PT978284E - Utilização de compostos 15-ceto-prostaglandina-e como antagonistas da endotelina - Google Patents

Utilização de compostos 15-ceto-prostaglandina-e como antagonistas da endotelina Download PDF

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Publication number
PT978284E
PT978284E PT98953058T PT98953058T PT978284E PT 978284 E PT978284 E PT 978284E PT 98953058 T PT98953058 T PT 98953058T PT 98953058 T PT98953058 T PT 98953058T PT 978284 E PT978284 E PT 978284E
Authority
PT
Portugal
Prior art keywords
keto
prostaglandin
compounds
endothelin antagonists
endothelin
Prior art date
Application number
PT98953058T
Other languages
English (en)
Inventor
Ryuji Ueno
Original Assignee
Sucampo Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sucampo Ag filed Critical Sucampo Ag
Publication of PT978284E publication Critical patent/PT978284E/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT98953058T 1997-11-28 1998-11-16 Utilização de compostos 15-ceto-prostaglandina-e como antagonistas da endotelina PT978284E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP32783297 1997-11-28

Publications (1)

Publication Number Publication Date
PT978284E true PT978284E (pt) 2008-10-07

Family

ID=18203488

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98953058T PT978284E (pt) 1997-11-28 1998-11-16 Utilização de compostos 15-ceto-prostaglandina-e como antagonistas da endotelina

Country Status (17)

