PT93588A - Processo para a preparacao de analogos da adenosina - Google Patents

Processo para a preparacao de analogos da adenosina

Info

Publication number: PT93588A
Authority: PT; Portugal
Prior art keywords: carbon atoms; adenosine; hydrogen; proviso; beta
Prior art date: 1989-03-29

Application number

PT93588A

Other languages

English (en)

Other versions

PT93588B (pt

Inventor

Norton Paul Peet

Nelsen Lowell Lentz

Shyam Sunder

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-29

Filing date

1990-03-28

Publication date

1990-11-20

1990-03-28 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1990-11-20 Publication of PT93588A publication Critical patent/PT93588A/pt

1996-08-30 Publication of PT93588B publication Critical patent/PT93588B/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Genetics & Genomics (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Vascular Medicine (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

PT93588A 1989-03-29 1990-03-28 Processo para a preparacao de analogos da adenosina PT93588B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US32991989A	1989-03-29	1989-03-29

Publications (2)

Publication Number	Publication Date
PT93588A true PT93588A (pt)	1990-11-20
PT93588B PT93588B (pt)	1996-08-30

Family

ID=23287579

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT93588A PT93588B (pt)	1989-03-29	1990-03-28	Processo para a preparacao de analogos da adenosina

Country Status (18)

Country	Link
EP (1)	EP0390112B1 (pt)
JP (1)	JP2954971B2 (pt)
KR (1)	KR0168647B1 (pt)
CN (1)	CN1034575C (pt)
AT (1)	ATE162791T1 (pt)
AU (1)	AU630439B2 (pt)
CA (1)	CA2013380C (pt)
DE (1)	DE69031989T2 (pt)
DK (1)	DK0390112T3 (pt)
ES (1)	ES2114524T3 (pt)
FI (1)	FI95910C (pt)
GR (1)	GR3026173T3 (pt)
HU (1)	HU206354B (pt)
IL (1)	IL93892A (pt)
NO (1)	NO173996C (pt)
NZ (1)	NZ233078A (pt)
PT (1)	PT93588B (pt)
ZA (1)	ZA902280B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9022644D0 (en) *	1990-10-18	1990-11-28	Ici Plc	Heterocyclic compounds
IT1254915B (it) *	1992-04-24	1995-10-11	Gloria Cristalli	Derivati di adenosina ad attivita' a2 agonista
EP0644935A1 (en) *	1992-06-12	1995-03-29	Garvan Institute Of Medical Research	DNA SEQUENCES ENCODING THE HUMAN A1, A2a and A2b ADENOSINE RECEPTORS
FR2741881B1 (fr)	1995-12-01	1999-07-30	Centre Nat Rech Scient	Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques
GB9613021D0 (en) *	1996-06-21	1996-08-28	Pharmacia Spa	Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors
AU4343500A (en)	1999-04-16	2000-11-02	Schering Corporation	Use of azetidinone compounds
GB0100621D0 (en)	2001-01-10	2001-02-21	Vernalis Res Ltd	Chemical compounds VI
KR100468352B1 (ko) *	2002-09-24	2005-01-27	한국과학기술연구원	신규 피라졸로피리미딘계 유도체, 그의 제조방법 및 이를 유효성분으로 하는 약학적 조성물
US7674791B2 (en)	2003-04-09	2010-03-09	Biogen Idec Ma Inc.	Triazolopyrazines and methods of making and using the same
US7285550B2 (en)	2003-04-09	2007-10-23	Biogen Idec Ma Inc.	Triazolotriazines and pyrazolotriazines and methods of making and using the same
WO2004092173A2 (en)	2003-04-09	2004-10-28	Biogen Idec Ma Inc.	A2a adenosine receptor antagonists
JP2015172077A (ja) *	2015-06-24	2015-10-01	中国医学科学院葯物研究所	Ｎ６−置換アデノシン誘導体とｎ６−置換アデニン誘導体の鎮静、催眠、抗うつ、抗痙攣、抗てんかん、抗パーキンソン病と認知証予防・治療の用途
CA3061590A1 (en) *	2017-04-27	2018-11-01	Takeda Pharmaceutical Company Limited	Heterocyclic compound

