PT716600E - Composicoes para administracao topica contendo derivados do acido 3-benzoilfenilacetico para o tratamento de doencas inflamatorias oftalmicas - Google Patents
Composicoes para administracao topica contendo derivados do acido 3-benzoilfenilacetico para o tratamento de doencas inflamatorias oftalmicasInfo
- Publication number
- PT716600E PT716600E PT95923733T PT95923733T PT716600E PT 716600 E PT716600 E PT 716600E PT 95923733 T PT95923733 T PT 95923733T PT 95923733 T PT95923733 T PT 95923733T PT 716600 E PT716600 E PT 716600E
- Authority
- PT
- Portugal
- Prior art keywords
- treatment
- ophthalmic
- acid
- compositions
- benzoylphenylic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/254,090 US5475034A (en) | 1994-06-06 | 1994-06-06 | Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
PT716600E true PT716600E (pt) | 2002-09-30 |
Family
ID=22962892
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT95923733T PT716600E (pt) | 1994-06-06 | 1995-06-06 | Composicoes para administracao topica contendo derivados do acido 3-benzoilfenilacetico para o tratamento de doencas inflamatorias oftalmicas |
Country Status (15)
Country | Link |
---|---|
US (1) | US5475034A (pt) |
EP (1) | EP0716600B1 (pt) |
JP (1) | JP2866744B2 (pt) |
KR (1) | KR100194242B1 (pt) |
CN (1) | CN1088992C (pt) |
AT (1) | ATE215366T1 (pt) |
CA (1) | CA2167524C (pt) |
DE (1) | DE69526183T2 (pt) |
DK (1) | DK0716600T3 (pt) |
ES (1) | ES2171543T3 (pt) |
HK (1) | HK1012554A1 (pt) |
MX (1) | MX9600487A (pt) |
PT (1) | PT716600E (pt) |
TW (1) | TW425382B (pt) |
WO (1) | WO1995033457A1 (pt) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5976566A (en) * | 1997-08-29 | 1999-11-02 | Macrochem Corporation | Non-steroidal antiinflammtory drug formulations for topical application to the skin |
US6066671A (en) | 1997-12-19 | 2000-05-23 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides |
US6646001B2 (en) | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
US20030086899A1 (en) * | 2000-03-14 | 2003-05-08 | Jafari Masoud R. | Chondroitin sulfate containing viscoelastics for use in treating joints |
AR030346A1 (es) * | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes neurodegenerativos de la retina y cabeza de nervio optico |
AR030345A1 (es) * | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes relacionados con angiogenesis |
AU2002247284A1 (en) | 2001-04-02 | 2002-10-15 | Alcon, Inc. | Method of treating ocular inflammatory and angiogenesis-related disorders using an amide derivative of flubiprofen or ketorolac |
US20040132773A1 (en) * | 2001-08-13 | 2004-07-08 | Gamache Daniel A | Method of treating neurodgenerative disorders of the retina and optic nerve head |
CN1649575A (zh) * | 2002-05-03 | 2005-08-03 | 爱尔康公司 | 用氨芬酸或奈帕芬胺治疗血管内皮生长因子介导的血管疾病的方法 |
DE602004013420T2 (de) | 2003-01-21 | 2009-06-04 | Senju Pharmaceutical Co., Ltd. | Wässrige flüssige zubereitung mit 2-amino-3-(4-bromobenzoyl)phenylessigsäure |
US20030187072A1 (en) * | 2003-02-14 | 2003-10-02 | Kapin Michael A. | Method of treating angiogenesis-related disorders |
RU2006101150A (ru) * | 2003-06-13 | 2006-06-10 | Алькон, Инк. (Ch) | Композиции нестероидных противовоспалительных средств для лечения патологического ангиогенеза глаз |
PL1683526T3 (pl) | 2003-11-14 | 2012-09-28 | Senju Pharma Co | Preparat wodnego roztworu zawierający antybiotyk aminoglikozydowy i bromfenak |
