SG11201505195TA - Methods For Reducing Aggregate Content In Protein Preparations - Google Patents

Methods For Reducing Aggregate Content In Protein Preparations

Info

Publication number
SG11201505195TA
SG11201505195TA SG11201505195TA SG11201505195TA SG11201505195TA SG 11201505195T A SG11201505195T A SG 11201505195TA SG 11201505195T A SG11201505195T A SG 11201505195TA SG 11201505195T A SG11201505195T A SG 11201505195TA SG 11201505195T A SG11201505195T A SG 11201505195TA
Authority
SG
Singapore
Prior art keywords
methods
protein preparations
aggregate content
reducing aggregate
reducing
Prior art date
Application number
SG11201505195TA
Inventor
Peter Stanley Gagnon
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Publication of SG11201505195TA publication Critical patent/SG11201505195TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/34—Size selective separation, e.g. size exclusion chromatography, gel filtration, permeation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3828—Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography
SG11201505195TA 2013-02-06 2014-02-05 Methods For Reducing Aggregate Content In Protein Preparations SG11201505195TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361761646P 2013-02-06 2013-02-06
PCT/SG2014/000046 WO2014123484A1 (en) 2013-02-06 2014-02-05 Methods For Reducing Aggregate Content In Protein Preparations

Publications (1)

Publication Number Publication Date
SG11201505195TA true SG11201505195TA (en) 2015-08-28

Family

ID=51299982

Family Applications (3)

Application Number Title Priority Date Filing Date
SG11201505195TA SG11201505195TA (en) 2013-02-06 2014-02-05 Methods For Reducing Aggregate Content In Protein Preparations
SG11201505460WA SG11201505460WA (en) 2013-02-06 2014-02-05 Methods for reducing aggregate levels in protein preparations by treatment with thio-heterocyclic cations
SG10201706205RA SG10201706205RA (en) 2013-02-06 2014-02-05 Methods for reducing aggregate levels in protein preparations by treatment with thio-heterocyclic cations

Family Applications After (2)

Application Number Title Priority Date Filing Date
SG11201505460WA SG11201505460WA (en) 2013-02-06 2014-02-05 Methods for reducing aggregate levels in protein preparations by treatment with thio-heterocyclic cations
SG10201706205RA SG10201706205RA (en) 2013-02-06 2014-02-05 Methods for reducing aggregate levels in protein preparations by treatment with thio-heterocyclic cations

Country Status (7)

Country Link
US (2) US9975919B2 (en)
EP (2) EP2953962A4 (en)
JP (2) JP6410734B2 (en)
KR (2) KR20150113027A (en)
CN (2) CN105026417A (en)
SG (3) SG11201505195TA (en)
WO (2) WO2014123486A1 (en)

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FR2902799B1 (en) 2006-06-27 2012-10-26 Millipore Corp METHOD AND UNIT FOR PREPARING A SAMPLE FOR THE MICROBIOLOGICAL ANALYSIS OF A LIQUID
US8569464B2 (en) 2006-12-21 2013-10-29 Emd Millipore Corporation Purification of proteins
US8362217B2 (en) 2006-12-21 2013-01-29 Emd Millipore Corporation Purification of proteins
US20100267933A1 (en) 2006-12-21 2010-10-21 Moya Wilson Purification of proteins
ES2749232T3 (en) 2008-12-16 2020-03-19 Emd Millipore Corp Stirred tank reactor and procedure
SG10201804385YA (en) 2010-05-17 2018-06-28 Emd Millipore Corp Stimulus responsive polymers for the purification of biomolecules
US10112971B2 (en) * 2013-02-26 2018-10-30 Agency For Science, Technology And Research Protein purification in the presence of nonionic organic polymers and electropositive surfaces
KR20150122650A (en) * 2013-02-28 2015-11-02 에이전시 포 사이언스, 테크놀로지 앤드 리서치 Protein purification in the presence of nonionic organic polymers at elevated conductivity
EP3110829A4 (en) * 2014-02-27 2017-10-11 Agency for Science, Technology and Research Antibody purification process
US10927145B2 (en) 2016-06-15 2021-02-23 Agency For Science, Technology And Research Method of enhancing the performance of chromatography methods for purification of proteins
EP3995196B1 (en) * 2020-11-04 2023-08-09 Sartorius BIA Separations d.o.o. Purification process for lipid-membrane-enclosed complex assemblages
CN117347617A (en) * 2022-06-27 2024-01-05 菲鹏生物股份有限公司 Diluent and application thereof, and method for determining analyte in sample

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US5283339A (en) 1988-11-23 1994-02-01 California Institute Of Technology Immobilized metal aqueous two-phase extraction and precipitation
US5691132A (en) 1994-11-14 1997-11-25 Cerus Corporation Method for inactivating pathogens in red cell compositions using quinacrine mustard
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US6503716B1 (en) * 2000-11-28 2003-01-07 Pe Corporation (Ny) Compositions and methods for extracting a nucleic acid
GB0101049D0 (en) * 2001-01-15 2001-02-28 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
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WO2005120700A2 (en) * 2004-06-14 2005-12-22 Novo Nordisk A/S Peptide purification by means of hard metal ion affinity chromatography
AU2006332457A1 (en) * 2005-12-30 2007-07-12 Bio-Layer Pty Limited Binding of molecules
US7691980B2 (en) * 2007-01-09 2010-04-06 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
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EP2291388A4 (en) * 2008-06-03 2013-02-13 Patrys Ltd Process for purification of antibodies
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EP2855502B1 (en) * 2012-05-31 2019-06-26 Agency For Science, Technology And Research Methods for reducing levels of protein-contaminant complexes and aggregates in protein preparations by treatment with electropositive organic additives
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Also Published As

Publication number Publication date
US20150368354A1 (en) 2015-12-24
KR20150115745A (en) 2015-10-14
SG10201706205RA (en) 2017-08-30
EP2953964A1 (en) 2015-12-16
EP2953964A4 (en) 2016-09-14
US9975919B2 (en) 2018-05-22
US20150376230A1 (en) 2015-12-31
SG11201505460WA (en) 2015-08-28
JP2016508499A (en) 2016-03-22
KR20150113027A (en) 2015-10-07
WO2014123484A1 (en) 2014-08-14
CN105051055A (en) 2015-11-11
JP6363621B2 (en) 2018-07-25
WO2014123486A1 (en) 2014-08-14
US9988418B2 (en) 2018-06-05
EP2953962A4 (en) 2016-10-19
JP2016506952A (en) 2016-03-07
CN105026417A (en) 2015-11-04
JP6410734B2 (en) 2018-10-24
EP2953962A1 (en) 2015-12-16

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