PT901466E - Bifenilsulfonamidas como inibidores de metaloproteinases da matriz - Google Patents
Bifenilsulfonamidas como inibidores de metaloproteinases da matrizInfo
- Publication number
- PT901466E PT901466E PT97918788T PT97918788T PT901466E PT 901466 E PT901466 E PT 901466E PT 97918788 T PT97918788 T PT 97918788T PT 97918788 T PT97918788 T PT 97918788T PT 901466 E PT901466 E PT 901466E
- Authority
- PT
- Portugal
- Prior art keywords
- biphenylsulfonamides
- alkyl
- matrix metaloproteinase
- metaloproteinase inhibitors
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/42—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1746096P | 1996-05-17 | 1996-05-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT901466E true PT901466E (pt) | 2002-04-29 |
Family
ID=21782716
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT97918788T PT901466E (pt) | 1996-05-17 | 1997-04-24 | Bifenilsulfonamidas como inibidores de metaloproteinases da matriz |
Country Status (23)
Country | Link |
---|---|
EP (1) | EP0901466B1 (pt) |
JP (1) | JP2000511175A (pt) |
KR (1) | KR20000011095A (pt) |
CN (1) | CN1077885C (pt) |
AT (1) | ATE207891T1 (pt) |
BG (1) | BG63940B1 (pt) |
BR (1) | BR9710841A (pt) |
CA (1) | CA2253342A1 (pt) |
CZ (1) | CZ294063B6 (pt) |
DE (1) | DE69707865T2 (pt) |
DK (1) | DK0901466T3 (pt) |
EA (1) | EA001561B1 (pt) |
EE (1) | EE03965B1 (pt) |
ES (1) | ES2167733T3 (pt) |
HK (1) | HK1019585A1 (pt) |
IL (1) | IL126832A0 (pt) |
NO (1) | NO312510B1 (pt) |
NZ (1) | NZ332711A (pt) |
PL (1) | PL186416B1 (pt) |
PT (1) | PT901466E (pt) |
SK (1) | SK282863B6 (pt) |
WO (1) | WO1997044315A1 (pt) |
ZA (1) | ZA974223B (pt) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2303850B (en) * | 1994-06-22 | 1998-06-10 | British Biotech Pharm | Metalloproteinase inhibitors |
US6124333A (en) * | 1995-06-22 | 2000-09-26 | British Biotech Pharmaceuticals Limited | Metalloproteinase inhibitors |
AU741768B2 (en) * | 1996-12-09 | 2001-12-06 | Warner-Lambert Company | Method for treating and preventing heart failure and ventricular dilatation |
PT946166E (pt) | 1996-12-17 | 2004-06-30 | Warner Lambert Co | Utilizacao de inibidores das metaloproteinases da matriz para tratar disturbios neurologicos e promover a cicatrizacao de feridas |
EP1366765A1 (en) * | 1996-12-17 | 2003-12-03 | Warner-Lambert Company Llc | Use of matrix metalloproteinase inhibitors for treating neurological disorders and promoting wound healing |
GB9706255D0 (en) | 1997-03-26 | 1997-05-14 | Smithkline Beecham Plc | Novel compounds |
DE19719621A1 (de) * | 1997-05-09 | 1998-11-12 | Hoechst Ag | Sulfonylaminocarbonsäuren |
US6423729B1 (en) * | 1997-07-22 | 2002-07-23 | Shionogi & Co., Ltd. | Therapeutic or prophylactic agent for glomerulopathy |
ES2184340T3 (es) * | 1997-12-23 | 2003-04-01 | Warner Lambert Co | Combinaciones de inhibidores de la enzima de conversion de la angiotensina e inhibidores de la enzima metaloproteinasa matricial. |
US6410580B1 (en) | 1998-02-04 | 2002-06-25 | Novartis Ag | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases |
HUP0101176A3 (en) | 1998-02-04 | 2002-06-28 | Novartis Ag | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases, process for their preparation and pharmaceutical compositions containing them |
AU1591699A (en) * | 1998-03-17 | 1999-10-11 | Warner-Lambert Company | Statin-matrix metalloproteinase inhibitor combinations |
EP0967201A1 (en) * | 1998-05-20 | 1999-12-29 | Roche Diagnostics GmbH | Pharmaceutical agents containing sulfonamids as matrix metalloproteinase inhibitors |
DE59903329D1 (en) * | 1998-07-16 | 2002-12-12 | Aventis Pharma Gmbh | Phosphin- und phosphonsäurederivate als arzneimittel |
EE200100046A (et) * | 1998-07-21 | 2002-06-17 | Warner-Lambert Company | ACAT ja MMP inhibiitorite koosmanustamine aterosklerootiliste kahjustuste raviks |
DE19851184A1 (de) * | 1998-11-06 | 2000-05-11 | Aventis Pharma Gmbh | N-Arylsulfonyl-aminosäure-omega-amide |
AU765203B2 (en) * | 1999-04-19 | 2003-09-11 | Shionogi & Co., Ltd. | Sulfonamide derivatives having oxadiazole rings |
GB9918684D0 (en) | 1999-08-09 | 1999-10-13 | Novartis Ag | Organic compounds |
