ES2181879T3 - Inhibidores de la agkytubacuib de las plaquetas que contienen restos de aminoacidos con cadenas laterales de c-terminal aminergicos. - Google Patents

Inhibidores de la agkytubacuib de las plaquetas que contienen restos de aminoacidos con cadenas laterales de c-terminal aminergicos.

Info

Publication number
ES2181879T3
ES2181879T3 ES96909731T ES96909731T ES2181879T3 ES 2181879 T3 ES2181879 T3 ES 2181879T3 ES 96909731 T ES96909731 T ES 96909731T ES 96909731 T ES96909731 T ES 96909731T ES 2181879 T3 ES2181879 T3 ES 2181879T3
Authority
ES
Spain
Prior art keywords
aminergicos
agkytubacuib
inhibitors
plates
terminal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96909731T
Other languages
English (en)
Inventor
Norman A Abood
Philippe R Bovy
Daniel L Flynn
Joseph G Rico
Thomas E Rogers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2181879T3 publication Critical patent/ES2181879T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)

Abstract

ESTA INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I) O SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS QUE SON UTILES EN LA INHIBICION DE LA AGREGACION PLAQUETARIA, A COMPOSICIONES FARMACEUTICAS QUE CONTIENEN DICHOS COMPUESTOS, A UN METODO PARA INHIBIR LA AGREGACION PLAQUETARIA EN MAMIFEROS MEDIANTE LA ADMINISTRACION DE DICHOS COMPUESTOS Y COMPOSICIONES.
ES96909731T 1995-04-11 1996-03-22 Inhibidores de la agkytubacuib de las plaquetas que contienen restos de aminoacidos con cadenas laterales de c-terminal aminergicos. Expired - Lifetime ES2181879T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/419,793 US5811398A (en) 1995-04-11 1995-04-11 Platelet aggregation inhibitors containing C-terminal aminergic side chain amino acid residues

Publications (1)

Publication Number Publication Date
ES2181879T3 true ES2181879T3 (es) 2003-03-01

Family

ID=23663785

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96909731T Expired - Lifetime ES2181879T3 (es) 1995-04-11 1996-03-22 Inhibidores de la agkytubacuib de las plaquetas que contienen restos de aminoacidos con cadenas laterales de c-terminal aminergicos.

Country Status (16)

Country Link
US (1) US5811398A (es)
EP (2) EP1215215A1 (es)
JP (1) JPH11503450A (es)
KR (1) KR19980703769A (es)
AT (1) ATE221897T1 (es)
AU (1) AU696893B2 (es)
BR (1) BR9604914A (es)
CA (1) CA2216996A1 (es)
CZ (1) CZ291646B6 (es)
DE (1) DE69622868T2 (es)
DK (1) DK0835265T3 (es)
ES (1) ES2181879T3 (es)
NO (1) NO974537L (es)
NZ (1) NZ305182A (es)
PT (1) PT835265E (es)
WO (1) WO1996032415A1 (es)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039805A (en) * 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
US5256812A (en) * 1989-01-31 1993-10-26 Hoffmann-La Roche Inc. Carboxamides and sulfonamides
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
CA2037153A1 (en) * 1990-03-09 1991-09-10 Leo Alig Acetic acid derivatives
US5273982A (en) * 1990-03-09 1993-12-28 Hoffmann-La Roche Inc. Acetic acid derivatives
US5481021A (en) * 1991-03-06 1996-01-02 G. D. Searle & Co. Phenyl amidines derivatives useful as platelet aggregation inhibitors
US5220050A (en) * 1991-05-17 1993-06-15 G. D. Searle & Co. Peptide mimetic compounds useful as platelet aggregation inhibitors
HUT63609A (en) * 1992-03-10 1993-09-28 Sandoz Ag Process for producing new derivatives and isosters of beta-amino acids and pharmaceutical compositions comprising such compounds

Also Published As

Publication number Publication date
JPH11503450A (ja) 1999-03-26
NO974537D0 (no) 1997-10-01
AU5331696A (en) 1996-10-30
DE69622868D1 (de) 2002-09-12
NZ305182A (en) 1998-07-28
DK0835265T3 (da) 2002-10-28
DE69622868T2 (de) 2003-04-10
KR19980703769A (ko) 1998-12-05
PT835265E (pt) 2002-11-29
EP1215215A1 (en) 2002-06-19
EP0835265B1 (en) 2002-08-07
US5811398A (en) 1998-09-22
ATE221897T1 (de) 2002-08-15
BR9604914A (pt) 1998-07-21
AU696893B2 (en) 1998-09-24
CA2216996A1 (en) 1996-10-17
WO1996032415A1 (en) 1996-10-17
CZ317697A3 (cs) 1998-03-18
CZ291646B6 (cs) 2003-04-16
EP0835265A1 (en) 1998-04-15
NO974537L (no) 1997-10-01

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TH18027A (th) อนุพันธ์ของอีพอกซิซัคฟินิคแอซิด