PT925301E - Derivados altamente lipofilos de camptotecina - Google Patents

Derivados altamente lipofilos de camptotecina

Info

Publication number
PT925301E
PT925301E PT97937656T PT97937656T PT925301E PT 925301 E PT925301 E PT 925301E PT 97937656 T PT97937656 T PT 97937656T PT 97937656 T PT97937656 T PT 97937656T PT 925301 E PT925301 E PT 925301E
Authority
PT
Portugal
Prior art keywords
compounds
lipofilos
camptotecin
camptothecin
highly
Prior art date
Application number
PT97937656T
Other languages
English (en)
Inventor
Dasharatha Gauravaram Reddy
Peddaiahgari Seetharamulu
Dhanabalan Murali
Frederick Herman Hausheer
Kochat Haridas
Shijie Yao
Pavankumar Petluru
Original Assignee
Bionumerik Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bionumerik Pharmaceuticals Inc filed Critical Bionumerik Pharmaceuticals Inc
Publication of PT925301E publication Critical patent/PT925301E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Saccharide Compounds (AREA)
PT97937656T 1996-08-19 1997-08-15 Derivados altamente lipofilos de camptotecina PT925301E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2417196P 1996-08-19 1996-08-19

Publications (1)

Publication Number Publication Date
PT925301E true PT925301E (pt) 2004-08-31

Family

ID=21819224

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97937656T PT925301E (pt) 1996-08-19 1997-08-15 Derivados altamente lipofilos de camptotecina

Country Status (17)