US8748402B2 (en) | 2004-06-07 | 2014-06-10 | Bausch & Lomb Pharma Holdings Corp. | Ophthalmic formulations and uses thereof |
US8372814B2 (en) | 2004-06-07 | 2013-02-12 | Ista Pharmaceuticals, Inc. | Ophthalmic formulations and uses thereof |
TWI358290B (en) * | 2004-12-02 | 2012-02-21 | Alcon Inc | Topical nepafenac formulations |
ES2322200T3 (es) * | 2005-05-10 | 2009-06-17 | Alcon, Inc. | Formulaciones en suspension que comprenden un principio activo, un tensioactivo poloxamero o meroxapol y un glicol, su uso para la fabricacion de un medicamento para tratar trastornos oftalmicos. |
DE602006003438D1 (de) * | 2005-05-10 | 2008-12-11 | Alcon Inc | Ophthalmische suspension aus einem ophthalmischen arzneimittel, einem poloxamin und glykol-tonizitätsanpassenden mittel, verwendung der zusammensetzung zur herstellung eines medikaments zur behandlung von augenerkrankungen |
EP1981491A4 (en) * | 2006-01-25 | 2009-09-23 | Aciex Inc | COMPOSITIONS AND METHODS FOR TREATING OPHTHALMIC DROUGHT |
US20100130580A1 (en) * | 2006-01-25 | 2010-05-27 | Aciex Therapeutics, Inc. | Formulations and Methods for Treating Dry Eye |
TW200812575A (en) * | 2006-04-28 | 2008-03-16 | Alcon Inc | Formulations containing amide derivatives of carboxylic acid NSAIDs for topical administration to the eye |
US20080153818A1 (en) * | 2006-12-21 | 2008-06-26 | Bingaman David P | Methods for preventing inflammation during surgery |
US20090105245A1 (en) * | 2006-12-21 | 2009-04-23 | Bingaman David P | Methods for treating macular edema and ocular angiogenesis using an anti-inflammatory agent and a receptor tyrosine kinase inhibitor |
US20080153819A1 (en) * | 2006-12-21 | 2008-06-26 | Bingaman David P | Methods for treating macular edema and pathologic ocular angiogenesis using a neuroprotective agent and a receptor tyrosine kinase inhibitor |
UY31058A1 (es) * | 2007-05-01 | 2008-10-31 | Alcon Res Ltd | Formulaciones de aminoacido n-halogenado con compuestos antiinflamatorios |
JP2010528014A (ja) * | 2007-05-24 | 2010-08-19 | アーシエックス セラピューティックス, インコーポレイテッド | ドライアイを処置するための処方物および方法 |
CN101889017B (zh) | 2007-10-05 | 2013-11-27 | 奥克塞拉有限公司 | 用于治疗疾病的烷氧基化合物 |
US20100292289A1 (en) * | 2007-11-30 | 2010-11-18 | Ampla Pharmaceuticals Inc. | Treatment of metabolic syndrome with novel amides |
US20090239909A1 (en) * | 2008-03-24 | 2009-09-24 | Ampla Pharmaceuticals Inc. | Treatment of metabolic syndrome with lactams |
CA2755314A1 (en) * | 2009-03-12 | 2010-09-16 | Medichem, S.A. | New crystals of a benzoylbenzeneacetamide derivative |
ES2897527T3 (es) | 2009-07-02 | 2022-03-01 | Acucela Inc | Farmacología de moduladores del ciclo visual |
BR112012013503B8 (pt) * | 2009-12-03 | 2021-05-25 | Alcon Res Llc | composição de suspensão oftálmica aquosa topicamente administrável, e método para manter sua viscosidade |
EP3013790A1 (en) | 2013-06-27 | 2016-05-04 | Mylan Laboratories Ltd. | Process for the preparation of nepafenac |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1226344A (pt) * | 1967-07-31 | 1971-03-24 | ||
CH577461A5 (pt) * | 1975-08-13 | 1976-07-15 | Robins Co Inc A H | |
US4318949A (en) * | 1976-09-16 | 1982-03-09 | Toray Industries, Inc. | Composite nap sheet and process for preparing the same |
US4313949A (en) * | 1979-09-26 | 1982-02-02 | A. H. Robins Company, Inc. | Method of producing an inhibitory effect on blood platelet aggregation |
