RO116771B1 - Metodă pentru prevenirea sau tratamentul dependenţei, toleranţei sau abuzului de benzodiazepine - Google Patents

Metodă pentru prevenirea sau tratamentul dependenţei, toleranţei sau abuzului de benzodiazepine

Info

Publication number
RO116771B1
RO116771B1 RO97-01338A RO9701338A RO116771B1 RO 116771 B1 RO116771 B1 RO 116771B1 RO 9701338 A RO9701338 A RO 9701338A RO 116771 B1 RO116771 B1 RO 116771B1
Authority
RO
Romania
Prior art keywords
benzodiazepines
patient
starts
period
moment
Prior art date
Application number
RO97-01338A
Other languages
English (en)
Inventor
Nava Zisapel
Original Assignee
Neurim Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurim Pharmaceuticals Ltd. filed Critical Neurim Pharmaceuticals Ltd.
Priority claimed from PCT/IB1996/000082 external-priority patent/WO1996023496A1/en
Publication of RO116771B1 publication Critical patent/RO116771B1/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Prezenta invenţie se referă la o metodă pentru prevenirea sau tratamentul dependenţei, toleranţei sau abuzului de benzodiazepine, utilizată în tratamentul medical. Metoda conform invenţiei cuprinde administrarea unui pacient a melatoninei, într-o doză zilnică cuprinsă în domeniul de la 0,01 la 100 mg, dar într-o doză zilnică mai mică de 10 mg, în cazul prevenirii, iar tratamentul, în cazul prevenirii, este început esenţial, în orice moment, în care pacientul începe să ia una sau mai multe benzodiazepine, şi se continuă pe o perioadă concurentă cu perioada de administrare a benzodiazepinei, iar perioada este aleasă conform uneia dintre alternativele (a şi b): (a) perioada începe în orice moment în care pacientul ia una sau mai multe benzodiazepine, care este apoi administrată concomitent cu melatonina într-o doză zilnică, care este scăzută progresiv până la atingerea unei doze stabilizate, predeterminate, de administrare a medicamentului sau a medicamentelor benzodiazepinice; sau (b)perioada începe în orice moment în care pacientul ia una sau mai multe benzodiazepine, care apoi se administrează concomitent cu melatonina într-o doză zilnică, care este scăzută progresiv până ce pacientul renunţă complet la benzodiazepină.
RO97-01338A 1995-02-01 1996-01-29 Metodă pentru prevenirea sau tratamentul dependenţei, toleranţei sau abuzului de benzodiazepine RO116771B1 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/381,535 US6469044B1 (en) 1995-02-01 1995-02-01 Method for treating patients suffering from drug dependencies which lead to plasma melationin deficiencies
EP95303853A EP0724878B1 (en) 1995-02-01 1995-06-06 Use of melatonin for treating patients suffering from drug dependencies
PCT/IB1996/000082 WO1996023496A1 (en) 1995-02-01 1996-01-29 Use of melatonin for treating patients suffering from drug addiction

Publications (1)

Publication Number Publication Date
RO116771B1 true RO116771B1 (ro) 2001-06-29

Family

ID=23505399

Family Applications (1)

Application Number Title Priority Date Filing Date
RO97-01338A RO116771B1 (ro) 1995-02-01 1996-01-29 Metodă pentru prevenirea sau tratamentul dependenţei, toleranţei sau abuzului de benzodiazepine

Country Status (13)

