PT3455213T - Método para purificar compostos canabinoides através de cromatografia em leito móvel simulado - Google Patents

Método para purificar compostos canabinoides através de cromatografia em leito móvel simulado

Info

Publication number
PT3455213T
PT3455213T PT167288414T PT16728841T PT3455213T PT 3455213 T PT3455213 T PT 3455213T PT 167288414 T PT167288414 T PT 167288414T PT 16728841 T PT16728841 T PT 16728841T PT 3455213 T PT3455213 T PT 3455213T
Authority
PT
Portugal
Prior art keywords
cannabinoid compounds
purifying
purifying cannabinoid
compounds
cannabinoid
Prior art date
Application number
PT167288414T
Other languages
English (en)
Original Assignee
Symrise Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symrise Ag filed Critical Symrise Ag
Publication of PT3455213T publication Critical patent/PT3455213T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • C07D311/80Dibenzopyrans; Hydrogenated dibenzopyrans
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/10Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
    • B01D15/1821Simulated moving beds
    • B01D15/185Simulated moving beds characterized by the components to be separated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/001Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
    • C07C37/002Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain by transformation of a functional group, e.g. oxo, carboxyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/02Preparation of carboxylic acid esters by interreacting ester groups, i.e. transesterification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2215/00Separating processes involving the treatment of liquids with adsorbents
    • B01D2215/02Separating processes involving the treatment of liquids with adsorbents with moving adsorbents
    • B01D2215/023Simulated moving beds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT167288414T 2016-05-13 2016-05-13 Método para purificar compostos canabinoides através de cromatografia em leito móvel simulado PT3455213T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2016/060905 WO2017194173A1 (en) 2016-05-13 2016-05-13 Method for purifying cannabinoid compounds

Publications (1)

Publication Number Publication Date
PT3455213T true PT3455213T (pt) 2022-03-01

Family

ID=56121022

Family Applications (1)

Application Number Title Priority Date Filing Date
PT167288414T PT3455213T (pt) 2016-05-13 2016-05-13 Método para purificar compostos canabinoides através de cromatografia em leito móvel simulado

Country Status (9)

