RS20080391A - Methods of treating inflammatory and autoimmune diseases with natalizumab - Google Patents
Methods of treating inflammatory and autoimmune diseases with natalizumabInfo
- Publication number
- RS20080391A RS20080391A RSP-2008/0391A RSP20080391A RS20080391A RS 20080391 A RS20080391 A RS 20080391A RS P20080391 A RSP20080391 A RS P20080391A RS 20080391 A RS20080391 A RS 20080391A
- Authority
- RS
- Serbia
- Prior art keywords
- natalizumab
- igg4
- levels
- autoimmune diseases
- patients
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Virology (AREA)
Abstract
Natalizumab je bezbedan i efikasan tretman zapaljenskih i autoimunih oboljenja, kao što je multipla skleroza, Kronova bolest i reumatoidni artritis. Zamena lanaca između natalizumaba i IgG4 molekula smanjuje koncentraciju dvovalentnog natalizumaba prisutnog nakon primene natalizumaba, samim tim smanjujući aktivnost natalizumaba kod pacijenta. Razlike u koncentracijama IgG4 kod različitih pacijenata ili kod pojedinačnog pacijenta s vremenom mogu da promene farmakokinetički profil natalizumaba. Kod pacijenata sa nižim koncentracijama IgG4 mogu da se jave više minimalne koncentracije natalizumaba u toku primene. Praćenje koncentracija IgG4 i/ili dvovalentnog natalizumaba i određivanje doze ili perioda primene na osnovu tog praćenja može da poboljša bezbednost i/ili efikasnost primene terapije natalizumabom.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77919006P | 2006-03-03 | 2006-03-03 | |
PCT/US2007/005265 WO2007103112A2 (en) | 2006-03-03 | 2007-03-02 | Methods of treating inflammatory and autoimmune diseases with natalizumab |
Publications (1)
Publication Number | Publication Date |
---|---|
RS20080391A true RS20080391A (en) | 2009-07-15 |
Family
ID=38475386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RSP-2008/0391A RS20080391A (en) | 2006-03-03 | 2007-03-02 | Methods of treating inflammatory and autoimmune diseases with natalizumab |
Country Status (18)
Country | Link |
---|---|
US (4) | US20070231319A1 (sr) |
EP (2) | EP3360900A1 (sr) |
JP (2) | JP5504390B2 (sr) |
KR (1) | KR20080104343A (sr) |
CN (1) | CN101437541A (sr) |
AU (1) | AU2007224228B2 (sr) |
BR (1) | BRPI0708392A2 (sr) |
CA (1) | CA2644110A1 (sr) |
EA (1) | EA016626B1 (sr) |
ES (1) | ES2663377T3 (sr) |
HK (1) | HK1256238A1 (sr) |
IL (1) | IL193775A (sr) |
MA (1) | MA30287B1 (sr) |
MX (1) | MX2008011176A (sr) |
RS (1) | RS20080391A (sr) |
SG (1) | SG170058A1 (sr) |
WO (1) | WO2007103112A2 (sr) |
ZA (1) | ZA200807346B (sr) |
Families Citing this family (32)
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CN101351710B (zh) | 2005-04-04 | 2013-06-05 | 生物基因Idecma公司 | 评价对治疗性蛋白质的免疫应答的方法和产品 |
CA2641513C (en) | 2006-02-28 | 2021-09-21 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with natalizumab |
WO2007100763A2 (en) | 2006-02-28 | 2007-09-07 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds |
KR20080104343A (ko) | 2006-03-03 | 2008-12-02 | 엘란 파마슈티칼스, 인크. | 나탈리주마브로 염증 및 자가면역 질환을 치료하는 방법 |
AU2008234248C1 (en) * | 2007-03-29 | 2015-01-22 | Genmab A/S | Bispecific antibodies and methods for production thereof |
EP2200611A4 (en) * | 2007-09-14 | 2010-09-22 | Biogen Idec Inc | COMPOSITIONS AND METHODS FOR TREATING PROGRESSIVE MULTIFOCAL LEUCOENCEPHALEPATHY (PML) |
EP2226392A1 (en) * | 2009-03-03 | 2010-09-08 | Assistance Publique - Hôpitaux de Paris | Method for detecting JCV infection |
ES2548999T3 (es) * | 2009-06-19 | 2015-10-22 | Teva Pharmaceutical Industries Ltd. | Tratamiento de la esclerosis múltiple con laquinimod |
JP5882208B2 (ja) * | 2009-07-30 | 2016-03-09 | テバ ファーマシューティカル インダストリーズ リミティド | ラキニモドによるクローン病の治療 |
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US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
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ES2601819T3 (es) * | 2010-03-03 | 2017-02-16 | Teva Pharmaceutical Industries Ltd. | Tratamiento de la artritis lúpica usando laquinimod |
