PT2970980T - Métodos de produção para controlor o teor de lisina c-terminal, galactose e ácido siálico em proteínas recombinantes - Google Patents

Métodos de produção para controlor o teor de lisina c-terminal, galactose e ácido siálico em proteínas recombinantes

Info

Publication number
PT2970980T
PT2970980T PT14768761T PT14768761T PT2970980T PT 2970980 T PT2970980 T PT 2970980T PT 14768761 T PT14768761 T PT 14768761T PT 14768761 T PT14768761 T PT 14768761T PT 2970980 T PT2970980 T PT 2970980T
Authority
PT
Portugal
Prior art keywords
galactose
control
acid content
sialic acid
manufacturing methods
Prior art date
Application number
PT14768761T
Other languages
English (en)
Inventor
Flikweert Marcel
Goochee Charles
Maslanka Francis
Johannes Ignatius Nagel Francisus
Ryland James
Schafer Eugene
Original Assignee
Janssen Biotech Inc
Janssen Biologics B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51528780&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2970980(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Biotech Inc, Janssen Biologics B V filed Critical Janssen Biotech Inc
Publication of PT2970980T publication Critical patent/PT2970980T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
PT14768761T 2013-03-15 2014-03-07 Métodos de produção para controlor o teor de lisina c-terminal, galactose e ácido siálico em proteínas recombinantes PT2970980T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361791094P 2013-03-15 2013-03-15

Publications (1)

Publication Number Publication Date
PT2970980T true PT2970980T (pt) 2018-11-19

Family

ID=51528780

Family Applications (1)

Application Number Title Priority Date Filing Date
PT14768761T PT2970980T (pt) 2013-03-15 2014-03-07 Métodos de produção para controlor o teor de lisina c-terminal, galactose e ácido siálico em proteínas recombinantes

Country Status (26)

Country Link
US (3) US20140273092A1 (pt)
EP (1) EP2970980B2 (pt)
JP (1) JP2016512029A (pt)
KR (1) KR102216003B1 (pt)
CN (1) CN105378086B (pt)
AR (2) AR095660A1 (pt)
AU (2) AU2014237635B2 (pt)
BR (1) BR112015022971B1 (pt)
CA (1) CA2907140A1 (pt)
CY (1) CY1120980T1 (pt)
DK (1) DK2970980T3 (pt)
EA (1) EA201591807A1 (pt)
ES (1) ES2690047T3 (pt)
HR (1) HRP20181741T1 (pt)
IL (1) IL240689B (pt)
LT (1) LT2970980T (pt)
MX (1) MX366910B (pt)
PH (1) PH12015501837B1 (pt)
PL (1) PL2970980T3 (pt)
PT (1) PT2970980T (pt)
RS (1) RS57791B1 (pt)
SG (1) SG11201507577RA (pt)
SI (1) SI2970980T1 (pt)
TW (1) TWI630216B (pt)
WO (1) WO2014149935A1 (pt)
ZA (1) ZA201507671B (pt)

