PT3166923T - Processo para preparar fenilalcanos substituídos - Google Patents
Processo para preparar fenilalcanos substituídosInfo
- Publication number
- PT3166923T PT3166923T PT158181685T PT15818168T PT3166923T PT 3166923 T PT3166923 T PT 3166923T PT 158181685 T PT158181685 T PT 158181685T PT 15818168 T PT15818168 T PT 15818168T PT 3166923 T PT3166923 T PT 3166923T
- Authority
- PT
- Portugal
- Prior art keywords
- preparing substituted
- phenylalkanes
- substituted phenylalkanes
- preparing
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462022815P | 2014-07-10 | 2014-07-10 | |
| US201562155913P | 2015-05-01 | 2015-05-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3166923T true PT3166923T (pt) | 2023-06-02 |
Family
ID=55064941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT158181685T PT3166923T (pt) | 2014-07-10 | 2015-07-10 | Processo para preparar fenilalcanos substituídos |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9556108B2 (pt) |
| EP (1) | EP3166923B1 (pt) |
| JP (1) | JP6502397B2 (pt) |
| AU (1) | AU2015287663B2 (pt) |
| BR (1) | BR112017000417B1 (pt) |
| CA (1) | CA2954642C (pt) |
| DK (1) | DK3166923T3 (pt) |
| ES (1) | ES2940904T3 (pt) |
| MX (1) | MX2017000023A (pt) |
| PT (1) | PT3166923T (pt) |
| WO (1) | WO2016007823A1 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3166923B1 (en) | 2014-07-10 | 2023-03-15 | SpecGx LLC | Process for preparing substituted phenylalkanes |
| US10118890B2 (en) | 2014-10-10 | 2018-11-06 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
| GB2539442A (en) * | 2015-06-16 | 2016-12-21 | Azad Pharmaceutical Ingredients Ag | New synthesis of tapentadol-HCI intermediates |
| CA2991421C (en) * | 2015-07-10 | 2019-04-30 | Mallinckrodt Llc | A two-step process for preparing 3-substituted phenylalkylamines |
| US10081636B2 (en) | 2016-07-08 | 2018-09-25 | Cody Laboratories, Inc. | Method for catalytic preparation of hydromorphone, hydrocodone, and other opiates |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2340812C2 (de) | 1973-08-11 | 1982-05-27 | Basf Ag, 6700 Ludwigshafen | Phenylpropanale sowie ein Verfahren zu deren Herstellung |
| DE4426245A1 (de) | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
| EP1278728B1 (en) * | 2000-04-20 | 2004-08-25 | F. Hoffmann-La Roche Ag | Pyrrolidine and piperidine derivatives and their use for the treatment of neurodegenerative disorders |
| HUP0401649A3 (en) | 2001-10-16 | 2007-05-29 | Reddys Lab Ltd Dr | Benzoxazine and benzothiazine derivatives and pharmaceutical compositions containing them |
| US7321038B2 (en) | 2002-11-11 | 2008-01-22 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone and hydromorphone |
| US7323565B2 (en) | 2002-11-11 | 2008-01-29 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone and hydromorphone |
| US7399858B2 (en) | 2002-11-11 | 2008-07-15 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof |
| JP4351859B2 (ja) * | 2003-04-14 | 2009-10-28 | 三菱レイヨン株式会社 | 光学活性β−アリ−ル化合物の製造法 |
| DE10328316A1 (de) * | 2003-06-23 | 2005-01-20 | Grünenthal GmbH | Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe |
| US7608709B2 (en) | 2005-07-25 | 2009-10-27 | National University Corporation Chiba University | 2, 3-bis(dialkylphosphino)pyrazine derivative, process of producing the same, and metal complex having the same as ligand |
| TWI401237B (zh) | 2006-07-24 | 2013-07-11 | ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備 | |
| US7399859B1 (en) | 2007-02-06 | 2008-07-15 | Cody Laboratories Inc. | Method for catalytic preparation of hydromorphone and hydrocodone |