SG183513A1 (en) * | 2010-03-03 | 2012-09-27 | Teva Pharma | Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate |
MX353144B (es) | 2010-04-20 | 2017-12-20 | Genmab As | Proteinas que contienen fc de anticuerpos heterodimericos y metodos para produccion de las mismas. |
LT3326645T (lt) | 2010-10-25 | 2020-08-10 | Biogen Ma Inc. | Alfa-4 integrino aktyvumo skirtumų, koreliuojant su skirtumais svcam ir (arba) smadcam lygiuose, nustatymo būdai |
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TW201400117A (zh) | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
WO2014193804A1 (en) | 2013-05-28 | 2014-12-04 | Biogen Idec Ma Inc. | Method of assessing risk of pml |
US10865253B2 (en) | 2014-12-19 | 2020-12-15 | Genmab A/S | Rodent bispecific heterodimeric proteins |
CN104865389B (zh) * | 2015-05-28 | 2017-06-06 | ***北京医院 | 一种检测人血清杂合轻链抗体的方法及试剂盒 |
US9856497B2 (en) | 2016-01-11 | 2018-01-02 | The Board Of Trustee Of The Leland Stanford Junior University | Chimeric proteins and methods of regulating gene expression |
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-
2007
- 2007-03-02 KR KR1020087023464A patent/KR20080104343A/ko not_active Application Discontinuation
- 2007-03-02 ES ES07751993.2T patent/ES2663377T3/es active Active
- 2007-03-02 JP JP2008558307A patent/JP5504390B2/ja active Active
- 2007-03-02 AU AU2007224228A patent/AU2007224228B2/en active Active
- 2007-03-02 SG SG201101499-0A patent/SG170058A1/en unknown
- 2007-03-02 EP EP17206297.8A patent/EP3360900A1/en active Pending
- 2007-03-02 RS RSP-2008/0391A patent/RS20080391A/sr unknown
- 2007-03-02 WO PCT/US2007/005265 patent/WO2007103112A2/en active Application Filing
- 2007-03-02 CA CA002644110A patent/CA2644110A1/en not_active Abandoned
- 2007-03-02 EP EP07751993.2A patent/EP1991267B1/en not_active Revoked
- 2007-03-02 MX MX2008011176A patent/MX2008011176A/es not_active Application Discontinuation
- 2007-03-02 EA EA200801933A patent/EA016626B1/ru not_active IP Right Cessation
- 2007-03-02 BR BRPI0708392-0A patent/BRPI0708392A2/pt not_active IP Right Cessation
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- 2007-03-02 US US11/713,000 patent/US20070231319A1/en not_active Abandoned
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2008
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- 2008-09-17 MA MA31249A patent/MA30287B1/fr unknown
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- 2012-12-03 JP JP2012264135A patent/JP5883377B2/ja active Active
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2018
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Also Published As
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US10466251B2 (en) | 2019-11-05 |
IL193775A0 (en) | 2011-08-01 |
US20200166521A1 (en) | 2020-05-28 |
EP1991267A2 (en) | 2008-11-19 |
EP1991267A4 (en) | 2010-02-10 |
CN101437541A (zh) | 2009-05-20 |
US20070231319A1 (en) | 2007-10-04 |
EA200801933A1 (ru) | 2009-04-28 |
EP3360900A1 (en) | 2018-08-15 |
ZA200807346B (en) | 2009-09-30 |
US11333670B2 (en) | 2022-05-17 |
WO2007103112A2 (en) | 2007-09-13 |
HK1256238A1 (zh) | 2019-09-20 |
JP5883377B2 (ja) | 2016-03-15 |
MA30287B1 (fr) | 2009-03-02 |
JP2013067640A (ja) | 2013-04-18 |
EA016626B1 (ru) | 2012-06-29 |
US20230082238A1 (en) | 2023-03-16 |
WO2007103112A3 (en) | 2007-11-29 |
JP5504390B2 (ja) | 2014-05-28 |
SG170058A1 (en) | 2011-04-29 |
AU2007224228B2 (en) | 2013-09-19 |
BRPI0708392A2 (pt) | 2011-05-24 |
AU2007224228A1 (en) | 2007-09-13 |
MX2008011176A (es) | 2008-09-10 |
JP2009529043A (ja) | 2009-08-13 |
ES2663377T3 (es) | 2018-04-12 |
EP1991267B1 (en) | 2017-12-20 |
KR20080104343A (ko) | 2008-12-02 |
IL193775A (en) | 2012-08-30 |
US20120177642A1 (en) | 2012-07-12 |
CA2644110A1 (en) | 2007-09-13 |
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