PT994728E - Anticorpos recombinantes específicos contra terminações beta-amilóide, codificação por adn e métodos de utilização destes - Google Patents
Anticorpos recombinantes específicos contra terminações beta-amilóide, codificação por adn e métodos de utilização destes Download PDFInfo
- Publication number
- PT994728E PT994728E PT98918035T PT98918035T PT994728E PT 994728 E PT994728 E PT 994728E PT 98918035 T PT98918035 T PT 98918035T PT 98918035 T PT98918035 T PT 98918035T PT 994728 E PT994728 E PT 994728E
- Authority
- PT
- Portugal
- Prior art keywords
- amyloid
- dna encoding
- beta
- methods
- antibodies specific
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4185097P | 1997-04-09 | 1997-04-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT994728E true PT994728E (pt) | 2008-11-11 |
Family
ID=21918670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT98918035T PT994728E (pt) | 1997-04-09 | 1998-04-09 | Anticorpos recombinantes específicos contra terminações beta-amilóide, codificação por adn e métodos de utilização destes |
Country Status (16)
Country | Link |
---|---|
US (2) | US20090069258A1 (pt) |
EP (3) | EP2305709A1 (pt) |
JP (3) | JP3816111B2 (pt) |
CN (1) | CN1177616C (pt) |
AT (1) | ATE402717T1 (pt) |
AU (1) | AU743827B2 (pt) |
CA (1) | CA2286305A1 (pt) |
CY (1) | CY1110371T1 (pt) |
DE (1) | DE69839808D1 (pt) |
DK (1) | DK0994728T3 (pt) |
ES (1) | ES2312185T3 (pt) |
IL (1) | IL132262A (pt) |
NZ (1) | NZ337765A (pt) |
PT (1) | PT994728E (pt) |
SI (1) | SI0994728T1 (pt) |
WO (1) | WO1998044955A1 (pt) |
Families Citing this family (97)
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US8173127B2 (en) * | 1997-04-09 | 2012-05-08 | Intellect Neurosciences, Inc. | Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof |
US6743427B1 (en) | 1997-12-02 | 2004-06-01 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US7964192B1 (en) * | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
US6787523B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
US20030147882A1 (en) | 1998-05-21 | 2003-08-07 | Alan Solomon | Methods for amyloid removal using anti-amyloid antibodies |
US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
AU2008203784B2 (en) * | 1999-05-28 | 2012-01-19 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidogenic disease |
UA81216C2 (en) * | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
AUPQ180499A0 (en) | 1999-07-23 | 1999-08-19 | Biomolecular Research Institute Limited | Beta-amyloid peptide inhibitors |
AU6766800A (en) * | 1999-08-13 | 2001-03-13 | Trustees Of Columbia University In The City Of New York, The | Methods of inhibiting binding of beta-sheet fibril to rage and consequences thereof |
DE60031792T2 (de) * | 1999-12-08 | 2007-02-22 | Intellect Neurosciences, Inc. | Schimärische amyloid-beta peptide |
IL151378A0 (en) | 2000-02-24 | 2003-04-10 | Univ Washington | Humanized antibodies that sequester amyloid beta peptide |
US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
US6815175B2 (en) | 2001-03-16 | 2004-11-09 | Cornell Research Foundation, Inc. | Anti-amyloid peptide antibody based diagnosis and treatment of a neurological disease or disorder |
ES2437875T3 (es) | 2001-04-30 | 2014-01-14 | Eli Lilly And Company | Anticuerpos humanizados que reconocen el péptido beta-amiloide |
ES2312569T3 (es) | 2001-04-30 | 2009-03-01 | Eli Lilly And Company | Anticuerpos humanizados. |
AU2002329775C1 (en) | 2001-08-17 | 2011-04-07 | Eli Lilly And Company | Assay method for alzheimer's disease |
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EP1523499A2 (en) * | 2002-07-24 | 2005-04-20 | Innogenetics N.V. | Fragments of beta-amyloid as targets for vaccination against alzheimer disease |
WO2004029629A1 (en) * | 2002-09-27 | 2004-04-08 | Janssen Pharmaceutica N.V. | N-11 truncated amyloid-beta nomoclonal antibodies, compositions, methods and uses |
CA2501945A1 (en) * | 2002-10-09 | 2004-04-22 | Rinat Neuroscience Corp. | Methods of treating alzheimer's disease using antibodies directed against amyloid beta peptide and compositions thereof |
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US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
PE20050627A1 (es) | 2003-05-30 | 2005-08-10 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido beta amiloideo |
MX2007003906A (es) * | 2004-10-05 | 2007-05-21 | Wyeth Corp | Metodos y composiciones para mejorar la produccion de proteinas recombinantes. |