Country Link
US (1) US6197821B1 (pt)
EP (1) EP0978284B1 (pt)
JP (1) JP4319256B2 (pt)
KR (1) KR100648868B1 (pt)
CN (1) CN1206997C (pt)
AT (1) ATE401894T1 (pt)
AU (1) AU739343B2 (pt)
CA (1) CA2279267C (pt)
DE (1) DE69839767D1 (pt)
DK (1) DK0978284T3 (pt)
ES (1) ES2310013T3 (pt)
HK (1) HK1025521A1 (pt)
NO (1) NO328460B1 (pt)
NZ (1) NZ336960A (pt)
PT (1) PT978284E (pt)
TW (1) TW592701B (pt)
WO (1) WO1999027934A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4786866B2 (ja) * 2001-08-31 2011-10-05 スキャンポ・アーゲー クロライドチャンネルオープナーとしてのプロスタグランジンアナログ
AR037524A1 (es) * 2001-11-14 2004-11-17 Sucampo Ag Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion
US7732487B2 (en) 2001-11-19 2010-06-08 Sucampo Ag Method for treating a disease or condition responsive to opening of C1C-2 channel
EP1575596B1 (en) * 2002-12-27 2016-06-22 Sucampo AG Derivatives of prostaglandins for treating irritable bowel syndrome and/or functional dyspepsia
US20040225014A1 (en) * 2003-02-14 2004-11-11 Sucampo Ag Method for treating ocular hypertension and glaucoma
CN101146541B (zh) * 2005-01-27 2012-04-11 苏坎波公司 用于治疗中枢神经***疾病的方法和组合物
CA2600331C (en) 2005-03-04 2014-07-08 Sucampo Ag Use of 11-deoxy-prostaglandin for treating peripheral vascular diseases
CA2819844C (en) * 2006-02-07 2015-09-15 R-Tech Ueno, Ltd. Prostaglandin derivatives
AR059636A1 (es) * 2006-02-28 2008-04-16 Sucampo Ag Metodo y composicion para tratar la enfermedad pulmonar obstructiva cronica
KR20080111137A (ko) * 2006-04-13 2008-12-22 액테리온 파마슈티칼 리미티드 초기 단계 특발성 폐 섬유증을 위한 엔도텔린 수용체 대항제
EP2114411A2 (en) * 2007-02-27 2009-11-11 Sucampo AG Composition and method for protecting mitochondria
US20090082442A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched lubiprostone
CN102050808B (zh) * 2009-11-02 2014-03-12 上海天伟生物制药有限公司 一种***素中间体的制备方法
EP2516412A4 (en) * 2009-12-18 2013-05-29 Apotex Pharmachem Inc PROCESS FOR CLEANING LUBIPROSTON
CN104557845B (zh) * 2015-01-13 2020-12-22 齐鲁制药有限公司 一种鲁比前列酮化合物的制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853951A (en) 1971-07-14 1974-12-10 American Cyanamid Co Preparation of 9-oxo-13-trans-prostenoic acid esters by alanate addition to cyclopentenone
US4018811A (en) 1972-02-11 1977-04-19 American Cyanamid Company 3-Alkyl-2-(6-carboxyhexyl)cyclopentanones and esters and salts thereof
US3981868A (en) 1973-05-31 1976-09-21 American Cyanamid Company Derivatives of 9-oxo-13-trans-prostenoic acid amides
CA1323364C (en) * 1987-01-28 1993-10-19 Ryuzo Ueno Prostaglandins e and anti ulcer agents containing same
JP2597649B2 (ja) * 1988-05-11 1997-04-09 株式会社上野製薬応用研究所 気管・気管支拡張剤
US5362751A (en) 1988-05-11 1994-11-08 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Tracheobronchodilator using 16-substituted PGEs
ES2055051T3 (es) * 1988-05-23 1994-08-16 Ueno Seiyaku Oyo Kenkyujo Kk Un metodo para la fabricacion de un medicamento eficaz para aumentar la presion sanguinea.
JPH0232031A (ja) * 1988-07-22 1990-02-01 Nippon Steel Chem Co Ltd イソプロピル化ｐ‐ターフェニル類の製造法
CA2027814C (en) * 1989-10-20 1996-07-30 Ryuji Ueno Treatment of hepatobiliary disease with 15-keto-prostaglandin compounds
CA2030344C (en) * 1989-11-22 2000-04-18 Ryuji Ueno Treatment of pulmonary dysfunction with 15-keto-prostaglandin compounds
CA2030346C (en) * 1989-11-22 2000-04-11 Ryuji Ueno Treatment of cardiac dysfunction with 15-keto-prostaglandin compounds
CA2030345C (en) * 1989-11-22 1998-12-08 Ryuji Ueno Use of 15-keto-prostaglandin compound for improvement of encephalic function
CA2039420C (en) * 1990-04-04 1996-12-10 Ryuji Ueno Treatment of cataract with 15-keto-prostaglandin compounds
ATE174221T1 (de) * 1990-05-01 1998-12-15 R Tech Ueno Ltd Behandlung von pankreaskrankheit mit 15-keto- prostaglandin e-derivaten
CA2046069C (en) * 1990-07-10 2002-04-09 Ryuji Ueno Treatment of inflammatory diseases with 15-keto-prostaglandin compounds
ES2093774T3 (es) * 1991-03-14 1997-01-01 R Tech Ueno Ltd Estimulacion de la curacion de heridas con un compuesto 15-cetoprostaglandina.
DK0857718T3 (da) 1996-06-10 2002-12-16 Sucampo Ag Endothelinantagonist
JPH107574A (ja) 1996-06-17 1998-01-13 R Tec Ueno:Kk エンドセリン拮抗剤

Also Published As

Publication number Publication date
JP4319256B2 (ja) 2009-08-26
TW592701B (en) 2004-06-21
US6197821B1 (en) 2001-03-06
DK0978284T3 (da) 2008-10-27
EP0978284A4 (en) 2001-07-18
KR100648868B1 (ko) 2006-11-24
NZ336960A (en) 2001-02-23
ATE401894T1 (de) 2008-08-15
CA2279267A1 (en) 1999-06-10
KR20000070508A (ko) 2000-11-25
WO1999027934A1 (fr) 1999-06-10
HK1025521A1 (en) 2000-11-17
CA2279267C (en) 2010-01-12
CN1206997C (zh) 2005-06-22
AU1053799A (en) 1999-06-16
DE69839767D1 (de) 2008-09-04
AU739343B2 (en) 2001-10-11
NO993647L (no) 1999-09-27
EP0978284A1 (en) 2000-02-09
CN1251040A (zh) 2000-04-19
NO993647D0 (no) 1999-07-27
NO328460B1 (no) 2010-02-22
EP0978284B1 (en) 2008-07-23
ES2310013T3 (es) 2008-12-16

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