PT2825559T - Anticorpos biespecíficos prontamente isolados com formato de imunoglobulina nativo - Google Patents

Anticorpos biespecíficos prontamente isolados com formato de imunoglobulina nativo

Info

Publication number
PT2825559T
PT2825559T PT13739281T PT13739281T PT2825559T PT 2825559 T PT2825559 T PT 2825559T PT 13739281 T PT13739281 T PT 13739281T PT 13739281 T PT13739281 T PT 13739281T PT 2825559 T PT2825559 T PT 2825559T
Authority
PT
Portugal
Prior art keywords
bispecific antibodies
readily isolated
native immunoglobulin
isolated bispecific
immunoglobulin format
Prior art date
Application number
PT13739281T
Other languages
English (en)
Inventor
Fischer Nicolas
Magistrelli Giovanni
Rousseau François
Masternak Krzysztof
Malinge Pauline
Original Assignee
Novimmune Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novimmune Sa filed Critical Novimmune Sa
Publication of PT2825559T publication Critical patent/PT2825559T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT13739281T 2012-03-13 2013-03-13 Anticorpos biespecíficos prontamente isolados com formato de imunoglobulina nativo PT2825559T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261610141P 2012-03-13 2012-03-13

Publications (1)

Publication Number Publication Date
PT2825559T true PT2825559T (pt) 2019-06-07

Family

ID=48803578

Family Applications (1)

Application Number Title Priority Date Filing Date
PT13739281T PT2825559T (pt) 2012-03-13 2013-03-13 Anticorpos biespecíficos prontamente isolados com formato de imunoglobulina nativo

Country Status (9)