Country Link
US (3) US5910491A (pt)
EP (1) EP0925301B1 (pt)
JP (1) JP4364305B2 (pt)
KR (1) KR100516593B1 (pt)
CN (1) CN1107678C (pt)
AT (1) ATE261974T1 (pt)
AU (1) AU718799C (pt)
BR (1) BR9711319B1 (pt)
CA (1) CA2262745C (pt)
DE (1) DE69728152T2 (pt)
DK (1) DK0925301T3 (pt)
ES (1) ES2214634T3 (pt)
IL (1) IL127800A (pt)
NZ (1) NZ334240A (pt)
PT (1) PT925301E (pt)
WO (1) WO1998007727A1 (pt)
ZA (1) ZA977437B (pt)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136978A (en) * 1993-06-30 2000-10-24 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6150343A (en) 1993-06-30 2000-11-21 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6743917B2 (en) 1993-06-30 2004-06-01 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
FR2790261B1 (fr) * 1999-02-26 2004-09-10 Sod Conseils Rech Applic Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6407118B1 (en) * 1996-01-30 2002-06-18 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
IT1282673B1 (it) * 1996-02-23 1998-03-31 Ist Naz Stud Cura Dei Tumori Derivati della camptotecina e loro uso come agenti antitumorali
BR9711319B1 (pt) * 1996-08-19 2009-08-11 derivados de camptotecina altamente lipofìlicos.
US6169080B1 (en) * 1997-02-13 2001-01-02 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives
US6057303A (en) * 1998-10-20 2000-05-02 Bionumerik Pharmaceuticals, Inc. Highly lipophilic Camptothecin derivatives
ATE216998T1 (de) * 1999-03-09 2002-05-15 Sigma Tau Ind Farmaceuti Camptothecin-derivate mit antitumor-wirkung
US7105492B2 (en) 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
US6207832B1 (en) 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
WO2000066127A1 (en) * 1999-05-04 2000-11-09 Bionumerik Pharmaceuticals, Inc. Novel highly lipophilic camptothecin analogs
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US7332550B2 (en) * 2000-10-06 2008-02-19 Carnegie Mellon University Stabilization of transition metal complexes for catalysis in diverse environments
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
US6855720B2 (en) 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6403604B1 (en) 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6372906B1 (en) 2001-04-12 2002-04-16 University Of Pittsburgh Synthesis of silyl camptothecins and silyl homocamptothecins
US6653319B1 (en) 2001-08-10 2003-11-25 University Of Kentucky Research Foundation Pharmaceutical formulation for poorly water soluble camptothecin analogues
US6723853B2 (en) 2001-08-27 2004-04-20 University Of Pittsburgh Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
US20040034050A1 (en) * 2002-06-03 2004-02-19 Yang Li-Xi Homo-camptothecin derivatives
AU2003243380A1 (en) * 2002-06-03 2003-12-19 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
US6723849B1 (en) * 2002-10-25 2004-04-20 Bionumerik Pharmaceuticals, Inc. Process for making camptothecin derivatives
US7067666B2 (en) * 2003-06-27 2006-06-27 Research Triangle Institute 7-substituted camptothecin and camptothecin analogs and methods for producing the same
CA2548543C (en) * 2003-12-17 2012-01-03 Bionumerik Pharmaceuticals, Inc. Process for making camptothecin derivatives
MXPA06006710A (es) * 2003-12-17 2006-08-31 Bionumerik Pharmaceuticals Inc Formulaciones farmaceuticas de camptotecinas y proceso para su elaboracion.
US7030243B1 (en) 2004-10-28 2006-04-18 Bionumerik Pharmaceuticals, Inc. Process for making camptothecin derivatives
US20060094692A1 (en) * 2004-10-28 2006-05-04 Bionumerik Pharmaceuticals, Inc. Pharmaceutical formulations of camptothecins and process for making same
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
MX2008013105A (es) * 2006-04-19 2008-10-27 Bionumerik Pharmaceuticals Inc Analogo de camptotecina con anillo e "basculante", estable en lactona, novedoso, y metodo para su fabricacion y uso.
WO2008021549A2 (en) * 2006-08-18 2008-02-21 Sidney Kimmel Cancer Center Methods and compositions for topoisomerase i modulated tumor suppression
CA2670590C (en) * 2006-12-01 2018-06-12 Wake Forest University Health Sciences Medical devices incorporating collagen inhibitors
US7687497B2 (en) 2007-10-16 2010-03-30 Bionumerik Pharmaceuticals, Inc. C10-substituted camptothecin analogs
US7687496B2 (en) 2007-10-16 2010-03-30 Bionumerik Pharmaceuticals, Inc. C7-substituted camptothecin analogs
WO2009051580A1 (en) * 2007-10-16 2009-04-23 Bionumerik Pharmaceuticals, Inc. C7-substituted camptothecin analogs
CA2700904C (en) * 2007-10-16 2014-10-14 Bionumerik Pharmaceuticals, Inc. C10-substituted camptothecin analogs
US20140073793A1 (en) * 2012-09-07 2014-03-13 BioNumeric Pharmaceuticals, Inc. Germanium-containing camptothecin analogues
CN110590796B (zh) * 2018-06-12 2022-07-15 青岛海洋生物医药研究院股份有限公司 喜树碱衍生物及其制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3894029A (en) * 1971-08-26 1975-07-08 Basf Ag Production of camptothecin and camptothecin-like compounds
DE2150234A1 (de) * 1971-10-08 1973-04-12 Basf Ag Verfahren zur herstellung von camptothecin und camptothecin-derivaten
DE2534601A1 (de) * 1975-08-02 1977-02-17 Basf Ag Verfahren zur herstellung von camptothecin-aehnlichen verbindungen
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
US4473692A (en) * 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS6019790A (ja) * 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (ja) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
US5405963A (en) * 1993-06-10 1995-04-11 Smithkline Beecham Corporation Process for asymmetric total synthesis of camptothecin analogues
US5468754A (en) * 1994-04-19 1995-11-21 Bionumerik Pharmaceuticals, Inc. 11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
BR9711319B1 (pt) * 1996-08-19 2009-08-11 derivados de camptotecina altamente lipofìlicos.

