PT742821E - Processo de preparacao de uma biblioteca multicombinatoria de vectores de expressao de genes de anticorpos - Google Patents
Processo de preparacao de uma biblioteca multicombinatoria de vectores de expressao de genes de anticorposInfo
- Publication number
- PT742821E PT742821E PT95908302T PT95908302T PT742821E PT 742821 E PT742821 E PT 742821E PT 95908302 T PT95908302 T PT 95908302T PT 95908302 T PT95908302 T PT 95908302T PT 742821 E PT742821 E PT 742821E
- Authority
- PT
- Portugal
- Prior art keywords
- genes
- vectors
- expression
- repertoire
- vector
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 239000013598 vector Substances 0.000 title abstract 6
- 238000002360 preparation method Methods 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
- C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- AIDS & HIV (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9401519A FR2715940B1 (fr) | 1994-02-10 | 1994-02-10 | Procédé de préparation d'une banque multicombinatoire de vecteurs d'expression de gènes d'anticorps, banque et systèmes d'expression d'anticorps "coliclonaux" obtenus. |
Publications (1)
Publication Number | Publication Date |
---|---|
PT742821E true PT742821E (pt) | 2006-06-30 |
Family
ID=9459966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT95908302T PT742821E (pt) | 1994-02-10 | 1995-02-02 | Processo de preparacao de uma biblioteca multicombinatoria de vectores de expressao de genes de anticorpos |
Country Status (11)
Country | Link |
---|---|
US (1) | US6599697B1 (pt) |
EP (1) | EP0742821B1 (pt) |
AT (1) | ATE323762T1 (pt) |
AU (1) | AU1666895A (pt) |
CA (1) | CA2183079C (pt) |
DE (1) | DE69534941T2 (pt) |
DK (1) | DK0742821T3 (pt) |
ES (1) | ES2257740T3 (pt) |
FR (1) | FR2715940B1 (pt) |
PT (1) | PT742821E (pt) |
WO (1) | WO1995021914A1 (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2731014B1 (fr) * | 1995-02-23 | 1997-03-28 | Rhone Poulenc Rorer Sa | Molecules d'adn, preparation et utilisation en therapie genique |
FR2741892B1 (fr) * | 1995-12-04 | 1998-02-13 | Pasteur Merieux Serums Vacc | Procede de preparation d'une banque multicombinatoire de vecteurs d'expression de genes d'anticorps, banque et systemes d'expression d'anticorps "coliclonaux" obtenus |
WO1998033901A2 (en) * | 1997-01-31 | 1998-08-06 | Cosmix Molecular Biologicals Gmbh | Generation of diversity in combinatorial libraries |
US6310191B1 (en) | 1998-02-02 | 2001-10-30 | Cosmix Molecular Biologicals Gmbh | Generation of diversity in combinatorial libraries |
CA2297070A1 (en) | 1997-08-01 | 1999-02-11 | Morphosys Ag | Novel method and phage for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex |
IL135776A0 (en) * | 1997-10-24 | 2001-05-20 | Life Technologies Inc | Recombinational cloning using nucleic acids having recombination sites |
US6410317B1 (en) * | 1999-07-14 | 2002-06-25 | Clontech Laboratories, Inc. | Recombinase-based methods for producing expression vectors and compositions for use in practicing the same |
GB2375112A (en) * | 2000-02-03 | 2002-11-06 | Domantis Ltd | Combinatorial protein domains |
AU2001277614A1 (en) * | 2000-08-07 | 2002-02-18 | Domantis Limited | Novel proteins |
US7198924B2 (en) | 2000-12-11 | 2007-04-03 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
US6610472B1 (en) * | 2000-10-31 | 2003-08-26 | Genetastix Corporation | Assembly and screening of highly complex and fully human antibody repertoire in yeast |
US20050196755A1 (en) * | 2000-11-17 | 2005-09-08 | Maurice Zauderer | In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells |
AU2001297872B2 (en) * | 2000-11-17 | 2006-11-09 | University Of Rochester | In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells |
US20020164703A1 (en) * | 2000-12-21 | 2002-11-07 | Krzysztof Pawlowski | Card-domain containing polypeptides, encoding nucleic acids, and methods of use |
WO2002086096A2 (en) * | 2001-01-23 | 2002-10-31 | University Of Rochester Medical Center | Methods of producing or identifying intrabodies in eukaryotic cells |
ATE469984T1 (de) | 2003-12-01 | 2010-06-15 | Life Technologies Corp | Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon |
CN102459591B (zh) * | 2009-05-20 | 2015-05-13 | 诺维莫尼公司 | 合成性的多肽文库以及用于建立具有天然多样性的多肽变体的方法 |
US9617329B2 (en) | 2010-10-01 | 2017-04-11 | Csl Limited | Method of cloning nucleic acid |
