KR (1) KR100540721B1 (sr)
CN (1) CN1123338C (sr)
AR (1) AR012698A1 (sr)
AT (1) ATE234078T1 (sr)
AU (1) AU722879B2 (sr)
BR (1) BR9809484A (sr)
CA (1) CA2290531C (sr)
CZ (1) CZ298972B6 (sr)
DE (1) DE69812089T2 (sr)
DK (1) DK0984773T3 (sr)
DZ (1) DZ2494A1 (sr)
EE (1) EE03903B1 (sr)
EG (1) EG24044A (sr)
ES (1) ES2195342T3 (sr)
HK (1) HK1025744A1 (sr)
HR (1) HRP980260B1 (sr)
HU (1) HU229154B1 (sr)
ID (1) ID24654A (sr)
IL (1) IL132895A0 (sr)
IS (1) IS2856B (sr)
MA (1) MA26497A1 (sr)
MY (1) MY122298A (sr)
NO (1) NO328100B1 (sr)
NZ (1) NZ500886A (sr)
PL (1) PL194634B1 (sr)
PT (1) PT984773E (sr)
RS (1) RS49629B (sr)
RU (1) RU2207121C2 (sr)
SA (1) SA98190304B1 (sr)
SE (1) SE9702000D0 (sr)
SI (1) SI0984773T1 (sr)
SK (1) SK286625B6 (sr)
TN (1) TNSN98068A1 (sr)
TR (1) TR199902890T2 (sr)
TW (1) TW575435B (sr)
UA (1) UA71541C2 (sr)
WO (1) WO1998053803A1 (sr)
ZA (1) ZA984178B (sr)

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US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6174548B1 (en) * 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6096340A (en) 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US20020039597A1 (en) * 1998-04-20 2002-04-04 Koji Ukai Stabilized compositions containing benzimidazole-type compounds
SE9803772D0 (sv) 1998-11-05 1998-11-05 Astra Ab Pharmaceutical formulation
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US6245913B1 (en) 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
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KR20020038759A (ko) 1999-10-20 2002-05-23 다니구치 미즈오 벤즈이미다졸계 화합물 안정화 방법
US20040092511A1 (en) * 1999-12-10 2004-05-13 Billstein Stephan Anthony Pharmaceutical combinations and their use in treating gastrointestinal and abdominal viscera disorders
US20020192299A1 (en) * 2000-12-28 2002-12-19 Rajneesh Taneja Pharmaceutical compositions of a non-enteric coated proton pump inhibitor with a carbonate salt and bicarbonate salt combination
JP2002234842A (ja) * 2001-02-09 2002-08-23 Kyowa Yakuhin Kogyo Kk 内服腸溶性製剤
MXPA04007169A (es) * 2002-01-25 2004-10-29 Santarus Inc Suministro transmucosal de inhibidores de bomba de protones.
US20040082618A1 (en) * 2002-07-03 2004-04-29 Rajneesh Taneja Liquid dosage forms of acid labile drugs
FR2843121B3 (fr) 2002-08-02 2004-09-10 Rhodia Chimie Sa Agent ignifugeant, procede de preparation et l'utilisation de cet agent
US20070243251A1 (en) * 2002-12-20 2007-10-18 Rajneesh Taneja Dosage Forms Containing A PPI, NSAID, and Buffer
US20040121004A1 (en) * 2002-12-20 2004-06-24 Rajneesh Taneja Dosage forms containing a PPI, NSAID, and buffer
US20040146558A1 (en) * 2003-01-28 2004-07-29 Kyowa Pharmaceutical Co., Ltd. Oral enteric-coated preparation
ZA200506397B (en) * 2003-01-29 2006-11-29 Takeda Pharmaceutical Process for producing coated preparation
MXPA05007883A (es) 2003-01-29 2005-09-21 Takeda Pharmaceutical Proceso para producir una preparacion recubierta.
JP4567340B2 (ja) * 2003-01-29 2010-10-20 武田薬品工業株式会社 被覆製剤の製造方法
TWI367759B (en) * 2003-02-20 2012-07-11 Santarus Inc A novel formulation, omeprazole antacid complex-immediate release, for rapid and sustained suppression of gastric acid
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
CN1311824C (zh) * 2004-04-21 2007-04-25 常州市第四制药厂有限公司 奥美拉唑肠溶微粒制剂及制备方法
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
ATE425791T1 (de) * 2005-07-29 2009-04-15 Rottapharm Spa Kombination aus itriglumid und ppi zur behandlung von gastrointestinalen- und assozierten krankheiten
EP2026768B1 (en) * 2006-06-01 2018-02-28 Dexcel Pharma Technologies Ltd. Multiple unit pharmaceutical formulation
KR101436516B1 (ko) * 2007-07-23 2014-09-02 주식회사태평양제약 코팅된 펠렛을 함유하는 현탁정 및 이의 제조방법
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CA2720800C (en) * 2008-03-28 2013-07-30 Ferrer Internacional S.A. Capsule for the prevention of cardiovascular diseases
DK2334378T3 (da) 2008-08-19 2014-07-07 Xenoport Inc Prodrugs af methylhydrogenfumarat, farmaceutiske sammensætninger deraf og fremgangsmåder til anvendelse
US10945984B2 (en) 2012-08-22 2021-03-16 Arbor Pharmaceuticals, Llc Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects
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CN102961356A (zh) * 2012-12-11 2013-03-13 山西云鹏制药有限公司 一种含奥美拉唑的蓝色肠溶片剂的制备方法
WO2014160633A1 (en) 2013-03-24 2014-10-02 Xenoport, Inc. Pharmaceutical compositions of dimethyl fumarate
TW201516020A (zh) 2013-09-06 2015-05-01 Xenoport Inc （ｎ，ｎ－二乙基胺甲醯基）甲基（２ｅ）丁－２－烯－１，４－二酸甲酯之晶形、合成方法及用途
WO2015042294A1 (en) * 2013-09-18 2015-03-26 Xenoport, Inc. Nanoparticle compositions of dimethyl fumarate
US9999672B2 (en) 2014-03-24 2018-06-19 Xenoport, Inc. Pharmaceutical compositions of fumaric acid esters
EP3288556A4 (en) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
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WO2021153525A1 (ja) 2020-01-27 2021-08-05 東和薬品株式会社 エソメプラゾール経口製剤およびその製造方法
KR102432084B1 (ko) 2021-11-16 2022-08-12 알리코제약(주) S-오메프라졸을 함유하는 안정성이 개선되고 소형화된 정제
WO2024075017A1 (en) 2022-10-04 2024-04-11 Zabirnyk Arsenii Inhibition of aortic valve calcification