Country Link
US (1) US10647691B2 (pt)
EP (1) EP3455213B1 (pt)
CN (1) CN109153661B (pt)
CA (1) CA3023760C (pt)
DK (1) DK3455213T3 (pt)
ES (1) ES2907623T3 (pt)
PL (1) PL3455213T3 (pt)
PT (1) PT3455213T (pt)
WO (1) WO2017194173A1 (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10239808B1 (en) 2016-12-07 2019-03-26 Canopy Holdings, LLC Cannabis extracts
US11213558B2 (en) 2017-05-17 2022-01-04 Orochem Technologies, Inc. CBX extraction-isolation process
US10189762B1 (en) * 2017-07-07 2019-01-29 Orochem Technologies, Inc. Process for purification and separation of cannabinoids, from dried hemp and cannabis leaves
US11202771B2 (en) 2018-01-31 2021-12-21 Treehouse Biotech, Inc. Hemp powder
US11192870B2 (en) 2018-03-07 2021-12-07 Socati Technologies—Oregon, Llc Continuous isolation of cannabidiol and conversion of cannabidiol to delta 8-tetrahydrocannabinol and delta 9-tetrahydrocannabinol
US11851415B2 (en) * 2018-03-07 2023-12-26 Cleen Technology Inc. Continuous isolation of cannabidiol and cannabinoids and conversion of cannabidiol to delta 8-tetrahydrocannabinol and delta 9-tetrahydrocannabinol
MX2020009335A (es) * 2018-03-07 2020-12-03 Socati Tech Oregon Llc Aislamiento continuo de cannabidiol y conversion de cannabidiol a delta 8-tetrahidro cannabinol y delta 9- tetrahidro cannabinol.
US11485700B2 (en) * 2018-06-28 2022-11-01 Symrise Ag Synthesis of (+)-cannabinoids and their therapeutic effects
CA3073093A1 (en) 2018-08-03 2020-02-06 Biomass Oil Separation Solutions, Llc Processes and apparatus for extraction of substances and enriched extracts from plant material
US20210236460A1 (en) 2018-08-20 2021-08-05 Bessor Pharma, Llc Applications of Known and Novel Cannabinoids
US11324718B2 (en) * 2018-10-09 2022-05-10 Sartorius Chromatography Equipment Method for purifying cannabinoids
CA3119729A1 (en) 2018-10-10 2020-04-16 Treehouse Biotech, Inc. Synthesis of cannabigerol
EP3890859A2 (en) * 2018-12-04 2021-10-13 Orochem Technologies, Inc. Process for purifying tetrahydrocannabinol using a chromatographic stationary phase
US10413845B1 (en) 2018-12-14 2019-09-17 Socati Technologies Processes for solvent extraction of cannabinoids, terpenes and flavonoids from biomass
CN109734591A (zh) * 2018-12-26 2019-05-10 江苏暨明医药科技有限公司 一种***二酚中间体及其制备方法与及应用
CN113950467A (zh) * 2019-05-10 2022-01-18 贝努维亚制造有限责任公司 生产***二酚或次***二酚的方法以及生产***二酚或次***二酚的中间体
CN111943813B (zh) * 2019-05-17 2023-04-14 上海特化医药科技有限公司 ***二酚类化合物的制备方法
BR112021023512A2 (pt) * 2019-05-23 2022-02-01 Kare Chemical Tech Inc Precursores e processos de canabinóides catalíticos
CN110270134A (zh) * 2019-05-31 2019-09-24 江苏哈工药机科技股份有限公司 一种高纯度cbd分离纯化装置及其分离纯化方法
US10799546B1 (en) 2019-07-26 2020-10-13 Biomass Oil Separation Solutions, Llc Modular, integrated process and apparatus for extracting, refining and remediating active substances from plant material
CN110724589B (zh) * 2019-08-27 2023-01-10 桂林莱茵生物科技股份有限公司 一种制备***二酚联产***全谱油的方法
US11542243B1 (en) 2019-09-26 2023-01-03 FusionFarms, LLC Method of converting delta9-THC to delta10-THC and the purification of the delta10-THC by crystallization
CN110746275A (zh) * 2019-11-08 2020-02-04 河南汉麻生物科技有限公司 一种利用连续色谱***分离***二酚的方法
CN113896616A (zh) * 2020-07-06 2022-01-07 复旦大学 一种***二酚的制备方法
CN114432187A (zh) * 2020-11-03 2022-05-06 北京东方淼森生物科技有限公司 一种桃花油的制备方法及在化妆品中的应用
WO2022125966A1 (en) * 2020-12-10 2022-06-16 Orochem Technologies Inc. Process for removing thc from cannabinoids
CN112843788B (zh) * 2021-01-19 2022-10-28 温州大学新材料与产业技术研究院 一种采用流动相独立环外置换的温度梯度模拟移动床装置及其分离方法
CN113135885A (zh) * 2021-04-07 2021-07-20 上海同田生物技术有限公司 一种高速逆流色谱分离纯化四氢次***酚的方法
LU500093B1 (de) * 2021-04-27 2022-10-31 K D Pharma Bexbach Gmbh Verfahren zum Trennen einer Stoffmischung
WO2022229284A1 (de) * 2021-04-27 2022-11-03 K.D. Pharma Bexbach Gmbh Verfahren zum trennen einer stoffmischung
CN113683490B (zh) * 2021-08-02 2022-03-25 云南翰谷生物科技有限公司 一种次***二酚晶体的制备方法
CN115010690B (zh) * 2022-06-06 2023-03-21 云南翰谷生物科技有限公司 一种高纯***酚晶体制备方法
CN115385780B (zh) * 2022-08-26 2024-02-27 晨光生物科技集团股份有限公司 一种次***二酚结晶多晶型物及其制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5342971A (en) 1992-12-29 1994-08-30 The Australian National University Process for the preparation of dibenzo[b,d]pyrans
WO2002045115A1 (en) 2000-11-28 2002-06-06 Orion Electric Co., Ltd. Color plasma display panel with an improvement of color temperature and brightness
DE10106024B4 (de) 2001-02-09 2004-10-14 Thc Pharm Gmbh Verfahren zur Herstellung von Dronabinol
GB0112752D0 (en) * 2001-05-25 2001-07-18 Johnson Matthey Plc Synthesis of cannabinoids
GB0329635D0 (en) 2003-12-23 2004-01-28 Johnson Matthey Plc Process for purifying trans-tetrahydrocannabinol
EP1773801A1 (de) 2004-07-19 2007-04-18 Cilag Ltd. Verfahren zur gewinnung von reinem tetrahydrocannabinol
TWI436991B (zh) * 2004-11-22 2014-05-11 Euro Celtique Sa 用於純化反-(-)-△9-四氫***酚與反-(+)-△9-四氫***酚之方法
DE102005028937B4 (de) 2005-06-22 2009-07-23 Bionorica Ag Verfahren zur Herstellung von Dronabinol
NZ567029A (en) * 2005-09-29 2011-09-30 Amr Technology Inc Process for production of delta-9- tetrahydrocannabinol
GB0807915D0 (en) 2008-05-01 2008-06-04 Resolution Chemicals Ltd Production of delta 9 tetrahydrocannabinol
DE102009019322A1 (de) * 2009-04-30 2010-11-11 The Health Concept Gmbh Verfahren zur Herstellung von Synthetischen Cannabinoiden
EP2760444B1 (de) 2011-09-29 2020-04-22 THC Pharm GmbH The Health Concept Cannabinoidcarbonsäuren, salze von cannabinoidcarbonsäuren, deren herstellung und anwendungen
ES2547354T3 (es) * 2013-09-03 2015-10-05 Symrise Ag Mezclas de compuestos cannabinoides, su preparación y uso

Also Published As

Publication number Publication date
CN109153661B (zh) 2023-01-17
CA3023760C (en) 2023-10-03
EP3455213A1 (en) 2019-03-20
ES2907623T3 (es) 2022-04-25
PL3455213T3 (pl) 2022-04-04
US10647691B2 (en) 2020-05-12
DK3455213T3 (da) 2022-03-07
CN109153661A (zh) 2019-01-04
WO2017194173A1 (en) 2017-11-16
EP3455213B1 (en) 2021-11-24
US20190144414A1 (en) 2019-05-16
CA3023760A1 (en) 2017-11-16

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