| US9446995B2 (en) * | 2012-05-21 | 2016-09-20 | Illinois Institute Of Technology | Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions |
| AU2009313838B2 (en) | 2008-11-14 | 2015-02-05 | University Of Kansas | Polymer-supported transition metal catalyst complexes and methods of use |
| JP5697215B2 (ja) * | 2009-06-11 | 2015-04-08 | マリンクロッド エルエルシー | 触媒的水素移動による６−α−アミノＮ−置換モルフィナンの合成 |
| CN102002065B (zh) | 2009-09-02 | 2014-09-10 | 上海特化医药科技有限公司 | 他喷他多的制备方法及其中间体 |
| WO2011067386A2 (de) * | 2009-12-04 | 2011-06-09 | Basf Se | Verfahren zur herstellung von aliphatischen aldehyden |
| BR112012016059A2 (pt) | 2009-12-29 | 2015-09-01 | Mapi Pharma Ltd | "compostos intermediários e processos para a preparação de tapentadol e compostos relacionados". |
| WO2011092719A2 (en) * | 2010-02-01 | 2011-08-04 | Ind-Swift Laboratories Limited | Process for the preparation of l-phenyl-3-dimethylaminopropane derivatives |
| WO2011107876A2 (en) * | 2010-03-05 | 2011-09-09 | Actavis Group Ptc Ehf | Improved resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol |
| EP2582659B1 (en) | 2010-06-15 | 2015-03-11 | Grünenthal GmbH | Process for the preparation of substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds |
| TWI396678B (zh) * | 2010-12-07 | 2013-05-21 | Nat Univ Tsing Hua | 二級醇製備方法 |
| WO2012089181A1 (en) * | 2010-12-30 | 2012-07-05 | Zentiva, K.S. | O-substituted (2r,3r)-3-(3-hydroxyphenyl)-2-methyl-4-pentenoic acids and a method of obtaining the same |
| WO2012146978A2 (en) * | 2011-04-28 | 2012-11-01 | Actavis Group Ptc Ehf | A novel process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof |
| WO2013090161A1 (en) * | 2011-12-12 | 2013-06-20 | Boehringer Ingelheim International Gmbh | Stereoselective synthesis of tapentadol and its salts |
| JP2013221025A (ja) * | 2012-04-19 | 2013-10-28 | Dainippon Sumitomo Pharma Co Ltd | ビフェニルアセトアミド誘導体の製造方法及びその中間体 |
| CA2873984A1 (en) * | 2012-05-23 | 2013-11-28 | Stemergie Biotechnology Sa | Inhibitors of the activity of complex (iii) of the mitochondrial electron transport chain and use thereof |
| CN102936205B (zh) * | 2012-11-12 | 2014-06-18 | 合肥市新星医药化工有限公司 | 一种他喷他多的合成方法 |
| EP3166923B1 (en) | 2014-07-10 | 2023-03-15 | SpecGx LLC | Process for preparing substituted phenylalkanes |
-
2015
- 2015-07-10 EP EP15818168.5A patent/EP3166923B1/en active Active
- 2015-07-10 MX MX2017000023A patent/MX2017000023A/es unknown
- 2015-07-10 WO PCT/US2015/039884 patent/WO2016007823A1/en active Application Filing
- 2015-07-10 JP JP2016575070A patent/JP6502397B2/ja active Active
- 2015-07-10 ES ES15818168T patent/ES2940904T3/es active Active
- 2015-07-10 CA CA2954642A patent/CA2954642C/en active Active
- 2015-07-10 AU AU2015287663A patent/AU2015287663B2/en active Active
- 2015-07-10 PT PT158181685T patent/PT3166923T/pt unknown
- 2015-07-10 US US14/796,069 patent/US9556108B2/en active Active
- 2015-07-10 BR BR112017000417-8A patent/BR112017000417B1/pt active IP Right Grant
- 2015-07-10 DK DK15818168.5T patent/DK3166923T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| MX2017000023A (es) | 2017-05-01 |
| EP3166923A1 (en) | 2017-05-17 |
| DK3166923T3 (da) | 2023-04-11 |
| CA2954642C (en) | 2023-04-11 |
| EP3166923B1 (en) | 2023-03-15 |
| WO2016007823A1 (en) | 2016-01-14 |
| AU2015287663B2 (en) | 2019-02-28 |
| CA2954642A1 (en) | 2016-01-14 |
| JP2017520566A (ja) | 2017-07-27 |
| US9556108B2 (en) | 2017-01-31 |
| EP3166923A4 (en) | 2018-02-21 |
| BR112017000417B1 (pt) | 2021-06-08 |
| AU2015287663A1 (en) | 2017-01-12 |
| US20160009635A1 (en) | 2016-01-14 |
| BR112017000417A2 (pt) | 2017-11-07 |
| ES2940904T3 (es) | 2023-05-12 |
| JP6502397B2 (ja) | 2019-04-17 |
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