US9969792B2 (en) * | 2015-06-12 | 2018-05-15 | Axiomx, Inc. | Methods and compositions for producing a chimeric polypeptide |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4673640A (en) * | 1984-04-30 | 1987-06-16 | Biotechnica International, Inc. | Regulated protein production using site-specific recombination |
DK0585287T3 (da) * | 1990-07-10 | 2000-04-17 | Cambridge Antibody Tech | Fremgangsmåde til fremstilling af specifikke bindingsparelementer |
CA2131151A1 (en) * | 1992-03-24 | 1994-09-30 | Kevin S. Johnson | Methods for producing members of specific binding pairs |
FR2741892B1 (fr) * | 1995-12-04 | 1998-02-13 | Pasteur Merieux Serums Vacc | Procede de preparation d'une banque multicombinatoire de vecteurs d'expression de genes d'anticorps, banque et systemes d'expression d'anticorps "coliclonaux" obtenus |
-
1994
- 1994-02-10 FR FR9401519A patent/FR2715940B1/fr not_active Expired - Lifetime
-
1995
- 1995-02-02 PT PT95908302T patent/PT742821E/pt unknown
- 1995-02-02 DK DK95908302T patent/DK0742821T3/da active
- 1995-02-02 WO PCT/FR1995/000127 patent/WO1995021914A1/fr active IP Right Grant
- 1995-02-02 ES ES95908302T patent/ES2257740T3/es not_active Expired - Lifetime
- 1995-02-02 DE DE69534941T patent/DE69534941T2/de not_active Expired - Lifetime
- 1995-02-02 EP EP95908302A patent/EP0742821B1/fr not_active Expired - Lifetime
- 1995-02-02 AU AU16668/95A patent/AU1666895A/en not_active Abandoned
- 1995-02-02 AT AT95908302T patent/ATE323762T1/de active
- 1995-02-02 US US08/693,234 patent/US6599697B1/en not_active Expired - Lifetime
- 1995-02-02 CA CA002183079A patent/CA2183079C/fr not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP3994291B2 (ja) | 2007-10-17 |
CA2183079A1 (fr) | 1995-08-17 |
DE69534941D1 (de) | 2006-05-24 |
FR2715940B1 (fr) | 1996-04-26 |
EP0742821B1 (fr) | 2006-04-19 |
CA2183079C (fr) | 2007-08-07 |
ES2257740T3 (es) | 2006-08-01 |
EP0742821A1 (fr) | 1996-11-20 |
JPH09509055A (ja) | 1997-09-16 |
DE69534941T2 (de) | 2006-09-28 |
FR2715940A1 (fr) | 1995-08-11 |
AU1666895A (en) | 1995-08-29 |
DK0742821T3 (da) | 2006-08-21 |
US6599697B1 (en) | 2003-07-29 |
ATE323762T1 (de) | 2006-05-15 |
WO1995021914A1 (fr) | 1995-08-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT742821E (pt) | Processo de preparacao de uma biblioteca multicombinatoria de vectores de expressao de genes de anticorpos | |
DE69633065D1 (de) | Herstellung einer multikombinatonischen bank von antikörpergenen exprimierendenvektoren | |
CA2282497A1 (en) | In vitro peptide or protein expression library | |
PT1418228E (pt) | Processo de preparacao de uma biblioteca multicombinatoria de vectores de expressao de genes de anticorpos. | |
GB2338237A (en) | In vitro peptide or protein expression library | |
SE9201331D0 (sv) | Protein l och hybridproteiner daerav | |
NO913271L (no) | Cdr-podete antistoffer. | |
BR9508053A (pt) | Construção de DNA vetor de expressão recombinante cepa de levedura e processo para a produção de uma proteina heteróloga | |
WO2002099119A3 (en) | B7-related nucleic acids and polypeptides useful for immunomodulation | |
DK0832258T3 (da) | Opstrøms aktivatorsekvenser og rekombinante promotorsekvenser, der er funktionelle i Yarrowia og vektorer indeholdende disse | |
ATE166882T1 (de) | Monoklonale antikörper (mak) gegen tumorassoziierte antigene, ihre herstellung und verwendung | |
WO1996027665A3 (en) | Neuron-restrictive silencer factor proteins | |
WO1998021333A3 (en) | Nucleic acid encoding schwannomin-binding-proteins and products related thereto | |
FR2755144B1 (fr) | Fragments d'anticorps a chaine unique anti-p53 et utilisation | |
ATE285474T1 (de) | Haemophilus adhäsionsproteinen | |
PT625157E (pt) | Epitopes p1a1 e p1a2 da gpiiia da plaqueta sua preparacao e utilizacao | |
FR2692282B1 (fr) | Clonage du gene codant pour la proteine gp28.5 de t. gondii; fragments peptidiques issus de ladite proteine et leurs applications. | |
ATE196317T1 (de) | Rekombinantes vektor für die exozelluläre verwendung von in bacillus subtilis exprimierten einkettigen antikörpern | |
KR970048455A (ko) | 매독 트레포네마 융합 항원 및 그 융합 항원을 사용한 항매독 트레포네마 항체의 측정 방법 | |
CA2199843A1 (en) | Novel PKA-Binding Proteins and Uses Thereof | |
ES2175184T3 (es) | Virus que expresan proteinas toxicas y leneas celulares productoras. | |
MX9701904A (es) | Proteinas de enlace de pka novedosas y usos de las mismas. | |
WO1995017678A3 (en) | Differentiation of htlv-i and htlv-ii using synthetic peptides | |
ATE213268T1 (de) | Fanconi-gen ii | |
WO1996030507A3 (en) | Vectors for differential expression |