RS20050884A - Pharmaceutical composition containing histone deacetylase inhibitor - Google Patents

Pharmaceutical composition containing histone deacetylase inhibitor

Info

Publication number
RS20050884A
RS20050884A YUP-2005/0884A YUP20050884A RS20050884A RS 20050884 A RS20050884 A RS 20050884A YU P20050884 A YUP20050884 A YU P20050884A RS 20050884 A RS20050884 A RS 20050884A
Authority
RS
Serbia
Prior art keywords
pharmaceutical composition
composition containing
histone deacetylase
deacetylase inhibitor
containing histone
Prior art date
Application number
YUP-2005/0884A
Other languages
English (en)
Inventor
Osamu Nakanishi
Taisuo Sugawara
Hideyuki Migita
Yasuhiro Matsuba
Original Assignee
Schering Aktiengesellschaft,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft, filed Critical Schering Aktiengesellschaft,
Priority to MEP-323/08A priority Critical patent/MEP32308A/xx
Publication of RS20050884A publication Critical patent/RS20050884A/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Opisan je lek protiv raka koji obezbeđuje sinergističko dejstvo derivata benzamida, kao što N-(2-aminofenil)-4-[N-(piridin-3-ilmetoksikarbonil)aminoetil]benzamid (MS-275), koji je inhibitor histonske deacetilaze, prilikom kombinovane upotrebe sa još jednom aktivnom antikancerskom supstancom.
YUP-2005/0884A 2003-05-26 2004-05-26 Pharmaceutical composition containing histone deacetylase inhibitor RS20050884A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MEP-323/08A MEP32308A (en) 2003-05-26 2004-05-26 Pharmaceutical composition containing histone deacetylase inhibitor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003148073 2003-05-26
PCT/JP2004/007562 WO2004103369A1 (en) 2003-05-26 2004-05-26 Pharmaceutical composition containing histone deacetylase inhibitor

Publications (1)

Publication Number Publication Date
RS20050884A true RS20050884A (en) 2008-04-04

Family

ID=33475383

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-2005/0884A RS20050884A (en) 2003-05-26 2004-05-26 Pharmaceutical composition containing histone deacetylase inhibitor

Country Status (27)

Country Link
US (1) US20070098816A1 (sr)
EP (1) EP1626719A1 (sr)
JP (1) JP2006526031A (sr)
KR (1) KR100938712B1 (sr)
CN (2) CN101322707A (sr)
AR (1) AR045318A1 (sr)
AU (1) AU2004241873C1 (sr)
BR (1) BRPI0410959A (sr)
CA (4) CA2634766A1 (sr)
CL (1) CL2004001278A1 (sr)
CO (1) CO5660262A2 (sr)
CR (1) CR8163A (sr)
CU (1) CU23490B7 (sr)
EC (1) ECSP056253A (sr)
IL (1) IL171941A0 (sr)
ME (1) MEP32308A (sr)
MX (1) MXPA05012345A (sr)
NO (1) NO20055417L (sr)
NZ (1) NZ543591A (sr)
PE (1) PE20050206A1 (sr)
RS (1) RS20050884A (sr)
RU (1) RU2322971C2 (sr)
TW (1) TW200505424A (sr)
UA (1) UA81499C2 (sr)
UY (1) UY28330A1 (sr)
WO (1) WO2004103369A1 (sr)
ZA (1) ZA200509515B (sr)