US4254146A (en) * | 1979-10-18 | 1981-03-03 | A. H. Robins Company, Inc. | 3-Benzoyl-2-nitrophenylacetic acids, metal salts, amides and esters |
IL61945A (en) * | 1980-02-19 | 1984-09-30 | Robins Co Inc A H | 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them |
DE3026402A1 (de) * | 1980-07-11 | 1982-02-04 | Syntex Corp., Palo Alto, Calif. | Die verwendung analgetischer und nicht-hormonaler, entzuendungshemmender mittel bei der behandlung von mikrovaskulaeren erkrankungen |
US4503073A (en) * | 1981-01-07 | 1985-03-05 | A. H. Robins Company, Incorporated | 2-Amino-3-(alkylthiobenzoyl)-phenylacetic acids |
IL64724A0 (en) * | 1981-02-17 | 1982-03-31 | Robins Co Inc A H | 2-amino-3-(halobenzoyl)-methylphenylacetic acids and esters and salts thereof and pharmaceutical compositions containing them |
US4568695A (en) * | 1983-12-07 | 1986-02-04 | A. H. Robins Company, Incorporated | 2-Amino-3-benzoyl-phenethylalcohols and intermediates therefor |
EP0195582B1 (en) * | 1985-03-14 | 1990-01-24 | SMITH KLINE DAUELSBERG GmbH | 5-aminosalicylic acid derivatives of non-steroidal antiinflammatory acids |
US4851443A (en) * | 1985-03-14 | 1989-07-25 | Smith Kline Dauelsberg, Gmbh | Carboxylic acid amides, compositions and medical use thereof |
US4683242A (en) * | 1985-10-28 | 1987-07-28 | A. H. Robins Company, Incorporated | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters |
US4910225A (en) * | 1988-01-27 | 1990-03-20 | Senju Pharmaceutical Co., Ltd. | Locally administrable therapeutic composition for inflammatory disease |
-
1994
- 1994-06-06 US US08/254,090 patent/US5475034A/en not_active Expired - Lifetime
-
1995
- 1995-06-06 ES ES95923733T patent/ES2171543T3/es not_active Expired - Lifetime
- 1995-06-06 DK DK95923733T patent/DK0716600T3/da active
- 1995-06-06 AT AT95923733T patent/ATE215366T1/de active
- 1995-06-06 JP JP8501284A patent/JP2866744B2/ja not_active Expired - Lifetime
- 1995-06-06 MX MX9600487A patent/MX9600487A/es unknown
- 1995-06-06 PT PT95923733T patent/PT716600E/pt unknown
- 1995-06-06 KR KR1019960700563A patent/KR100194242B1/ko not_active IP Right Cessation
- 1995-06-06 CN CN95190521A patent/CN1088992C/zh not_active Expired - Lifetime
- 1995-06-06 TW TW084105686A patent/TW425382B/zh not_active IP Right Cessation
- 1995-06-06 CA CA002167524A patent/CA2167524C/en not_active Expired - Lifetime
- 1995-06-06 EP EP95923733A patent/EP0716600B1/en not_active Expired - Lifetime
- 1995-06-06 WO PCT/US1995/007187 patent/WO1995033457A1/en active IP Right Grant
- 1995-06-06 DE DE69526183T patent/DE69526183T2/de not_active Expired - Lifetime
-
1998
- 1998-12-17 HK HK98113825A patent/HK1012554A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2171543T3 (es) | 2002-09-16 |
CA2167524C (en) | 2002-08-13 |
EP0716600A1 (en) | 1996-06-19 |
US5475034A (en) | 1995-12-12 |
DE69526183T2 (de) | 2002-09-26 |
AU2818495A (en) | 1996-01-04 |
KR100194242B1 (ko) | 1999-06-15 |
TW425382B (en) | 2001-03-11 |
CN1129397A (zh) | 1996-08-21 |
CA2167524A1 (en) | 1995-12-14 |
JPH08510479A (ja) | 1996-11-05 |
AU689277B2 (en) | 1998-03-26 |
ATE215366T1 (de) | 2002-04-15 |
WO1995033457A1 (en) | 1995-12-14 |
DE69526183D1 (de) | 2002-05-08 |
JP2866744B2 (ja) | 1999-03-08 |
DK0716600T3 (da) | 2002-06-24 |
CN1088992C (zh) | 2002-08-14 |
EP0716600B1 (en) | 2002-04-03 |
MX9600487A (es) | 1997-06-28 |
KR960703580A (ko) | 1996-08-31 |
HK1012554A1 (en) | 1999-08-06 |
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