MXPA02004985A (es) | 1999-11-26 | 2003-10-14 | Shionogi & Co | Antagonistas del neuropeptido y, y5. |
AU2001292285A1 (en) * | 2000-09-29 | 2002-04-15 | Shionogi And Co., Ltd. | Thiazole or oxazole derivatives |
GB0103303D0 (en) | 2001-02-09 | 2001-03-28 | Novartis Ag | Organic compounds |
MXPA01013326A (es) * | 2001-02-14 | 2002-08-26 | Warner Lambert Co | Bifenil sulfonamidas utiles como inhibisdores de metaloproteinasa de matriz. |
JP4219810B2 (ja) * | 2001-10-26 | 2009-02-04 | 塩野義製薬株式会社 | Mmp阻害作用を有するスルホンアミド誘導体 |
GB0314488D0 (en) * | 2003-06-20 | 2003-07-23 | Glaxo Group Ltd | Therapeutically useful compounds |
EP1689716A1 (en) * | 2003-12-04 | 2006-08-16 | Wyeth | Biaryl sulfonamides and methods for using same |
ATE449760T1 (de) | 2004-03-22 | 2009-12-15 | Southern Res Inst | Nichtpeptidinhibitoren von matrixmetalloproteinasen |
CN101279956B (zh) * | 2008-04-25 | 2011-06-15 | 南昌大学 | 一种基质金属蛋白酶抑制剂及合成方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5506242A (en) * | 1993-01-06 | 1996-04-09 | Ciba-Geigy Corporation | Arylsufonamido-substituted hydroxamic acids |
GB2303850B (en) * | 1994-06-22 | 1998-06-10 | British Biotech Pharm | Metalloproteinase inhibitors |
-
1997
- 1997-04-24 KR KR1019980709253A patent/KR20000011095A/ko not_active Application Discontinuation
- 1997-04-24 DE DE69707865T patent/DE69707865T2/de not_active Expired - Fee Related
- 1997-04-24 PT PT97918788T patent/PT901466E/pt unknown
- 1997-04-24 SK SK1577-98A patent/SK282863B6/sk unknown
- 1997-04-24 WO PCT/US1997/006801 patent/WO1997044315A1/en not_active Application Discontinuation
- 1997-04-24 DK DK97918788T patent/DK0901466T3/da active
- 1997-04-24 ES ES97918788T patent/ES2167733T3/es not_active Expired - Lifetime
- 1997-04-24 BR BR9710841A patent/BR9710841A/pt not_active IP Right Cessation
- 1997-04-24 NZ NZ332711A patent/NZ332711A/en unknown
- 1997-04-24 EE EE9800397A patent/EE03965B1/xx not_active IP Right Cessation
- 1997-04-24 EA EA199800988A patent/EA001561B1/ru not_active IP Right Cessation
- 1997-04-24 IL IL12683297A patent/IL126832A0/xx unknown
- 1997-04-24 CN CN97194719A patent/CN1077885C/zh not_active Expired - Fee Related
- 1997-04-24 PL PL97329929A patent/PL186416B1/pl not_active IP Right Cessation
- 1997-04-24 JP JP09542377A patent/JP2000511175A/ja not_active Abandoned
- 1997-04-24 CZ CZ19983668A patent/CZ294063B6/cs not_active IP Right Cessation
- 1997-04-24 CA CA002253342A patent/CA2253342A1/en not_active Abandoned
- 1997-04-24 AT AT97918788T patent/ATE207891T1/de not_active IP Right Cessation
- 1997-04-24 EP EP97918788A patent/EP0901466B1/en not_active Expired - Lifetime
- 1997-05-15 ZA ZA9704223A patent/ZA974223B/xx unknown
-
1998
- 1998-11-12 BG BG102918A patent/BG63940B1/bg unknown
- 1998-11-16 NO NO19985326A patent/NO312510B1/no not_active IP Right Cessation
-
1999
- 1999-10-27 HK HK99104791A patent/HK1019585A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU713286B2 (en) | 1999-11-25 |
CZ294063B6 (cs) | 2004-09-15 |
EA001561B1 (ru) | 2001-04-23 |
WO1997044315A1 (en) | 1997-11-27 |
SK282863B6 (sk) | 2002-12-03 |
HK1019585A1 (en) | 2000-02-18 |
NZ332711A (en) | 2000-06-23 |
AU2680397A (en) | 1997-12-09 |
SK157798A3 (en) | 1999-04-13 |
NO312510B1 (no) | 2002-05-21 |
JP2000511175A (ja) | 2000-08-29 |
CN1219166A (zh) | 1999-06-09 |
EE03965B1 (et) | 2003-02-17 |
IL126832A0 (en) | 1999-08-17 |
BR9710841A (pt) | 1999-08-17 |
CN1077885C (zh) | 2002-01-16 |
EE9800397A (et) | 1999-06-15 |
BG63940B1 (bg) | 2003-07-31 |
KR20000011095A (ko) | 2000-02-25 |
DE69707865D1 (de) | 2001-12-06 |
EP0901466A1 (en) | 1999-03-17 |
NO985326D0 (no) | 1998-11-16 |
CA2253342A1 (en) | 1997-11-27 |
ZA974223B (en) | 1997-12-10 |
EP0901466B1 (en) | 2001-10-31 |
DK0901466T3 (da) | 2002-02-18 |
CZ366898A3 (cs) | 1999-02-17 |
PL329929A1 (en) | 1999-04-26 |
NO985326L (no) | 1999-01-14 |
EA199800988A1 (ru) | 1999-04-29 |
ES2167733T3 (es) | 2002-05-16 |
BG102918A (en) | 1999-09-30 |
DE69707865T2 (de) | 2002-05-02 |
ATE207891T1 (de) | 2001-11-15 |
PL186416B1 (pl) | 2004-01-30 |
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