BG103986A - Derivatives of pyrrolidinecarboxylic acids as endotheline antagonists - Google Patents

Derivatives of pyrrolidinecarboxylic acids as endotheline antagonists

Info

Publication number
BG103986A
BG103986A BG103986A BG10398699A BG103986A BG 103986 A BG103986 A BG 103986A BG 103986 A BG103986 A BG 103986A BG 10398699 A BG10398699 A BG 10398699A BG 103986 A BG103986 A BG 103986A
Authority
BG
Bulgaria
Prior art keywords
derivatives
endotheline
endotheline antagonists
pyrrolidinecarboxylic acids
pyrrolidinecarboxylic
Prior art date
Application number
BG103986A
Other languages
Bulgarian (bg)
Inventor
Andrew Tasker
Martin Winn
Steven Boyd
Hwan-Soo Jae
GELDERN Thomas VON
Bryan SORENSEN
Kenneth HENRY
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of BG103986A publication Critical patent/BG103986A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

The invention relates to a compound with the formula or to its pharmaceutically acceptable salt, as well as methods and intermediate compounds for its preparation. It also relates to a method for endotheline antagonization. 36 claims
BG103986A 1997-06-17 1999-12-10 Derivatives of pyrrolidinecarboxylic acids as endotheline antagonists BG103986A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87718797A 1997-06-17 1997-06-17
PCT/US1998/011821 WO1998057933A1 (en) 1997-06-17 1998-06-08 Pyrrolidine carboxylic acid derivatives as endothelin antagonists

Publications (1)

Publication Number Publication Date
BG103986A true BG103986A (en) 2000-08-31

Family

ID=25369437

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103986A BG103986A (en) 1997-06-17 1999-12-10 Derivatives of pyrrolidinecarboxylic acids as endotheline antagonists

Country Status (8)

Country Link
AR (1) AR016071A1 (en)
AU (1) AU7826398A (en)
BG (1) BG103986A (en)
HU (1) HUP0002681A3 (en)
NO (1) NO996244L (en)
PL (1) PL348667A1 (en)
WO (1) WO1998057933A1 (en)
ZA (1) ZA985209B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7291626B1 (en) 1998-04-09 2007-11-06 John Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
ATE328002T1 (en) 1999-10-13 2006-06-15 Univ Johns Hopkins Med COMPOUNDS FOR REGULATING THE HEDGEHOG SIGNALING PATH, COMPOSITIONS AND USES THEREOF
US6552016B1 (en) 1999-10-14 2003-04-22 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
CA2388468C (en) * 1999-10-14 2011-01-25 Curis, Inc. Mediators of hedgehog signalling pathways, compositions and uses related thereto
AR044510A1 (en) * 2003-04-14 2005-09-14 Merck & Co Inc PROCEDURE AND INTERMEDIATES TO PREPARE CARBOXILIC ACIDS OF PIRROLIDINE
CN114507143A (en) * 2022-02-26 2022-05-17 江苏壹药新材料有限公司 Synthesis method of 2-ethyl-1-fluoro-4-nitrobenzene

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996006095A1 (en) * 1994-08-19 1996-02-29 Abbott Laboratories Endothelin antagonists
HUP9902316A3 (en) * 1996-02-13 2001-12-28 Abbott Lab 4-(benzo-1,3-dioxolyl)-pyrrolidine-3-carboxylic acid derivatives as endothelin antagonists and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
NO996244D0 (en) 1999-12-16
ZA985209B (en) 1999-01-06
HUP0002681A2 (en) 2001-08-28
PL348667A1 (en) 2002-06-03
HUP0002681A3 (en) 2001-09-28
AU7826398A (en) 1999-01-04
WO1998057933A1 (en) 1998-12-23
NO996244L (en) 2000-01-12
AR016071A1 (en) 2001-06-20

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