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US7244853B2 (en) 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
CA2540108A1 (en) 2003-09-25 2005-04-07 Astellas Pharma Inc. Antitumor agent_comprising a histone deacetylase inhibitor and a topoisomerase ii inhibitor
US7446126B2 (en) * 2004-10-08 2008-11-04 Indena S.P.A. Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel
EP1712552A1 (en) * 2005-04-11 2006-10-18 INDENA S.p.A. Semisynthesis process for the preparation of 10-deacetyl-n-debenzoyl-paclitaxel
AU2006223086A1 (en) * 2005-03-11 2006-09-21 The Regents Of The University Of Colorado Histone deacetylase inhibitors sensitize cancer cells to epidermal growth factor inhibitors
EP3354265A1 (en) 2005-03-22 2018-08-01 President and Fellows of Harvard College Treatment of solid tumors
BRPI0613429A2 (pt) 2005-07-14 2009-02-10 Takeda San Diego Inc inibidores de histona desacetilase
US8222423B2 (en) 2006-02-14 2012-07-17 Dana-Farber Cancer Institute, Inc. Bifunctional histone deacetylase inhibitors
BRPI0707826B1 (pt) * 2006-02-14 2022-04-19 Dana-Farber Cancer Institute, Inc. Compostos inibidores de histona desacetilase, composição farmacêutica e uso dos referidos compostos
CA2654540C (en) 2006-05-03 2017-01-17 President And Fellows Of Harvard College Histone deacetylase and tubulin deacetylase inhibitors
GB0625283D0 (en) * 2006-12-19 2007-01-24 Cyclacel Ltd Combination
RU2446796C2 (ru) * 2006-12-26 2012-04-10 Фармасайкликс, Инк. Способ использования ингибиторов гистондеацетилазы и мониторинга биомаркеров в комбинированной терапии
US20090131367A1 (en) * 2007-11-19 2009-05-21 The Regents Of The University Of Colorado Combinations of HDAC Inhibitors and Proteasome Inhibitors
CA2709383A1 (en) * 2007-12-14 2009-06-25 Milton L. Brown Histone deacetylase inhibitors
RU2515611C2 (ru) 2008-07-23 2014-05-20 Президент Энд Феллоуз Оф Гарвард Колледж Ингибиторы деацетилазы и их применение
GB2462893B (en) * 2008-08-29 2010-10-13 Bayer Schering Pharma Ag N-(2-aminophenyl)-4-[N-(pyridine-3-yl)-methoxycarbonyl-aminomethyl]-benzamide (MS-275) polymorph B
PE20110677A1 (es) * 2008-08-29 2011-09-16 Bayer Ip Gmbh Polimorfo b de la n-(2-aminofenil)-4-[n-(piridin-3-il) metoxicarbonilamino-metil]benzamida (ms-275)
WO2010071837A1 (en) 2008-12-19 2010-06-24 Vertex Pharmaceuticals Incorporated Pyrazine derivatives useful as inhibitors of atr kinase
WO2010093561A1 (en) * 2009-02-11 2010-08-19 Liangping Yu Particulate composition and the method of making the same
WO2010125462A2 (en) * 2009-05-01 2010-11-04 Oncozyme Pharma Inc. Pentamidine combinations for treating cancer
BRPI1010884A2 (pt) * 2009-06-08 2016-03-15 Gilead Sciences Inc composto inibidores hdac de alcanoilamino benzamida anilina
US8716344B2 (en) 2009-08-11 2014-05-06 President And Fellows Of Harvard College Class- and isoform-specific HDAC inhibitors and uses thereof
HUE029094T2 (hu) * 2009-08-25 2017-02-28 Abraxis Bioscience Llc Kombinációs terápia egy taxánt és egy albumint tartalmazó nanorészecskéket magába foglaló készítménnyel
US9630956B2 (en) 2010-05-12 2017-04-25 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
UA110853C2 (uk) 2011-09-13 2016-02-25 Фармасайклікс, Інк. Лікарські форми інгібітора гістондеацетилази у комбінації з бендамустином та їхнє застосування
JP6162126B2 (ja) * 2011-09-30 2017-08-23 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Ａｔｒ阻害剤による膵臓癌及び非小細胞肺癌の治療
CA2850566C (en) 2011-09-30 2022-05-03 Vertex Pharmaceuticals Incorporated Process for making 4-[chloro-n-hydroxycarbonimidoyl]phenyl derivative
WO2013085902A1 (en) * 2011-12-05 2013-06-13 The University Of Texas M.D. Combination therapy methods for treating an inflammatory breast cancer
RS56673B1 (sr) 2012-04-05 2018-03-30 Vertex Pharma Jedinjenja korisna kao inhibitori atr kinaze i kombinovane terapije koje ih koriste
DK2904406T3 (en) 2012-10-04 2018-06-18 Vertex Pharma METHOD OF DETERMINING THE ATR INHIBITION, INCREASED DNA DAMAGE
US9738637B2 (en) 2013-03-12 2017-08-22 Celgene Quantical Research, Inc. Histone demethylase inhibitors
US9963452B2 (en) * 2013-03-14 2018-05-08 Augusta Pharmaceuticals Inc. Methods, compounds, and compositions for inhibition of ROS
WO2015127227A1 (en) * 2014-02-21 2015-08-27 Cleveland Biolabs, Inc. Uses of flagellin for improved chemotherapy
CN107001330A (zh) 2014-09-17 2017-08-01 赛尔基因昆蒂赛尔研究公司 组蛋白脱甲基酶抑制剂
RU2768621C1 (ru) 2015-09-30 2022-03-24 Вертекс Фармасьютикалз Инкорпорейтед Способ лечения рака с использованием комбинации повреждающих днк средств и ингибиторов atr
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
US11596612B1 (en) 2022-03-08 2023-03-07 PTC Innovations, LLC Topical anesthetics