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WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
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US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
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WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
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KR102118240B1 (ko) 2013-08-20 2020-06-03 레크 파마슈티칼스 디.디. 폴리펩티드의 α-아미드화 및/또는 C-말단 아미노산 분열의 제어를 위한 세포 배양 매질 및 방법
US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
EP4046655A1 (en) 2015-11-03 2022-08-24 Janssen Biotech, Inc. Antibodies specifically binding pd-1 and their uses
CN108350416A (zh) * 2015-11-09 2018-07-31 百时美施贵宝公司 操纵在cho细胞中产生的多肽的品质属性的方法
US20180355043A1 (en) 2015-12-17 2018-12-13 Janssen Biotech, Inc. Antibodies Specifically Binding HLA-DR and Their Uses
US10669344B2 (en) 2016-08-12 2020-06-02 Janssen Biotech, Inc. Engineered antibodies and other Fc-domain containing molecules with enhanced agonism and effector functions
US20180044430A1 (en) 2016-08-12 2018-02-15 Janssen Biotech, Inc. FC Engineered Anti-TNFR Superfamily Member Antibodies Having Enhanced Atonistic Activity and Methods of Using Them
CN110785185B (zh) 2017-06-05 2024-05-24 詹森生物科技公司 具有非对称ch2-ch3区突变的工程化多特异性抗体和其他多聚体蛋白
JP7235733B2 (ja) 2017-06-05 2023-03-08 ヤンセン バイオテツク，インコーポレーテツド Ｐｄ－１に特異的に結合する抗体、及び使用方法
WO2019077628A1 (en) * 2017-10-16 2019-04-25 Council Of Scientific & Industrial Research ZINC SUPPLEMENTATION TO DECREASE GALACTOSYLATION OF RECOMBINANT GLYCOPROTEINS
EA202092849A1 (ru) 2018-05-24 2021-03-16 Янссен Байотек, Инк. Моноспецифические и мультиспецифические антитела к tmeff2 и их применение
MX2021008030A (es) * 2018-12-31 2021-08-05 Momenta Pharmaceuticals Inc Metodos para producir ustekinumab.
US20210040210A1 (en) 2019-07-26 2021-02-11 Janssen Biotech, Inc. Proteins Comprising Kallikrein Related Peptidase 2 Antigen Binding Domains And Their Uses
MX2022001799A (es) 2019-08-15 2022-03-11 Janssen Biotech Inc Materiales y metodos para fragmentos variables de cadena unica mejorados.
EP4233893A3 (en) 2020-03-13 2023-09-27 Janssen Biotech, Inc. Materials and methods for binding siglec-3/cd33
MX2022014938A (es) 2020-05-27 2023-03-06 Janssen Biotech Inc Proteínas que comprenden dominios de unión al antígeno de cd3 y usos de éstas.
CN116209681A (zh) 2020-07-29 2023-06-02 詹森生物科技公司 包含hla-g抗原结合结构域的蛋白质及其用途
UY39467A (es) 2020-10-13 2022-04-29 Janssen Biotech Inc Inmunidad mediada por células t de bioingeniería, materiales y otros métodos para modular el grupo de diferenciación iv y / o viii
TW202233672A (zh) 2020-10-22 2022-09-01 美商健生生物科技公司 包括類δ配體３（ＤＬＬ３）抗原結合區之蛋白質及其用途
EP4284838A2 (en) 2021-01-28 2023-12-06 Janssen Biotech, Inc. Psma binding proteins and uses thereof
AR125212A1 (es) 2021-03-24 2023-06-28 Janssen Biotech Inc Proteínas que comprenden dominios de unión al antígeno de cd3 y usos de estas
KR20230160314A (ko) 2021-03-24 2023-11-23 얀센 바이오테크 인코포레이티드 Cd22 및 cd79b를 표적화하는 항체
CA3229822A1 (en) 2021-09-13 2023-03-16 Patrick John DOONAN Cd33 x v?2 multispecific antibodies for the treatment of cancer
EP4405392A1 (en) 2021-09-24 2024-07-31 Janssen Biotech, Inc. Proteins comprising cd20 binding domains, and uses thereof
WO2023089587A1 (en) 2021-11-22 2023-05-25 Janssen Biotech, Inc. Compositions comprising enhanced multispecific binding agents for an immune response
WO2024089551A1 (en) 2022-10-25 2024-05-02 Janssen Biotech, Inc. Msln and cd3 binding agents and methods of use thereof

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Also Published As

Publication number Publication date
HRP20181741T1 (hr) 2018-12-28
CN105378086B (zh) 2019-05-28
PH12015501837A1 (en) 2015-11-09
BR112015022971B1 (pt) 2022-05-17
CA2907140A1 (en) 2014-09-25
ES2690047T3 (es) 2018-11-19
AU2014237635B2 (en) 2020-03-12
PL2970980T3 (pl) 2019-01-31
DK2970980T3 (en) 2018-10-22
EA201591807A1 (ru) 2016-02-29
TW201441263A (zh) 2014-11-01
AR124871A2 (es) 2023-05-17
MX2015012361A (es) 2016-04-28
EP2970980B1 (en) 2018-08-15
ZA201507671B (en) 2017-11-29
IL240689A0 (en) 2015-10-29
AR095660A1 (es) 2015-11-04
PH12015501837B1 (en) 2015-11-09
AU2014237635A1 (en) 2015-09-03
CY1120980T1 (el) 2019-12-11
EP2970980B2 (en) 2022-07-27
AU2020203864A1 (en) 2020-07-02
US20160237149A1 (en) 2016-08-18
CN105378086A (zh) 2016-03-02
SG11201507577RA (en) 2015-10-29
US11149085B2 (en) 2021-10-19
IL240689B (en) 2021-12-01
EP2970980A1 (en) 2016-01-20
AU2020203864B2 (en) 2022-05-26
KR20150129025A (ko) 2015-11-18
JP2016512029A (ja) 2016-04-25
TWI630216B (zh) 2018-07-21
LT2970980T (lt) 2018-10-25
RS57791B1 (sr) 2018-12-31
WO2014149935A1 (en) 2014-09-25
MX366910B (es) 2019-07-30
US20220089712A1 (en) 2022-03-24
SI2970980T1 (sl) 2018-11-30
BR112015022971A2 (pt) 2017-11-14
KR102216003B1 (ko) 2021-02-16
US20140273092A1 (en) 2014-09-18
EP2970980A4 (en) 2016-09-07

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