PT934280E - Derivados 2-cianoiminoimidazolo inibidores da pde iv - Google Patents

Derivados 2-cianoiminoimidazolo inibidores da pde iv

Info

Publication number
PT934280E
PT934280E PT97910380T PT97910380T PT934280E PT 934280 E PT934280 E PT 934280E PT 97910380 T PT97910380 T PT 97910380T PT 97910380 T PT97910380 T PT 97910380T PT 934280 E PT934280 E PT 934280E
Authority
PT
Portugal
Prior art keywords
cyanoiminoimidazole
pde
inhibitors
derivatives
cyanoiminoimidazole pde
Prior art date
Application number
PT97910380T
Other languages
English (en)
Inventor
Francisco Javi Fernandez-Gadea
Jose Ignacio Andres-Gil
Eddy Jean Edgard Freyne
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PT934280E publication Critical patent/PT934280E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/48—Nitrogen atoms not forming part of a nitro radical with acyclic hydrocarbon or substituted acyclic hydrocarbon radicals, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT97910380T 1996-10-02 1997-09-24 Derivados 2-cianoiminoimidazolo inibidores da pde iv PT934280E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96202749 1996-10-02

Publications (1)

Publication Number Publication Date
PT934280E true PT934280E (pt) 2003-08-29

Family

ID=8224456

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97910380T PT934280E (pt) 1996-10-02 1997-09-24 Derivados 2-cianoiminoimidazolo inibidores da pde iv

Country Status (31)

Country Link
US (1) US6051718A (pt)
EP (1) EP0934280B1 (pt)
JP (1) JP3068208B2 (pt)
KR (1) KR100520002B1 (pt)
CN (1) CN1106387C (pt)
AR (1) AR008875A1 (pt)
AT (1) ATE236884T1 (pt)
AU (1) AU719561B2 (pt)
BG (1) BG64278B1 (pt)
BR (1) BR9712256B1 (pt)
CA (1) CA2267322C (pt)
CY (1) CY2380B1 (pt)
CZ (1) CZ297474B6 (pt)
DE (1) DE69720757T2 (pt)
DK (1) DK0934280T3 (pt)
EE (1) EE03825B1 (pt)
ES (1) ES2196308T3 (pt)
HK (1) HK1020344A1 (pt)
HU (1) HU225158B1 (pt)
IL (2) IL129298A0 (pt)
MY (1) MY116980A (pt)
NO (1) NO312960B1 (pt)
NZ (1) NZ334971A (pt)
PL (1) PL194673B1 (pt)
PT (1) PT934280E (pt)
RU (1) RU2180902C2 (pt)
SI (1) SI0934280T1 (pt)
SK (1) SK285878B6 (pt)
TR (1) TR199900732T2 (pt)
UA (1) UA62939C2 (pt)
WO (1) WO1998014432A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2211061T3 (es) * 1998-04-01 2004-07-01 Janssen Pharmaceutica N.V. Derivados piridinicos que inhiben pde iv.
US6953774B2 (en) 2000-08-11 2005-10-11 Applied Research Systems Ars Holding N.V. Methods of inducing ovulation
WO2002088092A1 (fr) 2001-04-19 2002-11-07 Eisai Co., Ltd. Derive de 2-imino-imidazole (2)
ES2427930T3 (es) 2001-05-23 2013-11-04 Mitsubishi Tanabe Pharma Corporation Composición terapéutica para el tratamiento regenerativo de enfermedades de los cartílagos
US20040220227A1 (en) * 2001-07-11 2004-11-04 Shinji Ina Remedies for allergic eye diseases
TWI221838B (en) 2001-08-09 2004-10-11 Tanabe Seiyaku Co Pyrazinoisoquinoline compound or naphthalene compound
IL162506A0 (en) 2001-12-14 2005-11-20 Applied Research Systems Ovulation induction
CA2515715C (en) 2003-02-19 2012-05-08 Eisai Co., Ltd. Methods for producing cyclic benzamidine derivatives
AU2006282896A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2382975A3 (en) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
EP3409666A3 (en) * 2012-06-07 2019-01-02 Georgia State University Research Foundation, Inc. Seca inhibitors and methods of making and using thereof
GB2533925A (en) * 2014-12-31 2016-07-13 Univ Bath Antimicrobial compounds, compositions and methods
CN109438434B (zh) * 2018-11-19 2021-05-04 华南农业大学 一种含噁唑环的2-氰基亚氨基噻唑烷类化合物及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0784461B2 (ja) * 1986-12-19 1995-09-13 日本バイエルアグロケム株式会社 殺虫性ニトロイミノ又はシアノイミノ化合物
JPH05310650A (ja) * 1991-08-22 1993-11-22 Nippon Soda Co Ltd 新規なアミン誘導体、その製造方法及び殺虫剤
CA2140441C (en) * 1992-07-28 2006-11-21 Garry Fenton Inhibitors of c-amp phosphodiesterase and tnf
ES2192192T3 (es) * 1992-12-02 2003-10-01 Pfizer Dieteres de catecol como inhibidores selectivos de pde iv.
GB9304919D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
JP3775685B2 (ja) * 1993-07-28 2006-05-17 ローン−プーラン・ロレ・リミテツド Ｐｄｅ▲ｉｖ▼およびｔｎｆ抑制剤としての化合物
EP0714397A1 (en) * 1993-08-19 1996-06-05 Smithkline Beecham Corporation Phenethylamine compounds
GB9401460D0 (en) * 1994-01-26 1994-03-23 Rhone Poulenc Rorer Ltd Compositions of matter
EP0766676B1 (en) * 1994-06-24 2002-05-22 Euroceltique S.A. Compounds for inhibiting phosphodiesterase iv
TW375612B (en) * 1995-04-06 1999-12-01 Janssen Pharmaceutica Nv 1,3-dihydro-2H-imidazol-2-one derivatives for the treatment of disease states related to an abnormal enzymatic or catalytic activity of phosphodiesterase type IV, preparation thereof and pharmaceutical composition containing the same
TW424087B (en) * 1995-04-06 2001-03-01 Janssen Pharmaceutica Nv 1,3-dihydro-1-(phenylalkenyl)-2H-imidazol-2-one derivatives
TW332201B (en) * 1995-04-06 1998-05-21 Janssen Pharmaceutica Nv 1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives

Also Published As

Publication number Publication date
BR9712256B1 (pt) 2011-04-19
SI0934280T1 (en) 2003-12-31
CZ297474B6 (cs) 2006-12-13
ATE236884T1 (de) 2003-04-15
CZ102899A3 (cs) 1999-07-14
PL194673B1 (pl) 2007-06-29
CN1232456A (zh) 1999-10-20
AU4779297A (en) 1998-04-24
JP3068208B2 (ja) 2000-07-24
IL129298A0 (en) 2000-02-17
HUP9904063A3 (en) 2000-11-28
EE9900112A (et) 1999-10-15
MY116980A (en) 2004-04-30
CA2267322A1 (en) 1998-04-09
NO991560D0 (no) 1999-03-30
ES2196308T3 (es) 2003-12-16
CA2267322C (en) 2007-11-06
SK34499A3 (en) 2000-04-10
BG64278B1 (bg) 2004-08-31
PL332573A1 (en) 1999-09-27
KR100520002B1 (ko) 2005-10-13
HUP9904063A2 (hu) 2000-09-28
HU225158B1 (en) 2006-07-28
SK285878B6 (sk) 2007-10-04
DK0934280T3 (da) 2003-07-21
EP0934280A1 (en) 1999-08-11
HK1020344A1 (en) 2000-04-14
DE69720757D1 (de) 2003-05-15
WO1998014432A1 (en) 1998-04-09
KR20000029964A (ko) 2000-05-25
TR199900732T2 (xx) 1999-08-23
AU719561B2 (en) 2000-05-11
UA62939C2 (uk) 2004-01-15
CY2380B1 (en) 2004-06-04
NO312960B1 (no) 2002-07-22
US6051718A (en) 2000-04-18
AR008875A1 (es) 2000-02-23
NZ334971A (en) 2000-09-29
RU2180902C2 (ru) 2002-03-27
EP0934280B1 (en) 2003-04-09
BR9712256A (pt) 1999-08-24
IL129298A (en) 2006-04-10
CN1106387C (zh) 2003-04-23
BG103220A (en) 1999-11-30
NO991560L (no) 1999-06-02
EE03825B1 (et) 2002-08-15
DE69720757T2 (de) 2004-03-04
JP2000503678A (ja) 2000-03-28

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