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FR2697752B1 (fr) * 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
US6174905B1 (en) * 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
JP3354090B2 (ja) * 1996-09-30 2002-12-09 シエーリング アクチエンゲゼルシャフト 分化誘導剤
US6794392B1 (en) * 1996-09-30 2004-09-21 Schering Aktiengesellschaft Cell differentiation inducer
US5753637A (en) * 1996-10-09 1998-05-19 Ideal Ideas, Inc. Method of treating acne conditions
ID30046A (id) * 1998-09-25 2001-11-01 Warner Lambert Co Kemoterapi kanker dengan asetildinalina digabung dengan gemsitabina, kapestabina atau kisplatin
CA2369560C (en) * 1999-04-27 2011-02-01 Makoto Nakamuta Agent for prophylaxis and treatment of liver disease
PL355170A1 (en) * 1999-11-10 2004-04-05 Warner-Lambert Company Combination chemotherapy
US6905669B2 (en) * 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
CZ20022216A3 (cs) * 2001-07-02 2003-05-14 Warner-Lambert Company Kombinační chemoterapie
JP2003137866A (ja) * 2001-11-01 2003-05-14 Sankyo Co Ltd フェニレンジアミン誘導体

Also Published As

Publication number Publication date
KR100938712B1 (ko) 2010-01-25
CO5660262A2 (es) 2006-07-31
AU2004241873A1 (en) 2004-12-02
CA2634709A1 (en) 2004-12-02
CN101322707A (zh) 2008-12-17
CR8163A (es) 2006-07-14
NZ543591A (en) 2009-09-25
NO20055417D0 (no) 2005-11-16
CN1794991A (zh) 2006-06-28
CU23490B7 (es) 2010-02-23
CL2004001278A1 (es) 2005-05-06
CA2634766A1 (en) 2004-12-02
IL171941A0 (en) 2006-04-10
RU2005140570A (ru) 2006-06-10
EP1626719A1 (en) 2006-02-22
MEP32308A (en) 2010-10-10
CA2527191A1 (en) 2004-12-02
BRPI0410959A (pt) 2006-07-04
AU2004241873C1 (en) 2009-01-22
ECSP056253A (es) 2006-10-25
US20070098816A1 (en) 2007-05-03
CA2634765A1 (en) 2004-12-02
AU2004241873B2 (en) 2008-05-08
AR045318A1 (es) 2005-10-26
RU2322971C2 (ru) 2008-04-27
NO20055417L (no) 2005-12-19
ZA200509515B (en) 2006-07-26
TW200505424A (en) 2005-02-16
JP2006526031A (ja) 2006-11-16
MXPA05012345A (es) 2006-02-08
PE20050206A1 (es) 2005-03-26
WO2004103369A1 (en) 2004-12-02
UA81499C2 (en) 2008-01-10
AU2004241873B8 (en) 2008-05-29
UY28330A1 (es) 2004-12-31
KR20060009371A (ko) 2006-01-31

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