Also Published As

Publication number Publication date
JP4364305B2 (ja) 2009-11-18
EP0925301B1 (en) 2004-03-17
CA2262745C (en) 2006-04-04
KR20000068135A (ko) 2000-11-25
IL127800A0 (en) 1999-10-28
DK0925301T3 (da) 2004-07-12
US6194579B1 (en) 2001-02-27
US5910491A (en) 1999-06-08
AU718799C (en) 2004-02-12
WO1998007727A1 (en) 1998-02-26
KR100516593B1 (ko) 2005-09-22
US6028078A (en) 2000-02-22
EP0925301A1 (en) 1999-06-30
BR9711319A (pt) 2000-01-18
JP2000516933A (ja) 2000-12-19
CN1107678C (zh) 2003-05-07
DE69728152D1 (en) 2004-04-22
AU4020497A (en) 1998-03-06
BR9711319B1 (pt) 2009-08-11
ES2214634T3 (es) 2004-09-16
CN1227559A (zh) 1999-09-01
NZ334240A (en) 2000-01-28
DE69728152T2 (de) 2004-08-05
CA2262745A1 (en) 1998-02-26
ZA977437B (en) 1999-02-19
AU718799B2 (en) 2000-04-20
IL127800A (en) 2005-11-20
ATE261974T1 (de) 2004-04-15

Similar Documents

Publication Publication Date Title
PT925301E (pt) Derivados altamente lipofilos de camptotecina
ATE329903T1 (de) Hochgradig lipophile camptothecin-derivate
PT960107E (pt) Compostos de paclitaxel 6-tio-substituidos
TR200200717T2 (tr) Terapötik kinazolin türevleri.
PT1200412E (pt) Agentes anti-proliferativos de imidazole
AR028948A1 (es) Compuestos novedosos
CY1110914T1 (el) Δικυκλο-πυραζολες δραστικες ως αναστολεις kinασων, διεργασια για την παρασκευη τους και φαρμακευτικες συνθεσεις που τις περιλαμβανουν
PA8481301A1 (es) Derivados de 4,4-biarilpiperidina
PA8495101A1 (es) Derivados de 13-metileritromicina
DE60001974D1 (de) Derivate von flavonen, xanthonen und kumarinen
CY1106726T1 (el) Υποκατεστημενα βενζοπυρανια ως επιλεκτικοι συναγωνιστες οιστρογονικου υποδοχεα β
ATE359786T1 (de) Camptothecin derivate
ATE277062T1 (de) Neue makrolidderivate
ATE297904T1 (de) Halo-alkoxycarbonylverbindungen
PT1109560E (pt) Compostos uteis como inidores de aicarft
NO20031410D0 (no) Antitumorterapi innbefattende distamycinderivater
EE200200681A (et) Akrüloüüldistamütsiini derivaati sisaldav farmatseutiline kompositsioon, derivaadi kasutamine tuumorivastase ravimi valmistamiseks ning kombineeritudravimpreparaat
ATE237614T1 (de) Benzo(c)chinolizin derivate,deren herstellung und verwendung als 5-alfa-reduktase inhibitoren
BR0014687A (pt) Compostos de taxano pentacìclico
ATE285771T1 (de) Diaminotrifluoromethylpyrimidinderivate enthaltende antikrebs-zusammensetzung
DE60005334D1 (de) 6-o-carbamat ketolide derivate
SE9803107D0 (sv) Novel Compunds
EE200200688A (et) Akrüloüüldistamütsiini derivaati, mikrotuubulivastast toimeainet ja/või antimetaboliiti sisaldav farmatseutiline kompositsioon, derivaadi kasutamine tuumorivastase ravimi valmistamiseks ning kombineeritud ravimpreparaat
PT952157E (pt) Derivados 9a, 11b-desidro de 9-oxima-3-ceto-6-o-metileritromicina
SE9803277D0 (sv) Novel compounds