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE601946A (pt) *	1960-03-31
NL283192A (pt) *	1961-09-14
NL128629C (pt) *	1966-05-07
DE1795828A1 (de) *	1966-12-21	1975-11-27	Boehringer Mannheim Gmbh	Adenosinderivate
DE2139107A1 (de) *	1971-08-04	1973-02-15	Merck Patent Gmbh	Heterocyclisch substituierte adenosinverbindungen
US3862189A (en) *	1973-08-14	1975-01-21	Warner Lambert Co	Aralkyl-substituted purines and pyrimidines as antianginal bronchodilator agents
AU527013B2 (en) *	1979-01-10	1983-02-10	Imperial Chemical Industries Ltd.	Pure during derivatives and defoliation of cotton
US4388308A (en) *	1980-06-09	1983-06-14	G.D. Searle & Co.	N6 -[(2-Hydroxypropyl)aryl]adenosines
US4514405A (en) *	1981-09-17	1985-04-30	Merck Patent Gesellschaft Mit Beschrankter Haftung	Use of adenosine derivatives as anticonvulsants
DE3576344D1 (de) *	1984-04-18	1990-04-12	Whitby Research Inc	Cardio-vasodilatatore n-6-substituierte adenosine.
AU575438B2 (en) *	1984-10-26	1988-07-28	Warner-Lambert Company	N6 - substituted deoxyribose analogues of adenosines
DE3529497A1 (de) *	1985-08-17	1987-02-26	Boehringer Mannheim Gmbh	N(pfeil hoch)6(pfeil hoch)-disubstituierte purinderivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3712735A1 (de) *	1987-04-15	1988-11-10	Boehringer Mannheim Gmbh	Neue pyrazolo(3,4-d)pyrimidine, verfahren zu ihrer herstellung und verwendung als arzneimittel
WO1990009178A1 (en) *	1989-01-31	1990-08-23	Whitby Research, Inc.	N6-substituted 9-methyladenines: a new class of adenosine receptor antagonists

1990
- 1990-03-23 ZA ZA902280A patent/ZA902280B/xx unknown
- 1990-03-26 AU AU52215/90A patent/AU630439B2/en not_active Ceased
- 1990-03-26 IL IL9389290A patent/IL93892A/en not_active IP Right Cessation
- 1990-03-26 NZ NZ233078A patent/NZ233078A/en unknown
- 1990-03-27 HU HU901856A patent/HU206354B/hu not_active IP Right Cessation
- 1990-03-28 AT AT90105920T patent/ATE162791T1/de not_active IP Right Cessation
- 1990-03-28 KR KR1019900004159A patent/KR0168647B1/ko not_active IP Right Cessation
- 1990-03-28 DK DK90105920T patent/DK0390112T3/da active
- 1990-03-28 DE DE69031989T patent/DE69031989T2/de not_active Expired - Fee Related
- 1990-03-28 FI FI901549A patent/FI95910C/fi not_active IP Right Cessation
- 1990-03-28 EP EP90105920A patent/EP0390112B1/en not_active Expired - Lifetime
- 1990-03-28 CN CN90101711A patent/CN1034575C/zh not_active Expired - Fee Related
- 1990-03-28 NO NO901423A patent/NO173996C/no not_active IP Right Cessation
- 1990-03-28 ES ES90105920T patent/ES2114524T3/es not_active Expired - Lifetime
- 1990-03-28 PT PT93588A patent/PT93588B/pt not_active IP Right Cessation
- 1990-03-29 JP JP2079072A patent/JP2954971B2/ja not_active Expired - Fee Related
- 1990-03-29 CA CA002013380A patent/CA2013380C/en not_active Expired - Fee Related
1998
- 1998-02-18 GR GR980400348T patent/GR3026173T3/el unknown

