PT804418E - Inibidores da agregacao de plaquetas - Google Patents
Inibidores da agregacao de plaquetasInfo
- Publication number
- PT804418E PT804418E PT95944838T PT95944838T PT804418E PT 804418 E PT804418 E PT 804418E PT 95944838 T PT95944838 T PT 95944838T PT 95944838 T PT95944838 T PT 95944838T PT 804418 E PT804418 E PT 804418E
- Authority
- PT
- Portugal
- Prior art keywords
- platelet inhibitors
- compounds
- platelet aggregation
- mammals
- inhibition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/375,338 US5602155A (en) | 1995-01-17 | 1995-01-17 | Platelet aggregation inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
PT804418E true PT804418E (pt) | 2003-08-29 |
Family
ID=23480498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT95944838T PT804418E (pt) | 1995-01-17 | 1995-12-15 | Inibidores da agregacao de plaquetas |
Country Status (11)
Country | Link |
---|---|
US (2) | US5602155A (pt) |
EP (1) | EP0804418B1 (pt) |
JP (1) | JPH10512581A (pt) |
AT (1) | ATE235468T1 (pt) |
AU (1) | AU5710696A (pt) |
CA (1) | CA2210746A1 (pt) |
DE (1) | DE69530123T2 (pt) |
DK (1) | DK0804418T3 (pt) |
ES (1) | ES2194933T3 (pt) |
PT (1) | PT804418E (pt) |
WO (1) | WO1996023771A2 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5602155A (en) * | 1995-01-17 | 1997-02-11 | G. D. Searle & Co. | Platelet aggregation inhibitors |
US6087332A (en) * | 1997-12-23 | 2000-07-11 | Galler; Lawrence Isaac | Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy |
US6117842A (en) * | 1998-03-09 | 2000-09-12 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
ES2244474T3 (es) * | 1999-09-29 | 2005-12-16 | Ortho-Mcneil Pharmaceutical, Inc. | Isonipecotamida para el tratamiento de trastornos mediados por integrina. |
US20040058915A1 (en) * | 2000-08-29 | 2004-03-25 | Khanna Ish Kumar | Compounds containing a bicyclic ring system useful as alpha v beta 3 antagonists |
US6720327B2 (en) | 2000-09-27 | 2004-04-13 | Pharmacia Corporation | Lactone integrin antagonists |
US20020072500A1 (en) * | 2000-09-27 | 2002-06-13 | Thomas Rogers | Hydroxy acid integrin antagonists |
US7081460B2 (en) * | 2001-04-09 | 2006-07-25 | Ortho-Mcneil Pharmaceutical, Inc. | Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders |
US20040019206A1 (en) * | 2001-09-27 | 2004-01-29 | Peter Ruminiski | Lactone integrin antagonists |
WO2003050261A2 (en) | 2001-12-10 | 2003-06-19 | Bristol-Myers Squibb Company | (1-phenyl-2-heteroaryl)ethyl-guanidine compounds as inhibitors of mitochondrial f1f0 atp hydrolase |
AU2003299600A1 (en) * | 2002-12-20 | 2004-07-29 | Pharmacia Corpration | The r-isomer of beta amino acid compounds as integrin receptor antagonists derivatives |
JP6215324B2 (ja) | 2012-07-18 | 2017-10-18 | セントルイス ユニバーシティ | インテグリンアンタゴニストとしてのβアミノ酸誘導体 |
US8716226B2 (en) | 2012-07-18 | 2014-05-06 | Saint Louis University | 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists |
RU2729518C2 (ru) | 2015-12-30 | 2020-08-07 | Сент-Луис Юниверсити | Мета-азациклические производные аминобензойной кислоты в качестве антагонистов пан-интегрина |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4857508A (en) * | 1987-12-03 | 1989-08-15 | Monsanto Company | Novel platelet-aggregation inhibitor peptide derivatives |
US4879313A (en) * | 1988-07-20 | 1989-11-07 | Mosanto Company | Novel platelet-aggregation inhibitors |
US4952562A (en) * | 1989-09-29 | 1990-08-28 | Rorer Pharmaceutical Corporation | Anti-thrombotic peptides and pseudopeptides |
JPH05500954A (ja) * | 1989-09-29 | 1993-02-25 | ローヌ―プーラン ローラー インターナショナル(ホウルディングス) インコーポレイテッド | 抗血栓性ペプチド及び疑似ペプチド |
NZ239876A (en) * | 1990-09-27 | 1993-12-23 | Merck & Co Inc | Glycyl-b-alanine derivatives and pharmaceutical compositions thereof. |
WO1992013552A1 (en) * | 1991-02-05 | 1992-08-20 | Smithkline Beecham Corporation | Anti-aggregatory peptides containing an aromatic ester or amide |
MX9201416A (es) * | 1991-03-28 | 1992-10-01 | Rhone Poulenc Rorer Int | Peptidos y pseudopeptidos antitromboticos. |
US5321034A (en) * | 1991-05-07 | 1994-06-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
ATE158589T1 (de) * | 1991-11-22 | 1997-10-15 | Yeda Res & Dev | Nicht-peptidische surrogate der arg-gly-asp sequenz und entsprechende pharmazeutische zusammensetzungen |
US5614539A (en) * | 1993-03-15 | 1997-03-25 | G. D. Searle & Co. | Urea compounds which are useful as platelet aggregation inhibitors |
US5602155A (en) * | 1995-01-17 | 1997-02-11 | G. D. Searle & Co. | Platelet aggregation inhibitors |
-
1995
- 1995-01-17 US US08/375,338 patent/US5602155A/en not_active Expired - Fee Related
- 1995-12-15 DK DK95944838T patent/DK0804418T3/da active
- 1995-12-15 JP JP8523510A patent/JPH10512581A/ja not_active Ceased
- 1995-12-15 AU AU57106/96A patent/AU5710696A/en not_active Abandoned
- 1995-12-15 AT AT95944838T patent/ATE235468T1/de not_active IP Right Cessation
- 1995-12-15 DE DE69530123T patent/DE69530123T2/de not_active Expired - Fee Related
- 1995-12-15 WO PCT/US1995/015798 patent/WO1996023771A2/en active IP Right Grant
- 1995-12-15 EP EP95944838A patent/EP0804418B1/en not_active Expired - Lifetime
- 1995-12-15 CA CA002210746A patent/CA2210746A1/en not_active Abandoned
- 1995-12-15 PT PT95944838T patent/PT804418E/pt unknown
- 1995-12-15 ES ES95944838T patent/ES2194933T3/es not_active Expired - Lifetime
-
1996
- 1996-12-06 US US08/762,823 patent/US5798370A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69530123T2 (de) | 2004-02-05 |
DE69530123D1 (en) | 2003-04-30 |
EP0804418A2 (en) | 1997-11-05 |
DK0804418T3 (da) | 2003-07-07 |
US5602155A (en) | 1997-02-11 |
WO1996023771A2 (en) | 1996-08-08 |
EP0804418B1 (en) | 2003-03-26 |
AU5710696A (en) | 1996-08-21 |
ATE235468T1 (de) | 2003-04-15 |
CA2210746A1 (en) | 1996-08-08 |
WO1996023771A3 (en) | 1996-10-10 |
JPH10512581A (ja) | 1998-12-02 |
ES2194933T3 (es) | 2003-12-01 |
US5798370A (en) | 1998-08-25 |
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