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GB0424563D0 (en) | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
PE20061329A1 (es) | 2004-12-15 | 2006-12-08 | Neuralab Ltd | Anticuerpos ab humanizados para mejorar la cognicion |
WO2006081171A1 (en) | 2005-01-24 | 2006-08-03 | Amgen Inc. | Humanized anti-amyloid antibody |
CN1329413C (zh) * | 2006-01-23 | 2007-08-01 | 南京医科大学 | 一种治疗或预防老年性痴呆的抗体及其表达载体和在制药中的应用 |
ATE451392T1 (de) * | 2006-03-30 | 2009-12-15 | Glaxo Group Ltd | Gegen amyloid-beta peptid gerichtete antikörper |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
CA2764852C (en) | 2007-01-05 | 2018-09-18 | University Of Zurich | Method of providing disease-specific binding molecules and targets |
IL199534A (en) | 2007-01-05 | 2013-01-31 | Univ Zuerich | An isolated human antibody capable of detecting a neoepitope in a disease-related protein, a polynucleotide encoding an antibody, a vector containing the polynucleotide, a host cell containing the polynucleotide or vector, a preparation containing the antibody and related methods and uses. |
US7939075B2 (en) | 2007-01-11 | 2011-05-10 | Philipps-Universitaet Marburg | Human monoclonal anti-amyloid-beta antibodies |
EP1944315A1 (en) * | 2007-01-11 | 2008-07-16 | Philipps-Universität Marburg | Prophylaxis and therapy of alzheimer's disease and other neurodementing diseases |
KR101160385B1 (ko) | 2007-01-18 | 2012-07-10 | 일라이 릴리 앤드 캄파니 | 페길화된 Aβ FAB |
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KR20180078347A (ko) | 2014-04-10 | 2018-07-09 | 화이자 인코포레이티드 | 2-아미노-6-메틸-4,4a,5,6-테트라히드로피라노[3,4-d][1,3]티아진-8a(8H)-일-1,3-티아졸-4-일 아미드 |
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KR102061952B1 (ko) | 2014-08-06 | 2020-01-02 | 화이자 인코포레이티드 | 이미다조피리다진 화합물 |
HUE053239T2 (hu) | 2014-11-19 | 2021-06-28 | Axon Neuroscience Se | Humanizált tau-ellenanyagok Alzheimer-kór kezelésére |
MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
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JP6827959B2 (ja) | 2015-06-17 | 2021-02-10 | ファイザー・インク | 三環式化合物およびホスホジエステラーゼ阻害剤としてのそれらの使用 |
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-
1998
- 1998-04-09 EP EP10011650A patent/EP2305709A1/en not_active Withdrawn
- 1998-04-09 CA CA002286305A patent/CA2286305A1/en not_active Abandoned
- 1998-04-09 DE DE69839808T patent/DE69839808D1/de not_active Expired - Lifetime
- 1998-04-09 ES ES98918035T patent/ES2312185T3/es not_active Expired - Lifetime
- 1998-04-09 AU AU71034/98A patent/AU743827B2/en not_active Ceased
- 1998-04-09 EP EP08011798A patent/EP2006303A1/en not_active Withdrawn
- 1998-04-09 CN CNB988035464A patent/CN1177616C/zh not_active Expired - Fee Related
- 1998-04-09 SI SI9830913T patent/SI0994728T1/sl unknown
- 1998-04-09 DK DK98918035T patent/DK0994728T3/da active
- 1998-04-09 EP EP98918035A patent/EP0994728B1/en not_active Revoked
- 1998-04-09 JP JP54304398A patent/JP3816111B2/ja not_active Expired - Fee Related
- 1998-04-09 PT PT98918035T patent/PT994728E/pt unknown
- 1998-04-09 NZ NZ337765A patent/NZ337765A/en not_active IP Right Cessation
- 1998-04-09 WO PCT/US1998/006900 patent/WO1998044955A1/en active IP Right Grant
- 1998-04-09 AT AT98918035T patent/ATE402717T1/de active
-
1999
- 1999-10-07 IL IL132262A patent/IL132262A/en not_active IP Right Cessation
-
2005
- 2005-07-20 JP JP2005210196A patent/JP2005320349A/ja active Pending
-
2007
- 2007-05-08 US US11/745,759 patent/US20090069258A1/en not_active Abandoned
-
2008
- 2008-10-30 CY CY20081101230T patent/CY1110371T1/el unknown
-
2009
- 2009-05-07 JP JP2009113001A patent/JP2009173680A/ja active Pending
-
2010
- 2010-01-21 US US12/691,046 patent/US20110027279A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CY1110371T1 (el) | 2015-04-29 |
ATE402717T1 (de) | 2008-08-15 |
US20110027279A1 (en) | 2011-02-03 |
JP2002503092A (ja) | 2002-01-29 |
EP0994728A4 (en) | 2001-11-28 |
DE69839808D1 (de) | 2008-09-11 |
CA2286305A1 (en) | 1998-10-15 |
SI0994728T1 (sl) | 2009-02-28 |
EP2006303A1 (en) | 2008-12-24 |
JP2005320349A (ja) | 2005-11-17 |
EP0994728A1 (en) | 2000-04-26 |
NZ337765A (en) | 2001-09-28 |
JP2009173680A (ja) | 2009-08-06 |
DK0994728T3 (da) | 2008-12-01 |
AU743827B2 (en) | 2002-02-07 |
US20090069258A1 (en) | 2009-03-12 |
EP0994728B1 (en) | 2008-07-30 |
JP3816111B2 (ja) | 2006-08-30 |
WO1998044955A1 (en) | 1998-10-15 |
ES2312185T3 (es) | 2009-02-16 |
AU7103498A (en) | 1998-10-30 |
CN1177616C (zh) | 2004-12-01 |
EP2305709A1 (en) | 2011-04-06 |
IL132262A (en) | 2009-11-18 |
CN1254294A (zh) | 2000-05-24 |
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