PT712860E - Processo para purificacao e isolamento de 2'-deoxi-2', 2'-difluoronucleosidos - Google Patents

Processo para purificacao e isolamento de 2'-deoxi-2', 2'-difluoronucleosidos

Info

Publication number
PT712860E
PT712860E PT95308034T PT95308034T PT712860E PT 712860 E PT712860 E PT 712860E PT 95308034 T PT95308034 T PT 95308034T PT 95308034 T PT95308034 T PT 95308034T PT 712860 E PT712860 E PT 712860E
Authority
PT
Portugal
Prior art keywords
difluoronucleosidos
deoxy
isolation
purification
Prior art date
Application number
PT95308034T
Other languages
English (en)
Inventor
Ta-Sen Chou
Laurie Michelle Poteet
Douglas Patton Kjell
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23335711&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT712860(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PT712860E publication Critical patent/PT712860E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
PT95308034T 1994-11-17 1995-11-09 Processo para purificacao e isolamento de 2'-deoxi-2', 2'-difluoronucleosidos PT712860E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/340,972 US5606048A (en) 1992-06-22 1994-11-17 Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides

Publications (1)

Publication Number Publication Date
PT712860E true PT712860E (pt) 2002-05-31

Family

ID=23335711

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95308034T PT712860E (pt) 1994-11-17 1995-11-09 Processo para purificacao e isolamento de 2'-deoxi-2', 2'-difluoronucleosidos

Country Status (34)

Country Link
US (1) US5606048A (pt)
EP (1) EP0712860B1 (pt)
JP (1) JPH10509170A (pt)
KR (1) KR100424990B1 (pt)
CN (1) CN1044119C (pt)
AR (1) AR001045A1 (pt)
AT (1) ATE210142T1 (pt)
AU (1) AU702588B2 (pt)
BG (1) BG62737B1 (pt)
BR (1) BR9509904A (pt)
CA (1) CA2205350C (pt)
CO (1) CO4600741A1 (pt)
CZ (1) CZ292013B6 (pt)
DE (1) DE69524365T2 (pt)
DK (1) DK0712860T3 (pt)
ES (1) ES2164745T3 (pt)
HU (1) HU219019B (pt)
IL (1) IL115854A (pt)
MX (1) MX9703548A (pt)
MY (1) MY115183A (pt)
NO (1) NO308305B1 (pt)
NZ (1) NZ296712A (pt)
PE (1) PE50196A1 (pt)
PL (1) PL182052B1 (pt)
PT (1) PT712860E (pt)
RO (1) RO118296B1 (pt)
RU (1) RU2161622C2 (pt)
SI (1) SI0712860T1 (pt)
SK (1) SK283160B6 (pt)
TW (1) TW377356B (pt)
UA (1) UA53614C2 (pt)
WO (1) WO1996016072A1 (pt)
YU (1) YU49446B (pt)
ZA (1) ZA959321B (pt)