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Also Published As

Publication number Publication date
NO328100B1 (no) 2009-12-07
MY122298A (en) 2006-04-29
DK0984773T3 (da) 2003-07-07
EP0984773B1 (en) 2003-03-12
HU229154B1 (en) 2013-09-30
EE03903B1 (et) 2002-12-16
AU7680398A (en) 1998-12-30
TR199902890T2 (xx) 2000-02-21
KR100540721B1 (ko) 2006-01-10
HRP980260B1 (en) 2003-10-31
DE69812089T2 (de) 2004-03-04
HRP980260A2 (en) 1999-02-28
HK1025744A1 (en) 2000-11-24
ZA984178B (en) 1998-11-30
PL194634B1 (pl) 2007-06-29
CN1258217A (zh) 2000-06-28
SA98190304B1 (ar) 2006-10-11
DE69812089D1 (de) 2003-04-17
NZ500886A (en) 2001-11-30
SK286625B6 (sk) 2009-02-05
WO1998053803A1 (en) 1998-12-03
CN1123338C (zh) 2003-10-08
NO995809D0 (no) 1999-11-26
UA71541C2 (uk) 2004-12-15
AU722879B2 (en) 2000-08-10
KR20010013104A (ko) 2001-02-26
AR012698A1 (es) 2000-11-08
EP0984773A1 (en) 2000-03-15
PL337237A1 (en) 2000-08-14
HUP0002182A3 (en) 2003-02-28
IS5245A (is) 1999-11-11
CA2290531A1 (en) 1998-12-03
CA2290531C (en) 2006-12-12
DZ2494A1 (fr) 2003-01-25
ES2195342T3 (es) 2003-12-01
ATE234078T1 (de) 2003-03-15
HUP0002182A2 (hu) 2002-05-29
SK159099A3 (en) 2000-06-12
IS2856B (is) 2013-11-15
JP4649001B2 (ja) 2011-03-09
YU60899A (sh) 2002-06-19
SI0984773T1 (en) 2003-10-31
MA26497A1 (fr) 2004-12-20
RU2207121C2 (ru) 2003-06-27
EG24044A (en) 2008-04-13
CZ420299A3 (cs) 2000-05-17
JP2002500665A (ja) 2002-01-08
ID24654A (id) 2000-07-27
PT984773E (pt) 2003-07-31
CZ298972B6 (cs) 2008-03-26
TW575435B (en) 2004-02-11
NO995809L (no) 2000-01-28
IL132895A0 (en) 2001-03-19
SE9702000D0 (sv) 1997-05-28
US6090827A (en) 2000-07-18
BR9809484A (pt) 2000-06-20
TNSN98068A1 (fr) 2005-03-15
EE9900540A (et) 2000-06-15

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