Country Link
US (3) US6469044B1 (ro)
EP (1) EP0724878B1 (ro)
KR (1) KR100425045B1 (ro)
AR (1) AR003921A1 (ro)
DE (1) DE69512760T2 (ro)
ES (1) ES2139842T3 (ro)
HK (1) HK1001218A1 (ro)
IL (1) IL114296A (ro)
LT (1) LT4339B (ro)
RO (1) RO116771B1 (ro)
RU (1) RU2182001C2 (ro)
UA (1) UA63878C2 (ro)
ZA (1) ZA96548B (ro)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6469044B1 (en) * 1995-02-01 2002-10-22 Neurim Pharmaceuticals (1991) Ltd. Method for treating patients suffering from drug dependencies which lead to plasma melationin deficiencies
IL130171A (en) * 1999-05-27 2004-06-01 Neurim Pharma 1991 Melatonin for use in preventing and treating tardive dyskinesia, pharmaceutical preparations containing it and its use in the manufacture of medicines
IL144900A (en) * 2001-08-14 2013-12-31 Neurim Pharma 1991 Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs
US6998112B2 (en) * 2003-03-18 2006-02-14 Arthur Zuckerman Sleep inducing toothpaste made with natural herbs and a natural hormone
CA2556753C (en) * 2004-02-20 2014-11-25 Lifescape Biosciences Incorporated Compositions and methods for sleep regulation
US9532952B2 (en) 2011-01-28 2017-01-03 Physician's Seal, LLC Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients
US8691275B2 (en) 2011-01-28 2014-04-08 Zx Pharma, Llc Controlled-release melatonin compositions and related methods
US8911780B2 (en) 2011-02-11 2014-12-16 Zx Pharma, Llc Multiparticulate L-menthol formulations and related methods
US8808736B2 (en) 2011-02-11 2014-08-19 Zx Pharma, Llc Enteric coated multiparticulate controlled release peppermint oil composition and related methods
US8568776B2 (en) 2011-02-11 2013-10-29 Zx Pharma, Llc Multiparticulate L-menthol formulations and related methods
RU2488388C1 (ru) 2012-05-24 2013-07-27 Ооо "Валента Интеллект" Фармацевтическая композиция для профилактики и лечения психических, поведенческих, когнитивных расстройств
UA107653U (uk) 2012-10-01 2016-06-24 Общєство С Огранічєнной Отвєтствєнностью "Валєнта-Інтєллєкт" Композиція лікарських засобів для лікування та профілактики поведінкових, психічних та когнітивних розладів
CA2881992C (en) 2013-04-23 2016-11-22 Zx Pharma, Llc Enteric coated multiparticulate controlled release peppermint oil composition and related methods
HUE051362T2 (hu) * 2016-10-31 2021-03-01 Neurim Pharma 1991 Melatonin minitabletták és eljárás azok elõállítására
US10849856B2 (en) 2016-10-31 2020-12-01 Neurim Pharmaceuticals Ltd. Melatonin mini-tablets and method of manufacturing the same
WO2024079125A1 (en) 2022-10-14 2024-04-18 Société des Produits Nestlé S.A. Sustained release melatonin compositions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4600723A (en) 1983-05-18 1986-07-15 Monash University Method for minimizing disturbances in circadian rhythms of bodily performance and function
AU601736B2 (en) 1986-05-23 1990-09-20 Sanofi Sante Nutrition Animale Sa Coated veterinary implants
US4800087A (en) 1986-11-24 1989-01-24 Mehta Atul M Taste-masked pharmaceutical compositions
US5242941A (en) 1990-12-04 1993-09-07 State Of Oregon Methods of treating circadian rhythm disorders
EP0518468B1 (en) * 1991-05-09 1999-06-30 Neurim Pharmaceuticals (1991) Limited Melatonin containing compositions
IT1251544B (it) 1991-05-13 1995-05-17 Gabriele Biella Composizioni farmaceutiche attive nella terapia dei disturbi del sonno comprendenti melatonina o un suo derivato in associazione con un derivato benzodiazepinico
US5449683A (en) 1992-10-01 1995-09-12 Massachussetts Institute Of Technology Methods of inducing sleep using melatonin
US6469044B1 (en) * 1995-02-01 2002-10-22 Neurim Pharmaceuticals (1991) Ltd. Method for treating patients suffering from drug dependencies which lead to plasma melationin deficiencies

Also Published As

Publication number Publication date
LT97135A (en) 1997-12-29
KR19980701640A (ko) 1998-06-25
US20030040539A1 (en) 2003-02-27
US20020156121A1 (en) 2002-10-24
EP0724878A3 (ro) 1996-08-21
ZA96548B (en) 1996-08-14
AR003921A1 (es) 1998-09-30
UA63878C2 (en) 2004-02-16
IL114296A0 (en) 1995-10-31
RU2182001C2 (ru) 2002-05-10
HK1001218A1 (en) 1998-06-05
LT4339B (lt) 1998-05-25
IL114296A (en) 1999-10-28
DE69512760D1 (de) 1999-11-18
US6469044B1 (en) 2002-10-22
EP0724878B1 (en) 1999-10-13
KR100425045B1 (ko) 2004-09-01
EP0724878A2 (en) 1996-08-07
ES2139842T3 (es) 2000-02-16
US6833383B2 (en) 2004-12-21
DE69512760T2 (de) 2000-05-31

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