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US7435755B2 (en) * 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
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WO2004041203A2 (en) * 2002-11-04 2004-05-21 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
RU2005118421A (ru) 2002-11-15 2006-01-20 Айденикс (Кайман) Лимитед (Ky) 2'-разветвленные нуклеозиды и мутация flaviviridae
US7598373B2 (en) * 2002-12-12 2009-10-06 Idenix Pharmaceuticals, Inc. Process for the production of 2-C-methyl-D-ribonolactone
WO2006000922A2 (en) * 2004-06-23 2006-01-05 Idenix (Cayman) Limited 5-aza-7-deazapurine derivatives for treating infections with flaviviridae
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
KR20070073958A (ko) * 2004-12-08 2007-07-10 시코르, 인크. 디플루오로뉴클레오시드 및 이의 제조 방법
EP1831236A4 (en) * 2004-12-30 2013-11-20 Hanmi Science Co Ltd PROCESS FOR PREPARING 2'-DEOXY-2 ', 2'-DIFLUOROCYTIDINE
WO2006070985A1 (en) * 2004-12-30 2006-07-06 Hanmi Pharm. Co., Ltd. METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE
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JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
AU2011202539B2 (en) * 2005-06-03 2012-07-05 Scinopharm Taiwan, Ltd. Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
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JP2009513623A (ja) * 2005-10-28 2009-04-02 アーチ ファーマラブズ リミテッド 塩酸ジェムシタビンの改良された製造方法
WO2007075876A2 (en) * 2005-12-23 2007-07-05 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
US20090069557A1 (en) * 2006-02-06 2009-03-12 Dr. Reddy's Laboratories Ltd. Preparation of gemcitabine
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
WO2008064132A2 (en) * 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
CA2670099A1 (en) * 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthesis and biological activities of new tricyclic-bis-enones (tbes)
WO2008117955A1 (en) * 2007-03-23 2008-10-02 Dongwoo Syntech Co., Ltd. Process for preparing of 2'-deoxy-2'2'-difluorocytidine
CN100475832C (zh) * 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
US20090048205A1 (en) * 2007-08-15 2009-02-19 Colin Meyer Combination therapy with synthetic triterpenoids and gemcitabine
EP2050757A1 (en) 2007-10-10 2009-04-22 Cilag AG Method of producing 2' -deoxy-5-azacytidine (Decitabine)
JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain vehicles, installations and methods
PL2252283T3 (pl) 2008-01-11 2019-09-30 Reata Pharmaceuticals, Inc. Syntetyczne triterpenoidy i sposoby zastosowania w leczeniu choroby
CA2721665C (en) 2008-04-18 2017-01-24 Reata Pharmaceuticals, Inc. Compounds including an anti-inflammatory pharmacore and methods of use
ES2613964T3 (es) * 2008-04-18 2017-05-29 Reata Pharmaceuticals, Inc. Moduladores de inflamación antioxidantes: Derivados de ácido oleanólico homologado C-17
NZ588709A (en) * 2008-04-18 2012-11-30 Reata Pharmaceuticals Inc Antioxidant inflammation modulators: triterpenoid oleanolic acid derivatives with saturation in the c-ring
CN102083442B (zh) 2008-04-18 2014-08-13 里亚塔医药公司 抗氧化剂炎症调节剂：在c-17具有氨基和其它修饰的齐墩果酸衍生物
WO2009146216A2 (en) 2008-04-18 2009-12-03 Reata Pharmaceuticals. Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
WO2010011782A1 (en) 2008-07-22 2010-01-28 Trustees Of Dartmouth College Monocyclic cyanoenones and methods of use thereof
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
ES2628609T3 (es) * 2009-04-06 2017-08-03 Otsuka Pharmaceutical Co., Ltd. Combinación de fármacos antineoplásicos a base de citidina con inhibidor de citidina deaminasa y uso del mismo en el tratamiento de cáncer
TWI477508B (zh) * 2009-04-06 2015-03-21 Otsuka Pharma Co Ltd 用以治療癌症之組成物及方法
US8329666B2 (en) * 2009-04-06 2012-12-11 Eisai Inc. Compositions and methods for treating cancer
JP6042527B2 (ja) 2012-04-04 2016-12-14 ハロザイム インコーポレイテッド 抗ヒアルロナン剤と腫瘍標的タキサンの組み合わせ治療
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
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DE2628202A1 (de) * 1976-06-23 1977-12-29 Max Planck Gesellschaft Verfahren zur herstellung von 2'-substituierten-d-ribofuranosylpurinderivaten
DE2721466A1 (de) * 1977-05-12 1978-11-16 Robugen Gmbh Verfahren zur herstellung von 2'-desoxyribofuranosylnucleosiden
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
FR2531962B1 (fr) * 1982-08-17 1986-11-14 Sandoz Sa Nouveaux derives de la desoxyuridine, leur preparation et leur utilisation comme medicaments
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US4751221A (en) * 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides
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Also Published As

Publication number Publication date
EP0712860A2 (en) 1996-05-22
ATE210142T1 (de) 2001-12-15
EP0712860B1 (en) 2001-12-05
TW377356B (en) 1999-12-21
CN1165519A (zh) 1997-11-19
PL182052B1 (pl) 2001-10-31
SK283160B6 (sk) 2003-03-04
YU49446B (sh) 2006-03-03
ES2164745T3 (es) 2002-03-01
IL115854A (en) 2000-07-16
JPH10509170A (ja) 1998-09-08
AU4139396A (en) 1996-06-17
AR001045A1 (es) 1997-09-24
MX9703548A (es) 1997-08-30
CO4600741A1 (es) 1998-05-08
UA53614C2 (uk) 2003-02-17
BG101485A (en) 1998-03-31
NO308305B1 (no) 2000-08-28
NO972214L (no) 1997-05-14
YU70995A (sh) 1998-09-18
HU219019B (hu) 2001-01-29
SK48597A3 (en) 1997-11-05
DK0712860T3 (da) 2002-03-04
KR970707143A (ko) 1997-12-01
CN1044119C (zh) 1999-07-14
KR100424990B1 (ko) 2004-05-20
CZ148197A3 (en) 1997-08-13
PE50196A1 (es) 1996-11-30
CA2205350C (en) 2007-09-04
NZ296712A (en) 1999-01-28
US5606048A (en) 1997-02-25
DE69524365T2 (de) 2002-08-14
NO972214D0 (no) 1997-05-14
BG62737B1 (bg) 2000-06-30
HUT77926A (hu) 1998-11-30
RU2161622C2 (ru) 2001-01-10
DE69524365D1 (de) 2002-01-17
EP0712860A3 (en) 1996-09-25
SI0712860T1 (en) 2002-04-30
IL115854A0 (en) 1996-01-31
CA2205350A1 (en) 1996-05-30
RO118296B1 (ro) 2003-04-30
CZ292013B6 (cs) 2003-07-16
BR9509904A (pt) 1997-10-14
AU702588B2 (en) 1999-02-25
PL320634A1 (en) 1997-10-13
MY115183A (en) 2003-04-30
WO1996016072A1 (en) 1996-05-30
ZA959321B (en) 1997-05-05

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