Also Published As

Publication number	Publication date
AU5221590A (en)	1990-10-04
NZ233078A (en)	1993-11-25
JPH02289570A (ja)	1990-11-29
EP0390112B1 (en)	1998-01-28
CA2013380A1 (en)	1990-09-29
ZA902280B (en)	1990-12-28
DE69031989D1 (de)	1998-03-05
KR0168647B1 (ko)	1999-01-15
NO901423L (no)	1990-10-01
DE69031989T2 (de)	1998-09-03
FI901549A0 (fi)	1990-03-28
NO173996C (no)	1994-03-02
PT93588B (pt)	1996-08-30
CA2013380C (en)	2001-05-22
JP2954971B2 (ja)	1999-09-27
DK0390112T3 (da)	1998-09-23
ATE162791T1 (de)	1998-02-15
EP0390112A2 (en)	1990-10-03
CN1034575C (zh)	1997-04-16
AU630439B2 (en)	1992-10-29
GR3026173T3 (en)	1998-05-29
HUT53648A (en)	1990-11-28
IL93892A (en)	1994-11-28
HU901856D0 (en)	1990-08-28
NO901423D0 (no)	1990-03-28
ES2114524T3 (es)	1998-06-01
NO173996B (no)	1993-11-22
EP0390112A3 (en)	1992-02-12
FI95910B (fi)	1995-12-29
FI95910C (fi)	1996-04-10
KR900014389A (ko)	1990-10-23
CN1045973A (zh)	1990-10-10
HU206354B (en)	1992-10-28

Legal Events

Date

Code

Title

Description

1996-08-30

FG3A

Patent granted, date of granting

Effective date: 19960502

2004-02-27

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20031130

Publication	Publication Date	Title
PT93588A (pt)	1990-11-20	Processo para a preparacao de analogos da adenosina
GEP19960656B (en)	1996-12-24	Method for production of phenylalkylamines or its pharmaceutically acceptable salts
EP0339237A3 (en)	1991-01-09	Phenol substituted gem-diphosphonate derivatives, process for their preparation and pharmaceutical compositions containing them
KR880003622A (ko)	1988-05-28	카테콜유도체 및 그것을 함유하는 중추신경계 퇴행성 질환의 진행방지 및 치료제
ES2064461T3 (es)	1995-02-01	Derivados de xantina, procedimiento para su preparacion y composicion farmaceutica.
KR880011155A (ko)	1988-10-26	이미다조피리딘유도체, 그의 제법 및 치료에의 응용
EP0390111A3 (en)	1991-05-08	Selective adenosine receptor compounds
ES2008067T3 (es)	1994-11-16	Analogos de prostaciclina (pgi2).
EP0410305A3 (en)	1992-02-19	Use of bis(4-hydroxyphenylthio) methane derivatives in treating diabetes mellitus
EP0882734A3 (en)	2004-08-25	5'-Deoxy-cytidine derivatives
YU84886A (en)	1989-08-31	Process for obtaining derivatives of 14-beta-hydroxi-7,8-methylenedioxi-aloberan-13-carboxilate
ES2032386T3 (es)	1993-02-16	Un procedimiento para la preparacion de un derivado de glucopiranosa.
KR950703572A (ko)	1995-09-20	A-2 수용체 친화성을 갖는 2-치환된 아데노신[2-Substituted adenosines with A-2receptor affinity]
ES2061864T3 (es)	1994-12-16	Sustancia antitumoral, procedimiento para su preparacion, y agente anticanceroso que la contiene.
ES555671A0 (es)	1987-07-16	Un procedimiento para preparar un derivado de ergolina
ES2058761T3 (es)	1994-11-01	Proceso para la preparacion de derivados de dibenzodioxazecina y dibenzodioxaazacicloundecina.