Country Link
US (3) US9815909B2 (pt)
EP (2) EP2825559B1 (pt)
JP (3) JP6273219B2 (pt)
AU (2) AU2013234039B2 (pt)
CA (1) CA2867020C (pt)
DK (1) DK2825559T3 (pt)
ES (1) ES2728301T3 (pt)
PT (1) PT2825559T (pt)
WO (1) WO2013136186A2 (pt)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2592271T3 (es) 2005-03-31 2016-11-29 Chugai Seiyaku Kabushiki Kaisha Métodos de producción de polipéptidos mediante la regulación de la asociación de los polipéptidos
DK3056568T3 (da) 2006-03-31 2021-11-01 Chugai Pharmaceutical Co Ltd Fremgangsmåder til kontrollering af antistoffers blodfarmakokinetik
US9670269B2 (en) 2006-03-31 2017-06-06 Chugai Seiyaku Kabushiki Kaisha Methods of modifying antibodies for purification of bispecific antibodies
CN101874041B (zh) 2007-09-26 2013-06-19 中外制药株式会社 抗体恒定区修饰体
CN101874042B9 (zh) 2007-09-26 2019-01-01 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
EP2543730B1 (en) 2010-03-04 2018-10-31 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
KR102099580B1 (ko) 2010-11-17 2020-04-10 추가이 세이야쿠 가부시키가이샤 혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자
WO2012073985A1 (ja) 2010-11-30 2012-06-07 中外製薬株式会社 細胞傷害誘導治療剤
EP3401337A1 (en) 2012-09-25 2018-11-14 Glenmark Pharmaceuticals S.A. Purification of hetero-dimeric immunoglobulins
WO2015033223A2 (en) * 2013-09-03 2015-03-12 Novimmune S.A. Readily isolated bispecific binding molecules with native format having mutated constant regions
AU2014325063B2 (en) 2013-09-27 2019-10-31 Chugai Seiyaku Kabushiki Kaisha Method for producing polypeptide heteromultimer
GB201411420D0 (en) * 2014-06-26 2014-08-13 Ucb Biopharma Sprl Antibody constructs
AR101262A1 (es) * 2014-07-26 2016-12-07 Regeneron Pharma Plataforma de purificación para anticuerpos biespecíficos
GB201414823D0 (en) 2014-08-20 2014-10-01 Argen X Bv Multispecific antibodies
WO2016159213A1 (ja) 2015-04-01 2016-10-06 中外製薬株式会社 ポリペプチド異種多量体の製造方法
JP6962819B2 (ja) 2015-04-10 2021-11-05 アディマブ， エルエルシー 親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法
PL3294775T3 (pl) 2015-05-12 2021-12-13 Regeneron Pharmaceuticals, Inc. Oznaczanie czystości białka multimerycznego
WO2017005649A1 (en) 2015-07-09 2017-01-12 Genmab A/S Bispecific and multispecific antibodies and method for isolation of such
KR20180091918A (ko) * 2015-12-28 2018-08-16 추가이 세이야쿠 가부시키가이샤 Fc 영역 함유 폴리펩타이드의 정제를 효율화하기 위한 방법
US11291721B2 (en) 2016-03-21 2022-04-05 Marengo Therapeutics, Inc. Multispecific and multifunctional molecules and uses thereof
WO2018151820A1 (en) 2017-02-16 2018-08-23 Elstar Therapeutics, Inc. Multifunctional molecules comprising a trimeric ligand and uses thereof
WO2018212556A1 (en) * 2017-05-16 2018-11-22 Cj Healthcare Corporation A method for purifying an antibody or an antibody fragment thereof using affinity chromatography
JP2020522254A (ja) 2017-05-31 2020-07-30 エルスター セラピューティクス， インコーポレイテッド 骨髄増殖性白血病（ｍｐｌ）タンパク質に結合する多特異性分子およびその使用
EP3634486A4 (en) * 2017-06-05 2021-03-31 Janssen Biotech, Inc. GENETICALLY PRODUCED MULTISPECIFIC ANTIBODIES AND OTHER MULTIMERIC PROTEINS WITH ASYMMETRIC MUTATIONS OF THE CH2-CH3 REGION
WO2019035938A1 (en) 2017-08-16 2019-02-21 Elstar Therapeutics, Inc. MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF
MX2020004561A (es) * 2017-11-02 2020-08-13 Bayer Ag Anticuerpos biespecificos que se unen a alk-1 y bmpr-2.
CN111448217A (zh) 2017-12-22 2020-07-24 阿根思公司 双特异性抗原结合构建体
GB201802487D0 (en) 2018-02-15 2018-04-04 Argenx Bvba Cytokine combination therapy
US20210238280A1 (en) 2018-03-14 2021-08-05 Elstar Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
US20210009711A1 (en) 2018-03-14 2021-01-14 Elstar Therapeutics, Inc. Multifunctional molecules and uses thereof
CA3104390A1 (en) 2018-06-22 2019-12-26 Genmab A/S Method for producing a controlled mixture of two or more different antibodies
US11845797B2 (en) 2018-07-03 2023-12-19 Marengo Therapeutics, Inc. Anti-TCR antibody molecules and uses thereof
CA3113057A1 (en) * 2018-09-21 2020-03-26 Teneobio, Inc. Methods for purifying heterodimeric, multispecific antibodies
EP3902825A1 (en) 2018-12-24 2021-11-03 Sanofi Pseudofab-based multispecific binding proteins
GB2597851B (en) 2019-02-21 2024-05-29 Marengo Therapeutics Inc Antibody molecules that bind to NKP30 and uses thereof
JP2022523197A (ja) 2019-02-21 2022-04-21 マレンゴ・セラピューティクス，インコーポレーテッド Ｔ細胞関連のがん細胞に結合する多機能性分子およびその使用
JP2022521750A (ja) 2019-02-21 2022-04-12 マレンゴ・セラピューティクス，インコーポレーテッド カルレティキュリンに結合する多機能性分子およびその使用
GB2599227B (en) 2019-02-21 2024-05-01 Marengo Therapeutics Inc Multifunctional molecules that bind to T cells and uses thereof to treat autoimmune disorders
JP2022521751A (ja) 2019-02-21 2022-04-12 マレンゴ・セラピューティクス，インコーポレーテッド 抗ｔｃｒ抗体分子およびその使用
WO2021138407A2 (en) 2020-01-03 2021-07-08 Marengo Therapeutics, Inc. Multifunctional molecules that bind to cd33 and uses thereof
BR112022018452A2 (pt) 2020-03-25 2022-11-01 Lilly Co Eli Proteínas de ligação multiespecíficas e métodos de desenvolvimento das mesmas
AU2021261420A1 (en) 2020-04-24 2022-12-01 Marengo Therapeutics, Inc. Multifunctional molecules that bind to T cell related cancer cells and uses thereof
JP2023540248A (ja) 2020-08-26 2023-09-22 マレンゴ・セラピューティクス，インコーポレーテッド Ｔｒｂｃ１またはｔｒｂｃ２を検出する方法
EP4204096A2 (en) 2020-08-26 2023-07-05 Marengo Therapeutics, Inc. Antibody molecules that bind to nkp30 and uses thereof
EP4204450A2 (en) 2020-08-26 2023-07-05 Marengo Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
CN117597359A (zh) 2021-04-08 2024-02-23 马伦戈治疗公司 与tcr结合的多功能分子及其用途
US20240209100A1 (en) 2022-10-21 2024-06-27 Diagonal Therapeutics Inc. Heteromeric agonistic antibodies to il-18 receptor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020062010A1 (en) 1997-05-02 2002-05-23 Genentech, Inc. Method for making multispecific antibodies having heteromultimeric and common components
BR0110610A (pt) * 2000-04-11 2003-04-29 Genentech Inc Anticorpos isolados, imunoconjugados, cadeias de polipeptìdeos, ácido nucléico isolado, vetor, célula hospedeira, processo de produção de anticorpo ou cadeia de polipeptìdeos, método de tratamento de disfunções em mamìferos, método de indução da apoptose de uma célula cancerosa, método para matar uma célula b, método para matar uma célula que expresse um receptor de erbb e usos dos anticorpos isolados
EP3272770B1 (en) 2004-07-22 2023-12-20 Erasmus University Medical Center Rotterdam Method for the production of a vh heavy chain-only antibody in a transgenic mammal and binding polypeptide complex consisting of a dimer of a first chain and a second chain wherein each chain consists of two antigen-specific vh binding domains linked by a dimerisation domain
EP2035456A1 (en) * 2006-06-22 2009-03-18 Novo Nordisk A/S Production of bispecific antibodies
EP2143345A1 (en) * 2008-07-09 2010-01-13 Reemtsma Cigarettenfabriken GmbH Cigarette paper
KR20120027055A (ko) 2009-06-26 2012-03-20 리제네론 파라마큐티칼스 인코포레이티드 천연 면역글로불린 포맷을 가지는 용이하게 분리된 이중특이성 항체

Also Published As

Publication number Publication date
EP2825559A2 (en) 2015-01-21
US10494446B2 (en) 2019-12-03
AU2017279804A1 (en) 2018-01-25
WO2013136186A2 (en) 2013-09-19
US9815909B2 (en) 2017-11-14
CA2867020C (en) 2022-11-15
CA2867020A1 (en) 2013-09-19
DK2825559T3 (da) 2019-06-03
EP3517548A1 (en) 2019-07-31
EP2825559B1 (en) 2019-02-27
US20200231707A1 (en) 2020-07-23
AU2013234039A1 (en) 2014-09-25
US20180057611A1 (en) 2018-03-01
JP2021091701A (ja) 2021-06-17
JP2018083829A (ja) 2018-05-31
US20140051833A1 (en) 2014-02-20
JP2015510764A (ja) 2015-04-13
WO2013136186A3 (en) 2014-01-23
JP6273219B2 (ja) 2018-01-31
AU2013234039B2 (en) 2018-02-01
ES2728301T3 (es) 2019-10-23
AU2017279804B2 (en) 2020-03-12

Similar Documents

Publication Publication Date Title
PT2825559T (pt) Anticorpos biespecíficos prontamente isolados com formato de imunoglobulina nativo
HUS2400016I1 (hu) FCRN elleni antitestek
HRP20181717T1 (hr) Bispecifična igg protutijela kao aktivatori t stanice
HK1210620A1 (en) Multi-specific monoclonal antibodies
HK1210027A1 (en) Anti-human b7-h4 antibodies and their uses b7-h4
HK1204571A1 (en) Protease-regulated antibodies
IL235397B (en) Antibodies specific for cll-1
HK1210192A1 (en) Anti-siglec-15 antibodies siglec-15
EP3083698A4 (en) Monoclonal anti-tk1 antibodies
IL235059A0 (en) Anti–il–23p19 antibodies
EP2844290A4 (en) NOVEL ANTIBODIES
ZA201407272B (en) Anti-baff-anti-il-17 bispecific antibodies
HK1210186A1 (en) Anti-h7cr antibodies h7cr
EP3088519A4 (en) Novel anti-human bdca-2 antibody
HK1202454A1 (en) Anti-p-selectin antibody formulation -p-
EP2804876A4 (en) NEW ANTIBODIES
IL235188A0 (en) Antibodies against c-pdgf